70221

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Photocatalytic reduction of nitrate using titanium dioxide for regeneration of ion exchange brine.

Ting Yang et al.

Water research, 47(3), 1299-1307 (2013-01-02)

Nitrate is often removed from groundwater by ion exchange (IX) before its use as drinking water. Accumulation of nitrate in IX brine reduces the efficiency of IX regeneration and the useful life of the regeneration brine. For the first time

UPLC-MS/MS method for determination of selected pyrrolizidine alkaloids in feed.

Martina Bolechová et al.

Food chemistry, 170, 265-270 (2014-10-13)

Alkaloids known as secondary metabolites are grouped by typical structural characteristics into large families such as pyrrolizidine alkaloids (PAs) comprising more than 350 individual heterocyclic compounds. The PAs present a serious health risk to human and livestock; hence there is

Identification of new synthetic PDE-5 inhibitors analogues found as minor components in a dietary supplement.

Nicholas Schramek et al.

Journal of pharmaceutical and biomedical analysis, 96, 45-53 (2014-04-15)

A dietary supplement sold in erotic shops was analysed. It contains dithiodesmethylcarbodenafil as the major component, which was already reported as an adulterant in dietary supplements. Additionally three more compounds were found and their structures were elucidated after isolation using

Liquid chromatographic-tandem mass spectrometric method for the simultaneous determination of alkylphenols polyethoxylates, alkylphenoxy carboxylates and alkylphenols in wastewater and surface-water.

L Ciofi et al.

Journal of chromatography. A, 1362, 75-88 (2014-08-31)

Four different pellicular stationary phases (i.e. octadecylsilane, octasilane, Phenyl-Hexyl and pentafluorophenyl) were investigated for the chromatographic resolution of alkylphenols (APs), alkylphenols polyethoxylates (APnEOs) and alkylphenoxy carboxylates (APECs) using mixtures of water and organic solvents (i.e. methanol, acetonitrile and tetrahydrofuran) as

Effect of different aging techniques on the polysaccharide and phenolic composition and sensory characteristics of Syrah red wines fermented using different yeast strains.

Rubén del Barrio-Galán et al.

Food chemistry, 179, 116-126 (2015-02-28)

The effect of high levels of the polysaccharide Saccharomyces cerevisiae yeast strain (HPS) and another conventional yeast strain (FERM) on the polysaccharide and phenolic composition of Syrah red wines during alcoholic fermentation and subsequent aging on lees, with or without

Temporal metabolic response yields a dynamic biosignature of inflammation.

Jesse T Peach et al.

iScience, 24(8), 102817-102817 (2021-08-07)

Chronic low-grade inflammation is a subclinical condition directly and indirectly linked to the development of a wide range of diseases responsible for the vast majority of morbidity. To examine mechanisms coupled to chronic disease, a group of overweight and obese

Fenofibrate causes elevation of betaine excretion but not excretion of other osmolytes by healthy adults.

Michael Lever et al.

Journal of clinical lipidology, 8(4), 433-440 (2014-08-12)

Cross-sectional data suggest that bezafibrate increases betaine excretion in dyslipidemic patients. We aimed to demonstrate that fenofibrate induces increased betaine excretion in normal subjects and explore whether other 1-carbon metabolites and osmolytes are similarly affected. Urine was collected from 26

Stable-isotope dilution LC-MS/MS measurement of nitrite in human plasma after its conversion to S-nitrosoglutathione.

Erik Hanff et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 970, 44-52 (2014-09-23)

A specific, sensitive and fast LC-MS/MS method with positive electrospray ionization for the quantitative determination of nitrite in human plasma is reported. Added [(15)N]nitrite served as the internal standard (IS). Endogenous nitrite and IS were converted to their S-nitrosoglutathione (GSNO)

Effect of excipients on the particle size of precipitated pioglitazone in the gastrointestinal tract: impact on bioequivalence.

Masaru Sugita et al.

The AAPS journal, 16(5), 1119-1127 (2014-07-30)

This study sought to understand the reasons for the bioinequivalence of a newly developed generic product of pioglitazone hydrochloride and to improve its formulation so that it is equivalent to that of the reference listed drug (RLD). In this clinical

Hydrophilic interaction liquid chromatography-solid phase extraction directly combined with protein precipitation for the determination of triptorelin in plasma.

Jixia Wang et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 960, 214-221 (2014-05-14)

Peptide drugs play a critical role in therapeutic treatment. However, as the complexity of plasma, determination of peptide drugs using liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a daunting task. To solve this problem, hydrophilic interaction liquid chromatography-solid phase extraction (HILIC-SPE)

Blood pressure-lowering peptides from neo-fermented buckwheat sprouts: a new approach to estimating ACE-inhibitory activity.

