326488

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Cord Langner et al.

Virchows Archiv : an international journal of pathology, 445(2), 111-118 (2004-06-19)

Wilson disease (WD) is an autosomal recessive disorder of copper metabolism. Since daily copper intake exceeds the body's requirements, effective means of excreting excess copper are essential. These are accomplished by ATP7B, a new member of the cation-transporting p-type ATPase

Serum calcium, zinc, and copper in relation to biomarkers of lead and cadmium in men.

Alica Pizent et al.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 17(3), 199-205 (2004-02-19)

The influence of exposure to lead and cadmium on serum concentrations of calcium, zinc, and copper was examined in 299 healthy Croatian men 20-55 years of age, including 143 workers in a lead battery factory and 156 control subjects. The

Diagnostic use of cerebral and extracerebral oxysterols.

Valerio Leoni et al.

Clinical chemistry and laboratory medicine, 42(2), 186-191 (2004-04-06)

24S-Hydroxycholesterol (24OHC) and 27-hydroxycholesterol (27OHC) are two structurally similar oxysterols of different origins--the former almost exclusively formed in the brain and the latter formed to a lesser extent in the brain than in most other organs. HYPOTHESIS TO BE TESTED:

Solid-phase extraction of copper(II) in water and food samples using silica gel modified with bis(3-aminopropyl)amine and determination by flame atomic absorption spectrometry.

Duygu Cagirdi et al.

Journal of AOAC International, 97(4), 1137-1142 (2014-08-26)

A simple and selective separation and preconcentration method was developed for the determination of Cu(ll) ions. This method is based on adsorption of Cu(ll) ions from aqueous solution on a bis(3-aminopropyl)amine modified silica gel column and flame atomic absorption spectrometric

A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.

Xiaowen Xu et al.

Organic letters, 16(13), 3540-3543 (2014-06-17)

A novel straightforward synthesis of both symmetrical and unsymmetrical 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF as a one-carbon synthon has been developed. The presented method allows synthesizing the products that are currently inaccessible or challenging to prepare

Time-resolved infrared spectroscopic studies of ligand dynamics in the active site from cytochrome c oxidase.

Marten H Vos et al.

Biochimica et biophysica acta, 1847(1), 79-85 (2014-08-15)

The catalytic site of heme-copper oxidases encompasses two close-lying ligand binding sites: the heme, where oxygen is bound and reduced and the CuB atom, which acts as ligand entry and release port. Diatomic gaseous ligands with a dipole moment, such

Histatins: salivary peptides with copper(II)- and zinc(II)-binding motifs: perspectives for biomedical applications.

Sonia Melino et al.

The FEBS journal, 281(3), 657-672 (2013-11-14)

Natural antimicrobial peptides represent a primordial mechanism of immunity in both vertebrate and nonvertebrate organisms. Among them, histatins belong to a family of human salivary metal-binding peptides displaying potent antibacterial, antifungal and wound-healing activities. These properties, along with the ability

CuZn dendritic alloys: their template-free electrochemical preparation and morphology-dependent wettability.

Ru Qiao et al.

Journal of nanoscience and nanotechnology, 13(6), 4247-4251 (2013-07-19)

In this paper, we report a preparation of CuZn dendritic microstructures through a tunable template-free electrochemical approach. By simply tunning the applied depositing current, the morphology of the product can be well controlled. The growth mechanism of CuZn dendritic alloys

Comparative assessment of alignment efficiency and space closure of active and passive self-ligating vs conventional appliances in adolescents: a single-center randomized controlled trial.

Goldie Songra et al.

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 145(5), 569-578 (2014-05-03)

The aim of this study was to compare the time to initial alignment and extraction space closure using conventional brackets and active and passive self-ligating brackets. One hundred adolescent patients 11 to 18 years of age undergoing maxillary and mandibular

The role of zinc and copper in autism spectrum disorders.

Geir Bjorklund

Acta neurobiologiae experimentalis, 73(2), 225-236 (2013-07-05)

Autism spectrum disorders (ASDs) are a group of developmental disabilities that can cause significant social, communication and behavioral challenges. Several studies have suggested a disturbance in the copper (Cu) and zinc (Zn) metabolism in ASDs. Zinc deficiency, excess Cu levels

Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid.

M A Lovell et al.

