CN
Search Within
220051
应用筛选条件
关键词:'220051'
显示 1-30 共 89 条结果 关于 "220051" 范围 论文
Efficient kinetic resolution of racemic amino aldehydes by oxidation with N-iodosuccinimide.
Daishirou Minato et al.
Angewandte Chemie (International ed. in English), 47(49), 9458-9461 (2008-11-01)
Mark C Bagley et al.
Molecules (Basel, Switzerland), 15(5), 3211-3227 (2010-07-27)
Cyclodehydration of Bohlmann-Rahtz aminodienone intermediates using N-iodosuccinimide as a Lewis acid proceeds at low temperature under very mild conditions to give the corresponding 2,3,6-trisubstituted pyridines in high yield and with total regiocontrol.
Taichi Kano et al.
Journal of the American Chemical Society, 130(12), 3728-3729 (2008-03-07)
A direct asymmetric iodination reaction of aldehydes with NIS was found to be catalyzed by the novel axially chiral bifunctional amino alcohol (S)-1d. This method represents the rare example of the catalytic and highly enantioselective synthesis of optically active alpha-iodoaldehydes.
Carmel M McVicar et al.
Diabetologia, 58(5), 1129-1137 (2015-02-18)
The receptor for AGEs (RAGE) is linked to proinflammatory pathology in a range of tissues. The objective of this study was to assess the potential modulatory role of RAGE in diabetic retinopathy. Diabetes was induced in wild-type (WT) and Rage
N V Yaglova et al.
Bulletin of experimental biology and medicine, 160(2), 231-233 (2015-12-02)
The mechanism of disruptive action of dichlorodiphenyltrichloroethane (DDT) on the function of thyroid follicular epitheliocytes was examined in mature male Wistar rats administered with a daily dose of DDT (2 μg/kg) for 6 or 10 weeks. In 6 weeks, the
Juan Zhang et al.
Organic & biomolecular chemistry, 10(46), 9237-9242 (2012-10-30)
A simple, efficient and practical copper-catalyzed aerobic oxidative synthesis of α-ketoamides from aryl methyl ketones, aliphatic amines and N-iodosuccinimide (NIS) has been developed. The one-pot reaction may proceed smoothly at room temperature in the open air. The possible mechanism for
André Uchimura Bastos et al.
European journal of endocrinology, 173(4), 525-540 (2015-09-05)
Thyroid cancer incidence has dramatically increased worldwide over the last two decades. The rise is mostly due to an increased detection of small papillary thyroid carcinomas (PTCs) (≤20 mm), predominantly microPTC (≤10 mm). Although small tumors generally have an excellent
Cong-Ying Zhou et al.
Organic letters, 12(9), 2104-2107 (2010-04-15)
Iodination of arene-containing natural products employing N-iodosuccinimide catalyzed by In(OTf)(3) at ambient temperature is reported as a versatile and mild method for natural product derivatization amenable to small scale. This process facilitates natural product derivatization of arene moieties for SAR
Tetsuya Kajimoto et al.
Bioorganic & medicinal chemistry letters, 16(22), 5736-5739 (2006-09-15)
p-Octyloxybenzenethiol (2) was synthesized as a new odorless benzenethiol. Moreover, preparation of thioglycosides using 2 and their application for glycosylation reactions were attempted. As a result, it was found that the thioglycosides were as excellent glycosyl donors as 4-dodecylphenyl 1-thio-glycosides
Saumya Saurabh et al.
ACS nano, 8(11), 11138-11146 (2014-11-09)
While DNA-directed nanotechnology is now a well-established platform for bioinspired nanoscale assembly in vitro, the direct targeting of various nanomaterials in living biological systems remains a significant challenge. Hybrid biological systems with integrated and targeted nanomaterials may have interesting and
Menstrual cycle distribution of uterine natural killer cells is altered in heavy menstrual bleeding.
Sourima Biswas Shivhare et al.
Journal of reproductive immunology, 112, 88-94 (2015-09-24)
Heavy menstrual bleeding (HMB) affects 30% of women of reproductive age and significantly interferes with quality of life. Altered endometrial vascular maturation has been reported in HMB and recurrent miscarriage, the latter associated with increased uterine natural killer (uNK) cell
Majed Afana et al.
Clinical cardiology, 38(1), 13-19 (2014-10-23)
Acute coronary syndromes account for half of all deaths secondary to cardiovascular disease and represent a significant economic burden in the United States. Therefore, assessing hospitalization costs relative to Medicare reimbursement for these patients is important in understanding the impact
Rohan Khera et al.
JAMA internal medicine, 175(6), 941-950 (2015-03-31)
Percutaneous ventricular assist devices (PVADs) provide robust hemodynamic support compared with intra-aortic balloon pumps (IABPs), but clinical use patterns are unknown. To examine contemporary patterns in PVAD use in the United States and compare them with use of IABPs. Retrospective
Elisabeth Holen et al.
Fish & shellfish immunology, 45(2), 695-703 (2015-05-25)
Future feed for farmed fish are based on untraditional feed ingredients, which will change nutrient profiles compared to traditional feed based on marine ingredients. To understand the impact of oils from different sources on fish health, n-6 and n-3 polyunsaturated
Kristin M Lefebvre et al.
