跳转至内容
Merck
CN
  • A very active cu-catalytic system for the synthesis of aryl, heteroaryl, and vinyl sulfides.

A very active cu-catalytic system for the synthesis of aryl, heteroaryl, and vinyl sulfides.

The Journal of organic chemistry (2010-05-01)
M Shahjahan Kabir, Michael Lorenz, Michael L Van Linn, Ojas A Namjoshi, Shamim Ara, James M Cook
摘要

cis-1,2-Cyclohexanediol (L3) has been shown to be an efficient and versatile bidentate O-donor ligand that provides a highly active Cu-catalytic system. It was more effective than diols such as trans-1,2-cyclohexanediol or ethylene glycol. This commercially available cis-1,2-cyclohexanediol ligand facilitated the Cu-catalyzed cross-coupling reactions of alkyl, aryl, or heterocyclic thiols with either alkyl, aryl, heterocyclic, or substituted vinyl halides. This new catalytic system promoted the mild and efficient stereo- and regiospecific synthesis of biologically important vinyl sulfides. The yields obtained using electron-rich substituted vinyl sulfides with this catalyst system are generally 75-98%. Most importantly, this singular catalyst system is extremely versatile and provides entry into a wide range of sulfides. This method is particularly noteworthy given its mild reaction conditions, simplicity, generality, and exceptional level of functional group tolerance.

材料
产品编号
品牌
产品描述

Sigma-Aldrich
反-1,2-环己二醇, 98%
Sigma-Aldrich
顺式-1,2-环己二醇, 99%