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Sigthor Petursson
Carbohydrate research, 338(9), 963-968 (2003-04-12)
The paper reports the tin(II) chloride catalyzed reactions of diazodiphenylmethane with the cis- and trans-1,2-cyclohexanediols and R,S-1,2-propanediol in 1,2-dimethoxyethane and the identification of the monodiphenylmethyl ethers formed. The catalyst is shown to work for both the cis- and trans-cyclohexanediols, but
Andreas Hartung et al.
The Journal of organic chemistry, 72(26), 10235-10238 (2007-11-16)
Comparison is made between the preparation of trans-1,2-cyclohexanediol in standard glassware (conventional batch production) and in a microreactor (continuous flow production). The reaction sequence involved two exothermic steps where the standard procedure demands slow reagent addition and careful temperature control.
C B Shinisha et al.
Organic letters, 11(15), 3242-3245 (2009-09-02)
The relative energies of cyclohexane-1,2-diols and chiral tetrapeptide (2 (Boc) or 3 (Moc)) complexes calculated using DFT indicate a thermodynamic preference for chiral recognition toward (1R,2R)(e,e)-alpha isomer. The barrier for stereoselective acyl transfer is identified as lower for trans-(1R,2R)-cyclohexane-1,2-diol, leading
R J Swift et al.
Applied microbiology and biotechnology, 55(6), 721-726 (2001-08-30)
Benzene dioxygenase (BDO; EC 1.14.12.3) from Pseudomonas putida ML2 dihydroxylates benzene to produce cis-1,2-dihydroxy-cyclohexa-3,5-diene. As well as oxidising benzene and toluene, cell-free extracts of Escherichia coli JM109 expressing recombinant BDO oxidised cyclohexene, 1-methylcyclohexene and 3-methylcyclohexene. In an attempt to construct
Ine Lentacker et al.
Journal of controlled release : official journal of the Controlled Release Society, 132(3), 279-288 (2008-07-29)
After administration to the body, nucleic acid containing nanoparticles (NANs) need to cross several extra- and intracellular barriers to reach the cytoplasm or nucleus of the target cells. In the last decade several groups tried to overcome these barriers by
T Kiguchi et al.
Chemical & pharmaceutical bulletin, 48(10), 1536-1540 (2000-10-25)
Asymmetric spirocyclization based on intramolecular conjugate addition using a combination of a Lewis acid and an optically active cyclohexane-1,2-diol has been studied in connection with 1) the effect of substituents on the cyclohexane-1,2-diol and 2) the effect of substituents on
G A Mills et al.
Clinical chemistry, 36(6), 870-874 (1990-06-01)
Using gas chromatography-mass spectrometry, we investigated the urinary excretion of organic acids of 278 newborn babies in a special care unit to obtain reference data and monitor metabolism. In 101 of 584 urine samples analyzed, we found isomers of cyclohexanediol.
Ivan Liashkovich et al.
Journal of controlled release : official journal of the Controlled Release Society, 160(3), 601-608 (2012-03-06)
The efficiency of gene therapy in non-dividing cells is particularly poor due to restricted nuclear delivery rates of exogenously applied macromolecules across the nuclear pore complexes (NPCs). Therefore, improved intranuclear delivery of transgenes requires an ability to modulate the barrier
A Perico et al.
International archives of occupational and environmental health, 72(2), 115-120 (1999-04-10)
This article reports the results obtained with the biological and environmental monitoring of occupational exposure to cyclohexane using 1,2-cyclohexanediol (1,2-DIOL) and 1,4-DIOL in urine. The kinetic profile of 1,2-DIOL in urine suggested by a physiologically based pharmacokinetic (PBPK) model was
Ruben Bartholomäus et al.
Inorganic chemistry, 52(8), 4282-4292 (2013-03-28)
The stabilization of Cr(V) by biological 1,2-diolato ligands, including carbohydrates, glycoproteins, and sialic acid derivatives, is likely to play a crucial role in the genotoxicity of Cr(VI) and has also been implicated in the antidiabetic effect of Cr(III). Previously, such
J Mráz et al.
Scandinavian journal of work, environment & health, 25(3), 233-237 (1999-08-18)
This study explored the acute effect of ethanol (EtOH) on the urinary excretion of cyclohexanol (CH-ol), 1,2- and 1,4-cyclohexanediol (CH-diol), biomarkers of exposure to important solvents, and chemical intermediates cyclohexanone (CH-one), cyclohexane (CH) and cyclohexanol. Volunteers (5-8 in each group)
Oxidation of trans-and cis-1, 2-cyclohexanediol by Gluconobacter oxydans.
Adlercreutz P.
Applied Microbiology and Biotechnology, 30(3), 257-263 (1989)
Yoshihito Shiota et al.
