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Codetection of blaOXA-23-like gene (blaOXA-133) and blaOXA-58 in Acinetobacter radioresistens: report from the SENTRY antimicrobial surveillance program.
Rodrigo E Mendes et al.
Antimicrobial agents and chemotherapy, 53(2), 843-844 (2008-11-19)
Mohamed Jawed Ahsan et al.
Bioorganic & medicinal chemistry letters, 21(24), 7246-7250 (2011-11-11)
In the present investigation, a series of 1,5-dimethyl-2-phenyl-4-{[(5-aryl-1,3,4-oxadiazol-2-yl)methyl]amino}-1,2-dihydro-3H-pyrazol-3-one were subjected to molecular properties prediction, drug-likeness by Molinspiration (Molinspiration, 2008) and MolSoft (MolSoft, 2007) software, lipophilicity and solubility parameters using ALOGPS 2.1 program. The compounds followed the Lipinski 'Rule of five'
Xavier Mulet et al.
Antimicrobial agents and chemotherapy, 53(4), 1552-1560 (2009-02-04)
Azithromycin (AZM) has shown promising results in the treatment of Pseudomonas aeruginosa chronic lung infections such as those occurring in cystic fibrosis (CF) patients. We evaluated the effect of hypermutation and alginate hyperproduction on the bactericidal activity and resistance development
Marco Pieroni et al.
Journal of medicinal chemistry, 53(11), 4466-4480 (2010-05-08)
The thiopyranopyridine moiety was synthesized as a new heterocyclic base to be inserted at the C-7 position of selected quinolone nuclei followed by a determination of antibacterial activity against strains of Staphylococcus aureus. Selected thiopyranopyridinylquinolones showed significant antimicrobial activity, including
Frédérique Vernel-Pauillac et al.
Antimicrobial agents and chemotherapy, 53(3), 1264-1267 (2009-01-07)
We report a duplex real-time PCR assay for the simultaneous screening of mutations involved in fluoroquinolone resistance within gyrA and parC quninolone resistance-determining regions (QRDRs) in Neisseria gonorrhoeae. Our assay clearly detects all mutated QRDRs and allows the identification of
David A Ostrov et al.
Antimicrobial agents and chemotherapy, 51(10), 3688-3698 (2007-08-08)
The bacterial type II topoisomerases DNA gyrase and topoisomerase IV are validated targets for clinically useful quinolone antimicrobial drugs. A significant limitation to widely utilized quinolone inhibitors is the emergence of drug-resistant bacteria due to an altered DNA gyrase. To
Nuno Mendonça et al.
Antimicrobial agents and chemotherapy, 51(6), 1946-1955 (2007-03-21)
Of the 181 unduplicated Escherichia coli strains isolated in nine different hospitals in three Portuguese regions, 119 were extended-spectrum beta-lactamase (ESBL)-CTX-M producers and were selected for phenotype and genotype characterization. CTX-M producer strains were prevalent among community-acquired infections (56%), urinary
Julien M Buyck et al.
Antimicrobial agents and chemotherapy, 59(1), 258-268 (2014-10-29)
Antibiotic combinations are often used for treating Pseudomonas aeruginosa infections but their efficacy toward intracellular bacteria has not been investigated so far. We have studied combinations of representatives of the main antipseudomonal classes (ciprofloxacin, meropenem, tobramycin, and colistin) against intracellular
Daniel E Rozen et al.
Antimicrobial agents and chemotherapy, 51(2), 412-416 (2006-11-23)
The fitness cost of the genes responsible for resistance to fluoroquinolones in clinical isolates of Streptococcus pneumoniae were estimated in vitro in a common genetic background. Naturally occurring parC, parE, and gyrA loci containing mutations in the quinolone-resistance-determining regions were
G Aridoss et al.
European journal of medicinal chemistry, 44(10), 4199-4210 (2009-06-19)
A stereospecific synthesis of some thiazolidinones and thiazoles was achieved conveniently through certain alpha-halo keto agents and reactivity of chloroacetyl chloride was successfully enhanced by CsF-Celite+CH(3)COONa. NMR studies revealed that the configuration of N-N bond is found to be anti
Hong Bin Kim et al.
