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Anthony Bertucci et al.
Bioorganic & medicinal chemistry letters, 21(2), 710-714 (2011-01-07)
The catalytic activity and the inhibition of a new coral carbonic anhydrase (CA, EC 4.2.1.1), from the scleractinian coral Stylophora pistillata, STPCA-2, has been investigated. STPCA-2 has high catalytic activity for the physiological reaction being less sensitive to anion and
Hiroo Yamashita et al.
Life sciences, 93(20), 732-741 (2013-10-08)
In the present study, we found that saccharin, an artificial calorie-free sweetener, promotes neurite extension in the cultured neuronal cells. The purposes of this study are to characterize the effect of saccharine on neurite extension and to determine how saccharin
Maryka Quik et al.
Biochemical pharmacology, 86(8), 1153-1162 (2013-07-09)
Accumulating evidence supports the idea that drugs acting at nicotinic acetylcholine receptors (nAChRs) may be beneficial for Parkinson's disease, a neurodegenerative movement disorder characterized by a loss of nigrostriatal dopaminergic neurons. Nicotine administration to parkinsonian animals protects against nigrostriatal damage.
A Guerra et al.
European journal of medicinal chemistry, 45(3), 930-940 (2009-12-22)
A neural model based on a numerical molecular representation using CODES program to predict oral absorption of any structure is described. This model predicts both high and low-absorbed compounds with a global accuracy level of 74%. CODES/ANN methodology shows promising
Saccharin consumption increases food consumption in rats.
Nutrition reviews, 48(3), 163-165 (1990-03-01)
Alessandra T Peana et al.
Behavioural pharmacology, 25(7), 618-628 (2014-08-15)
Recent evidence has shown that Withania somnifera Dunal (Ashwagandha or Indian ginseng), a herbal remedy used in traditional medicine, impairs morphine-elicited place conditioning. Here, we investigated the effect of W. somnifera roots extract (WSE) on motivation for drinking ethanol using
AnneMarie Levy et al.
Nutrients, 7(5), 3869-3890 (2015-05-27)
This study explored whether different ratios of fructose (F) and glucose (G) in sugar can engender significant differences in self-administration and associated neurobiological and physiological responses in male Sprague-Dawley rats. In Experiment 1, animals self-administered pellets containing 55% F +
Camilla Karlsson et al.
Pharmacology, biochemistry, and behavior, 102(3), 400-406 (2012-06-19)
The hypothalamic neuropeptide melanin-concentrating hormone and its MCH1 receptor have been implicated in regulation of feeding and energy homeostasis, as well as modulation of reward-related behaviors. Here, we examined whether the MCH system plays a role both in caloric and
A M Barkley-Levenson et al.
Genes, brain, and behavior, 14(5), 398-410 (2015-05-20)
The High Drinking in the Dark (HDID) mice have been selectively bred for reaching high blood ethanol concentrations (BECs) following the limited access Drinking in the Dark (DID) test. We have shown previously that mice from the first HDID replicate
Jennifer K Roebber et al.
Pharmacology, biochemistry, and behavior, 133, 18-24 (2015-03-31)
In rodents, saccharin consumption is suppressed when the sweet taste stimulus is paired with moderate doses of cocaine. Several hypotheses have been used to explain the seemingly contradictory effect of decreased consumption of a normally preferred substance following a highly
Marilyn E Carroll et al.
Behavioural pharmacology, 19(5-6), 435-460 (2008-08-12)
A positive relationship between the consumption of sweetened dietary substances (e.g. saccharin and sucrose) and drug abuse has been reported in both the human and other animal literature. The proposed genetic contribution to this relationship has been based on evidence
Bo Liu et al.
Biochemical and biophysical research communications, 427(2), 431-437 (2012-09-25)
The family C G protein-coupled receptor (GPCR) T1R2 and T1R3 heterodimer functions as a broadly acting sweet taste receptor. Perception of sweet taste is a species-dependent physiological process. It has been widely reported that New World monkeys and rodents are
Alessandra Cincinelli et al.
Bioorganic & medicinal chemistry, 19(6), 1847-1851 (2011-03-08)
A high activity α-carbonic anhydrase (CA, EC 4.2.1.1) has been purified from various tissues of the Antarctic seal Leptonychotes weddellii. The new enzyme, denominated lwCA, has a catalytic activity for the physiologic CO(2) hydration to bicarbonate reaction, similar to that
Tara L Fidler et al.
Alcoholism, clinical and experimental research, 33(11), 1909-1923 (2009-08-14)
Many studies have shown that chronic ethanol exposure can enhance later self-administration of ethanol, but only a few studies have identified critical parameters for such exposure. The present studies examined temporal and other parameters of chronic ethanol exposure on subsequent
Status report on saccharin in humans.
G R Newell et al.
Journal of the National Cancer Institute, 61(2), 275-276 (1978-08-01)
Organ-specific modifying effects of phenobarbital, saccharin and antioxidants on 2-stage chemical carcinogenesis.
N Ito
Developments in toxicology and environmental science, 12, 359-369 (1986-01-01)
Jagdishwar R Patel et al.
