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显示 1-30 共 374 条结果 关于 "184861" 范围 论文
Wen-Ting Hsiao et al.
Nutrition research and practice, 13(4), 286-294 (2019-08-08)
Docosahexaenoic acid (DHA), an n-3 long chain polyunsaturated fatty acid (LCPUFA), is acquired by dietary intake or the in vivo conversion of α-linolenic acid. Many enzymes participating in LCPUFA synthesis are regulated by peroxisome proliferator-activated receptor alpha (PPARα). Therefore, it
Yan Luo et al.
Toxicology and applied pharmacology, 403, 115159-115159 (2020-07-30)
Dihydroartemisinin (DHA) is an artemisinin derivative commonly used in malaria therapy, and a growing number of studies have focused on the potent anticancer activity of DHA. However, the reproductive toxicity of anticancer drugs is a major concern for young female
Yafei Duan et al.
The Science of the total environment, 754, 141867-141867 (2020-09-09)
Ammonia and thermal stress frequently have harmful effects on aquatic animals. The intestine is an important barrier allowing the body to defend against stress. In this study, we investigated the intestinal microbiota and transcriptomic and metabolomic responses of Litopenaeus vannamei
James R Petrie et al.
Frontiers in plant science, 11, 727-727 (2020-07-01)
Plant seeds have long been promoted as a production platform for novel fatty acids such as the ω3 long-chain (≥ C20) polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) commonly found in fish oil. In this article we
Shan Jiang et al.
Food research international (Ottawa, Ont.), 137, 109428-109428 (2020-11-26)
Previous studies have reported that phospholipids rich in n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) in the form of liposome exhibited superior bioactivities than other formulation. However, the digestion and absorption characteristics of n-3 LCPUFA-enriched phospholipids were still unclear, restricting
N A Wilson et al.
Prostaglandins, leukotrienes, and essential fatty acids, 152, 102037-102037 (2019-12-08)
Omega-3 DHA is important for the prevention of preterm birth, however there is limited knowledge of the determinants of omega-3 status during pregnancy. The primary objective of this systematic review was to synthesise data from existing studies assessing relationships between
Ken Arai et al.
Journal of atherosclerosis and thrombosis, 27(11), 1216-1229 (2020-07-01)
We evaluated the relationship between the ratios of eicosapentaenoic acid and arachidonic acid (EPA/AA), docosahexaenoic acid (DHA)/AA, and delta-5 desaturase activity (D5D) and atherogenic lipid profiles (ALP) and coronary atherosclerosis. Polyunsaturated fatty acids (PUFA) and ALP were assessed in 436
Xian-Ke Chen et al.
Applied and environmental microbiology, 86(11) (2020-04-05)
Acidophiles play a dominant role in driving elemental cycling in natural acid mine drainage (AMD) habitats and exhibit important application value in bioleaching and bioremediation. Acidity is an inevitable environmental stress and a key factor that affects the survival of
N Sáinz et al.
Food & function, 11(10), 9057-9066 (2020-10-07)
Chemerin is a pro-inflammatory adipokine that is increased in obesity and associated with obesity-related comorbidities. The aim of this study was to investigate the effects of omega-3 polyunsaturated fatty acids, eicosapentaenoic and docosahexaenoic acids (EPA and DHA), on basal and
Hai Zhang et al.
Frontiers in oncology, 10, 595466-595466 (2020-11-17)
Radiation resistance is linked to immune escaping and radiation sensitivity. In this study, we found that the PD-L1 expressions of non-killed tumor cells in NSCLC were enhanced after radiotherapy, and dihydroartemisinin (DHA) could synergistically enhance the antitumor effect of radiotherapy
Smitha Padmanabha et al.
Biochemical and biophysical research communications, 529(2), 425-431 (2020-07-25)
Loss of α-crystallin chaperone function results in the lens protein aggregation leading to cataract. In this study, we evaluated the efficacy of micellar lutein with different fatty acids in modulating α-crystallin chaperone function under selenite cataract conditions. Cataract was induced
Bofeng Wei et al.
Journal of chromatography. A, 1625, 461326-461326 (2020-07-28)
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are essential fatty acids for human body, which are widely used in the field of healthy food and medicine. Meanwhile, there are some differences in their physiological functions, such as "scavenger for blood
Lee Call et al.
Journal of lipid research, 61(7), 1038-1051 (2020-05-01)
Multi-component lipid emulsions, rather than soy-oil emulsions, prevent cholestasis by an unknown mechanism. Here, we quantified liver function, bile acid pools, and gut microbial and metabolite profiles in premature parenterally fed pigs given a soy-oil lipid emulsion, Intralipid (IL), a
Kaustubh Parashar et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(6), 7733-7744 (2020-04-12)
Our previous results showed that the specialized pro-resolving mediator (SPM) Resolvin D1 (RvD1) promotes resolution of inflammation in salivary glands in non-obese diabetic (NOD)/ShiLtJ, a mouse model for Sjögren's syndrome (SS). Additionally, mice lacking the RvD1 receptor ALX/FPR2 show defective
Tamara Hoppenbrouwers et al.
Frontiers in immunology, 11, 748-748 (2020-05-21)
Allergy is becoming a rapidly increasing problem worldwide, and in vitro models are frequently used to study the mechanisms behind the different types of allergic response. The dendritic cell (DC)-T-cell model can be used to study sensitization. However, lipopolysaccharide (LPS)
Michael J Lynch et al.
