搜索范围
33975
应用筛选条件
关键词:'33975'
显示 1-30 #N/A 87 条结果 关于 "33975" 范围 论文
Jin-Hyung Shim et al.
Tissue engineering. Part A, 20(13-14), 1980-1992 (2014-02-13)
In this study, recombinant human bone morphogenetic protein-2 (rhBMP-2) delivery system with slow mode was successfully developed in three-dimensional (3D) printing-based polycaprolactone (PCL)/poly(lactic-co-glycolic acid) (PLGA) scaffolds for bone formation of critical-sized rabbit segmental diaphyseal defect. To control the delivery of
Matias Knuuttila et al.
The American journal of pathology, 184(8), 2163-2173 (2014-06-21)
Androgens are key factors involved in the development and progression of prostate cancer (PCa), and PCa growth can be suppressed by androgen deprivation therapy. In a considerable proportion of men receiving androgen deprivation therapy, however, PCa progresses to castration-resistant PCa
R J van der Vijver et al.
Surgical innovation, 20(2), 113-118 (2012-04-26)
The authors examined the potential of the cyclooxygenase 2 (COX-2) inhibitor carprofen to reproducibly induce anastomotic leakage. In experiment 1, an anastomosis was constructed in both ileum and colon of 20 rats, and they were given carprofen (5 mg/kg subcutaneously
Cecilia Engdahl et al.
Arthritis research & therapy, 16(4), R150-R150 (2014-07-17)
Estrogen (E2) delays onset and decreases severity of experimental arthritis. The aim of this study was to investigate the importance of total estrogen receptor alpha (ERα) expression and cartilage-specific ERα expression in genetically modified mice for the ameliorating effect of
Cornelia B Landersdorfer et al.
Journal of pharmaceutical sciences, 104(5), 1848-1855 (2015-03-11)
Gender and immune status can considerably impact on the pharmacokinetics (PK) of macromolecular and small molecule drugs. However, these effects are often not considered in drug development. We aimed to quantitatively evaluate effects of gender and immune status on the
Maria C Mavroudi et al.
Electrophoresis, 35(18), 2573-2578 (2014-05-24)
The aim of the present study is the CE performance evaluation for the separation of 2-arylpropionic acid nonsteroidal anti-inflammatory drugs. In particular, the separation of indoprofen, carprofen, ketoprofen, ibuprofen, and flurbiprofen was obtained by supporting the BGE either with SDS
Blandine Poulet et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(7), 1832-1842 (2014-03-14)
Osteoarthritis (OA) is a common chronic disease for which disease-modifying therapies are not currently available. Studies to seek new targets for slowing the progress of OA rely on mouse models, but these do not allow for longitudinal monitoring of disease
Laura Bertolacci et al.
Journal of the American Chemical Society, 135(1), 22-25 (2012-12-18)
In addition to inhibiting the cyclooxygenase (COX)-mediated biosynthesis of prostanoids, various widely used nonsteroidal anti-inflammatory drugs (NSAIDs) enhance endocannabinoid signaling by blocking the anandamide-degrading membrane enzyme fatty acid amide hydrolase (FAAH). The X-ray structure of FAAH in complex with the
Neil R Marshall et al.
Experimental neurology, 263, 79-90 (2014-09-24)
Injection of lysosomal enzyme into cisternal or ventricular cerebrospinal fluid (CSF) has been carried out in 11 lysosomal storage disorder models, with each study demonstrating reductions in primary substrate and secondary neuropathological changes, and several reports of improved neurological function.
Zilli Huma et al.
Neuroscience letters, 591, 197-201 (2015-02-26)
It is now well established that the cerebellum receives input from nociceptors which may serve to adjust motor programmes in response to pain and injury. In this study, we investigated the possibility that spinoreticular neurons (SRT) which project to a
Gro K Povlsen et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(2), 329-337 (2014-11-20)
Cerebral vasospasm and late cerebral ischemia (LCI) remain leading causes of mortality in patients experiencing a subarachnoid hemorrhage (SAH). This occurs typically 3 to 4 days after the initial bleeding and peaks at 5 to 7 days. The underlying pathophysiology
Tawina J Zollinger et al.
Journal of avian medicine and surgery, 25(3), 173-184 (2012-01-06)
To evaluate the pathologic effects of carprofen in a pigeon model (Columba livia), 52 young adult pigeons were used in a randomized control study design. Sixteen pigeons were randomly assigned to 1 of 3 treatment groups and received carprofen by
Nadja Grobe et al.
PloS one, 10(2), e0117899-e0117899 (2015-02-24)
It is well documented that angiotensin (Ang) II contributes to kidney disease progression. The protease prolyl carboxypeptidase (PRCP) is highly expressed in the kidney and may be renoprotective by degrading Ang II to Ang-(1-7). The aim of the study was
Dietmar Zechner et al.
BMC cancer, 15, 51-51 (2015-04-18)
We explored if known risk factors for pancreatic cancer such as type II diabetes and chronic inflammation, influence the pathophysiology of an established primary tumor in the pancreas and if administration of metformin has an impact on tumor growth. Pancreatic
Naomi J McKay et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(49), 16417-16423 (2014-12-05)
Glucagon-like peptide-1 (GLP-1) is produced in the ileum and the nucleus of the solitary tract. It is well known that GLP-1 controls food intake, but there is a growing literature indicating that GLP-1 also is involved in fluid intake. It
Zachary C Dobbin et al.
