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Hadi Yaziji et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 19(4), 514-523 (2006-03-24)
We evaluated the sensitivity and specificity of 10 monoclonal and two polyclonal antibodies for distinguishing epithelioid mesothelioma from adenocarcinoma (AdCA) using immunohistochemistry (IHC). The antibodies were directed against the mesothelial-associated antigens mesothelin, calretinin, cytokeratin 5, thrombomodulin, Wilms' tumor-1 (WT-1) gene
Z Luo et al.
The Journal of biological chemistry, 265(35), 21804-21810 (1990-12-15)
cDNA clones coding for the regulatory subunit (RII beta) of type II cAMP-dependent protein kinase were isolated from a bovine brain cDNA expression library in lambda gt11. The cDNA codes for a protein of 418 amino acids which is 98%
Bharat Rekhi et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 126(1), 45-55 (2017-12-22)
Clear cell carcinoma (CCC) of the ovary is an uncommon, but an aggressive epithelial ovarian cancer (EOC), which has overlapping histopathologic features with other ovarian tumours. Lately, Napsin A has been identified as its useful diagnostic immunohistochemical (IHC) marker. Fifty-eight
Lizhu Chen et al.
Drug testing and analysis, 11(6), 898-905 (2019-01-08)
Chiral analysis is a crucial way to differentiate selegiline (SG) intake from drug abuse. Oral fluid (OF) has been successfully used as an alternative matrix for blood testing in several pharmacokinetic studies. The aim of this study is to describe
Yao-Fang Xia et al.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 11(8), 645-648 (2009-08-22)
To study the concentrations of IL-4 and IL-13 in bronchoalveolar lavage fluid (BALF) in neonates with respiratory distress syndrome (RDS) and concurrent ventilator-associated pneumonia (VAP). Sixty-eight neonates with RDS undergoing mechanical ventilation for over 48 hrs were enrolled. IL-4 and
Gao-Song Wu et al.
Hepatobiliary & pancreatic diseases international : HBPD INT, 1(3), 429-433 (2003-11-11)
To investigate the expression of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in extra-hepatic cholangiocarcinoma and the relationship between their expression and clinicopathological parameters. COX-1 and COX-2 were detected in 56 extra-hepatic cholangiocarcinomas, including 31 matched tissues originating from non-tumorous bile ductal
Kamolporn Amornsupak et al.
Clinical breast cancer, 17(6), 441-452 (2017-05-24)
The influence of cancer-associated fibroblasts (CAFs) and high mobility group box 1 (HMGB1) has been recognized in several cancers, although their roles in breast cancer are unclear. The present study aimed to determine the levels and prognostic significance of α-smooth
David C Chhieng et al.
Human pathology, 34(10), 1016-1021 (2003-11-11)
Ovarian carcinoma has a high mortality rate, because most ovarian carcinomas are detected at a late stage. Traditional therapies, such as surgical debulking and chemotherapy, have not been successful in improving the long-term survival of these patients. Alternative therapies targeting
Nelson G Ordóñez
The American journal of surgical pathology, 27(8), 1031-1051 (2003-07-29)
A large number of immunohistochemical markers that can facilitate the distinction between epithelioid pleural mesotheliomas and pulmonary peripheral adenocarcinomas have recently become available. The aim of this study is to compare the value of these new markers with others that
Benedicte Jørgenrud et al.
Journal of pharmacological and toxicological methods, 107, 106939-106939 (2020-12-02)
Most bioanalytical LC-MS/MS methods are developed for determination of single drugs or classes of drugs, but a multi-compound LC-MS/MS method that can replace several methods could reduce both analysis time and costs. The aim of this study was to develop
Peiguo G Chu et al.
The American journal of surgical pathology, 26(8), 978-988 (2002-08-10)
Hepatocyte monoclonal antibody (Hep) (alternatively Hep Par 1 for Hep paraffin 1) has been reported to stain normal hepatic tissue and hepatocellular carcinoma (HCC) with high specificity. We have studied the Hepatocyte expression in 96 cases of HCC and 311
Viktor V Husak et al.
Aquatic toxicology (Amsterdam, Netherlands), 155, 181-189 (2014-07-19)
Molecular mechanisms of toxicity by the metribuzin-containing herbicide Sencor to living organisms, particularly fish, have not yet been extensively investigated. In the present work, we studied the effects of 96 h exposure to 7.14, 35.7, or 71.4 mg L(-1) of
M Esquivel et al.
Clinical and investigative medicine. Medecine clinique et experimentale, 10(5), 363-367 (1987-09-01)
To determine the effect of liver dysfunction on the absorption and disposition of isoxicam, we administered a single oral dose of 200 mg to 8 patients with alcoholic cirrhosis, and followed the plasma concentration-time curve for 96 h. The calculated
Jing-Yi Wu et al.
Zhongguo shi yan xue ye xue za zhi, 16(4), 738-741 (2008-08-23)
This study was aimed to explore fgfr3 gene expression in leukemic cells and its clinical significance. The expression levels of fgfr3 mRNA in 4 leukemic cell lines and bone marrow samples from 96 patients with leukemia and 14 controls were
Sandra S Wise et al.
Chemical research in toxicology, 19(11), 1492-1498 (2006-11-23)
One of the hallmarks of lung cancer is chromosome instability (CIN), particularly a tetraploid phenotype, which is normally prevented by the spindle assembly checkpoint. Hexavalent chromium Cr(VI) is an established human lung carcinogen, and Cr(VI) induces tumors at lung bifurcation
Punit Sharma et al.