Nature chemical biology, 15(10), 959-965 (2019-08-14)
The flagellar hook protein FlgE from spirochaete bacteria self-catalyzes the formation of an unusual inter-subunit lysinoalanine (Lal) crosslink that is critical for cell motility. Unlike other known examples of Lal biosynthesis, conserved cysteine and lysine residues in FlgE spontaneously react
Angela Maria Rizzo et al.
Cells, 10(1) (2021-01-21)
(1) Background: Lipid metabolism is a fundamental hallmark of all tumors, especially of breast cancer. Few studies describe the different lipid metabolisms and sensitivities to the microenvironment of breast cancer cell subtypes that influence the proliferation, aggressiveness, and success of
Shiqi Yuan et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 126, 110102-110102 (2020-03-22)
Monocytes play a crucial role in Alzheimer's disease (AD), and docosahexaenoic acid (DHA) has a neuroprotective effect for many neurodegenerative diseases. However, mechanisms that regulate monocyte and Aβ protein interaction in AD and the effects of DHA on monocytes in
Walaa F Awadin et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 228, 108668-108668 (2019-11-13)
This study was performed to evaluate the effects of omega-3 supplementation on growth performance, clinical signs, post-mortem lesions, haemagglutination inhibition (HI) antibody titres, gene expression and histopathology in quails (Coturnix coturnix japonica) infected with Newcastle disease virus (NDV) and avian
Catherine Chunda-Liyoka et al.
BMC pregnancy and childbirth, 20(1), 93-93 (2020-02-12)
Nut butter-based Ready to Use Supplemental Foods (RUSF) are an effective way to add nutrients and calories to diets of malnourished and food insecure populations. The RUSF formulations have been further modified to add micronutrients including iron and folic acid
DHA Attenuates Hypoxia/Reoxygenation Injury by Activating SSeCKS in Human Cerebrovascular Pericytes.
Yanli Yu et al.
Neurochemical research, 45(2), 310-321 (2019-11-30)
Docosahexaenoic acid (DHA) can alleviate cerebral ischemia/reperfusion injury by reducing blood-brain barrier permeability and maintaining its integrity, accompanied by an increased Ang-1/Ang-2 ratio; however, the underlying mechanisms of these effects remain unclear. Src-suppressed C kinase substrates (SSeCKS), a substrate of
Yunzhi Liu et al.
Oxidative medicine and cellular longevity, 2020, 8096847-8096847 (2020-09-11)
Acetaminophen (APAP) toxicity is the leading cause of drug-induced liver failure, which is closely related to mitochondrial dysfunction and oxidative damage. Studies in clinical trials and in animal models have shown that omega-3 polyunsaturated fatty acids (n-3 PUFAs) affect the
Mutay Aslan et al.
Toxicology in vitro : an international journal published in association with BIBRA, 66, 104836-104836 (2020-03-30)
This study evaluated polyunsaturated fatty acids (PUFAs) in human kidney epithelial cells exposed to diclofenac (DCL) toxicity. Kidney cells were treated with DCL to induce cytotoxicity and thymoquinone (TQ) was administered to decrease cytotoxic effects. Levels of arachidonic acid (AA
Einar Vargas-Bello-Pérez et al.
Veterinary sciences, 6(2) (2019-06-20)
A prior study in bovine mammary (MACT) cells indicated that long-chain fatty acids (LCFA) C16:0 and C18:0, but not unsaturated LCFA, control transcription of milk fat-related genes partly via the activation of peroxisome proliferator-activated receptor gamma (PPARγ). However, in that
Shuli Yang et al.
Journal of diabetes research, 2019, 7074042-7074042 (2020-01-21)
To investigate the effects of cod-liver oil on metabolic status and high-sensitivity C-reactive protein (hs-CRP) in patients with gestational diabetes mellitus (GDM). This study was a randomized, double-blinded, placebo-controlled trial with the allocation ratio of 1 : 1. The contents of EPA
Heitor O Santos et al.
Nutrients, 12(10) (2020-10-22)
Cardiovascular diseases remain a global challenge, and lipid-associated biomarkers can predict cardiovascular events. Extensive research on cardiovascular benefits of omega-3 polyunsaturated fatty acids (n3-PUFAs) is geared towards fish oil supplementation and fish-rich diets. Nevertheless, vegetarianism and veganism are becoming more
Xinyu Zhou et al.
Cancers, 12(9) (2020-09-10)
Artemisinin derivatives, widely known as commercial anti-malaria drugs, may also have huge potential in treating cancer cells. It has been reported that artemisinin derivatives can overcome resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in liver and cervical cancer
Évelin Maria Brand et al.
PloS one, 14(10), e0222786-e0222786 (2019-10-03)
TB/HIV coinfection is a serious public health issue in Brazil, and patients with coinfection have difficulty adhering to treatments. Directly observed treatment (DOT) has been recommended by the World Health Organization, considering the vulnerability of those affected. The purpose is
Janne Bredehöft et al.
ACS chemical neuroscience, 10(10), 4394-4406 (2019-09-13)
Lipids, including omega-3 polyunsaturated fatty acids (n-3-PUFAs), modulate brain-intrinsic inflammation during systemic inflammation. The vascular organ of the lamina terminalis (OVLT) is a brain structure important for immune-to-brain communication. We, therefore, aimed to profile the distribution of several lipids (e.g.
Kento Sawane et al.
Nutrients, 11(12) (2019-11-27)
The metabolism and generation of bioactive lipid mediators are key events in the exertion of the beneficial effects of dietary omega-3 fatty acids in the regulation of allergic inflammation. Here, we found that dietary linseed oil, which contains high amounts
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