50-30-6

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Composite organization of the cobalamin binding and cubilin recognition sites of intrinsic factor.

Sergey N Fedosov et al.

Biochemistry, 44(9), 3604-3614 (2005-03-02)

Intrinsic factor (IF(50)) is a cobalamin (Cbl)-transporting protein of 50 kDa, which can be cleaved into two fragments: the 30 kDa N-terminal peptide IF(30) and the 20 kDa C-terminal glycopeptide IF(20). Experiments on binding of Cbl to IF(30), IF(20), and

A 50% vs 30% dose of verteporfin (photodynamic therapy) for acute central serous chorioretinopathy: one-year results of a randomized clinical trial.

Mingwei Zhao et al.

JAMA ophthalmology, 133(3), 333-340 (2015-01-03)

A randomized clinical trial is needed to evaluate what is the best photodynamic therapy (PDT) protocol to use for acute central serous chorioretinopathy. To compare the efficacy and safety of a 50% dose of verteporfin (a method of PDT) with

[Influence of electroacupuncture stimulation of delivery-facilitating acupoints with different stimulating parameters on serum endocrine hormones of late-stage pregnant rats].

Hong-Wen Yuan et al.

Zhen ci yan jiu = Acupuncture research, 38(2), 112-117 (2013-07-04)

To observe the influence of electroacupuncture (EA) stimulation of "Hegu" (LI 4) and "Sanyinjiao"(SP 6; a classical delivery-facilitating acupoint recipe) at different parameters on endocrine hormone levels of late-stage pregnant rats, so as to find the better stimulation parameters for

Comparison of systemic inflammation response and vital organ damage induced by severe burns in different area.

Lingying Liu et al.

International journal of clinical and experimental pathology, 8(6), 6367-6376 (2015-08-12)

In this study, we will establish a stable and optimized rat model that can meet strictly diagnosed criteria and serve as a tool to investigate the potential of novel therapeutics in this preclinical model through comparative analysis of systemic alterations

Teratologic evaluation of orally administered nitrapyrin in rats and rabbits.

N M Berdasco et al.

Fundamental and applied toxicology : official journal of the Society of Toxicology, 11(3), 464-471 (1988-10-01)

Pregnant Fischer 344 rats and New Zealand White rabbits were orally administered 0, 5, 15, or 50 mg nitrapyrin/kg/day on Gestation Days 6 through 15 (rats) or 0, 3, 10, or 30 mg/kg/day on Gestation Days 6 through 18 (rabbits).

6-Nitrobenzimidazole derivatives: potential phosphodiesterase inhibitors: synthesis and structure-activity relationship.

K M Khan et al.

Bioorganic & medicinal chemistry, 20(4), 1521-1526 (2012-01-24)

6-Nitrobenzimidazole derivatives (1-30) synthesized and their phosphodiesterase inhibitory activities determined. Out of thirty tested compounds, ten showed a varying degrees of phosphodiesterase inhibition with IC(50) values between 1.5±0.043 and 294.0±16.7 μM. Compounds 30 (IC(50)=1.5±0.043 μM), 1 (IC(50)=2.4±0.049 μM), 11 (IC(50)=5.7±0.113

Design of N-acetyl-6-sulfo-beta-d-glucosaminide-based inhibitors of influenza virus sialidase.

Kenji Sasaki et al.

Bioorganic & medicinal chemistry, 12(6), 1367-1375 (2004-03-17)

Biological activity of N-acetyl-6-sulfo-beta-d-glucosaminides (6-sulfo-GlcNAc 1) having a structural homology to N-acetylneuraminic acid (Neu5Ac 2) and 2-deoxy-2,3-dehydro-N-acetylneuraminic acid (Neu5Ac2en 3) was examined in terms of inhibitory activity against influenza virus sialidase (influenza, A/Memphis/1/71 H3N2). pNP 6-Sulfo-GlcNAc 1a was proved to

Roles of plant growth regulators on yield, grain qualities and antioxidant enzyme activities in super hybrid rice (Oryza sativa L.).

