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O V Kalinina et al.
Patologicheskaia fiziologiia i eksperimental'naia terapiia, (1)(1), 70-74 (2013-06-29)
We studied the role of the natural triterpenoid miliacin (3-3-methoxy-Al8-oleanene) in the regulation of oxidative stress in the liver of (CBAxC57B1(6))F1 mice exposed to methotrexate. Miliacin attenuated methotrexate-induced lipid peroxidation as determined by an attenuation of thiobarbituric acid-reacting products in
Hala O El Mesallamy et al.
Journal of cancer research and clinical oncology, 140(8), 1359-1365 (2014-04-11)
High-dose methotrexate (HD-MTX) is a cornerstone antineoplastic drug in most treatment protocols of pediatric acute lymphoblastic leukemia (ALL). Among the membrane efflux transporters of MTX, the human breast cancer resistant protein is the second member of the G subfamily of
Response to H Zeidler's comments on the CONCERTO study.
Gerd R Burmester et al.
Annals of the rheumatic diseases, 73(8), e51-e51 (2014-06-11)
Sara Verazza et al.
Clinical and experimental rheumatology, 31(4 Suppl 78), S98-101 (2013-11-06)
Several studies have examined effects of discontinuing treatment after clinical remission in children with JIA. So far, only methotrexate and tumour necrosis factor α (TNF) inhibitors have been investigated. Overall, the relapse rate after termination of these medications was substantial.
Arjun V Balar et al.
Cancer, 121(2), 179-187 (2014-08-06)
Urothelial cancer has long been known as a chemotherapy-sensitive disease. However, clinical trial data to date suggest a plateau to the magnitude of benefit from cytotoxic therapy alone. In spite of level 1 evidence supporting cisplatin-based chemotherapy for patients with
[Serious organ damage and intractable clinical conditions in rheumatic and connective tissue disease--progress in pathophysiology and treatment. Topics: II. Clinical conditions special attention needed to be paid to; 4. Macrophage activating syndrome and hemophagocytic syndrome].
Yoshinori Komagata
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 102(10), 2639-2644 (2014-01-10)
A Perez-Delboy et al.
BJOG : an international journal of obstetrics and gynaecology, 121(2), 163-169 (2014-01-01)
Abnromalities of placentation, including placenta accreta, represent a major source of morbidity and mortality among women. Traditional management consists of peripartum hysterectomy at the time of delivery, although more conservative treatments have also been developed recently. In this review we
Cutaneous Rosai-Dorfman disease successfully treated with low-dose methotrexate.
Natalie Z Sun et al.
JAMA dermatology, 150(7), 787-788 (2014-05-03)
Chen Lossos et al.
British journal of haematology, 165(5), 640-648 (2014-02-28)
Primary central nervous system lymphoma (PCNSL) is an aggressive sub-variant of non-Hodgkin lymphoma (NHL) with morphological similarities to diffuse large B-cell lymphoma (DLBCL). While methotrexate (MTX)-based therapies have improved patient survival, the disease remains incurable in most cases and its
Nathalie K Zgheib et al.
Pharmacogenetics and genomics, 24(8), 387-396 (2014-07-10)
The aim of this study is to analyze polymorphisms in genes involved in 6-mercaptopurine detoxification (TPMT); methotrexate (MTX) metabolism including ABCB1 (or MDR1), ABCC2, SLC19A1 (or RFC1), and SLCO1B1; and the MTX effect mainly MTHFR and TYMS, and to assess
Atsuo Tanimoto et al.
BMC musculoskeletal disorders, 16, 339-339 (2015-11-08)
Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to joint destruction, disability, and decreased quality of life (QOL). Inhibition of Janus kinase (JAK) signaling ameliorates articular inflammation and joint destruction in animal models of RA, but its effects
Kazuhisa Katayama et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 40(5), 655-658 (2013-07-19)
Carcinomatous peritonitis may develop after operation for gastric cancer. As ascites are difficult to control, especially for gastric cancer postoperative carcinomatous peritonitis, many cases are difficult to treat. The present case was a female patient with carcinomatous peritonitis that occurred
Zibin Yang et al.
International journal of clinical pharmacology and therapeutics, 52(5), 346-351 (2014-03-13)
The aim of this study was to evaluate the efficacy of methotrexate (MTX) in the treatment of ankylosing spondylitis (AS). The literature on controlled clinical trials was searched from MEDLINE, EMBASE, OVID, and Cochrane Library databases up to November 2012.
Koya Fushimi et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 41(4), 449-453 (2014-04-20)
Japanese clinical trials of a tegafur/uracil(UFT)-based postoperative chemotherapy regimen compared with cyclophosphamide, methotrexate, and fluorouracil(CMF)treatment have shown that UFT is not inferior to CMF for the treatment of hormone receptor-positive breast cancer patients. However, the usefulness of UFT for hormone
Daisy Puttevils et al.
