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Ocular manifestations of monoclonal copper-binding immunoglobulin.

Ocular manifestations of monoclonal copper-binding immunoglobulin.

Survey of ophthalmology (2013-10-12)

Sejal Shah, Edgar M Espana, Curtis E Margo

摘要

The dense accumulation of copper in Descemet membrane and lens capsule is the characteristic manifestation of a circulating monoclonal antibody with strong affinity for copper. The overproduction of this monoclonal immunoglobulin may be associated with either multiple myeloma or a benign monoclonal gammopathy. Despite prolonged exposure to elevated serum copper, no other tissues in the body are adversely affected by this redox metal. We describe the clinical and pathological findings in a 46-year-old woman with this disorder.

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铜, powder, <425 μm, 99.5% trace metals basis

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铜, powder, <75 μm, 99%

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铜, wire, diam. 1.0 mm, ≥99.9%

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铜, powder (dendritic), <45 μm, 99.7% trace metals basis

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铜, foil, thickness 1.0 mm, 99.999% trace metals basis

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铜, foil, thickness 0.5 mm, 99.98% trace metals basis

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