Oncotarget, 5(18), 8750-8764 (2014-09-12)
A cornerstone of preclinical cancer research has been the use of clonal cell lines. However, this resource has underperformed in its ability to effectively identify novel therapeutics and evaluate the heterogeneity in a patient's tumor. The patient-derived xenograft (PDX) model
Oeystein Roed Brekk et al.
Molecular and cellular neurosciences, 95, 1-12 (2018-12-19)
Chaperone-mediated autophagy (CMA) is a substrate-specific mode of lysosomal proteolysis, with multiple lines of evidence connecting its dysfunction to both ageing and disease. We have recently shown that CMA impairment through knock-down of the lysosomal receptor LAMP2A is detrimental to
Louise Grahnemo et al.
The Journal of endocrinology, 224(1), 97-108 (2014-11-02)
Treatment with anti-inflammatory glucocorticoids is associated with osteoporosis. Many of the treated patients are postmenopausal women, who even without treatment have an increased risk of osteoporosis. Lymphocytes have been shown to play a role in postmenopausal and arthritis-induced osteoporosis, and
W M O'Brien et al.
Pharmacotherapy, 7(1), 16-24 (1987-01-01)
Because a patient with arthritis (especially rheumatoid arthritis) may respond to one NSAID but not another, any addition to the ranks of these agents may be of clinical benefit to at least some of the millions of patients afflicted with
Gabor Szalai et al.
PloS one, 9(11), e110867-e110867 (2014-11-14)
Soluble fms-like tyrosine kinase (sFlt)-1-e15a, a primate-specific sFlt-1-isoform most abundant in the human placenta in preeclampsia, can induce preeclampsia in mice. This study compared the effects of full-length human (h)sFlt-1-e15a with those of truncated mouse (m)sFlt-1(1-3) used in previous preeclampsia
Angelo D Favia et al.
Journal of medicinal chemistry, 55(20), 8807-8826 (2012-10-10)
Pain and inflammation are major therapeutic areas for drug discovery. Current drugs for these pathologies have limited efficacy, however, and often cause a number of unwanted side effects. In the present study, we identify the nonsteroidal anti-inflammatory drug carprofen as
Danielle L Freeborn et al.
Toxicology and applied pharmacology, 282(2), 184-194 (2014-12-09)
The electroencephalogram (EEG) is an apical measure, capable of detecting changes in brain neuronal activity produced by internal or external stimuli. We assessed whether pesticides with different modes of action produced different changes in the EEG of adult male Long-Evans
Christoph Haller et al.
Nucleic acid therapeutics, 25(1), 20-26 (2014-12-11)
A multitude of stem cell types has been extensively studied and used for myocardial regenerative therapy. Amongst these endothelial progenitor cells form a promising source. In our present study, we investigated a one-staged approach for isolation and application of autologous
Yoshihiko Sawa et al.
PloS one, 9(5), e97165-e97165 (2014-05-20)
The toll-like receptor (TLR) has been suggested as a candidate cause for diabetic nephropathy. Recently, we have reported the TLR4 expression in diabetic mouse glomerular endothelium. The study here investigates the effects of the periodontal pathogen Porphyromonas gingivalis lipopolysaccharide (LPS)
Darryl R Overby et al.
Investigative ophthalmology & visual science, 55(8), 4922-4933 (2014-07-17)
To determine whether dexamethasone (DEX)-induced ocular hypertension (OHT) in mice mimics the hallmarks of steroid-induced glaucoma (SIG) in humans, including reduced conventional outflow facility (C), increased extracellular matrix (ECM), and myofibroblasts within the outflow pathway. Osmotic mini-pumps were implanted subcutaneously
Hakki Oguz Kazancioglu et al.
Acta odontologica Scandinavica, 73(1), 21-27 (2014-11-07)
The aim of this study is to analyze histologically the effect of CAPE on bone healing of Critical Size Defect (CSD) in rat calvaria. Thirty-two 3-month-old male rats were used. The animals were randomly divided into four groups. Group A
Mark C van Baal et al.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 14(6), 470-477 (2014-12-03)
Recently, a randomized controlled trial showed that probiotic prophylaxis was associated with an increased mortality in enterally fed patients with predicted severe pancreatitis. In a rat model for acute pancreatitis, we investigated whether an association between probiotic prophylaxis and enteral
Margi A Gilmour et al.
American journal of veterinary research, 73(5), 698-703 (2012-04-27)
To compare the effects of meloxicam, carprofen, and flunixin meglumine administered IV on the concentration of prostaglandin E(2) (PGE(2)) in the aqueous humor of dogs with aqueocentesis-induced anterior uveitis. 15 adult dogs with ophthalmically normal eyes. Each dog was assigned
Nadine K Gut et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(12), 4792-4803 (2015-03-27)
The pedunculopontine tegmental nucleus (PPTg) has been proposed as a target for deep brain stimulation (DBS) in parkinsonian patients, particularly for symptoms such as gait and postural difficulties refractory to dopaminergic treatments. Several patients have had electrodes implanted aimed at
K R Lezak et al.
Psychoneuroendocrinology, 45, 11-20 (2014-05-23)
Single nucleotide polymorphisms (SNP) in the genes for pituitary adenylate cyclase-activating polypeptide (PACAP) and the PAC1 receptor have been associated with several psychiatric disorders whose etiology has been associated with stressor exposure and/or dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. In
1/3