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显示 91-120 共 142 条结果 关于 "719099" 范围 论文
Chih-Chuan Teng et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 147, 111856-111856 (2020-11-28)
CIL-102 (1-[4-(furo [2,3-b]quinolin-4-ylamino)phenyl]ethanone) is a major active agent and an alkaloid derivative of Camptotheca acuminata, which has valuable biological properties, including anti-tumorigenic activity. However, the molecular mechanisms of CIL-102 related to inductive apoptosis in human gastric cancer remain unclear. By
Mykola P Shandura et al.
Organic & biomolecular chemistry, 11(5), 835-841 (2012-12-14)
Two versions of a facile and efficient synthetic approach to 3,5-bis(acetaldehyde) substituted BODIPY have been developed and this compound has been used to obtain, in high yields, a variety of 3,5-divinyl BODIPY derivatives (vinylacetates, enamines, vinyl chlorides, and some multiple-functionalized
Agata Dąbrowska et al.
Environmental monitoring and assessment, 186(7), 4569-4580 (2014-03-29)
The paper presents results concerning the changes in the content of aldehydes in samples of lake water collected near the lake surface. The study of lake waters was undertaken to explain which physicochemical parameters of the environment have the greatest
William Rodgers et al.
DNA repair, 27, 19-27 (2015-01-28)
V(D)J recombination of lymphocyte antigen receptor genes occurs via the formation of DNA double strand breaks (DSBs) through the activity of RAG1 and RAG2. The co-existence of RAG-independent DNA DSBs generated by genotoxic stressors potentially increases the risk of incorrect
Ching-Long Lai et al.
Chemico-biological interactions, 202(1-3), 275-282 (2012-12-12)
Previous studies have reported that cimetidine, an H2-receptor antagonist used to treat gastric and duodenal ulcers, can inhibit alcohol dehydrogenases (ADHs) and ethanol metabolism. Human alcohol dehydrogenases and aldehyde dehydrogenases (ALDHs), the principal enzymes responsible for metabolism of ethanol, are
Caio L Firme et al.
The journal of physical chemistry. A, 117(2), 439-450 (2012-12-20)
The density functional theory (DFT) and quantum theory of atoms in molecules (QTAIM) have been used to study the lowest lying spin states of the photochemical hydrogen abstraction reaction by formaldehyde, acetaldehyde, and acetone in the presence of different hydrogen
Roderick F A Tummers-de Lind van Wijngaarden et al.
Nederlands tijdschrift voor geneeskunde, 157(1), A5240-A5240 (2013-01-10)
Disulfiram is a substance often used to treat alcohol dependency. The agent may be effective when used as supportive therapy. Disulfiram causes an accumulation of acetaldehyde when alcohol is consumed, which results in unpleasant sensations such as warmth, nausea, vomiting
Etienne Quertemont et al.
Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism, 29(4), 258-265 (2007-08-28)
Acetaldehyde is the first active breakdown product (i.e., metabolite) generated during alcohol metabolism. It has toxic properties but also exerts other actions on the body (i.e., has pharmacological properties). Recent studies have shown that the direct administration of acetaldehyde, especially
Kazuhiro Tokuda et al.
Neuroscience letters, 537, 40-43 (2013-01-29)
Consistent with the ability of severe alcohol intoxication to impair memory, high concentrations of ethanol (60mM) acutely inhibit long-term potentiation (LTP) in the CA1 region of rat hippocampal slices. To account for this, we hypothesized that local metabolism to acetaldehyde
C Forn-Frías et al.
Revista de neurologia, 37(5), 485-493 (2003-10-09)
The purpose of this study is to collect and evaluate the experimental evidence suggesting that acetaldehyde, the first oxidative metabolite of ethyl alcohol (ethanol), plays a mediating role in the brain damage associated with the chronic consumption of this substance.
N É Petushok et al.
Biomeditsinskaia khimiia, 59(1), 76-80 (2013-05-09)
The effects of some ethanol-metabolising systems (aldehyde dehydrogenase, catalase, cytochrome P450 2E1) on activation of lipid peroxidation (LPO) processes in gastrointestinal tract of rats have been studied using inhibitors of these systems. The intensity of LPO processes was evaluated by
Venkataramanan Subramanian et al.
Journal of proteome research, 13(12), 5431-5451 (2014-10-22)
Chlamydomonas reinhardtii is well adapted to survive under different environmental conditions due to the unique flexibility of its metabolism. Here we report metabolic pathways that are active during acclimation to anoxia, but were previously not thoroughly studied under dark, anoxic
Jacob A Theruvathu et al.
Nucleic acids research, 33(11), 3513-3520 (2005-06-24)
Alcoholic beverage consumption is associated with an increased risk of upper gastrointestinal cancer. Acetaldehyde (AA), the first metabolite of ethanol, is a suspected human carcinogen, but the molecular mechanisms underlying AA carcinogenicity are unclear. In this work, we tested the
M Apte et al.
Novartis Foundation symposium, 285, 200-211 (2007-06-27)
Alcohol abuse is a major cause of pancreatitis, a condition that can manifest as both acute necroinflammation and chronic damage (acinar atrophy and fibrosis). It is generally accepted that alcohol-induced pancreatic injury is a consequence of the metabolism of alcohol
Yu Wang et al.
Journal of agricultural and food chemistry, 63(28), 6293-6296 (2015-07-08)
Inflammation-related reactive oxygen species (ROS) and reactive nitrogen species (RNS) are associated with the development of cancer. ROS and RNS can directly damage biomacromolecules such as proteins, DNA, and lipids. Lipid peroxidation, however, can result in reactive carbonyl species (RCS)
J Obermeier et al.
