CN
Search Within
613428
应用筛选条件
关键词:'613428'
显示 1-30 共 363 条结果 关于 "613428" 范围 论文
Marie-France Penet et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(2), 386-395 (2014-11-06)
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal disease that develops relatively symptom-free and is therefore advanced at the time of diagnosis. The absence of early symptoms and effective treatments has created a critical need for identifying and developing
Anil K Gorle et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(29), 10472-10481 (2015-06-05)
Ruthenium(II) complexes containing the tetradentate ligand bis[4(4'-methyl-2,2'-bipyridyl)]-1,n-alkane ("bbn "; n=10 and 12) have been synthesised and their geometric isomers separated. All [Ru(phen)(bbn )](2+) (phen=1,10-phenanthroline) complexes exhibited excellent activity against Gram-positive bacteria, but only the cis-α-[Ru(phen)(bb12 )](2+) species showed good activity
Sabrina D Lamour et al.
PLoS neglected tropical diseases, 9(10), e0004200-e0004200 (2015-10-28)
Human African trypanosomiasis (HAT) remains a major neglected tropical disease in Sub-Saharan Africa. As clinical symptoms are usually non-specific, new diagnostic and prognostic markers are urgently needed to enhance the number of identified cases and optimise treatment. This is particularly
Łukasz Jaremko et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(46), 16555-16563 (2015-09-24)
The translocator protein (TSPO) is an integral membrane protein that interacts with a wide variety of endogenous ligands, such as cholesterol and porphyrins, and is also the target for several small molecules with substantial in vivo efficacy. When complexed with
Geoffrey P Noble et al.
PLoS pathogens, 11(6), e1005017-e1005017 (2015-07-01)
Infectious prions contain a self-propagating, misfolded conformer of the prion protein termed PrPSc. A critical prediction of the protein-only hypothesis is that autocatalytic PrPSc molecules should be infectious. However, some autocatalytic recombinant PrPSc molecules have low or undetectable levels of
Teresa C Delgado et al.
American journal of physiology. Endocrinology and metabolism, 304(4), E384-E391 (2012-12-06)
Dietary fructose can benefit or hinder glycemic control, depending on the quantity consumed, and these contrasting effects are reflected by alterations in postprandial hepatic glycogen synthesis. Recently, we showed that ²H enrichment of glycogen positions 5 and 2 from deuterated
Guillaume G B Tcherkez et al.
Biochemistry, 52(5), 869-877 (2013-01-11)
d-Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is the most abundant enzyme on Earth and is responsible for the fixation of atmospheric CO(2) into biomass. The reaction consists of incorporation of CO(2) and solvent H(2)O into d-ribulose 1,5-bisphosphate (RuBP) to yield 3-phospho-d-glycerate. The reaction
Stijn H S Koshari et al.
Journal of chromatography. A, 1399, 45-52 (2015-05-13)
Measurements of the nanoscale structure of chromatographic adsorbents and the associated distribution of sorbed protein within the media can facilitate improvements in such media. We demonstrate a new technique for this purpose using small-angle neutron scattering (SANS) to characterize the
Limiao Jiang et al.
Molecular bioSystems, 10(11), 2914-2922 (2014-08-19)
Mequindox is widely used as an antibacterial veterinary drug and a feeding additive for farm animals in China. Although its toxicity has been widely studied, little is known regarding the metabolic effects of subchronic exposure to mequindox, which is vital
Graeme J Stasiuk et al.
Dalton transactions (Cambridge, England : 2003), 44(11), 4986-4993 (2015-01-22)
Non-invasive imaging of the inflammatory process can provide great insight into a wide variety of disease states, aiding diagnosis, evaluation and effective targeted treatment. During inflammation, blood borne leukocytes are recruited, through a series of activation and adhesion steps, to
Kun Xu et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 72(6), 889-895 (2015-09-12)
Series of anionic flocculants with outstanding flocculation performance, poly(acrylic acid-co-acrylamide)/diatomite composite flocculants (PAAD) were successfully prepared through aqueous solution copolymerization and applied to flocculate from oil-field fracturing waste-water. The structure of PAAD was characterized by Fourier transform infra-red spectroscopy, (13)C
Rostislav Chudnovskiy et al.
PloS one, 9(10), e108408-e108408 (2014-10-09)
To determine the metabolic effects of grapefruit juice consumption we established a model in which C57Bl/6 mice drank 25-50% sweetened GFJ, clarified of larger insoluble particles by centrifugation (cGFJ), ad libitum as their sole source of liquid or isocaloric and
Lu Ren et al.
Carbohydrate research, 406, 19-26 (2015-02-07)
A purified water-soluble fraction (ICP5) of a polysaccharide, isolated from a local Maori mushroom Iliodiction cibarium in New Zealand, was investigated for its structural properties. Size exclusion chromatography and dynamic light scattering showed that ICP5 had a large MW of
Alycia M Palmer et al.
Dalton transactions (Cambridge, England : 2003), 44(8), 3640-3646 (2015-01-06)
The interactions between the 6-mer duplex oligonucleotide d(GTCGAC)2 and the photoactive dirhodium complexes cis-H,H-[Rh2(HNOCCH3)2(L)(CH3CN)4](2+), where L represents bpy (1, 2,2'-bipyridine) and dppz (2, dipyrido[3,2-a:2',3'-c]phenazine), were probed using 2D (1)H-(1)H NOESY NMR spectroscopy. Complex does not interact with the duplex in
Chenchen Qin et al.