Inorganic chemistry, 50(13), 6200-6209 (2011-06-04)
The catalytic conversion of 1,2-cyclohexanediol to adipic anhydride by Ru(IV)O(tpa) (tpa ═ tris(2-pyridylmethyl)amine) is discussed using density functional theory calculations. The whole reaction is divided into three steps: (1) formation of α-hydroxy cyclohexanone by dehydrogenation of cyclohexanediol, (2) formation of
Roosmarijn E Vandenbroucke et al.
Nucleic acids research, 35(12), e86-e86 (2007-06-23)
One of the major obstacles in non-viral gene transfer is the nuclear membrane. Attempts to improve the transport of DNA to the nucleus through the use of nuclear localization signals or importin-beta have achieved limited success. It has been proposed
Uta Griesenbach et al.
The journal of gene medicine, 14(7), 491-500 (2012-06-20)
The nuclear membrane of differentiated airway epithelial cells is a significant barrier for nonviral vectors. Trans-cyclohexane-1,2-diol (TCHD) is an amphipathic alcohol that has been shown to collapse nuclear pore cores and allow the uptake of macromolecules that would otherwise be
M Tanaka et al.
The Journal of organic chemistry, 66(8), 2667-2673 (2001-04-17)
Diastereoselective alkylation of ethyl 2-methyl- and/or 2-ethylacetoacetates using the (S,S)-cyclohexane-1,2-diol as an acetal chiral auxiliary afforded enol ethers (2a-f and 5a-f) of 92->95% de in 31-70% yields. Removal of the cyclohexane-1,2-diol with BF(3)-OEt(2) afforded beta-keto esters (3 and 6) bearing
Yun Wang et al.
Materials (Basel, Switzerland), 12(20) (2019-10-12)
Catalyzed organic solvent-free (ep)oxidation were achieved using H3PM12O40 (M = Mo or W) complexes ionically grafted on APTES-functionalized nano-silica beads obtained from straightforward method (APTES = aminopropyltriethoxysilane). Those catalysts have been extensively analyzed through morphological studies (Dynamic Light Scattering (DLS)
J Mráz et al.
International archives of occupational and environmental health, 71(8), 560-565 (1998-12-22)
The metabolism and toxicokinetics of cyclohexane (CH) and cyclohexanol (CH-ol), important solvents and chemical intermediates, were studied in volunteers after 8-h periods of inhalation exposure at concentrations of 1010 and 236 mg m(-3), respectively (occupational exposure limits: CH, 1050 mg
Kango Fujitani et al.
Journal of oleo science, 58(6), 323-328 (2009-05-12)
Oxidation of cyclohexanediol derivatives with 12-tungstophospholic acid-hydrogen peroxide system was investigated focusing on a reaction mechanism in the preparation of dicarboxylic acids from olefin because oxidative cleavage of vicinal diols would be a rate-determining step in oxidative cleavage of carbon-carbon
M Shahjahan Kabir et al.
The Journal of organic chemistry, 75(11), 3626-3643 (2010-05-01)
cis-1,2-Cyclohexanediol (L3) has been shown to be an efficient and versatile bidentate O-donor ligand that provides a highly active Cu-catalytic system. It was more effective than diols such as trans-1,2-cyclohexanediol or ethylene glycol. This commercially available cis-1,2-cyclohexanediol ligand facilitated the
L Xia et al.
Se pu = Chinese journal of chromatography, 17(1), 43-45 (2003-01-29)
The enantiomeric resolution of racemic mixtures of thirteen trans-1,2-disubstituted cyclopropane was achieved with HPLC by using Chiralcel OD and Chiralcel OJ as chiral stationary phase and hexane/2-propanol mixtures with different concentrations as eluent. The chromatographic parameters of these racemates on
Jean Detry et al.
Applied microbiology and biotechnology, 72(6), 1107-1116 (2006-04-06)
Two extracellular lipases from Bacillus subtilis, B. subtilis lipase A and lipase B, have been expressed in the heterologous host Escherichia coli, biochemically characterized and used for the kinetic resolution of (rac)-trans-1,2-diacetoxycyclohexane. Both enzymes were selectively acting on the (R,R)-enantiomer
Keiji Yamamoto et al.
Journal of pharmacological sciences, 92(4), 387-399 (2003-08-27)
trans-1,2-Cyclohexanediol, the major metabolite of the cilexetil moiety of candesartan cilexetil (CC), has been reported to have potent pro-arrhythmic effects in dogs with congestive heart failure (CHF), especially when co-administered with digoxin. To verify this and to clarify the clinical
Bao-Hui Chen et al.
Dalton transactions (Cambridge, England : 2003), 44(3), 1023-1038 (2014-11-20)
A simple and convenient approach denoted as gel-deposition-precipitation (G-D-P) for the preparation of core-shell-like silica@nickel species nanoparticles was studied systematically. Core-shell-like silica@nickel species nanoparticles consisted of a Si-rich core and a Ni-rich shell. The G-D-P process included two steps: one
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