Clinical nuclear medicine, 40(7), e351-e356 (2015-03-19)
The aim of this study was to evaluate the role of ⁶⁸Ga DOTANOC PET/CT imaging in patients with multiple endocrine neoplasia (MEN) syndromes. Data of 33 patients (age, 33.5 [13.8] years; male 14/female 19) with MEN syndromes (MEN 1, 9;
Sebastiaan M Bol et al.
PloS one, 6(2), e17190-e17190 (2011-03-03)
HIV-1 infected macrophages play an important role in rendering resting T cells permissive for infection, in spreading HIV-1 to T cells, and in the pathogenesis of AIDS dementia. During highly active anti-retroviral treatment (HAART), macrophages keep producing virus because tissue
Thomas E Hutson et al.
The Lancet. Oncology, 14(13), 1287-1294 (2013-11-12)
In previous clinical trials of patients with metastatic renal-cell carcinoma, patients treated with axitinib as second-line therapy had longer median progression-free survival than those treated with sorafenib. We therefore undertook a phase 3 trial comparing axitinib with sorafenib in patients
M José Villarroel et al.
Environmental toxicology and pharmacology, 35(3), 465-472 (2013-03-19)
The present study investigates energy stores changes in the aquatic invertebrate Daphnia magna following a 5-d exposure to propanil. Juveniles of D. magna were exposed to sublethal propanil concentrations (0.07, 0.10, 0.21 and 0.55 mgl(-1)) which were used previously to
Abbas Güngördü
Aquatic toxicology (Amsterdam, Netherlands), 140-141, 220-228 (2013-07-09)
The assessments of pesticide toxicity on nontarget organisms have largely been focused on the determination of median lethal concentration (LC50) values using single/laboratory species. Although useful, these studies cannot describe the biochemical mechanisms of toxicity and also cannot explain the
Xu-Liang Cao et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 33(2), 373-382 (2016-01-06)
Volatile organic compounds (VOCs) are ubiquitous in the environment due to evaporation and incomplete combustion of fuels, use of consumer and personal care products, etc. and they can accumulate in foods. Some VOCs in foods can also be formed during
C Nascimento et al.
European journal of endocrinology, 169(5), 689-693 (2013-08-14)
Thyroglobulin (Tg) measurement is a major tool for the follow-up of differentiated thyroid cancer (DTC) patients; however, in patients who do not undergo radioactive iodine (RAI) ablation, normal ultrasensitive Tg levels measured under levothyroxine treatment (usTg/l-T4) are not well defined.
Yiguo Zhang et al.
The Journal of biological chemistry, 284(5), 3195-3210 (2008-12-03)
Transcription factor Nrf3 (NF-E2 p45-related factor 3) is targeted to the endoplasmic reticulum (ER). Mouse Nrf3 is subject to proteolysis, Asn glycosylation, and deglycosylation reactions. It is synthesized as a approximately 96-kDa protein that is subsequently converted into isoforms of
C Labbé-Jullié et al.
Endocrinology, 131(4), 1999-2009 (1992-10-01)
To compare the structural topology of the human TSH to that of the structurally related gonadotropins, 10 peptides covering the entire primary sequence of the alpha- and beta-subunits of TSH were synthesized and used as antigens for the preparation of
Mohammad Enamul Hoque Kayesh et al.
Virus research, 237, 47-57 (2017-05-30)
To date, the chimpanzee has been used as the natural infection model for hepatitis B virus (HBV). However, as this model is very costly and difficult to use because of ethical and animal welfare issues, we aimed to establish the
J E King et al.
Histopathology, 48(3), 223-232 (2006-01-25)
Immunohistochemistry is frequently employed to aid the distinction between mesothelioma and pulmonary adenocarcinoma metastatic to the pleura, but there is uncertainty as to which antibodies are most useful. We analysed published data in order to establish sensitivity and specificity of
Alan S Go et al.
Journal of thrombosis and thrombolysis, 15(1), 41-46 (2003-10-24)
Atrial fibrillation is a major cause of cardioembolic stroke. Since atrial and venous pressures are similar, genetic variants that promote venous thromboembolism may increase the risk of atrial thrombi and subsequent stroke in atrial fibrillation. We conducted a nested case-control
Differential expression of HO-1 and CYP1A2 during up-regulation of ERK in stressed fish hepatocytes.
Ekambaram Padmini et al.
Environmental monitoring and assessment, 187(1), 4147-4147 (2014-12-05)
Induction of heme oxygenase-1 (HO-1) and extracellular signal-regulated kinase (ERK) is a crucial step in the cellular response to oxidative stress. Altered expression of such proteins in response to stress conditions is a key factor for the maintenance of cellular
Judith A Engeler Dusel et al.
Kidney international, 68(1), 256-262 (2005-06-16)
Podocin, encoded by NPHS2 and mapped to 1q25.2, is an integral membrane protein exclusively expressed in glomerular podocytes. Mutations in the NPHS2 gene cause autosomal-recessive nephrotic syndrome and have been associated with proteinuria in several populations. Evidence for linkage of
Stefano Christian Londero et al.
Acta oncologica (Stockholm, Sweden), 47(3), 451-457 (2007-10-02)
Papillary microcarcinomas (PMC) of the thyroid gland are defined according to The WHO Committee as papillary carcinomas measuring 10 mm or less in diameter. A large proportion of these tumours are found coincidentally in the treatment of symptomatic goitre and
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