120-36-5

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Hyperimmune Bovine Colostral Anti-CS17 Antibodies Protect Against Enterotoxigenic Escherichia coli Diarrhea in a Randomized, Doubled-Blind, Placebo-Controlled Human Infection Model.

Stephen J Savarino et al.

The Journal of infectious diseases, 220(3), 505-513 (2019-03-22)

Enterotoxigenic Escherichia coli (ETEC) commonly cause diarrhea in children living in developing countries and in travelers to those regions. ETEC are characterized by colonization factors (CFs) that mediate intestinal adherence. We assessed if bovine colostral IgG (bIgG) antibodies against a

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18-59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial.

Yanjun Zhang et al.

The Lancet. Infectious diseases, 21(2), 181-192 (2020-11-21)

With the unprecedented morbidity and mortality associated with the COVID-19 pandemic, a vaccine against COVID-19 is urgently needed. We investigated CoronaVac (Sinovac Life Sciences, Beijing, China), an inactivated vaccine candidate against COVID-19, containing inactivated severe acute respiratory syndrome coronavirus 2

Sildenafil stimulates aqueous humor turnover in rabbits.

Lawrence J Alvarez et al.

Experimental eye research, 111, 67-70 (2013-04-09)

Sildenafil citrate increases ocular blood flow and accelerates the rate of anterior chamber refilling after paracentesis. The latter effect could have resulted from a reduction in outflow facility or from an increase in aqueous humor (AH) production. In this study

Successful reversal of life threatening cardiac effect following dosulepin overdose using intravenous lipid emulsion.

Soeren Boegevig et al.

Clinical toxicology (Philadelphia, Pa.), 49(4), 337-339 (2011-05-14)

CONTEXT. We report a successful acute reversal of potential life threatening QRS complex widening and prolonged QT interval following dosulepin overdose using intravenous lipid emulsion 20% in an unstable patient. CASE DETAILS. A 36-year-old female following the ingestion of 5.25 g of

The predicted coiled-coil domain of myosin 10 forms a novel elongated domain that lengthens the head.

Peter J Knight et al.

The Journal of biological chemistry, 280(41), 34702-34708 (2005-07-21)

Myosin 10 contains a region of predicted coiled coil 120 residues long. However, the highly charged nature and pattern of charges in the proximal 36 residues appear incompatible with coiled-coil formation. Circular dichroism, NMR, and analytical ultracentrifugation show that a

Development and validation of a sensitive method for alkyl sulfonate genotoxic impurities determination in drug substances using gas chromatography coupled to triple quadrupole mass spectrometry.

Zhen Liu et al.

Journal of pharmaceutical and biomedical analysis, 168, 23-29 (2019-02-21)

Alkyl sulfonate esters have been widely concerned as genotoxic impurities (GTIs). A gas chromatography triple-quadrupole mass spectrometry (GC-MS/MS) method has been developed for trace determination of 9 commonly encountered sulfonate esters in drug substances. Three different solvents of acetonitrile (ACN)

Ank3 (epithelial ankyrin), a widely distributed new member of the ankyrin gene family and the major ankyrin in kidney, is expressed in alternatively spliced forms, including forms that lack the repeat domain.

L L Peters et al.

The Journal of cell biology, 130(2), 313-330 (1995-07-01)

We cloned a novel ankyrin, Ank3, from mouse kidney cDNA. The full-length transcript is predicted to encode a 214-kD protein containing an 89 kD, NH2 terminal "repeat" domain; a 65 kD, central "spectrin-binding" domain; and a 56 kD, COOH-terminal "regulatory"

Multidetector CT measurement of myocardial extracellular volume in acute patchy and contiguous infarction: validation with microscopic measurement.

Robert Jablonowski et al.

Radiology, 274(2), 370-378 (2014-09-24)

To provide proof of concept that expansion of myocardial extracellular volume (MECV), measured at contrast material-enhanced multidetector computed tomography (CT), can be used as a (a) marker for viability based on histologic confirmation and (b) predictor of severity of myocardial

Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia.

Masaya Tanno et al.

Circulation research, 93(3), 254-261 (2003-06-28)

The ischemic activation of p38alpha mitogen-activated protein kinase (p38alpha-MAPK) is thought to contribute to myocardial injury. Under other circumstances, activation is through dual phosphorylation by MAPK kinase 3 (MKK3). Therefore, the mkk3-/- murine heart should be protected during ischemia. In

Polymorphism of the uteroglobin gene in systemic lupus erythematosus and IgA nephropathy.

Elisa Menegatti et al.

Laboratory investigation; a journal of technical methods and pathology, 82(5), 543-546 (2002-05-11)

Uteroglobin (UG) is a multifunctional protein with anti-inflammatory/immunomodulatory properties. The UG gene is located on the long arm of chromosome 11 (11q12.3-q13.1) in a region linked to some immune disorders. A guanine-adenine substitution at position 38 (A38G) has been found

Somatostatin receptors in Neuro2A neuroblastoma cells: operational characteristics.

