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The HLA-B gene and Hashimoto disease in Han Chinese children: a case-control and family-based study.
C-Y Huang et al.
Tissue antigens, 80(5), 431-436 (2012-10-02)
Hashimoto disease (HD) is an autoimmune thyroid disease resulting from complex interactions between genetic and environmental factors. The human leukocyte antigen (HLA) gene has been established to be involved in the susceptibility to HD. We aim to investigate the associations
Nasrien E Ibrahim et al.
Journal of the American College of Cardiology, 73(11), 1273-1284 (2019-03-23)
With sacubitril/valsartan treatment, B-type natriuretic peptide (BNP) concentrations increase; it remains unclear whether change in BNP concentrations is similar across all assays for its measurement. Effects of sacubitril/valsartan on atrial natriuretic peptide (ANP) concentrations in patients are unknown. Lastly, the
Kenneth Offit et al.
BMC medical genetics, 4, 1-1 (2003-01-17)
The 1100delC CHEK2 allele has been associated with a 1.4-4.7 fold increased risk for breast cancer in women carrying this mutation. While the frequency of 1100delC was 1.1-1.4% in healthy Finnish controls, the frequency of this allele in a North
Qinglong Li et al.
Journal of experimental & clinical cancer research : CR, 28, 65-65 (2009-05-19)
An increasing number of studies have shown that ERK and PI3-K/AKT signaling pathways are involved in various human cancers including hepatocellular carcinoma and cholangiocarcinoma. However, few studies have examined gallbladder cancer specimens, and little is known about the clinical and
M DesGroseilliers et al.
Cytogenetic and genome research, 112(1-2), 176-179 (2005-11-09)
Sex reversal is characterized by discordance between genetic and phenotypic sex. Most XX males result from an unequal interchange between X and Y chromosomes during paternal meiosis, therefore transferring SRY to the X chromosome, which explains the male development in
Seong Hyun Jeong et al.
Japanese journal of clinical oncology, 38(10), 661-669 (2008-09-06)
The present study evaluated the prognostic significance of apoptosis-related proteins p53, Bax and galectin-3 in patients with non-small cell lung cancer (NSCLC) treated with surgical resection. We investigated the expression of these proteins and their association with clinicopathologic characteristics including
L Grande Posa et al.
Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva, 83(4), 229-234 (1993-04-01)
The effect of postprandial administration of a new formulation of almagate (1.5 g, po) or an association of alginate + antacid (2.4 g, po) on gastric alkalinization and gastroesophageal reflux were assessed in a randomized, single-blind, cross-over study in 21
C F Holmes et al.
European journal of biochemistry, 155(1), 173-182 (1986-02-17)
The complete primary structure of inhibitor-2, a specific inhibitor of protein phosphatase-1, has been determined. The protein consists of a single polypeptide chain of 203 residues, and has a relative molecular mass of 22835 Da. This molecular mass is significantly
J Wang et al.
Poultry science, 91(9), 2221-2228 (2012-08-23)
To evaluate the effect of flavin-containing monooxygenase 3 (FMO3) genotype and dietary choline supplementation on trimethylamine (TMA) metabolism in HyLine Brown laying hens, a 3 × 2 two-factorial arrangement was employed with FMO3 genotypes (AA, AT, and TT) and dietary
Oxaliplatin-based chemotherapy in patients aged 75 years or older with metastatic colorectal cancer.
Minoru Fukuchi et al.
Anticancer research, 33(10), 4627-4630 (2013-10-15)
To evaluate the tolerability and efficacy of oxaliplatin-based chemotherapy (OBC) in patients ≥ 75 years old with metastatic colorectal cancer (CRC). We reviewed the medical records of 126 patients with unresectable stage IV CRC in terms of OBC administered as
J Falandysz et al.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 40(9), 1665-1678 (2005-09-02)
Aroclor 1268, Chlorofen, and Clophen T 64 technical chlorobiphenyl formulations were examined for 75 congeners of chlorodibenzo-p-dioxin (CDD) and 135 congeners of chlorodibenzofuran (CDF) using isotope dilution technique, separation, and enrichment on silica gel impregnated with activated carbon and final
Kadriye Altok Reis et al.
Renal failure, 33(5), 469-474 (2011-04-20)
Diabetic nephropathy (DN) is a leading cause of diabetes-related morbidity and mortality. The aim of this study was to evaluate the relationship of AGT M235T and apoprotein E (APO E) gene polymorphism with DN in Turkish patients of Type 2
Ajmal Gardiwal et al.
Journal of cardiac failure, 13(8), 687-693 (2007-10-10)
Mice with a knockout (KO) of muscle LIM protein (MLP) exhibit many morphologic and clinical features of human cardiomyopathy. In humans, MLP-expression is downregulated both in ischemic and dilative cardiomyopathy. In this study, we investigated the effects of MLP on
Sandra S Wise et al.
Toxicology and applied pharmacology, 279(2), 113-118 (2014-06-22)
Sea turtles are a charismatic and ancient ocean species and can serve as key indicators for ocean ecosystems, including coral reefs and sea grass beds as well as coastal beaches. Genotoxicity studies in the species are absent, limiting our understanding
Necip Ilhan et al.
Cell biochemistry and function, 25(5), 527-532 (2006-08-26)
Type 2 diabetes causes premature morbidity and mortality due to the complications of atherosclerosis and diabetic nephropathy (DN). Polymorphism of Apo E gene is known to influence lipid metabolism. Apo E is polymorphic, consisting of three common isoforms (epsilon2, epsilon3
Ihn Suk Lee et al.
