Merck
CN

Microbiology of urinary tract infections in Gaborone, Botswana.

PloS one (2013-03-08)
Andrew J Renuart, David M Goldfarb, Margaret Mokomane, Ephraim O Tawanana, Mohan Narasimhamurthy, Andrew P Steenhoff, Jonathan A Silverman
摘要

The microbiology and epidemiology of UTI pathogens are largely unknown in Botswana, a high prevalence HIV setting. Using laboratory data from the largest referral hospital and a private hospital, we describe the major pathogens causing UTI and their antimicrobial resistance patterns. This retrospective study examined antimicrobial susceptibility data for urine samples collected at Princess Marina Hospital (PMH), Bokamoso Private Hospital (BPH), or one of their affiliated outpatient clinics. A urine sample was included in our dataset if it demonstrated pure growth of a single organism and accompanying antimicrobial susceptibility and subject demographic data were available. A total of 744 samples were included. Greater than 10% resistance was observed for amoxicillin, co-trimoxazole, amoxicillin-clavulanate, and ciprofloxacin. Resistance of E. coli isolates to ampicillin and co-trimoxazole was greater than 60% in all settings. HIV status did not significantly impact the microbiology of UTIs, but did impact antimicrobial resistance to co-trimoxazole. Data suggests that antimicrobial resistance has already emerged to most oral antibiotics, making empiric management of outpatient UTIs challenging. Ampicillin, co-trimoxazole, and ciprofloxacin should not be used as empiric treatment for UTI in this context. Nitrofurantoin could be used for simple cystitis; aminoglycosides for uncomplicated UTI in inpatients.

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Sigma-Aldrich
氨苄西林 钠盐
Sigma-Aldrich
环丙沙星, ≥98% (HPLC)
Supelco
盐酸环丙沙星, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
环丙沙星, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
呋喃妥因, 98.0-102.0% (EP, UV)
Supelco
环丙沙星, VETRANAL®, analytical standard
Supelco
呋喃妥因, Pharmaceutical Secondary Standard; Certified Reference Material
盐酸环丙沙星, European Pharmacopoeia (EP) Reference Standard
Supelco
呋喃妥因, VETRANAL®, analytical standard
环丙沙星, European Pharmacopoeia (EP) Reference Standard
盐酸环丙沙星, European Pharmacopoeia (EP) Reference Standard