Vascular medicine (London, England), 20(1), 51-59 (2015-02-11)
The purpose of this study was to examine trends in racial and gender disparities in the severity of lower extremity amputation among individuals with peripheral artery disease (PAD) over the period of a decade (2002-2011). This is a longitudinal secondary
Danielle L Gainor et al.
JAMA otolaryngology-- head & neck surgery, 141(8), 739-744 (2015-06-05)
Sodium iodide symporter (NIS) expression in adenoid cystic carcinoma (ACC) has not been fully elucidated in the literature, and it is unclear whether radioactive iodine may be a potential therapeutic modality. To our knowledge, the present study includes the largest
Canadian Journal of Chemistry, 84, 66-66 (2006)
Aparna Lakshmanan et al.
Endocrine-related cancer, 22(1), 11-21 (2014-11-19)
Na(+)/I(-) symporter (NIS)-mediated radioiodide uptake (RAIU) serves as the basis for targeted ablation of thyroid cancer remnants. However, many patients with thyroid cancer have reduced NIS expression/function and hence do not benefit from radioiodine therapy. microRNA (miR) has emerged as
Jessica L Mellinger et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 13(3), 577-584 (2014-09-30)
Little is known about geographic variations in health care for patients with cirrhosis. We studied geographic and hospital-level variations in care of patients with cirrhosis in the United States by using inpatient mortality as an outcome for comparing hospitals. We
Ana Paula Santin Bertoni et al.
International journal of endocrinology, 2015, 864852-864852 (2015-06-20)
Thyroid cancer and thyroid nodules are more prevalent in women than men, so female sex hormones may have an etiological role in these conditions. There are no data about direct effects of progesterone on thyroid cells, so the aim of
Shuo Shi et al.
Current gene therapy, 15(5), 460-471 (2015-04-22)
Heart tissue has a diminished ability to repair after myocardial infarction (MI). Bone marrow- derived mesenchymal stem cells (BMSCs) have been used effectively to heal damaged tissue after MI. Hypoxia-inducible factor-1α (HIF-1α) can induce transcription of numerous pro-angiogenic genes and
Abby J Isaacs et al.
The Journal of thoracic and cardiovascular surgery, 149(5), 1262-1269 (2015-03-21)
Substantial controversy surrounds the choice between a mechanical versus bioprosthetic prosthesis for aortic valve replacement (AVR), based on age. This study aims to investigate national trends and in-hospital outcomes of the 2 prosthesis choices. All patients aged >18 years in
Anup M Jawalekar et al.
Chemical communications (Cambridge, England), 47(10), 2796-2798 (2011-02-03)
2'-O-(3-(Furan-2-yl)propyl)adenosine was synthesized and evaluated for interstrand crosslink (ICL) formation in DNA duplexes. In situ oxidation of the furan moiety with NIS showed rapid crosslink formation to dA and dC, while dT and dG were inactive.
Xiaoyun Dai et al.
Molecular oncology, 9(4), 818-833 (2015-01-28)
Deregulated activation of oncogenic transcription factors such as signal transducer and activator of transcription 3 (STAT3) plays a pivotal role in proliferation and survival of hepatocellular carcinoma (HCC). Thus, agents which can inhibit STAT3 activation may have an enormous potential
Noriyasu Hada et al.
Carbohydrate research, 343(13), 2315-2324 (2008-06-07)
Novel neutral glycosphingolipids (NGSLs) containing Gal-alpha1-->6Gal, previously found in the Zygomycetes species Mucor hiemalis, were synthesized. The structures of these compounds are different from those of other fungal GSLs, and they are expected to be involved in host-parasite interactions. A
Juan Pablo Nicola et al.
The Journal of clinical endocrinology and metabolism, 100(10), E1353-E1361 (2015-07-24)
Iodide (I(-)), an essential constituent of the thyroid hormones, is actively accumulated in the thyroid by the Na(+)/I(-) symporter (NIS), a key plasma membrane protein encoded by the slc5a5 gene. Mutations in slc5a5 cause I(-) transport defects (ITDs), autosomal-recessive disorders
Shuo Shi et al.
PloS one, 10(1), e0116531-e0116531 (2015-01-27)
Despite recent improvements in the survival rates for nasopharyngeal carcinoma (NPC), novel treatment strategies are required to improve distant metastasis-free survival. The sodium iodine symporter (NIS) gene has been applied for in vivo imaging and cancer therapy. In this study
Hakim Bouamar et al.
Molecular and cellular biology, 35(8), 1329-1340 (2015-02-04)
In biological processes, the balance between positive and negative inputs is critical for an effective physiological response and to prevent disease. A case in point is the germinal center (GC) reaction, wherein high mutational and proliferation rates are accompanied by
Yuxin Qian et al.
The Journal of organic chemistry, 77(1), 96-107 (2011-12-07)
A novel class of 1-C-arylglycals was developed and subjected to N-iodosuccinimide-mediated glycosylations with alcohols. Unexpectedly, all reactions provided 2-iodo-β-D-ketopyranosides in high yields and excellent stereoselectivity. After removal of the 2-iodide by radical conditions, the aryl group was smoothly oxidized to
H Lee et al.
Mucosal immunology, 8(5), 1083-1098 (2015-02-12)
Intranasal (i.n.) vaccination generates immunity across local, regional, and distant sites. However, nasal dendritic cells (DCs), pivotal for the induction of i.n. vaccine-induced immune responses, have not been studied in detail. Here, by using a variety of parameters, we define
1/3