Shenggang Pan et al.

Rice (New York, N.Y.), 6(1), 9-9 (2013-11-28)

Plant growth regulators play important roles in plant growth and development, but little is known about roles of plant growth regulators in yield, grain qualities and antioxidant enzyme activities in super hybrid rice. In this study, gibberellic acid(GA3), paclobutrazol (PBZ)

[Comparative study of IL-4, IFN-gamma gene methylation for the epigenetics of allergic rhinitis in Xinjiang Uygur, Han people].

Zhongzhang Lou et al.

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 26(18), 795-797 (2012-12-25)

To investigate the differences of IL-4, IFN-gamma gene promoter methylation of allergic rhinitis patients between Uygur and Han people of Xinjiang. Methylation-specific PCR (MSP) detected IL-4, IFN-gamma gene methylation of each of 50 patients with allergic rhinitis in Uygur and

Total resection of any segment of the lateral meniscus may cause early cartilage degeneration: Evaluation by magnetic resonance imaging using T2 mapping.

Koji Murakami et al.

Medicine, 97(23), e11011-e11011 (2018-06-08)

The aim of this study was to perform quantitative evaluation of degeneration of joint cartilage using T2 mapping in magnetic resonance imaging (MRI) after arthroscopic partial resection of the lateral meniscus.The subjects were 21 patients (23 knees) treated with arthroscopic

Inflammatory Response 24 h Post-Exercise in Youth with Juvenile Idiopathic Arthritis.

Emmanuelle Rochette et al.

International journal of sports medicine, 39(11), 867-874 (2018-08-18)

The aim of this study was to measure the impact, at 24 h post-exercise, of a single exercise bout on plasma inflammatory markers such as calprotectin, IL-6, sIL-6 R, sgp130 and the hypothalamic-pituitary-adrenal (HPA) axis in children with juvenile idiopathic arthritis (JIA).Twelve

Transformation of 2-aminoacetophenone to ( S) -2-amino-1-phenylethanol by Arthrobacter sulfureus.

Guogang Zhao et al.

Biotechnology letters, 26(16), 1255-1259 (2004-10-16)

A new isolate of Arthrobacter sulfureus , when incubated at 50 g resting cells (dry cell wt) l(-1) with 50 g glucose l(-1) and 1 g 2-aminoacetophenone l(-1) in 50 mm potassium buffer (pH 7, 4 ml) at 30 degrees

Cytokines derived from cultured skeletal muscle cells after mechanical strain promote neutrophil chemotaxis in vitro.

Jennifer M Peterson et al.

Journal of applied physiology (Bethesda, Md. : 1985), 106(1), 130-137 (2008-11-01)

We tested the hypothesis that cytokines derived from differentiated skeletal muscle cells in culture induce neutrophil chemotaxis after mechanical strain. Flexible-bottom plates with cultured human muscle cells attached were exposed to mechanical strain regimens (ST) of 0, 10, 30, 50

Structure-activity relationships of adenosines with heterocyclic N6-substituents.

T D Ashton et al.

Bioorganic & medicinal chemistry letters, 17(24), 6779-6784 (2007-10-31)

Two series of N(6)-substituted adenosines with monocyclic and bicyclic N(6) substituents containing a heteroatom were synthesized in good yields. These derivatives were assessed for their affinity ([(3)H]CPX), potency, and intrinsic activity (cAMP accumulation) at the A(1) adenosine receptor in DDT(1)

Effect of nutritional imbalances on cytochrome P-450 isozymes in rat liver.

Z Amelizad et al.

Biochemical pharmacology, 37(17), 3245-3249 (1988-09-01)

Male Sprague-Dawley rats were fed for six weeks either a control diet containing 22% casein (C) and 5% fat (F) or a low-protein diet (6% C, 5% F) or high-lipid diet (30% C, 30% F). A group of rats received

Effect of topical Beta blocker (Timolol maleate 0.5%) in primary open angle glaucoma.