Antimicrobial agents and chemotherapy, 53(8), 3582-3584 (2009-06-17)
The genes for multidrug efflux pump OqxAB, which is active on fluoroquinolones, were found in human clinical isolates on a plasmid in Escherichia coli and on the chromosome of Klebsiella pneumoniae. IS26-like sequences flanked the plasmid-mediated oqxAB genes, suggesting that
Chengxin Zhi et al.
Journal of medicinal chemistry, 49(4), 1455-1465 (2006-02-17)
Novel Gram-positive (Gram+) antibacterial compounds consisting of a DNA polymerase IIIC (pol IIIC) inhibitor covalently connected to a topoisomerase/gyrase inhibitor are described. Specifically, 3-substituted 6-(3-ethyl-4-methylanilino)uracils (EMAUs) in which the 3-substituent is a fluoroquinolone moiety (FQ) connected by various linkers were
Tie Yi Kiew et al.
International journal of pharmaceutics, 484(1-2), 115-123 (2015-03-01)
While the supersaturation generation capability of amorphous nanopharmaceuticals (NPs) in their aqueous suspension form has been well established, their supersaturation generation is adversely affected after drying. Herein we investigated the effects of freeze drying on the supersaturation generation capability of
First organisms with acquired metallo-beta-lactamases (IMP-13, IMP-22, and VIM-2) reported in Austria.
Wojciech Duljasz et al.
Antimicrobial agents and chemotherapy, 53(5), 2221-2222 (2009-02-19)
Enrique Llobet et al.
Antimicrobial agents and chemotherapy, 53(1), 298-302 (2008-11-19)
A Klebsiella pneumoniae ompA mutant was more susceptible to antimicrobial peptides (APs) than the wild type. Susceptibility did not result from surface changes other than the absence of OmpA. Our data suggest that OmpA is implicated in the activation of
Luz Balsalobre et al.
Antimicrobial agents and chemotherapy, 52(3), 822-830 (2007-12-28)
The low prevalence of ciprofloxacin-resistant (Cp r) Streptococcus pneumoniae isolates carrying recombinant topoisomerase IV genes could be attributed to a fitness cost imposed by the horizontal transfer, which often implies the acquisition of larger-than-normal parE-parC intergenic regions. A study of
Yudong Liu et al.
Antimicrobial agents and chemotherapy, 53(2), 512-518 (2008-11-26)
Methicillin (meticillin)-resistant Staphylococcus aureus (MRSA) is a serious problem worldwide. To investigate the molecular epidemiology of MRSA isolates in China, a total of 702 MRSA isolates collected from 18 teaching hospitals in 14 cities between 2005 and 2006 were characterized
Reinhild Feuerstein et al.
Journal of immunology (Baltimore, Md. : 1950), 194(6), 2735-2745 (2015-02-15)
When Staphylococcus aureus penetrates the epidermis and reaches the dermis, polymorphonuclear leukocytes (PMLs) accumulate and an abscess is formed. However, the molecular mechanisms that orchestrate initiation and termination of inflammation in skin infection are incompletely understood. In human myeloid differentiation
Jiunn-Jong Wu et al.
Antimicrobial agents and chemotherapy, 51(4), 1223-1227 (2007-01-24)
The prevalence of three plasmid-mediated quinolone resistance determinants, QnrA, QnrB, and QnrS, among 526 nonreplicate clinical isolates of Enterobacter cloacae collected at a Taiwanese university hospital in 2004 was determined by PCR and colony hybridization, and the association of Qnr
B China Raju et al.
Bioorganic & medicinal chemistry letters, 21(10), 2855-2859 (2011-04-22)
Series of 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives 7a-7zb, 8a-8d and 9a-9d were synthesized and screened for their in vitro anti-mycobacterial activity against Mycobacterium tuberculosis H(37)Rv (MTB) and cytotoxicity against three human cancer cell lines including A549, SK-N-SH and HeLa. The results indicate that
Michael L Beeton et al.