Archives of neurology, 58(3), 392-396 (2001-03-20)

Markers of oxidative stress are increased in cerebrospinal fluid (CSF) of patients with Alzheimer disease (AD), although none of those reported are appropriate diagnostic markers because of the overlap between patients with AD and control subjects. To determine the ratio

Ocular manifestations of monoclonal copper-binding immunoglobulin.

Sejal Shah et al.

Survey of ophthalmology, 59(1), 115-123 (2013-10-12)

The dense accumulation of copper in Descemet membrane and lens capsule is the characteristic manifestation of a circulating monoclonal antibody with strong affinity for copper. The overproduction of this monoclonal immunoglobulin may be associated with either multiple myeloma or a

Alpha-tocopherol in the ventricular cerebrospinal fluid of Parkinson's disease patients: dose-response study and correlations with plasma levels.

E J Pappert et al.

Neurology, 47(4), 1037-1042 (1996-10-01)

To determine if ventricular cerebrospinal fluid (vCSF) alpha-tocopherol levels in Parkinson's disease (PD) patients can be increased by oral alpha-tocopherol supplementation and whether vCSF levels are linearly related to plasma alpha-tocopherol levels. In spite of its putative neuroprotective properties, alpha-tocopherol

Metals: setting a trap for copper.

Valeria Culotta

Nature chemical biology, 10(12), 986-987 (2014-10-27)

Cerebrospinal fluid levels of thiamine in patients with Alzheimer's disease.

J A Molina et al.

Journal of neural transmission (Vienna, Austria : 1996), 109(7-8), 1035-1044 (2002-07-12)

Thiamine is an essential cofactor for several important enzymes involved in brain oxidative metabolism, such as the alpha-ketoglutarate dehydrogenase complex (KGDHC), pyruvate-dehydrogenase complex (PDHC), and transketolase. Some investigators reported decreased thiamine-diphosphate levels and decreased activities of KGDHC, pyruvate-dehydrogenase complex and

Involvement of CTR1 and ATP7A in lead (Pb)-induced copper (Cu) accumulation in choroidal epithelial cells.

Gang Zheng et al.

Toxicology letters, 225(1), 110-118 (2013-12-10)

The blood-cerebrospinal fluid barrier (BCB) plays a key role in maintaining copper (Cu) homeostasis in the brain. Cumulative evidences indicate that lead (Pb) exposure alters cerebral Cu homeostasis, which may underlie the development of neurodegenerative diseases. This study investigated the

Presence of N-methyl-norsalsolinol in the CSF: correlations with dopamine metabolites of patients with Parkinson's disease.

A Moser et al.

Journal of the neurological sciences, 131(2), 183-189 (1995-08-01)

We could identify the MPTP-like compound and isoquinoline derivative N-methyl-norsalsolinol (2-MDTIQ) in cerebrospinal fluid (CSF) of patients with Parkinson's disease. The presence of 2-MDTIQ negatively correlated with the disease duration. In order to study the relationship between presence of 2-MDTIQ

Is vetiver grass of interest for the remediation of Cu and Cd to protect marketing gardens in Burkina Faso?

Norbert Ondo Zue Abaga et al.

Chemosphere, 113, 42-47 (2014-07-30)

In Burkina-Faso, urban vegetable agriculture is often characterized by urban solid waste fertilizer inputs containing heavy metals such as Cu and Cd. Thus, the relevance of surrounding urban vegetable plots with vetiver hedges to reduce environmental pollution by Cu and

Acute and chronic toxicities of zinc pyrithione alone and in combination with copper to the marine copepod Tigriopus japonicus.

Vivien W W Bao et al.

Aquatic toxicology (Amsterdam, Netherlands), 157, 81-93 (2014-12-03)

Zinc pyrithione (ZnPT) is a widely used booster biocide in combination with copper (Cu) in antifouling paints as a substitute for tributyltin. The co-occurrence of ZnPT and Cu in coastal marine environments is therefore very common, and may pose a

Racemic synthesis and solid phase peptide synthesis application of the chimeric valine/leucine derivative 2-amino-3,3,4-trimethyl-pentanoic acid.

M Pelà et al.

Die Pharmazie, 69(7), 496-499 (2014-07-31)

The synthesis of non natural amino acid 2-amino-3,3,4-trimethyl-pentanoic acid (Ipv) ready for solid phase peptide synthesis has been developed. Copper (I) chloride Michael addition, followed by a Curtius rearrangement are the key steps for the lpv synthesis. The racemic valine/leucine

Determination of traces of copper and zinc in honeys by the solid phase extraction pre-concentration followed by the flame atomic absorption spectrometry detection.