Acta cardiologica, 69(2), 111-118 (2014-05-03)
Patients with established rheumatoid arthritis (RA) have a higher cardiovascular morbidity and mortality in comparison with the general population. It is considered to be an independent risk factor for cardiovascular disease. The purpose of this article is to describe the
Shilpen A Patel et al.
American journal of clinical oncology, 38(1), 47-50 (2015-01-24)
Malignant pleural mesothelioma (MPM) is a fatal disease lacking standardized treatment. We describe the use of fast neutron radiation therapy in MPM patients referred to the Department of Radiation Oncology at the University of Washington Medical Center. Retrospective chart review
P M Tedeschi et al.
Cell death & disease, 4, e877-e877 (2013-10-26)
Recent observations on cancer cell metabolism indicate increased serine synthesis from glucose as a marker of poor prognosis. We have predicted that a fraction of the synthesized serine is routed to a pathway for ATP production. The pathway is composed
Pityriasis rubra pilaris treated with methotrexate resolving with an erythema gyratum repens-like appearance.
Michael A Marchetti et al.
Journal of the American Academy of Dermatology, 69(1), e32-e33 (2013-06-19)
Etanercept tapering in rheumatoid arthritis.
Paul Emery et al.
The New England journal of medicine, 372(5), 489-490 (2015-01-30)
Tapan M Kadia et al.
American journal of hematology, 90(2), 120-124 (2014-11-05)
Newer approaches are needed for the treatment of relapsed and refractory acute lymphoblastic leukemia (ALL). Asparaginase-based regimens are active in the treatment of pediatric ALL and may be important in salvage therapy for adult patients. We conducted a pilot trial
Toward a practical renaming of bullous pemphigoid and all its variants: cutaneous pemphigoid.
Luca Borradori et al.
JAMA dermatology, 150(4), 459-459 (2014-04-11)
Folic acid or folinic acid for reducing side effects of methotrexate for people with rheumatoid arthritis.
Beverley Shea
Journal of evidence-based medicine, 6(3), 202-203 (2013-12-12)
Bowen disease of the vulva successfully treated with intraarterial infusion chemotherapy.
Yi-Shuan Sheen et al.
Journal of the American Academy of Dermatology, 69(6), e305-e306 (2013-11-19)
Junko Takeshita et al.
Journal of the American Academy of Dermatology, 71(6), 1167-1175 (2014-09-28)
The effectiveness of psoriasis therapies in real-world settings remains relatively unknown. We sought to compare the effectiveness of less commonly used systemic therapies and commonly used combination therapies for psoriasis. This was a multicenter cross-sectional study of 203 patients with
Ajay Vora et al.
The Lancet. Oncology, 15(8), 809-818 (2014-06-14)
No randomised study has shown whether stratification of treatment by minimal residual disease (MRD) response improves outcome in children and young people with acute lymphoblastic leukaemia (ALL). We assessed whether children and young people with clinical standard and intermediate-risk ALL
Tomohiro Yamakawa et al.
[Rinsho ketsueki] The Japanese journal of clinical hematology, 55(3), 321-326 (2014-04-01)
A 70-year-old woman with rheumatoid arthritis treated with methotrexate (MTX) complained of right arm weakness. On CT and MRI, tumors were found in the right frontal lobe, bilateral lungs, and left renal parenchyma. She was diagnosed as having lymphomatoid granulomatosis
Paul Emery et al.
The New England journal of medicine, 371(19), 1781-1792 (2014-11-06)
We assessed the effects of reduction and withdrawal of treatment in patients with rheumatoid arthritis who had a remission while receiving etanercept-plus-methotrexate therapy. Patients with early active disease who had not previously received methotrexate or biologic therapy received 50 mg
Jun Kaneko et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 40(12), 2454-2456 (2014-01-08)
We report our experience with a case of iatrogenic immunodeficiency-associated lymphoproliferative disease in a patient who had been treated with methotrexate (MTX) for rheumatoid arthritis for 9 consecutive years, which showed natural remission after discontinuation of the MTX therapy. The
Coxiella burnetii infection (Q fever) in rheumatoid arthritis patients with and without anti-TNFα therapy.
T Schoffelen et al.
Annals of the rheumatic diseases, 73(7), 1436-1438 (2014-05-06)
Delwar Hossain
Leprosy review, 84(1), 105-112 (2013-06-08)
Erythema nodosum leprosum (ENL) is a chronic recurrent systemic complication of multi-bacillary leprosy frequently associated with the development of neuritis, iritis, orchitis, arthritis and dactylitis. It is well managed by thalidomide, but thalidomide is not available in Bangladesh. The World
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