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关键词:'516-12-1'
显示 1-13 共 13 条结果 关于 "516-12-1" 范围 论文
Kin Wang To et al.
Therapeutic drug monitoring, 31(4), 527-530 (2009-06-18)
Cytochrome P450 2B6 (CYP2B6) is the main metabolizing pathway for efavirenz (EFV), the prescription of which is associated with neurologic side effects. The authors conducted a study on the prevalence of CYP2B6 polymorphism, profile of side effects, and pharmacokinetics of
A O Chua et al.
Journal of immunology (Baltimore, Md. : 1950), 153(1), 128-136 (1994-07-01)
A cDNA encoding a human IL-12R subunit was isolated by expression cloning. This subunit is a 662 amino acid type I transmembrane protein with an extracellular domain of 516 amino acids and a cytoplasmic domain of 91 amino acids. It
Zhengfang Yi et al.
Biochemical and biophysical research communications, 320(2), 409-415 (2004-06-29)
The zinc-finger motif found in many transcription factors is thought to be important for human heart development and diseases. In this study, we have identified and characterized a novel zinc-finger gene named ZNF480 using degenerate primers from an early human
Guadalupe de la Lanza Espino et al.
PloS one, 10(6), e0125562-e0125562 (2015-06-26)
The surficial sediments recovered from 12 sites located near the channel axis of the Florida Straits and the lower slope off NW Cuba were analyzed for total organic carbon (TOC), nitrogen (TN), phosphorus (TP), elemental C:N:P ratios, C and N
Akihiro Nakamura et al.
Mutation research, 502(1-2), 19-24 (2002-05-09)
E-cadherin is a tumor suppressor involved in epithelial cell-cell interactions. Some of the nucleotide variation in the 5'-promoter region of the gene influences transcriptional efficiency. We investigated single nucleotide polymorphisms (SNPs) in the promoter-exon 1 region of the E-cadherin gene
V Pokorny et al.
Annals of the rheumatic diseases, 64(3), 487-490 (2004-08-28)
Ligands of chemokine receptor CCR5, including MIP-1 alpha, MIP-1 beta, and RANTES, have been implicated in rheumatoid arthritis. To test whether CCR5 d32 polymorphism has a negative association with rheumatoid arthritis in a New Zealand cohort. 516 white patients with
Julia Kirchheiner et al.
British journal of clinical pharmacology, 55(1), 51-61 (2003-01-22)
The cytochrome P450 enzyme CYP2C9 catalyses the 4'-hydroxylation of the nonsteroidal analgesic drug diclofenac in humans. We studied the influences of the known amino acid variants, CYP2C9*2 (Arg144Cys) and CYP2C9*3 (Ile359Leu), on diclofenac pharmacokinetics after a 50-mg oral dose of
Angel Chamorro et al.
The Lancet. Neurology, 13(5), 453-460 (2014-04-08)
Uric acid is an antioxidant with neuroprotective effects in experimental models of stroke. We assessed whether uric acid therapy would improve functional outcomes at 90 days in patients with acute ischaemic stroke. URICO-ICTUS was a randomised, double-blind, placebo-controlled, phase 2b/3
Tobias Brockmann et al.
JAMA ophthalmology, 133(7), 813-819 (2015-05-01)
The management of graft failure is increasingly relevant with the spread and growing acceptance of endothelial keratoplasty. To investigate the functional and anatomical results of secondary Descemet membrane endothelial keratoplasty (DMEK) for graft failure after Descemet stripping endothelial keratoplasty (DSEK)
Soraya Sin et al.
Journal of the National Cancer Institute, 103(17), 1323-1337 (2011-08-13)
Fermitin family member 1 (FERMT1, Kindlin-1) is an epithelial-specific regulator of integrin functions and is associated with Kindler syndrome, a genetic disorder characterized by skin blistering, atrophy, and photosensitivity. However, the possible role of kindlin-1 in cancer remains unknown. Kindlin-1
Akihiko Saitoh et al.
AIDS (London, England), 21(16), 2191-2199 (2007-12-20)
Cytochrome P450 2B6 (CYP2B6)-G516T genotype is associated with altered activity of hepatic CYP2B6 and efavirenz pharmacokinetics, but the relationship between the CYP2B6-G516T genotype and nevirapine (NVP) pharmacokinetics in plasma and cerebrospinal fluid (CSF) is limited. In 126 children who received
P Y Caux et al.
Reviews of environmental contamination and toxicology, 133, 1-58 (1993-01-01)
Literature on the environmental fate and effects of the benzoic acid herbicide dicamba was reviewed to provide a scientific basis to derive Canadian Water Quality Guidelines. Included in the review was information on the uses and production of dicamba, its
Wen-jing Zhao et al.
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 22(7), 410-413 (2010-07-29)
To observe the changes in heme oxygenase-1 (HO-1) expression in lung tissue with ventilator induced lung injury (VILI) in rats, and to explore the mechanism of preventive effect of HO-1 inducer hemin on VILI. Fifty-six male Sprague-Dawley (SD) rats were
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