N Khan et al.

Mymensingh medical journal : MMJ, 21(4), 648-653 (2012-11-09)

The study was undertaken to measure the effects of Beta blocker (Timolol maleate 0.5%) in moderate and advanced stage of primary open angle glaucoma by controlling intra-ocular pressure (IOP) and assessing the visual acuity (VA) and mean sensitivity (MS) of

Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents.

Dan Niculescu-Duvaz et al.

Bioorganic & medicinal chemistry, 21(5), 1284-1304 (2013-02-05)

The RAS-RAF-MEK-ERK pathway is hyperactivated in 30% of human cancers. BRAF is a serine-threonine kinase, belonging to this pathway that is mutated with high frequency in human melanoma and other cancers thus BRAF is an important therapeutic target in melanoma.

Comparison of the effects of preoperative and intraoperative intravenous application of dexketoprofen on postoperative analgesia in septorhinoplasty patients: randomised double blind clinical trial.

A B Ozer et al.

European review for medical and pharmacological sciences, 16(13), 1828-1833 (2012-12-05)

Postoperative analgesia is important because it prevents the adverse effects of pain. To study the effect of preoperative or intraoperative application of dexketoprofen on postoperative analgesia and patient comfort in patients undergoing septorhinoplasty. A randomized, double-blind, placebo-controlled study. The study

Detection of nanosized ordered domains in DOPC/DPPC and DOPC/Ch binary lipid mixture systems of large unilamellar vesicles using a TEMPO quenching method.

Keishi Suga et al.

Langmuir : the ACS journal of surfaces and colloids, 29(15), 4830-4838 (2013-03-20)

Nanosized ordered domains formed in 1,2-dioleoyl-sn-glycero-3-phosphocholine/1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DOPC/DPPC) and DOPC/cholesterol (Ch) liposomes were characterized using a newly developed (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) quenching method. The membrane fluidity of the DOPC/DPPC liposomes, evaluated by the use of 1,6-diphenyl-1,3,5-hexatriene (DPH), increased significantly above their phase-transition

A comparison of the efficacy of three different peak airway pressures on intraoperative bleeding point detection in patients undergoing thyroidectomy: a randomized, controlled, clinical trial.

Cigdem Akyol Beyoglu et al.

BMC surgery, 20(1), 69-69 (2020-04-12)

Various techniques are used to detect intraoperative bleeding points in thyroid surgery. We aimed to assess the effect of increasing peak airway pressure to 30, 40 and 50 cm H2O manually in detecting intraoperative bleeding points. One hundred and 34 patients

Enhanced photodynamic activity of meso-tetra(4-hydroxyphenyl)porphyrin by incorporation into sub-200 nm nanoparticles.

Yvette Niamien Konan et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 18(3-4), 241-249 (2003-03-28)

A photosensitizer, meso-tetra(hydroxyphenyl)porphyrin (p-THPP) was incorporated into sterile submicronic nanoparticles of poly(D,L-lactide-co-glycolide) (50:50 and 75:25 PLGA) and poly(D,L-lactide) (PLA). With all polymers used, sub-130 nm p-THPP-loaded nanoparticles with similar drug loadings and entrapment efficiencies were produced using the emulsification-diffusion technique.

Olfactory and hepatic changes following a single inhalation exposure of 3-trifluoromethyl pyridine in rats: concentration and temporal aspects.

B A Gaskell et al.

Toxicology, 62(1), 35-51 (1990-05-14)

The effects of a single exposure to 3-trifluoromethyl pyridine (3FMP), were investigated in two studies. In the first study, rats were exposed nose only to 0, 50 or 800 ppm 3FMP for periods of 15 min to 4 h. Half

Preparation of Margarine Stock Rich in Naturally Bioactive Components by Enzymatic Interesterification.

Dianyu Yu et al.