Masahiro Koyama et al.

PloS one, 9(9), e105802-e105802 (2014-09-16)

Neo-fermented buckwheat sprouts (neo-FBS) contain angiotensin-converting enzyme (ACE) inhibitors and vasodilators with blood pressure-lowering (BPL) properties in spontaneously hypertensive rats (SHRs). In this study, we investigated antihypertensive mechanisms of six BPL peptides isolated from neo-FBS (FBPs) by a vasorelaxation assay

Multidrug toxicity involving sumatriptan.

Jessica L Knittel et al.

Journal of analytical toxicology, 39(1), 75-79 (2014-10-18)

A multidrug fatality involving sumatriptan is reported. Sumatriptan is a tryptamine derivative that acts at 5-HT(1B/1D) receptors and is used for the treatment of migraines. The decedent was a 21-year-old white female found dead in bed by her spouse. No

Dried blood spot analysis of creatinine with LC-MS/MS in addition to immunosuppressants analysis.

Remco A Koster et al.

Analytical and bioanalytical chemistry, 407(6), 1585-1594 (2014-12-30)

In order to monitor creatinine levels or to adjust the dosage of renally excreted or nephrotoxic drugs, the analysis of creatinine in dried blood spots (DBS) could be a useful addition to DBS analysis. We developed a LC-MS/MS method for

Syntheses and radiosyntheses of two carbon-11 labeled potent and selective radioligands for imaging vesicular acetylcholine transporter.

Prashanth K Padakanti et al.

Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 16(6), 765-772 (2014-05-31)

The vesicular acetylcholine transporter (VAChT) is a specific biomarker for imaging presynaptic cholinergic neurons. The syntheses and C-11 labeling of two potent enantiopure VAChT inhibitors are reported here. Two VAChT inhibitors, (±)-2 and (±)-6, were successfully synthesized. A chiral HPLC

Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor.

W Guo et al.

Cell death & disease, 5, e1409-e1409 (2014-09-05)

Btk and Etk/BMX are Tec-family non-receptor tyrosine kinases. Btk has previously been reported to be expressed primarily in B cells and has an important role in immune responses and B-cell malignancies. Etk has been shown previously to provide a strong

Metabolomic method: UPLC-q-ToF polar and non-polar metabolites in the healthy rat cerebellum using an in-vial dual extraction.

Amera A Ebshiana et al.

PloS one, 10(4), e0122883-e0122883 (2015-04-09)

Unbiased metabolomic analysis of biological samples is a powerful and increasingly commonly utilised tool, especially for the analysis of bio-fluids to identify candidate biomarkers. To date however only a small number of metabolomic studies have been applied to studying the

Effect of mushroom diet on pharmacokinetics of gabapentin in healthy Chinese subjects.

Dorothy Su Lin Toh et al.

British journal of clinical pharmacology, 78(1), 129-134 (2013-10-31)

This study evaluated the pharmacokinetics of gabapentin in Chinese subjects who received a diet rich in shiitake mushrooms. Shiitake mushrooms have been shown to contain high amount of ergothioneine. In vitro studies have shown that OCTN1-mediated secretion of gabapentin is

Analysis of peptides and protein digests by reversed phase high performance liquid chromatography-electrospray ionisation mass spectrometry using neutral pH elution conditions.

Yuanzhong Yang et al.

Analytica chimica acta, 872, 84-94 (2015-04-22)

In this study, the advantages of carrying out the analysis of peptides and tryptic digests of proteins under gradient elution conditions at pH 6.5 by reversed-phase liquid chromatography (RP-HPLC) and in-line electrospray ionisation mass spectrometry (ESI-MS) are documented. For these

Development and validation of an LC-MS/MS method for the determination of pelubiprofen and its active metabolite, trans-alcohol, in human plasma and its application to pharmacokinetic study.

Ju-Hee Ryu et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 983-984, 62-67 (2015-01-27)

A suitable liquid chromatography tandem mass spectrometry (LC-MS/MS) method is required to determine pelubiprofen and its active metabolite, trans-alcohol (M-D), in human plasma for pharmacokinetic studies of pelubiprofen preparations. After one-step liquid-liquid extraction (LLE) using methyl tert-butyl ether (MTBE), pelubiprofen

Mechanistic understanding of brain drug disposition to optimize the selection of potential neurotherapeutics in drug discovery.

Irena Loryan et al.

