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显示 1-30 共 106 条结果 关于 "CO-RO" 范围 论文
Yaqing Zhang et al.
Frontiers in pharmacology, 11, 600994-600994 (2021-02-02)
Background: Drug resistance is a major obstacle in chemotherapy for ovarian cancer, wherein the up regulation of drug-resistant genes plays an important role. The cytoplasmic polyadenylation element binding protein 4 (CPEB4) is an RNA binding protein that controls mRNA cytoplasmic
Xin Yi et al.
Molecular medicine reports, 27(3) (2023-02-18)
3‑Chloropropane‑1,2‑diol (3‑MCPD) is an internationally recognized food pollutant. 3‑MCPD has reproductive, renal and neurotoxic properties. However, whether 3‑MCPD induces human umbilical vein endothelial cell (HUVEC) injury has not been previously reported. In the present study, HUVECs were treated using 2 µg/ml
Jithin D Nair et al.
STAR protocols, 2(4), 100992-100992 (2021-12-23)
Here, we detail a surface biotinylation technique used to label surface-expressed proteins in primary neuronal cultures. Surface proteins are labeled with membrane-impermeant Sulfo-NHS-SS-biotin, and isolated by pull-down with streptavidin beads followed by western blotting to measure levels of surface expression
Anita Reddy et al.
Cell, 183(1), 62-75 (2020-09-19)
In response to skeletal muscle contraction during exercise, paracrine factors coordinate tissue remodeling, which underlies this healthy adaptation. Here we describe a pH-sensing metabolite signal that initiates muscle remodeling upon exercise. In mice and humans, exercising skeletal muscle releases the
Taichiro Iki et al.
Cell reports, 33(6), 108380-108380 (2020-11-12)
In gene silencing, Hsp90 chaperone machinery assists Argonaute (Ago) binding and unwinding of silencing small RNA (sRNA) duplexes. This enables the formation of effector RNA-induced silencing complex (RISC) that often displays cargo preferences. Hence, in Drosophila, microRNAs (miRNAs) and small-interfering
Ke Xu et al.
eLife, 12 (2023-03-22)
The acrosome is a membranous organelle positioned in the anterior portion of the sperm head and is essential for male fertility. Acrosome biogenesis requires the dynamic cytoskeletal shuttling of vesicles toward nascent acrosome which is regulated by a series of
Macarena Tejos-Bravo et al.
Neurobiology of stress, 14, 100306-100306 (2021-03-06)
Sex differences in the brain have prompted many researchers to investigate the underlying molecular actors, such as the glucocorticoid receptor (GR). This nuclear receptor controls gene expression, including microRNAs (miRNAs), in non-neuronal cells. Here, we investigated sex-biased effects of GR
Andrew Philp et al.
The Journal of biological chemistry, 286(35), 30561-30570 (2011-07-16)
The protein deacetylase, sirtuin 1 (SIRT1), is a proposed master regulator of exercise-induced mitochondrial biogenesis in skeletal muscle, primarily via its ability to deacetylate and activate peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). To investigate regulation of mitochondrial biogenesis by SIRT1 in
Pauline C Xu et al.
Scientific reports, 12(1), 1659-1659 (2022-02-02)
Pancreatic ductal adenocarcinoma (PDAC) patients display distinct phenotypes of cachexia development, with either adipose tissue loss preceding skeletal muscle wasting or loss of only adipose tissue. Activin A levels were measured in serum and analyzed in tumor specimens of both
Gabriel Cara-Fuentes et al.
iScience, 25(8), 104694-104694 (2022-07-19)
Steroid-sensitive nephrotic syndrome (SSNS) in childhood is usually due to minimal change disease (MCD). Unlike many glomerular conditions, SSNS/MCD is commonly precipitated by respiratory infections. Of interest, pulmonary inflammation releases surfactants in circulation which are soluble agonists of SIRPα, a
Dharma Pally et al.
ACS central science, 7(1), 110-125 (2021-02-04)
Heterogeneity in phenotypes of malignantly transformed cells and aberrant glycan expression on their surface are two prominent hallmarks of cancers that have hitherto not been linked to each other. In this paper, we identify differential levels of a specific glycan
Michal A Stanczak et al.