International journal of pharmaceutics, 436(1-2), 685-706 (2012-07-31)
Cocrystals of tenoxicam, a non-steroidal anti-inflammatory drug, are screened, prepared, and characterized in this study. Nine tenoxicam cocrystals were identified using solvent-drop grinding (SDG) techniques. Structural characterization was performed using powder X-ray diffraction (PXRD), differential scanning calorimetry, and multinuclear solid-state
L B Ellwein et al.
Critical reviews in toxicology, 20(5), 311-326 (1990-01-01)
Almost from its discovery in 1879, the use of saccharin as an artificial, non-nutritive sweetener has been the center of several controversies regarding potential toxic effects, most recently focusing on the urinary bladder carcinogenicity of sodium saccharin in rats when
Ceyda Icsel et al.
DNA and cell biology, 32(4), 165-172 (2013-03-12)
The aim of the present study is to investigate DNA binding interactions of two highly cytotoxic palladium(II) saccharinate (sac) complexes with 2,2':6',2″-terpyridine (terpy), [Pd(sac)(terpy)](sac)·4H(2)O (1) and [PdCl(terpy)](sac)·2H(2)O (2). UV-Vis spectroscopy, fluorescence spectroscopy, thermal denaturation, viscosity, and gel electrophoresis measurements were
Fabrizio Carta et al.
Bioorganic & medicinal chemistry letters, 19(23), 6649-6654 (2009-10-23)
The Rv3588c gene product of Mycobacterium tuberculosis, a beta-carbonic anhydrase (CA, EC 4.2.1.1) denominated here mtCA 2, shows the highest catalytic activity for CO(2) hydration (k(cat) of 9.8 x 10(5)s(-1), and k(cat)/K(m) of 9.3 x 10(7)M(-1)s(-1)) among the three beta-CAs
Hugh P Morgan et al.
The Biochemical journal, 448(1), 67-72 (2012-08-22)
PYK (pyruvate kinase) plays a central role in the metabolism of many organisms and cell types, but the elucidation of the details of its function in a systems biology context has been hampered by the lack of specific high-affinity small-molecule
D C Martyn et al.
Current pharmaceutical design, 5(6), 405-415 (1999-07-03)
The inhibition of human leukocyte elastase (HLE), and other serine proteases, by succinimide and saccharin-based compounds is reviewed. The succinimide compounds are unique in that the inactivating species is generated within the enzyme active site via a molecular rearrangement. The
Feray Kockar et al.
Bioorganic & medicinal chemistry, 18(15), 5498-5503 (2010-07-14)
Site-directed mutagenesis has been used to change one amino acid residue considered non essential (Phe91Asn) to catalysis in carbonic anhydrase (CA, EC 4.2.1.1) isozyme I (hCA I), but which is near the substrate binding pocket of the enzyme. This change
G M Prashant et al.
The journal of contemporary dental practice, 13(6), 749-752 (2013-02-14)
To evaluate the in vitro antimicrobial activity of three commercially available intense sweeteners against two common periodontal pathogens Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. Three commercially available intense sweeteners namely saccharin, aspartame and sucralose were obtained and powdered. Necessary concentrations of
S A Miller et al.
Diabetes care, 12(1), 74-80 (1989-01-01)
Saccharin, a nonnutritive sweetener discovered in 1879, has been the subject of controversy concerning its effect on public health on several occasions during this century. Over this period, the substance has come to be regarded as a useful commodity in
Jeff A Beeler et al.
The European journal of neuroscience, 36(4), 2533-2546 (2012-06-21)
Recent findings suggest the reward system encodes metabolic value independent of taste, provoking speculation that the hedonic value of taste could be derived from nutritional value as a secondary appetitive property. We therefore dissociated and compared the impact of nutrition
Zheng Tian et al.
Langmuir : the ACS journal of surfaces and colloids, 30(41), 12411-12420 (2014-09-25)
Carbon films with interdigitated bimodal three-dimensionally ordered mesoporosity (ib3DOm) are realized by a scalable nanoreplication process that removes the common need plaguing hard-templating strategies for multistep prefabrication of porous sacrificial templates. Specifically, evaporation-induced convective codeposition of size-tunable (ca. 20-50 nm)
Katharine J Tuerke et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(40), 13709-13717 (2012-10-05)
A taste associated with emetic drugs produces conditioned disgust reactions in rats (predominantly gaping), unlike nonemetic drugs that can still produce conditioned taste avoidance but not conditioned disgust. That difference suggests nausea is a prerequisite for learning disgust reactions to
Araceli Martínez-Moreno et al.
Frontiers in behavioral neuroscience, 5, 61-61 (2011-10-01)
It has been proposed that long-term memory (LTM) persistence requires a late protein synthesis-dependent phase, even many hours after memory acquisition. Brain-derived neurotrophic factor (BDNF) is an essential protein synthesis product that has emerged as one of the most potent
Aleš Rajchl et al.
Journal of mass spectrometry : JMS, 50(11), 1214-1221 (2015-10-28)
DART (Direct Analysis in Real Time) coupled with Time-of-Flight Mass Spectrometry (TOF/MS) has been used for analyses of ice-teas. The article focuses on quality and authenticity of ice-teas as one of the most important tea-based products on the market. Twenty-one
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