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Vivek Agrahari et al.
Drug testing and analysis, 7(3), 207-213 (2014-05-13)
Tenofovir (TFV) has been proven to prevent the transmission of the Human Immunodeficiency Virus (HIV) through the vagina. But, there is little information available about its stability under various storage and stress conditions. Hence, this study aimed to investigate the
Ellen P Preece et al.
Environmental monitoring and assessment, 187(2), 12-12 (2015-01-27)
Ingestion of water contaminated with the cyanotoxin, microcystin (MC), can pose serious health risks to humans. MC is also known to accumulate in seafood; however, this exposure pathway is much less understood. A fundamental element of this uncertainty is related
Zhouen Zhang et al.
Journal of labelled compounds & radiopharmaceuticals, 57(8), 540-549 (2014-07-06)
The nucleosides zidovudine (AZT), stavudine (d4T), and telbivudine (LdT) are approved for use in the treatment of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections. To promote positron emission tomography (PET) imaging studies on their pharmacokinetics, pharmacodynamics, and
Youn Gee Seo et al.
Archives of pharmacal research, 38(2), 223-228 (2014-08-20)
The purpose of this study was to develop a novel tacrolimus-loaded solid self-emulsifying drug delivery system (SEDDS) using Labrafac as an oil phase. The ternary phase diagram was plotted with Labrafac, Labrasol and Lauroglycol used as an oil, surfactant and
Weixia Li et al.
Journal of chromatography. A, 1346, 49-56 (2014-05-06)
The compatibility of Angelicae Sinensis Radix (Danggui, DG) and Chuanxiong Rhizoma (Chuanxiong, CX), a famous herb pair Gui-Xiong (GX), can produce synergistic and complementary hematopoiesis. In present study, global metabolic profiling with ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass
Cordula Stillhart et al.
Pharmaceutical research, 31(12), 3426-3444 (2014-06-26)
In vitro lipolysis is widely utilized for predicting in vivo performance of oral lipid-based formulations (LBFs). However, evaluation of LBFs in the absence of an absorption sink may have limited in vivo relevance. This study aimed at employing biopharmaceutical modeling
Naveen K Bejugam et al.
Drug development and industrial pharmacy, 41(2), 333-341 (2013-11-28)
To develop a tablet formulation for an active pharmaceutical ingredient for which sticking and filming problems occurred during tablet punching. Direct compression and dry granulation tableting techniques were evaluated using factorial experimental design. The effects of chrome-coated punch tips, filler
Petra C Lindholm-Lehto et al.
Environmental science and pollution research international, 22(21), 17209-17223 (2015-07-04)
The presence of five different pharmaceuticals, consisting of four anti-inflammatory and one antiepileptic drug, was determined in influent and effluent of a municipal wastewater treatment plant (WWTP) near the city of Jyväskylä, Finland, and in the receiving water, northern Lake
Timothy Paul Wood et al.
Environmental pollution (Barking, Essex : 1987), 199, 235-243 (2015-02-15)
The study and quantification of personal care products, such as pharmaceuticals, in surface water has become popular in recent years; yet very little description of these compounds' presence in South African surface water exists in the literature. Antiretrovirals (ARVs), used
Johannes Bertsch et al.
Journal of bacteriology, 197(9), 1681-1689 (2015-03-04)
The methylenetetrahydrofolate reductase (MTHFR) of acetogenic bacteria catalyzes the reduction of methylene-THF, which is highly exergonic with NADH as the reductant. Therefore, the enzyme was suggested to be involved in energy conservation by reducing ferredoxin via electron bifurcation, followed by
Raúl Pérez-Ortuño et al.
Analytical and bioanalytical chemistry, 407(28), 8463-8473 (2015-09-08)
A straightforward, high-throughput method was developed and fully validated for the simultaneous determination of the specific tobacco biomarkers nicotine and its main metabolite cotinine in a wide dynamic range and supporting the most common human biological matrices (urine, oral fluid
Markus Berger et al.
Archives of toxicology, 89(3), 459-483 (2014-05-07)
Lonomia obliqua caterpillar envenomation causes acute kidney injury (AKI), which can be responsible for its deadly actions. This study evaluates the possible mechanisms involved in the pathogenesis of renal dysfunction. To characterize L. obliqua venom effects, we subcutaneously injected rats
Vesna Petrovska-Jovanovska et al.
International journal of pharmaceutics, 484(1-2), 75-84 (2015-02-25)
In this study, hybrid silica xerogel particles were developed as carriers of budesonide (BDS) for efficient local treatment of inflammatory bowel diseases (IBD). Organically modified silica particles (ORMOSILs) were prepared by co-condensation of 3-aminopropyltriethoxysilane (APTES) and tetraethyl orthosilicate (TEOS) by
Alexandros G Asimakopoulos et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 986-987, 85-93 (2015-03-01)
A rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and optimized for the simultaneous determination of bisphenol A, 4-t-octylphenol and 4-nonylphenol in human blood serum. For the first time, the electrospray ionization (ESI) parameters of probe position, voltage potential
Surya Prakash Rao Pydimarry et al.
Journal of chromatographic science, 52(1), 42-51 (2012-12-22)
A simple, sensitive, precise and accurate stability-indicating ultra-performance liquid chromatography (UPLC) method was developed for the quantitative determination of the purity of the active pharmaceutical ingredient of milnacipran hydrochloride (MCP) and its pharmaceutical dosage form in the presence of its
Yi Chen Lu et al.