Journal of Korean medical science, 25(9), 1379-1383 (2010-09-03)
Glucocorticoid-remediable aldosteronism (GRA) is an autosomal-dominant inheritable form of hyperaldosteronism with early onset hypertension. GRA is caused by unequal crossing-over of the steroid 11 beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) genes. As a result of chimeric gene duplication, aldosterone is
Eman Mosad et al.
Oncology, 83(3), 128-134 (2012-07-21)
Therapy-related acute myeloid leukemias (t-AML), with balanced translocations affecting the 11q23 point in the myeloid/lymphoid leukemia (MLL) gene, are one of the most serious complications of treatments with topoisomerase II inhibitors. However, only a few reports of t-AML exist. We
Judith Conroy et al.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 150B(4), 535-544 (2008-10-11)
Autism (OMIM %209850) is a neurodevelopmental disorder with a strong genetic component. We previously reported a de novo rearrangement of chromosome 2q31 in a patient with autism [Gallagher et al. (2003); J Autism Dev Disord 33(1):105-108]. Further cytogenetic analysis revealed
Keith S Kaye et al.
Scandinavian journal of infectious diseases, 44(12), 948-955 (2012-07-27)
Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of invasive surgical site infection (SSI) in the USA. Antimicrobial prophylaxis for SSI typically includes a cephalosporin. Vancomycin is used to provide MRSA coverage, but the timing of administration is challenging. Linezolid
Silvia Fustinoni et al.
The Science of the total environment, 408(14), 2840-2849 (2010-04-27)
The aim of this work was to evaluate urinary benzene, toluene, ethylbenzene, m+p-xylene, o-xylene (BTEX), methyl tert-butyl ether (MTBE), ethyl tert-butyl ether (ETBE), and naphthalene (NAP) as biomarkers of exposure to environmental pollutants. Personal air and urine samples from 108
Jian Zou et al.
Calcified tissue international, 100(6), 551-564 (2017-03-02)
Our study explored the effects of SOST gene silencing on the proliferation, apoptosis, invasion, and migration of human osteosarcoma cells through Wnt/β-catenin signaling pathway. Fresh tissues were obtained from 108 patients with osteosarcoma and 46 patients with osteochondroma. Human osteosarcoma
Angela García et al.
Anatomical record (Hoboken, N.J. : 2007), 295(5), 776-785 (2012-02-23)
This study sought to chart the ontogenesis of the goat rumen by histomorphometric examination, scanning electron microscopy and immunohistochemical analysis. A total of 140 goat embryos and fetuses were used, from the first stage of prenatal life until birth. The
Wai-Kay Seto et al.
PloS one, 7(2), e32622-e32622 (2012-03-06)
We determined the association between various clinical parameters and significant liver injury in both hepatitis B e antigen (HBeAg)-positive and HBeAg-negative patients. From 1994 to 2008, liver biopsy was performed on 319 treatment-naïve CHB patients. Histologic assessment was based on
Carmen Fiuza-Luces et al.
PloS one, 6(3), e17558-e17558 (2011-03-17)
Exercise phenotypes have played a key role for ensuring survival over human evolution. We speculated that some genetic variants that influence exercise phenotypes could be associated with exceptional survival (i.e. reaching ≥100 years of age). Owing to its effects on
Seok Won Jung et al.
Journal of hepatology, 57(3), 621-627 (2012-06-05)
We aimed at determining whether single nucleotide polymorphisms (SNPs) of DNA repair genes influence the development and clinical outcomes of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). We evaluated 14 SNPs of eight DNA repair genes in 708 patients with
Julie A Sloniger et al.
American journal of physiology. Endocrinology and metabolism, 288(6), E1074-E1081 (2005-01-20)
Essential hypertension is frequently associated with insulin resistance of skeletal muscle glucose transport, with a potential role of angiotensin II in the pathogenesis of both conditions. The male heterozygous TG(mREN2)27 rat harbors the mouse transgene for renin, exhibits local elevations
Arithat Limsatanun et al.
Avian diseases, 60(4), 799-804 (2016-12-03)
Mycoplasma gallisepticum (MG) is one of the major pathogens that cause respiratory signs in the poultry industry. To control MG infection, vaccination is the useful procedure. In this study, MG vaccine was developed by using the local Thai MG isolate
Naoko Kato et al.
Journal of cellular biochemistry, 97(2), 368-379 (2005-09-28)
Lipopolysaccharide (LPS) is a major mediator of inflammatory responses in periodontal disease that inhibits bone formation and stimulates bone resorption. To determine the molecular mechanisms involved in the suppression of bone formation, we have analyzed the effects of LPS on
Yongmei Chen et al.
Frontiers in bioscience : a journal and virtual library, 11, 3121-3128 (2006-05-25)
Brain arteriovenous malformations (BAVM) have high matrix metalloproteinase-9 (MMP-9) expression, the source of which is unclear. We hypothesized MMP-9 production might be due to inflammation in BAVM. Compared to control brain tissues (n = 5), BAVM tissue (n = 139)
J Laco et al.
Neoplasma, 65(1), 113-123 (2018-01-13)
The aim of this study was a detailed clinicopathological investigation of sinonasal NUT midline carcinoma (NMC), including analysis of DNA methylation and microRNA (miRNA) expression. Three (5%) cases of NMC were detected among 56 sinonasal carcinomas using immunohistochemical screening and
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