切向流过滤固定器和系统
得益于我们在切向流过滤（TFF）方面领先的生物工艺知识和工程专长，我们开发出了多用途、单用途和工艺开发系统，其中包含许多独特、创新和智能的功能。我们的系统旨在满足切向流过滤净化的成功标准，包括低滞留量、最大体积浓度和最佳产品回收，以提高工艺性能。
部分概述
Products
过程规模一次性使用 TFF 系统
我们的 Mobius® FlexReady 解决方案适用于 TFF 和 Mobius® TFF 80 系统。 TFF 80 系统提供一次性使用的 Flexware® 组件和硬件组合，专门用于高效浓缩和重过滤蛋白质。我们的一次性 TFF 系统可安装的过滤面积从 0.5 到 20 平方米不等，流量范围从 2 到 80 升/分钟不等，罐体大小从 50 到 500 升不等，能满足您从临床前到生产规模的各种工艺需求。通过专门设计的流路和设备，可实现封闭式操作，从而降低污染风险，保护操作人员，同时提高灵活性和效率。该系列设备具有以下特点：
- 临床到大规模能力，质量不打折扣
- 优化产量和产品回收的设计
- 多产品和多处理模式
- 全自动化，用户友好
工艺开发 TFF 系统
我们的 Cogent® 实验室系统系列采用了与我们的制造级设备类似的设计、传感技术和附件。我们的系统采用同质设计，流量范围从 20 到 6000 mL/min，专门用于简化工艺开发。Cogent® Lab 150、800 和 6000 系统经过优化，具有较高的产品回收率和排水性，可确保小规模 TFF 操作的成功。
- One family of TFF systems with harmonized design and linear performance ensures successful and seamless scale-up or scale-down
- User-friendly Bio4C® Control Software offers pre-defined recipe steps, real-time data visualization and export capabilities assuring reliable and reproducible results
- Cogent® Lab systems can be tailored to your specific process with an extensive list of options
- Flexibly operates in UF/DF, microfiltration or SPTFF mode and across a wide range of parameters
用于 Pellicon® 平板设备的夹持器
我们的系统最适合与 Pellicon® 一次性使用（Pellicon® 胶囊）或多次使用（Pellicon® 2sup>® 一次性（Pellicon® Capsule）或多次使用（Pellicon® 2 和 3）消耗品。购买 TFF 系统时可能会附带支架；详情请参考相应的数据表。根据消耗品的不同，我们提供过滤面积从 88 cm² 到 130 m² 的独立支架。
- XX42PMICR0 用于 Pellicon® 3 micro 的支架，过滤面积从 88 cm² 到 264 cm²
- XX42PMINI 用于 Pellicon® 2 和 3 micro 的支架，过滤面积从 0.1 m² 至 0.55 m²
- Pellicon® 工艺栅尺支架，用于 Pellicon® 2 和 3 从 0.5 m² 及以上
可提供增加安装表面和以单程模式运行的选项。
相关资源
- Data Sheet: Mobius® TFF 80 System
Single-use Tangential Flow Filtration Solution that offers flexible operating modes and is designed for large-scale processing.
- Performance Guide: Mobius® TFF 80 System
This guide includes information from a number of applications and case studies that were designed and/or selected to provide a diverse overview of the system performance under a range of expected processing conditions.
- Spare Parts List: Mobius® TFF 80 System
To help you select and manage the spare parts required for your system, our experts have performed a risk assessment to determine which parts to keep in stock. The risk assessment is based on our experience; each customer must perform their individual risk assessment for their process, to check the alignment with our strategy and review the stock requirements accordingly.
- Data Sheet: Mobius® FlexReady Solution for TFF
The Mobius® FlexReady Solution with Smart Flexware® Assemblies is flexible, allowing you to have a single system for tangential flow filtration (TFF) at various scales.
- Performance Guide: Mobius® FlexReady Solution (TF2S) with Smart Flexware® Assemblies for TFF with Closed Enabled Configuration
This Performance Guide is a reference document that provides highlights of key performance aspects of the Mobius® FlexReady Solution with Smart Flexware® Assemblies for Tangential Flow Filtration (TFF) used with a closed-enabled flowpath.
- Spec. Sheet: Mobius® FlexReady Solution with Smart Flexware® Assemblies for TFF
Flexible design options; Unique feed tank design and performance; Smart Flexware® full single-use flow paths; Excellent product recovery and purification; Implement with ease and lower risks; Full process automation with flexible recipes using the Common Control Platform® (CCP®)
- Spare Parts List: Mobius® FlexReady Solution
To help you select and manage the spare parts required for your system, our experts have performed a risk assessment to determine which parts to keep in stock. The risk assessment is based on our experience; each customer must perform their individual risk assessment for their process, to check the alignment with our strategy and review the stock requirements accordingly.
- Data Sheet: Cogent® Process-scale Tangential Flow Filtration System
Fully automated, configurable systems for biopharmaceutical manufacturing and cGMP process scale applications
- Data Sheet: Cogent® Lab Systems
A family of modular and flexible systems for TFF at process development scale
- Spare Parts List: Cogent® Lab Systems
To help you select and manage the spare parts required for your system, our experts have performed a risk assessment to determine which parts to keep in stock.
- Application Note: Running a TFF optimization study with Cogent® Lab Systems and Bio4C® Control Software
This application note describes the recommended methods and techniques for optimizing a tangential flow filtration (TFF) process using a Cogent® Lab system.
- Brochure: Process Development and Drug Manufacturing: Support Services
We provide comprehensive services for drug development and manufacturing, including technical and regulatory expertise and process development support.
- Application Note: Closed Tangential Flow Filtration Processing at Benchtop Scale with Mobius® Assemblies
Mobius® assemblies offer a customizable, closed processing option for tangential flow filtration (TFF) operations.
相关网络研讨会
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