J A Koenig et al.

British journal of pharmacology, 120(1), 45-51 (1997-01-01)

1. We have used somatostatin (SRIF) receptor subtype-selective ligands to determine some of the operational characteristics of somatostatin receptors in Neuro2A mouse neuroblastoma cells. The potent SRIF1-receptor selective ligand, BIM-23027, was able to displace completely the specific binding of radioiodinated

De novo CD5+ diffuse large B-cell lymphoma: results of a detailed clinicopathological review in 120 patients.

Motoko Yamaguchi et al.

Haematologica, 93(8), 1195-1202 (2008-06-17)

De novo CD5-positive diffuse large B-cell lymphoma (CD5(+) DLBCL) is clinicopathologically and genetically distinct from CD5-negative (CD5(-)) DLBCL and mantle cell lymphoma. The aim of this retrospective study was to clarify the histopathological spectrum and obtain new information on the

Performing Reliable Lens Capsulotomy in the Presence of Corneal Edema With a Femtosecond Laser.

Geraint P Williams et al.

Investigative ophthalmology & visual science, 58(11), 4490-4498 (2017-09-06)

To determine the effects of the Ziemer LDV Z8 liquid interface femtosecond laser platform during capsulotomy under different energy settings in the presence of corneal edema. Cadaveric porcine eyes (n = 36) employed at less than 6 and greater than

Markers of blood coagulation and fibrinolysis in patients with early and delayed microsurgical reconstructions in the lower extremities.

Oliver Kloeters et al.

Journal of plastic surgery and hand surgery, 51(6), 420-426 (2017-03-21)

In this study, markers of coagulation and fibrinolysis were assessed during early and delayed microsurgical reconstruction in patients with traumatic defects of their lower legs to analyse whether an imbalance of the hemostasis after trauma might predispose the development of

Application of the extraction induced by emulsion breaking for the determination of chromium and manganese in edible oils by electrothermal atomic absorption spectrometry.

Nicolle F Robaina et al.

Talanta, 99, 104-112 (2012-09-13)

This work reports the optimization of a method, based on the extraction induced by emulsion breaking, for the determination of trace concentrations of Cr and Mn in edible oils by electrothermal atomic absorption spectrometry (ETAAS). In the method, a water-in-oil

Spectrum of USH2A mutations in Scandinavian patients with Usher syndrome type II.

Bo Dreyer et al.

Human mutation, 29(3), 451-451 (2008-02-15)

Usher syndrome type II (USH2) is an autosomal recessive disorder, characterised by moderate to severe high-frequency hearing impairment, normal balance function and progressive visual impairment due to retinitis pigmentosa. Usher syndrome type IIa, the most common subtype, is defined by

Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices.

T Almeida et al.

Neuroscience, 122(1), 111-121 (2003-11-05)

Electrophysiological recordings were used to investigate the effects of ATP analogues on theta-burst-induced long-term potentiation (LTP) in rat hippocampal slices. alpha,beta-Methylene ATP (alpha,beta-MeATP; 20 microM) decreased LTP from 36+/-9% to 17+/-5%, an effect prevented by adenosine A(1) receptor blockade in

The effect of toothbrushing on surface gloss of resin composites.

Dorien Lefever et al.

American journal of dentistry, 25(1), 54-58 (2012-05-09)

To determine the changes in surface gloss of different composite materials after laboratory toothbrushing simulation. 36 specimens were fabricated for each material and polished with 120-, 220-, 500-, 1200-, 2400- and 4000-grit SiC abrasive paper, respectively. Gloss measurements were made

Molecular cloning and ultrastructural localization of the core protein of an eggshell matrix proteoglycan, ovocleidin-116.

M T Hincke et al.

The Journal of biological chemistry, 274(46), 32915-32923 (1999-11-07)

The role of avian eggshell matrix proteins in shell formation is poorly understood. This calcitic biomaterial forms in a uterine fluid where the protein composition varies during the initial, calcification, and terminal phases of eggshell deposition. A specific antibody was

Effect of 2,3-butanedione monoxime on force of contraction and protein phosphorylation in bovine smooth muscle.

R Waurick et al.

Naunyn-Schmiedeberg's archives of pharmacology, 359(6), 484-492 (1999-08-04)

The aim of the study was to investigate the effects of the putative protein phosphatase (PP) activator 2,3-butanedione monoxime (BDM) in vascular smooth muscle. BDM concentration-dependently increased PP activity in homogenates of bovine coronary arteries and led to dephosphorylation of

Appropriate Neck Ultrasonography Surveillance During the First 10 Years After Hemithyroidectomy in Papillary Thyroid Microcarcinoma Patients: A Single-Center Study.

Yun Seok Choi et al.