Nanoscale, 7(47), 20197-20210 (2015-11-18)
To optimize synergistic cancer therapy, we rationally assemble an inorganic-organic nanocomplex using a folate-modified lipid bilayer spread on photosensitizer-entrapped mesoporous silica nanoparticle (MSN) coated gold nanorods (AuNRs). In this hybrid bioconjugate, the large specific surface area and pore size of
Component reductions in oxygen delivery generate variable haemodynamic and stress hormone responses.
A Dyson et al.
British journal of anaesthesia, 113(4), 708-716 (2014-05-24)
In clinical practice, global oxygen delivery (DO2) is often considered as a whole; however pathological and adaptive responses after a decrease in individual constituents of the DO2 equation (cardiac output, haemoglobin, oxyhaemoglobin saturation) are likely to be diverse. We hypothesized
Saurav Mallik et al.
Journal of biomolecular structure & dynamics, 33(3), 639-656 (2014-04-05)
Using the available crystal structures of 50S ribosomal subunits from three prokaryotic species: Escherichia coli (mesophilic), Thermus thermophilus (thermophilic), and Haloarcula marismortui (halophilic), we have analyzed different structural features of ribosomal RNAs (rRNAs), proteins, and of their interfaces. We have
Małgorzata Cebo et al.
Analytical and bioanalytical chemistry, 406(30), 8013-8020 (2014-10-31)
Isotope exchange at the histidine C2 atom of imidazole in D2O solution is well known to occur at a significantly slower rate than the exchange of amide protons. Analysis of the kinetics of this isotope-exchange reaction is proposed herein as
Stephan-Nicollas M C G Oliveira et al.
Thrombosis and haemostasis, 113(1), 53-65 (2014-09-26)
Biosimilar enoxaparins have been available for clinical use in Brazil since 2009. Although their use has reduced costs of treatment expenses, their implementation still raises some concerns about efficiency, safety, regularity and reproducibility of batches. We undertook structural and functional
Andrew Bowman et al.
Nucleic acids research, 42(9), 6038-6051 (2014-04-02)
NAP-1 fold histone chaperones play an important role in escorting histones to and from sites of nucleosome assembly and disassembly. The two NAP-1 fold histone chaperones in budding yeast, Vps75 and Nap1, have previously been crystalized in a characteristic homodimeric
Luís M P Veríssimo et al.
International journal of pharmaceutics, 479(2), 306-311 (2014-12-30)
Mutual diffusion coefficients, densities and viscosities are reported for aqueous solutions of ethambutol as its dihydrochloride (EMBDHC) at finite concentrations and at 298.15K. From these experimental results and by using the appropriate models (Stokes-Einstein and Hartley), the hydrodynamic radii Rh
Pei Li et al.
Journal of pharmaceutical and biomedical analysis, 117, 184-194 (2015-09-12)
The anticonvulsive properties of diazepam have been extensively studied, mainly focusing on the γ-amino butyrate (GABA) system. The aim of this investigation was to integrally analyze the metabolic events related to neuroprotection of diazepam on anisatin-induced convulsive seizures by a
Seoncheol Cha et al.
Physical chemistry chemical physics : PCCP, 17(44), 29786-29792 (2015-10-22)
Advantage of ionic liquids as designer solvents can be maximized by mixing different ionic liquids (ILs) for a possibility of continuous tunability of material properties. The property of these mixed ILs would be determined by their microscopic conformation between cations
Julfikar Hassan Mondal et al.
Soft matter, 11(24), 4912-4920 (2015-05-27)
A systematic study of the ternary complex formation process for aromatic amino acids using ucurbit[8]uril (CB[8]) and a viologen amphiphile shows that the affinity of the amino acid needs to be higher or in a comparable range to that of
Thomas Poiger et al.
Journal of agricultural and food chemistry, 63(10), 2583-2590 (2015-03-06)
Haloxyfop-methyl is a chiral herbicide that was first introduced as racemate and later replaced by "haloxyfop-P-methyl", mainly consisting of the R-enantiomer, which carries the herbicidal activity. We studied the ester cleavage of haloxyfop-methyl and further degradation and chiral inversion of
Miaomiao Jiang et al.
BMC complementary and alternative medicine, 14, 350-350 (2014-09-25)
Metabonomics is a useful tool for studying mechanisms of drug treatment using systematic metabolite profiles. Ginsenosides Rg1 and Rb1, ophiopogonin D, and schizandrin are the main bioactive components of a traditional Chinese formula (Sheng-Mai San) widely used for the treatment
Daniel J Shaw et al.
The Journal of chemical physics, 142(21), 212401-212401 (2015-06-08)
The results of infrared spectroscopic investigations into the band assignments, vibrational relaxation, and solvation dynamics of the common anti-tuberculosis treatment Isoniazid (INH) are reported. INH is known to inhibit InhA, a 2-trans-enoyl-acyl carrier protein reductase enzyme responsible for the maintenance
Arpana Dutta et al.
Biochemistry, 53(46), 7160-7169 (2014-10-01)
Rhodopsin is a model system for understanding membrane protein folding. Recently, conditions that allow maximally denaturing rhodopsin without causing aggregation have been determined, opening the door to the first structural characterization of denatured states of rhodopsin by nuclear magnetic resonance
Barry W Hyland et al.
Clinical oral investigations, 19(6), 1395-1404 (2014-11-09)
This study aimed to develop and characterise a new three-component dental whitening formulation which is as effective as the currently used carbamide peroxide but at significantly lower hydrogen peroxide concentrations. The new formulation (Carbamide Plus) was prepared containing hydrogen peroxide
Pengfei Ding et al.
PLoS pathogens, 11(6), e1004967-e1004967 (2015-06-13)
Bacterial xenogeneic silencing proteins selectively bind to and silence expression from many AT rich regions of the chromosome. They serve as master regulators of horizontally acquired DNA, including a large number of virulence genes. To date, three distinct families of
1/13