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Characteristics of urea transport of cells derived from rabbit thick ascending limb of Henle's loop.
R W Grunewald et al.
Kidney international, 54(1), 152-159 (1998-07-02)
The thick ascending limb of Henle's loop (TALH) is thought to be involved in the regulation of the renal urea gradient. We have characterized the uptake of urea (oil density centrifugation and 2-compartment-culture) and volume regulation (impedance measurement) in highly
Ferdinando Maggioni et al.
The journal of headache and pain, 6(4), 322-324 (2005-12-20)
We conducted a study on 367 patients (86% female, 14% male; mean age 37+/-15 years) suffering from migraine with and without aura and chronic tension-type headache to evaluate the incidence of weight gain, an undesirable side effect observed during prophylactic
L Bai et al.
Biochimica et biophysica acta, 1522(1), 42-45 (2001-11-24)
We report the novel cloning and preliminary characterization of a murine type III sodium-dependent phosphate cotransporter (Pit-2) gene promoter. Five promoter/luciferase reporter gene constructs, -1816/+61, -1620/+61, -1223/+61, -600/+61 and -225/+61, showed significant luciferase activity (6-14-fold over background) when transfected into
Roy Fleischmann et al.
Rheumatology (Oxford, England), 53(12), 2167-2174 (2014-02-11)
The aim of this study was to evaluate the pharmacodynamics (PDs), pharmacokinetics (PKs) and safety of lesinurad (selective uric acid reabsorption inhibitor) in combination with febuxostat (xanthine oxidase inhibitor) in patients with gout. This study was a phase IB, multicentre
Manlio F Márquez et al.
Heart rhythm, 9(12), 1995-2000 (2012-10-13)
To prevent the recurrence of ventricular arrhythmias (VA) in Brugada syndrome (BrS), only quinidine has been consistently reported to have a beneficial effect. Recommended doses are ≥ 1 g/d. The efficacy of lower doses of quinidine has been suggested on
Pau Aceves Baldó et al.
International journal of clinical pharmacology and therapeutics, 51(3), 215-218 (2013-01-30)
To assess the effect of the UGT inhibitor probenecid on the pharmacokinetics of dalcetrapib, an investigational drug whose pharmacologically active thiol form undergoes glucuronidation (fm UGT ≥ 0.25). A two-way crossover study in 20 healthy subjects. Subjects received a single
Michael J Derelanko et al.
Drug and chemical toxicology, 26(3), 147-168 (2003-09-05)
The developmental toxicity of methyl ethyl ketoxime (MEKO), an industrial antioxidant used primarily as an antiskinning agent in alkyd paint, was investigated in rats and rabbits. Following preliminary dose range finding studies, groups of 25 pregnant rats or 18 pregnant
Yanjun Zhang et al.
The Lancet. Infectious diseases, 21(2), 181-192 (2020-11-21)
With the unprecedented morbidity and mortality associated with the COVID-19 pandemic, a vaccine against COVID-19 is urgently needed. We investigated CoronaVac (Sinovac Life Sciences, Beijing, China), an inactivated vaccine candidate against COVID-19, containing inactivated severe acute respiratory syndrome coronavirus 2
National Toxicology Program technical report series, (543)(543), 1-210 (2008-08-08)
alpha-Methylstyrene is used in the production of acrylonitrile-butadiene-styrene resins and copolymers, which improve the impact and heat-resistant properties of polymers, specialty grades of plastics, rubber, and protective coatings. alpha-Methylstyrene also moderates polymerization rates and improves product clarity in coatings and
J H Edmonson et al.
Cancer investigation, 19(6), 597-602 (2001-08-07)
Between March 1992 and November 1994, 91 patients with stage III and IV ovarian carcinoma were enrolled in a randomized comparative study of cyclophosphamide 600 mg/m2 plus carboplatin 300 mg/m2 vs. cyclophosphamide 600 mg/m2 plus carboplatin 600 mg/m2, each regimen
Craig Reynolds et al.
Investigational new drugs, 30(3), 1232-1240 (2011-09-17)
Uncontrolled studies comparing pentostatin (P), cyclophosphamide (C), and rituximab (R) (PCR) to fludarabine plus C+R (FCR) suggest similar efficacy with fewer infectious complications with PCR. We compared FCR and PCR in previously-untreated or minimally-treated B-cell chronic lymphocytic leukemia (CLL). FCR
He Li et al.
Food chemistry, 310, 125947-125947 (2019-12-17)
An ultra performance liquid chromatography-Triple time of flight mass spectrometry (UPLC-Triple TOF-MS/MS) method were established to characterize the lipid profiles in four shellfish species. More than 600 lipid molecular species belonging to 14 classes were detected. Phospholipids (PLs) were predominant
T Cai et al.
Journal of chemotherapy (Florence, Italy), 21(5), 535-541 (2009-11-26)
Recurrent urinary tract infections (UTI) are very common in otherwise healthy young women, and can have a very negative social and economic impact. In order to evaluate the tolerability and efficacy of a 14-day course of prulifloxacin orally administered once
N Frontali et al.
Clinical toxicology, 18(12), 1357-1367 (1981-12-01)
Rats were intermittently exposed (9 to 10 h/d, 5 to 6 d/week) to controlled concentrations of single analytical grad solvents in ambient air. After periods ranging from 7 to 30 weeks the animals were perfused with glutaraldehyde and samples of
Yoshinori Nishijima et al.
Physiological reports, 2(1), e00199-e00199 (2014-04-20)
Transient receptor potential vanilloid type 4 (TRPV4) is an endothelial Ca(2+) entry channel contributing to endothelium-mediated dilation in conduit and resistance arteries. We investigated the role of TRPV4 in the regulation of blood pressure and endothelial function under hypertensive conditions.