Ultrasound quarterly, 35(3), 275-280 (2019-02-23)

This study aimed to assess the prevalence of tumor recurrence/persistence and determine the appropriate frequency and interval of follow-up neck ultrasonography (US) in papillary thyroid microcarcinoma (PTMC) patients who underwent hemithyroidectomy and long-term follow-up US. From January 2005 to December

Paneth cells expand from newly created and preexisting cells during repair after doxorubicin-induced damage.

Stephanie L King et al.

American journal of physiology. Gastrointestinal and liver physiology, 305(2), G151-G162 (2013-05-11)

Paneth cell numbers increase following intestinal damage, but mechanisms driving this process are not understood. We hypothesized that the increase in Paneth cell numbers is due to recruitment of cells from a preexisting pool of secretory progenitors. Mice were given

Human intestinal epithelial cells secrete interleukin-1 receptor antagonist and interleukin-8 but not interleukin-1 or interleukin-6.

R Daig et al.

Gut, 46(3), 350-358 (2000-02-15)

There is growing evidence that intestinal epithelial cells (IECs) are involved in the mucosal immune system. To assess the pattern of cytokines secreted by IECs and lamina propria mononuclear cells (LPMNCs). To achieve this, the expression and secretion of interleukin

Roles of vasoconstrictor prostaglandins, COX-1 and -2, and AT1, AT2, and TP receptors in a rat model of early 2K,1C hypertension.

William J Welch et al.

American journal of physiology. Heart and circulatory physiology, 293(5), H2644-H2649 (2007-09-04)

Angiotensin (ANG) II activating type 1 receptors (AT(1)Rs) enhances superoxide anion (O(2)*(-)) and arachidonate (AA) formation. AA is metabolized by cyclooxygenases (COXs) to PGH(2), which is metabolized by thromboxane (Tx)A(2) synthase to TxA(2) or oxidized to 8-isoprostane PGF(2alpha) (8-Iso) by

Dosage finding for low-dose spinal anaesthesia using hyperbaric prilocaine in patients undergoing perianal outpatient surgery.

V Gebhardt et al.

Acta anaesthesiologica Scandinavica, 57(2), 249-256 (2012-12-04)

Hyperbaric prilocaine 20 mg/ml may be preferable for perianal outpatient surgery. The aim of this prospective, single-centre, randomised, single-blinded, controlled clinical trial was to determine the optimal dosage of hyperbaric prilocaine 20 mg/ml for a spinal anaesthesia (SPA) in patients

Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5.

P Clement-Lacroix et al.

Osteoarthritis and cartilage, 30(2), 291-301 (2021-10-10)

A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is a key enzyme in degradation of cartilage in osteoarthritis (OA). We report the pharmacological characterization of GLPG1972/S201086, a new, potent and selective small-molecule ADAMTS5 inhibitor. Potency and selectivity of GLPG1972/S201086

Prevalence and risk factors associated with Clostridium difficile shedding in veal calves in Italy.

Chiara Francesca Magistrali et al.

Anaerobe, 33, 42-47 (2015-02-02)

The aim of this study is to describe the prevalence and risk factors of Clostridium difficile shedding in six farms belonging to two companies in Northern Italy. Four hundred and twenty veal calves, randomly selected and individually identified, were sampled

Vaginal Myomectomy Using the Dührssen (Longitudinal Median Cervical) Incision: A Case Series of 19 Patients.

Wai Yoong et al.

Journal of minimally invasive gynecology, 24(5), 811-814 (2017-04-16)

To examine demographics and outcome measures of women having undergone vaginal excision of myomas through the Dührssen (longitudinal median cervical) incision. Prospective case series (Canadian Task Force classification II-3). A London teaching hospital. Nineteen patients with either a submucous myoma

Reversible blockade of complex I or inhibition of PKCβ reduces activation and mitochondria translocation of p66Shc to preserve cardiac function after ischemia.

Meiying Yang et al.

PloS one, 9(12), e113534-e113534 (2014-12-02)

Excess mitochondrial reactive oxygen species (mROS) play a vital role in cardiac ischemia reperfusion (IR) injury. P66Shc, a splice variant of the ShcA adaptor protein family, enhances mROS production by oxidizing reduced cytochrome c to yield H2O2. Ablation of p66Shc

Multiresidue analysis of 88 polar organic micropollutants in ground, surface and wastewater using online mixed-bed multilayer solid-phase extraction coupled to high performance liquid chromatography-tandem mass spectrometry.

Sebastian Huntscha et al.

Journal of chromatography. A, 1268, 74-83 (2012-11-10)

An automated multiresidue method consisting of an online solid-phase extraction step coupled to a high performance liquid chromatography-tandem mass spectrometer (online-SPE-HPLC-MS/MS method) was developed for the determination of 88 polar organic micropollutants with a broad range of physicochemical properties (logD(OW)

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