Pharmaceutical research, 31(8), 2203-2219 (2014-03-14)

The current project was undertaken with the aim to propose and test an in-depth integrative analysis of neuropharmacokinetic (neuroPK) properties of new chemical entities (NCEs), thereby optimizing the routine of evaluation and selection of novel neurotherapeutics. Forty compounds covering a

Mike Lange et al.

Cell reports. Medicine, 2(10), 100407-100407 (2021-11-11)

Obesity, characterized by expansion and metabolic dysregulation of white adipose tissue (WAT), has reached pandemic proportions and acts as a primer for a wide range of metabolic disorders. Remodeling of WAT lipidome in obesity and associated comorbidities can explain disease

Potent anti-proliferative, pro-apoptotic activity of the Maytenus royleanus extract against prostate cancer cells: evidence in in-vitro and in-vivo models.

Maria Shabbir et al.

PloS one, 10(3), e0119859-e0119859 (2015-03-24)

Prostate cancer is a leading of cause of cancer related death in men. Despite intensive investment in improving early diagnosis, it often escapes timely detection. Mortality remains high in advanced stage prostate cancer where palliative care remains the only option.

Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance.

W Miklos et al.

Cancer letters, 361(1), 112-120 (2015-03-10)

Although triapine is promising for treatment of advanced leukemia, it failed against solid tumors due to widely unknown reasons. To address this issue, a new triapine-resistant cell line (SW480/tria) was generated by drug selection and investigated in this study. Notably

Development of a stability-indicating HPLC method of etifoxine with characterization of degradation products by LC-MS/TOF, 1H and 13C NMR.

Nadia Djabrouhou et al.

Journal of pharmaceutical and biomedical analysis, 100, 11-20 (2014-08-15)

This paper describes a new LC-MS/TOF method for the degradation products determination when Etifoxine (ETI) is submitted to different stress conditions. Chromatography is performed by using Kromasil C18 column (250mm×4.6mm, 5μm particle size). The selected mobile phase consists of formate

Stability of extemporaneously compounded dexamethasone in glass and plastic bottles and plastic syringes.

Mary H H Ensom et al.

The Canadian journal of hospital pharmacy, 67(4), 274-279 (2014-09-13)

Dexamethasone is widely used to treat rheumatic and endocrine disorders and chemotherapy-induced nausea and vomiting. A palatable, alcohol-free liquid formulation, with a suitable concentration to allow reasonable administration volume, is available only via extemporaneous compounding. To evaluate the stability of

In vitro assessment of time-dependent inhibitory effects on CYP2C8 and CYP3A activity by fourteen protein kinase inhibitors.

Anne M Filppula et al.

Drug metabolism and disposition: the biological fate of chemicals, 42(7), 1202-1209 (2014-04-10)

Previous studies have shown that several protein kinase inhibitors are time-dependent inhibitors of cytochrome P450 (CYP) 3A. We screened 14 kinase inhibitors for time-dependent inhibition of CYP2C8 and CYP3A. Amodiaquine N-deethylation and midazolam 1'-hydroxylation were used as marker reactions for

Liquid chromatography-tandem mass spectrometry assay for the simultaneous quantification of simvastatin, lovastatin, atorvastatin, and their major metabolites in human plasma.

Jiang Wang et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 983-984, 18-25 (2015-01-24)

Millions of individuals are treated with a variety of statins that are metabolized to a variety of active metabolites. A single assay capable of simultaneously quantifying commonly used statins and their major metabolites has not been previously reported. Herein we

Analysis of phthalates in milk and milk products by liquid chromatography coupled to quadrupole Orbitrap high-resolution mass spectrometry.

Wei Jia et al.

Journal of chromatography. A, 1362, 110-118 (2014-08-27)

A new analytical method was developed and validated for simultaneous analysis of 27 phthalates in milk and milk products. Response surface methodology was employed to optimize a quick, easy, cheap, effective, rugged, and safe (QuEChERS) sample preparation method. Ultrahigh-performance liquid

[Ureido-¹⁵N]citrulline UPLC-MS/MS nitric oxide synthase (NOS) activity assay: development, validation, and applications to assess NOS uncoupling and human platelets NOS activity.

Anke Böhmer et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 965, 173-182 (2014-07-18)

In healthy human subjects, less than 0.2% of l-arginine is converted to l-citrulline and nitric oxide (NO) by NO synthases (NOS), a metabolic pathway present in all cell types. Assessment of NOS activity in vitro and in vivo by measuring

An efficient CoAuPd/C catalyst for hydrogen generation from formic acid at room temperature.

Zhi-Li Wang et al.

Angewandte Chemie (International ed. in English), 52(16), 4406-4409 (2013-03-21)

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