Soad K Al-Jaouni et al.
BMC research notes, 4, 436-436 (2011-10-25)
The development of polymerase chain reaction (PCR)-based methods for the detection of known mutations has facilitated detecting specific red blood cell (RBC) enzyme deficiencies. We carried out a study on glucose-6-phosphate dehydrogenase (G6PD) deficient subjects in Jeddah to evaluate the
Pia Haslund Jørgensen et al.
Contact dermatitis, 56(3), 146-150 (2007-02-14)
Hydroxyisohexyl-3-cyclohexene carboxaldehyde (HICC) known as Lyral is a frequent allergen. It is used in more than 50% of marketed deodorants. The aim of the present study was to determine elicitation thresholds for HICC under simulated conditions of deodorant use. 15
Fumihiko Horio et al.
Journal of nutritional science and vitaminology, 52(1), 28-32 (2006-04-28)
ODS rat has a hereditary defect in ascorbic acid biosynthesis and is a useful animal model for elucidating the physiological role of ascorbic acid. We previously demonstrated by using ODS rats that ascorbic acid deficiency changes the hepatic gene expression
Luciana Fávaro Francisconi-dos-Rios et al.
The journal of adhesive dentistry, 17(2), 133-139 (2015-04-23)
To assess the long-term effect of a 2% aqueous chlorhexidine (CHX) solution on bond strength to artificially eroded dentin compared to sound dentin. Flat mid-coronal dentin surfaces of extracted third molars (n = 28) were subjected only to grinding with
Jiyoung Jeong et al.
Archives of toxicology, 90(4), 817-828 (2015-03-04)
Indium is an essential element in the manufacture of liquid crystal displays and other electronic devices, and several forms of indium compounds have been developed, including nanopowders, films, nanowires, and indium metal complexes. Although there are several reports on lung
National Toxicology Program technical report series, (555)(555), 1-171 (2010-08-21)
1,2-Dibromo-2,4-dicyanobutane is used in cosmetics and other household products. 1,2-Dibromo-2,4-dicyanobutane was nominated for study by the National Institute of Environmental Health Sciences because of its widespread use as a component of numerous over-the-counter health care products. Male and female F344/N
Reshma Rangwala et al.
Autophagy, 10(8), 1369-1379 (2014-07-06)
Blocking autophagy with hydroxychloroquine (HCQ) augments cell death associated with alkylating chemotherapy in preclinical models. This phase I study evaluated the maximum tolerated dose (MTD), safety, preliminary activity, pharmacokinetics, and pharmacodynamics of HCQ in combination with dose-intense temozolomide (TMZ) in
R Schmied et al.
Circulation research, 68(2), 597-604 (1991-02-01)
Recent studies suggest that inhibition of Na+,K(+)-ATPase may contribute to the positive inotropic action of the imidazopyridine sulmazole. Therefore, we investigated the effect of sulmazole and its stereoisomers and for comparison the effect of the cardioactive steroid dihydroouabain (DHO) on
H Wietholtz et al.
Journal of hepatology, 24(6), 713-718 (1996-06-01)
Rifampin was shown to relieve pruritus in cholestatic liver diseases. There has been much speculation about the origin of pruritus, but it has not yet been comprehensively explained. The role of bile acids in producing pruritus is obscure and still
K P Makaritsis et al.
Hypertension (Dallas, Tex. : 1979), 34(3), 403-407 (1999-09-18)
Presynaptic alpha(2)-adrenergic receptors (alpha(2)-AR) are distributed throughout the central nervous system and are highly concentrated in the brain stem, where they contribute to neural baroreflex control of blood pressure (BP). To explore the role of the alpha(2A)-AR subtype in this
L Trementino et al.
Endocrine, 50(1), 154-161 (2014-12-17)
Pasireotide is a multireceptor-targeted somatostatin analog effective in the treatment of Cushing's disease (CD). We evaluate the value of an acute pasireotide suppression test (PST) in predicting response to medium/long-term treatment in CD. Nineteen patients with active CD were prospectively
B Hunyady et al.
Journal of physiology, Paris, 95(1-6), 147-151 (2001-10-12)
Recently we demonstrated that gastric mucosa of rats can synthesize, store and release dopamine. Out of five different subtypes, mRNA of D5 (=D1b) dopamine receptor is very abundant in the gastric epithelium. D1 receptor selective dopamine agonists have been shown
Hiroyuki Gatanaga et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 45(9), 1230-1237 (2007-10-06)
Efavirenz (EFV) is metabolized primarily by cytochrome P450 2B6 (CYP2B6), and high plasma concentrations of the drug are associated with a G-->T polymorphism at position 516 (516G-->T) of CYP2B6 and frequent central nervous system (CNS)-related side effects. Here, we tested
P Limprasert et al.
American journal of medical genetics, 98(3), 224-229 (2001-02-13)
The prevalence of fragile X syndrome (FXS) is approximately 7% in Thai boys with developmental delay of unknown cause. To determine if FXS might have a specific haplotype association, we analyzed 125 unrelated control subjects and 25 unrelated FXS patients
A Torchinsky et al.
American journal of reproductive immunology (New York, N.Y. : 1989), 34(5), 288-298 (1995-11-01)
The present study was carried out to evaluate an involvement of MHC-associated maternal immunoreactivity in response to environmental teratogens. Two chemicals, cyclophosphamide (CP) and 2,3-quinoxalinedimetanol, 1,4-dioxide (QD) were used as the reference teratogens (RT). The response to these RT was
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