Journal of oleo science, 67(1), 29-37 (2017-12-15)

Fully hydrogenated expanded press soybean oil (FHEPSO) rich in naturally bioactive components was prepared using Palladium on Carbon (Pd/C) catalyst. Interesterified fat was prepared from binary blends of FHEPSO and cold press corn oil (CPCO) with FHEPSO/CPCO mass ratios of

Serum interleukin-6 concentration reflects the extent of asymptomatic left ventricular dysfunction and predicts progression to heart failure in patients with stable coronary artery disease.

Bartosz Hudzik et al.

Cytokine, 54(3), 266-271 (2011-03-09)

Left ventricular ejection fraction (LVEF) remains one of the strongest predictors of long-term prognosis in patients with stable coronary artery disease (CAD). Asymptomatic left ventricular systolic dysfunction (LVSD) often precedes clinically overt heart failure (HF) and is an area of

Severe preservation injury induces Il-6/STAT3 activation with lack of cell cycle progression after partial liver graft transplantation.

Fotini Debonera et al.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 4(12), 1964-1971 (2004-12-04)

Partial liver graft transplantation is a surgical advance developed to overcome severe donor shortage. Survival of these grafts involves recovery from cold ischemia and reperfusion (CIR) injury, immediate regeneration and maintenance of function. Here we examined the outcome of partial

Alpha-fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide, a novel potent anticonvulsant derivative of a cyclic analogue of valproic acid.

Neta Pessah et al.

Journal of medicinal chemistry, 52(8), 2233-2242 (2009-03-20)

2,2,3,3-Tetramethylcyclopropanecarboxylic acid (TMCA, 4) is a cyclic analogue of the antiepileptic drug (AED) valproic acid (VPA) (1). alpha-F, alpha-Cl, alpha-Br, and alpha-methyl derivatives of 4 and their amides were synthesized and tested in rodent models for anticonvulsant potency and AED-induced

Early administration of entacapone prevents levodopa-induced motor fluctuations in hemiparkinsonian rats.

C Marin et al.

Experimental neurology, 192(1), 184-193 (2005-02-09)

The purpose of this study was to investigate the effect of the catechol-O-methyltransferase (COMT) inhibitor, entacapone, in the reversal and prevention of "wearing-off" phenomena in hemiparkinsonian rats. Catechol-O-methyltransferase (COMT) inhibitors increase the half-life and bioavailability of levodopa, providing more continuous

Pomegranate juice protects macrophages from triglyceride accumulation: inhibitory effect on DGAT1 activity and on triglyceride biosynthesis.

Mira Rosenblat et al.

Annals of nutrition & metabolism, 58(1), 1-9 (2011-01-08)

To analyze the effects of pomegranate juice (PJ) and punicalagin on macrophage triglyceride metabolism. Triglyceride metabolism was analyzed in PJ- or punicalagin-treated J774A.1 macrophages or in mouse peritoneal macrophages (MPM) harvested from C57BL/6 mice or from paraoxonase 2 (PON2)-deficient mice.

Purification and kinetics study of thermostable cellulase free xylanase from Bacillus subtilis.

Muhammad Irfan et al.

Protein and peptide letters, 20(11), 1225-1231 (2013-05-30)

Present study dealt with the production, purification and characterization of xylanase from Bacillus subtilis- BS05 grown in submerged fermentation at 37(o)C for 48h using sugarcane bagasse as a substrate. Xylanase enzyme was purified to homogeneity by ammonium sulphate fractionation followed

Peripheral nerve regeneration in interleukin 6-deficient mice.

M M Inserra et al.

Archives of otolaryngology--head & neck surgery, 126(9), 1112-1116 (2000-09-09)

Interleukin 6 (IL-6) is a multifunctional cytokine with effects on central and peripheral neurons. To investigate the role of IL-6 in peripheral nerve regeneration by comparing IL-6 knockout and wild-type mice in a sciatic nerve model of injury and repair.

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