Antimicrobial agents and chemotherapy, 53(5), 2020-2027 (2009-03-11)
Antibiotic resistance determination of Ureaplasma spp. (Ureaplasma parvum and Ureaplasma urealyticum) usually requires predetermination of bacterial titer, followed by antibiotic interrogation using a set bacterial input. This 96-well method allows simultaneous quantification of bacteria in the presence and absence of
Xin Yang et al.
Environmental science and pollution research international, 20(8), 5864-5875 (2013-04-24)
The occurrence and fate of eight PPCPs was studied in river waters from upstream to downstream of the three rivers in the Pearl River Delta, China. The correlations of PPCP levels and water quality parameters were also investigated. The analytes
Pramodini B Kale-Pradhan et al.
Expert review of gastroenterology & hepatology, 7(3), 281-288 (2013-03-01)
This review summarizes literature regarding the role of antimicrobials for induction and maintenance of Crohn's disease (CD) remission. PubMed was searched (1966 to October 2012) for controlled trials involving adults and written in English. Five of the 13 identified studies
Philippe Villain-Guillot et al.
Antimicrobial agents and chemotherapy, 51(9), 3117-3121 (2007-07-04)
Staphylococcus epidermidis is a major cause of nosocomial infections because of its ability to form biofilms on the surface of medical devices. Only a few antibacterial agents are relatively active against biofilms, and rifampin, a transcription inhibitor, ranks among the
Andrew J Renuart et al.
PloS one, 8(3), e57776-e57776 (2013-03-08)
The microbiology and epidemiology of UTI pathogens are largely unknown in Botswana, a high prevalence HIV setting. Using laboratory data from the largest referral hospital and a private hospital, we describe the major pathogens causing UTI and their antimicrobial resistance
Mark A Toleman et al.
Antimicrobial agents and chemotherapy, 51(7), 2636-2638 (2007-04-18)
The metallo-beta-lactamase gene bla(VIM-2) was identified in a strain of Pseudomonas aeruginosa isolated in India. The integron encoding bla(VIM-2) was virtually identical to those recently found in the United States and Russia. These unusual structures are likely to have arisen
K D Thomas et al.
European journal of medicinal chemistry, 46(6), 2503-2512 (2011-04-15)
Three new series of quinoline-4-yl-1,2,3-triazoles carrying amides, sulphonamides and amidopiperazines were synthesized through multi-step reactions. The required intermediate, [1-(6-methoxy-2-methylquinolin-4-yl)-1H-1,2,3-triazol-4-yl]methanol (2) was prepared by treating 4-azido-6-methoxy-2-methylquinoline (1) with propargyl alcohol. Three different series of compounds were synthesized from this intermediate. All
Louis B Rice et al.
Antimicrobial agents and chemotherapy, 52(9), 3427-3429 (2008-06-25)
The bla(KPC-3) and qnrB19 determinants of transferable Klebsiella pneumoniae plasmid pLRM24 reside within a complex region consisting of a Tn1331 backbone into which a Tn4401-like element and qnrB19 mobilized by an adjacent ISEcp1 insertion sequence have been inserted. This novel
Shimon P Francis et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(5), 1999-2014 (2015-02-06)
Approximately one-third of known deafness genes encode proteins located in the hair bundle, the sensory hair cell's mechanoreceptive organelle. In previous studies, we used mass spectrometry to characterize the hair bundle's proteome, resulting in the discovery of novel bundle proteins.
Kohei Ohata et al.
Bioorganic & medicinal chemistry letters, 18(20), 5598-5600 (2008-09-23)
The title congeners were synthesized by employing our efficient synthetic route previously explored for preparing enantiomeric pairs of thiolactomycin and its 3-demethyl derivative. While all the synthesized congeners lacked in vitro antibacterial activity, some of the congeners bearing an (E)-cyclohept-2-enylidenemethyl
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