Helena Stecka et al.

Environmental monitoring and assessment, 186(10), 6145-6155 (2014-05-30)

A simple and fast solid phase extraction procedure was developed to pre-concentrate traces of Cu and Zn prior to their determination in honey samples by flame atomic absorption spectrometry. The sample preparation included dissolution of honey samples and the passage

Cellular distribution of copper to superoxide dismutase involves scaffolding by membranes.

Christopher R Pope et al.

Proceedings of the National Academy of Sciences of the United States of America, 110(51), 20491-20496 (2013-12-04)

Efficient delivery of copper ions to specific intracellular targets requires copper chaperones that acquire metal cargo through unknown mechanisms. Here we demonstrate that the human and yeast copper chaperones (CCS) for superoxide dismutase 1 (SOD1), long thought to exclusively reside

Copper-catalyzed oxidative decarboxylative couplings of sulfoximines and aryl propiolic acids.

Daniel L Priebbenow et al.

Organic letters, 15(24), 6155-6157 (2013-11-28)

A method has been developed for the preparation of N-alkynylated sulfoximines involving the copper-catalyzed decarboxylative coupling of sulfoximines with aryl propiolic acids. A range of substituents on both the sulfoximidoyl moiety and the aryl group of the propiolic acid were

Copper-catalyzed oxidative three-component synthesis of N, N',N″-trisubstituted guanidines.

Jihui Li et al.

Organic letters, 15(24), 6124-6127 (2013-11-26)

A copper-catalyzed three-component synthesis of trisubstituted N-aryl guanidines involving cyanamides, arylboronic acids, and amines has been developed. This operationally simple oxidative process, which is performed in the presence of K2CO3, a catalytic amount of CuCl2·2H2O, bipyridine, and oxygen (1 atm)

Bony adaptation after expansion with light-to-moderate continuous forces.

Collin D Kraus et al.

The purpose of this study was to evaluate the biologic response of dentoalveolar bone to archwire expansion with light-to-moderate continuous forces. With a split-mouth experimental design, the maxillary right second premolars of 7 adult male dogs were expanded for 9

Copper rewired.

Nature, 508(7495), 150-150 (2014-04-12)

The copper intrauterine device for emergency contraception: an opportunity to provide the optimal emergency contraception method and transition to highly effective contraception.

Amna I Dermish et al.

Expert review of medical devices, 10(4), 477-488 (2013-07-31)

Worldwide, 40% of all pregnancies are unintended. Widespread, over-the-counter availability of oral emergency contraception (EC) has not reduced unintended pregnancy rates. The EC visit presents an opportunity to initiate a highly effective method of contraception in a population at high

Role of chelating agents on release kinetics of metals and their uptake by maize from chromated copper arsenate-contaminated soil.

Yaser A Almaroai et al.

Environmental technology, 34(5-8), 747-755 (2013-07-11)

Kinetic aspects of metal release were investigated to understand the effects of synthetic chelating agents (EDTA, EDDS and NTA) and low molecular weight (LMW) organic acids (oxalic and citric acids) on the release kinetics of Cr, Cu and As in

Copper storage diseases: Menkes, Wilsons, and cancer.

Kenyon G Daniel et al.

Frontiers in bioscience : a journal and virtual library, 9, 2652-2662 (2004-09-11)

The trace element copper is vital to the healthy functioning of organisms. Copper is used in a multitude of cellular activities including respiration, angiogenesis, and immune responses. Like other metals, copper homeostasis is a tightly regulated process. Copper is transported

Use of nanoporous Cu(II) ion imprinted polymer as a new sorbent for preconcentration of Cu(II) in water, biological, and agricultural samples and its determination by electrothermal atomic absorption spectrometry.

Hamid Fazelirad et al.

Journal of AOAC International, 97(4), 1159-1166 (2014-08-26)

A new and selective Cu(ll) ion imprinted polymer was prepared by formation of 1-(2-pyridylazo)-2-naphthol complex for selective extraction and preconcentration of Cu ions. Polymerization was performed with ethylene glycol dimethacrylate as a crosslinking monomer and methacrylic acid as a functional

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