Journal of breath research, 9(1), 016008-016008 (2015-03-10)
Bulky and hyphenated laboratory-based analytical instrumentation such as gas chromatography/mass spectrometry is still required to trace breath biomarkers in the low ppbV level. Innovative sensor-based technologies could provide on-site and point-of-care (POC) detection of volatile biomarkers such as breath aldehydes
Hugh D Lothrop et al.
Journal of medical entomology, 49(6), 1466-1472 (2012-12-29)
Laboratory and field research was conducted to determine if Culex tarsalis Coquillett expectorated West Nile virus (WNV) during sugar feeding and if a lure or bait station could be developed to exploit this behavior for WNV surveillance. Experimentally infected Cx.
Rubén del Barrio-Galán et al.
Journal of the science of food and agriculture, 95(10), 2132-2144 (2014-09-27)
The objective of this work was to study the effect of two Saccharomyces cerevisiae yeast strains with different capabilities of polysaccharide liberation during alcoholic fermentation in addition to subsequent aging on lees with or without oak wood chips as well
Miriam Melis et al.
Alcohol (Fayetteville, N.Y.), 43(7), 531-539 (2009-11-17)
There has been a great deal of activity in recent years in the study of the direct effects of ethanol on the dopamine reward system originating in the ventral tegmental area (VTA). In addition, recent evidence suggests that acetaldehyde formed
Gerald A Deehan et al.
Current topics in behavioral neurosciences, 13, 163-184 (2012-02-22)
Alcohol abuse and alcoholism represent substantial problems that affect a large portion of individuals throughout the world. Extensive research continues to be conducted in an effort to identify the biological basis of the reinforcing properties of alcohol in order to
Rui Guo et al.
International journal of environmental research and public health, 7(4), 1285-1301 (2010-07-10)
Alcohol abuse is a serious medical and social problem. Although light to moderate alcohol consumption is beneficial to cardiovascular health, heavy drinking often results in organ damage and social problems. In addition, genetic susceptibility to the effect of alcohol on
Jiamin Chen et al.
Planta, 242(1), 137-151 (2015-04-22)
TraeALDH7B1 - 5A , encoding aldehyde dehydrogenase 7 in wheat, conferred significant drought tolerance to Arabidopsis , supported by molecular biological and physiological experiments. Drought stress significantly affects wheat yields. Aldehyde dehydrogenase (ALDH) is a family of enzymes catalyzing the
Kavitha Swaminathan et al.
Life sciences, 92(6-7), 325-336 (2013-01-29)
Ethanol metabolism leads to the formation of acetaldehyde and malondialdehyde. Acetaldehyde and malondialdehyde can together form malondialdehyde-acetaldehyde (MAA) adducts. The role of alcohol dehydrogenase (ADH) and cytochrome P4502E1 (CYP2E1) in the formation of MAA-adducts in liver cells has been investigated.
Shou-Lun Lee et al.
Biochemical pharmacology, 95(1), 71-79 (2015-03-17)
Previous studies have reported that aspirin significantly reduced the first-pass metabolism (FPM) of ethanol in humans thereby increasing adverse effects of alcohol. The underlying causes, however, remain poorly understood. Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), principal enzymes responsible for
Bing-Gui Li et al.
Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control, 24(5), 564-566 (2013-02-05)
To evaluate the molluscicidal effect of 26% suspension concentrate of metaldehyde and niclosamide (MNSC) in the fields of mountainous areas in Yunnan Province. Some representative Oncomelania snail environments of schistosomiasis endemic regions were selected as study areas in Heqing County
Gaeun Kang et al.
Alcoholism, clinical and experimental research, 38(6), 1502-1509 (2014-05-07)
It has been known that ADH1B*2 allele has a protective effect against the development of alcohol dependence. However, the protection mechanism is still unknown. We investigated whether ADH1B gene polymorphism affects ethanol (EtOH) metabolism. In a parent study, we conducted
Lidija Djokic et al.
Bioprocess and biosystems engineering, 38(12), 2389-2395 (2015-09-28)
The enzyme 4-oxalocrotonate tautomerase (4-OT) encoded by the xylH gene is a part of the degradation pathway of aromatic compounds in Pseudomonas putida mt-2. 4-OT was described to catalyze Michael-type addition of acetaldehyde to β-nitrostyrene, and the whole cell system
Zheng Luo et al.
PloS one, 8(2), e55860-e55860 (2013-02-15)
Discoidin domain receptor 2 (DDR2) is involved in fibrotic disease. However, the exact pathogenic implications of the receptor in early alcoholic liver disease are still controversial. We constructed plasmid vectors encoding short-hairpin RNA against DDR2 to investigate its role in
Johanna Mock et al.
Journal of bacteriology, 197(18), 2965-2980 (2015-07-08)
Most acetogens can reduce CO2 with H2 to acetic acid via the Wood-Ljungdahl pathway, in which the ATP required for formate activation is regenerated in the acetate kinase reaction. However, a few acetogens, such as Clostridium autoethanogenum, Clostridium ljungdahlii, and
J Latvala et al.
Alcoholism, clinical and experimental research, 25(11), 1648-1653 (2001-11-15)
Acetaldehyde-derived protein condensates (adducts) have been suggested as promising biological markers of alcohol abuse because they represent actual metabolites of ethanol. However, the detection of such condensates in vivo has been hampered by a lack of sensitive and specific methods.
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