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Chunhui Deng et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 775(1), 115-120 (2002-07-09)
A new method for quantifying specific amino acids in small volumes of plasma and whole blood has been developed. Volatile derivatives of amino acids are analyzed by gas chromatography-mass spectrometry. The method only takes a few minutes to perform and
H Drechsel et al.
Journal of bacteriology, 175(9), 2727-2733 (1993-05-01)
Growth promotion and iron transport studies revealed that certain alpha-keto acids generated by amino acid deaminases, by enterobacteria of the Proteus-Providencia-Morganella group (of the tribe Proteeae), show significant siderophore activity. Their iron-binding properties were confirmed by the chrome azurol S
T Kuhara et al.
Clinica chimica acta; international journal of clinical chemistry, 133(2), 133-140 (1983-09-30)
Using gas chromatography-mass spectrometry (GC/MS), urinary organic acid profile studies were carried out on a patient with dihydrolipoyl dehydrogenase (E3) deficiency. Elevated levels of 2-hydroxyglutaric acid, 2-hydroxyisocaproic acid and 2-oxoisocaproic acid were observed in addition to lactic acid, 2-oxoglutaric acid
C Jakobs et al.
Clinica chimica acta; international journal of clinical chemistry, 140(2), 157-166 (1984-07-16)
A method is described in which ammonia chemical ionization gas chromatography-mass spectrometry was utilized in the selected ion monitoring mode to provide an accurate, selective approach to the quantification in amniotic fluid of a number of hydroxylated organic acids derived
Jan Labuta et al.
Nature communications, 4, 2188-2188 (2013-07-19)
Enantiomeric excess of chiral compounds is a key parameter that determines their activity or therapeutic action. The current paradigm for rapid measurement of enantiomeric excess using NMR is based on the formation of diastereomeric complexes between the chiral analyte and
Antti A Mero et al.
Journal of the International Society of Sports Nutrition, 7, 1-1 (2010-01-07)
Alfa-Hydroxy-isocaproic acid (HICA) is an end product of leucine metabolism in human tissues such as muscle and connective tissue. According to the clinical and experimental studies, HICA can be considered as an anti-catabolic substance. The present study investigated the effects
Veronika Walser et al.
Molecules (Basel, Switzerland), 26(5) (2021-04-04)
The emetic Bacillus cereus toxin cereulide presents an enormous safety hazard in the food industry, inducing emesis and nausea after the consumption of contaminated foods. Additional to cereulide itself, seven structurally related isoforms, namely the isocereulides A-G, have already been
K D Webster et al.
Archives of biochemistry and biophysics, 273(2), 562-571 (1989-09-01)
L-Thiomorpholine-3-carboxylic acid (L-TMC) is a cyclized analog of S-(2-chloroethyl)-L-cysteine, which is cytotoxic in vitro and nephrotoxic in vivo. To determine whether L-TMC may play a role in S-(2-chloroethyl)-L-cysteine-induced toxicity, the cytotoxicity of L-TMC was studied in isolated rat kidney cells.
L J Spaapen et al.
Journal of inherited metabolic disease, 10(4), 383-390 (1987-01-01)
Analysis of urinary organic acids in patients admitted for screening for inborn errors of metabolism incidentally revealed the presence of abnormal amounts of 4-hydroxyphenyllactate (4-HPLA) and phenyllactate (PLA). These compounds are found in tyrosinaemia and phenylketonuria but in our patients
P Schadewaldt et al.
Journal of inherited metabolic disease, 22(6), 706-722 (1999-09-03)
In maple syrup urine disease (MSUD), branched-chain L-amino (BCAA) and 2-oxo acids (BCOA) accumulate in body fluids owing to an inherited deficiency of branched-chain 2-oxo acid dehydrogenase complex activity. In MSUD, little information is available on the significance of urinary
H M Liebich et al.
Journal of chromatography, 309(2), 225-242 (1984-08-10)
Hydroxy- and oxomonocarboxylic acids in urine of healthy individuals and of patients with diabetic ketoacidosis are analysed as methyl esters and methyl esters/O-methyloximes, respectively, by gas chromatography and gas chromatography-mass spectrometry. The derivatives are pre-fractionated by thin-layer chromatography. The acids
K P Boebel et al.
The Journal of nutrition, 112(10), 1929-1939 (1982-10-01)
Several experiments were conducted to quantitatively evaluate the growth-promoting capacity of the isomers of the branched-chain amino acids (BCAA) and their alpha-hydroxy and alpha-keto analogs for the chick and rat. Basal chemically defined diets were formulated to be singly deficient
M Friedrich et al.
Zeitschrift fur Urologie und Nephrologie, 82(2), 105-112 (1989-02-01)
Rats were fed protein-restricted after unilateral nephrectomy (6.7% casein). Comparatively other animals were fed with experimental diets, at which 20% of the casein have been replaced by Ketosteril or a mixture of hydroxy acid. The constituents of this mixture are
Takayoshi Awakawa et al.
Nature communications, 9(1), 3534-3534 (2018-09-01)
Reprogramming of the NRPS/PKS assembly line is an attractive method for the production of new bioactive molecules. However, it is usually hampered by the loss of intimate domain/module interactions required for the precise control of chain transfer and elongation reactions.
P Schadewaldt et al.
Clinical chemistry, 45(10), 1734-1740 (1999-10-03)
The significance of plasma L-alloisoleucine, which is derived from L-isoleucine in vivo, for diagnosis of maple syrup urine disease (MSUD) was examined. Branched-chain L-amino acids were measured by automatic amino acid analysis. Alloisoleucine reference values in plasma were established in
Fernanda U Fontella et al.
Metabolic brain disease, 17(1), 47-54 (2002-03-16)
In this study we investigated the in vitro effects of the metabolites accumulating in maple syrup urine disease on lipid peroxidation in brain of young rats. Chemiluminescence and thiobarbituric acid-reactive substances were measured in brain homogenates from 7- and 30-day-old
E Haan et al.
European journal of pediatrics, 144(1), 63-65 (1985-05-01)
An 8-year-old boy with a short gut had six episodes of metabolic acidosis and neurological dysfunction over a 1 month period. The neurological features consisted of a depressed conscious state, confusion, aggressive behaviour, slurred speech and ataxia. The organic acid
2-Hydroxyisocaproic acid (HICA): a new potential topical antibacterial agent.
M Sakko et al.
International journal of antimicrobial agents, 39(6), 539-540 (2012-04-10)
Continuous enzymatically catalyzed production of L-leucine from the corresponding racemic hydroxy acid.
B Bossow et al.
Annals of the New York Academy of Sciences, 506, 325-336 (1987-01-01)
Charles H Lang et al.
American journal of physiology. Endocrinology and metabolism, 305(3), E416-E428 (2013-06-13)
Muscle disuse atrophy is observed routinely in patients recovering from traumatic injury and can be either generalized resulting from extended bed rest or localized resulting from single-limb immobilization. The present study addressed the hypothesis that a diet containing 5% α-hydroxyisocaproic
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