Journal of agricultural and food chemistry, 63(1), 92-103 (2014-12-17)
This study investigated the herbicide isoproturon (IPU) residues in soil, where wheat was cultivated and sprayed with salicylic acid (SA). Provision of SA led to a lower level of IPU residues in rhizosphere soil compared to IPU treatment alone. Root
Li-hua Fan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 986-987, 18-22 (2015-02-24)
A rapid, sensitive and selective ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was developed and validated for the determination and pharmacokinetic investigation of acacetin in rat plasma. Sample preparation was accomplished through a simple one-step deproteinization procedure with 0.2 mL
Norie Inukai et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 20(46), 15159-15168 (2014-09-23)
This work demonstrates a selection criteria that determines whether molecular assembly occurs through a one-step or stepwise manner in ligand-bridged dinuclear zinc(II) (Zn(2+)) complex formation, which is associated with the π stacking of building blocks. The building blocks of carbazole
Jixia Wang et al.
Journal of chromatography. A, 1361, 153-161 (2014-08-27)
Characterization of reverse-phase column selectivity is helpful for chromatographers to select an optimal column. A novel method, based on linear solvation energy relationships (LSERs) combined with fundamental retention equations, was developed to characterize and compare reversed-phase column selectivity. The retention
Wentao Zhou et al.
Journal of AOAC International, 97(6), 1552-1562 (2015-01-30)
During the synthesis of Azilsartan (AZS), it was speculated that 15 potential impurities would arise. This study investigated the possible mechanism for the formation of 14 of them, and their structures were characterized and confirmed by IR, NMR, and MS
Zong-Quan Ou et al.
The Journal of pharmacy and pharmacology, 66(7), 998-1008 (2014-04-05)
To investigate effects of different postharvest drying processes and storage conditions on key antioxidants in Sonchus oleraceus L. leaves. Fresh leaves were oven-dried (60°C), freeze-dried or air-dried (∼25°C) for 6 h, 24 h and 3 days, respectively. Design of experiments (DOE)
Sylwia K Paszun et al.
Acta poloniae pharmaceutica, 70(6), 1079-1085 (2014-01-05)
The presented study aimed at the evaluation of hydrochlorothiazide influence on cilazapril stability in model mixture and fixed dose tablet formulation. The degradation of cilazapril in the presence of hydrochlorothiazide took place according to autocatalytic reaction kinetic mechanism, described mathematically
Lucía Lourido et al.
Journal of proteome research, 13(12), 6096-6106 (2014-11-11)
Osteoarthritis (OA) is the most common rheumatic pathology and is characterized primarily by articular cartilage degradation. Despite its high prevalence, there is no effective therapy to slow disease progression or regenerate the damaged tissue. Therefore, new diagnostic and monitoring tests
John Warner et al.
Talanta, 146, 279-284 (2015-12-24)
Solvent tolerance of immobilized enzymes is important for many biosensing and biotechnological applications. In this paper we report an acetylcholinesterase (AChE) biosensor based on chitosan that exhibits high solvent resistance and enables sensitive detection of pesticides in presence of a
Karen E Parrish et al.
Molecular cancer therapeutics, 14(12), 2735-2743 (2015-10-07)
PARP inhibition can enhance the efficacy of temozolomide and prolong survival in orthotopic glioblastoma (GBM) xenografts. The aim of this study was to evaluate the combination of the PARP inhibitor rucaparib with temozolomide and to correlate pharmacokinetic and pharmacodynamic studies
Qingce Zang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 989, 91-97 (2015-03-31)
Usually, insufficient intratumoral concentration of therapeutic drugs is one of the reasons for tumor treatment failure. However, little is known about intratumoral distribution of bromocriptine in non-responding prolactinomas because of extremely low drug concentration and small prolactinoma tissue samples. In
Rina Kuswahyuning et al.
Pharmaceutical research, 31(6), 1501-1511 (2014-01-24)
This study sought to understand the mechanism by which the steady state flux of nicotine across the human skin from aqueous solutions is markedly decreased at higher nicotine concentrations. Nicotine's steady state flux through human epidermis and its amount in
Pratistha Dwivedi et al.
Anaerobe, 35(Pt B), 77-91 (2015-08-05)
The prevailing scenario of bioterrorism warrants development of medical countermeasures with expanded coverage of select agents. Clostridium perfringens is a pathogen of medical, veterinary and military importance, and has been listed as Validated Biological Agent. We employed 2DE-MS approach to
Indu Choudhary et al.
Journal of proteomics, 128, 123-131 (2015-07-21)
Nemopilema nomurai is one of the largest species of jellyfish in the world. It blooms mainly offshore of Korea, China, and Japan. Increasing population numbers of N. nomurai is increasing the risk of sea bathers to the jellyfish stings and
John F Valliere-Douglass et al.
Journal of pharmaceutical sciences, 104(2), 652-665 (2014-12-04)
We report that a unique type of chemical modification occurs on lyophilized proteins. Freeze-dried mAbs and antibody-drug conjugates (ADCs) can be covalently modified with buffer and excipient molecules on the side chains of Glu, Asp, Thr, and Ser amino acids
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