Science translational medicine, 14(669), eabj1270-eabj1270 (2022-11-03)
Immune checkpoint blockade (ICB) has substantially improved the prognosis of patients with cancer, but the majority experiences limited benefit, supporting the need for new therapeutic approaches. Up-regulation of sialic acid-containing glycans, termed hypersialylation, is a common feature of cancer-associated glycosylation
Yanan Yang et al.
Experimental and therapeutic medicine, 22(5), 1305-1305 (2021-10-12)
Lung cancer is one of the most common types of cancer, with the highest mortality rate worldwide. MicroRNAs play notable roles in the chemotherapeutic effects of anticancer drugs. The present study used reverse transcription-quantitative PCR, western blotting and cell migration
Miroslava Kacířová et al.
Journal of neuroinflammation, 18(1), 141-141 (2021-06-24)
Obesity leads to low-grade inflammation in the adipose tissue and liver and neuroinflammation in the brain. Obesity-induced insulin resistance (IR) and neuroinflammation seem to intensify neurodegeneration including Alzheimer's disease. In this study, the impact of high-fat (HF) diet-induced obesity on
Miao Gui et al.
Cell, 184(23), 5791-5806 (2021-10-30)
Dynein-decorated doublet microtubules (DMTs) are critical components of the oscillatory molecular machine of cilia, the axoneme, and have luminal surfaces patterned periodically by microtubule inner proteins (MIPs). Here we present an atomic model of the 48-nm repeat of a mammalian
Modulation of alpha-adrenoceptor signalling protects photoreceptors after retinal detachment by inhibiting oxidative stress and inflammation
Li T, et al.
British Journal of Pharmacology, 176(6), 801-813 (2019)
Chengfeng Xiao et al.
Developmental neurobiology, 67(4), 438-455 (2007-04-20)
Heat shock preconditioning can enhance locomotor and synaptic performance during subsequent hyperthermia. The molecular basis underlying this neural phenotypic modification is largely unknown. Here we report that directing the expression of the 70 kDa heat shock protein (HSP70) to motoneurons
Ee-Chun Cheng et al.
Cell reports, 34(1), 108575-108575 (2021-01-07)
SETDB1 is a histone-lysine N-methyltransferase critical for germline development. However, its function in early meiotic prophase I remains unknown. Here, we report that Setdb1 null spermatocytes display aberrant centromere clustering during leptotene, bouquet formation during zygotene, and subsequent failure in
Andreas Puyskens et al.
Cell host & microbe, 27(2), 238-248 (2020-01-07)
Antimicrobial resistance in tuberculosis (TB) is a public health threat of global dimension, worsened by increasing drug resistance. Host-directed therapy (HDT) is an emerging concept currently explored as an adjunct therapeutic strategy for TB. One potential host target is the
Iman Lohraseb et al.
Nature communications, 13(1), 2018-2018 (2022-04-21)
The ubiquitin ligase NEDD4 promotes neural crest cell (NCC) survival and stem-cell like properties to regulate craniofacial and peripheral nervous system development. However, how ubiquitination and NEDD4 control NCC development remains unknown. Here we combine quantitative analysis of the proteome
Richard J Y Liu et al.
The Journal of biological chemistry, 299(6), 104718-104718 (2023-04-17)
Loss-of-function variants of vacuolar protein sorting proteins VPS33B and VPS16B (VIPAS39) are causative for arthrogryposis, renal dysfunction, and cholestasis syndrome, where early lethality of patients indicates that VPS33B and VPS16B play essential cellular roles. VPS33B is a member of the
Haopeng Xiao et al.
Cell, 185(24), 4654-4673 (2022-11-06)
Brown adipose tissue (BAT) regulates metabolic physiology. However, nearly all mechanistic studies of BAT protein function occur in a single inbred mouse strain, which has limited the understanding of generalizable mechanisms of BAT regulation over physiology. Here, we perform deep
Maria Shoykhet et al.
Frontiers in cell and developmental biology, 11, 1021595-1021595 (2023-02-04)
A Disintegrin And Metalloprotease (ADAM) family proteins are involved in several cardiac diseases, and some ADAMs have been associated with cardiomyopathies. ADAM17 is known to cleave desmoglein 2 (DSG2), one of the proteins involved in the pathogenesis of arrhythmogenic cardiomyopathy
Andrea M Pesch et al.
JCI insight, 7(3) (2021-12-22)
Standard radiation therapy (RT) does not reliably provide locoregional control for women with multinode-positive breast cancer and triple-negative breast cancer (TNBC). We hypothesized that CDK4/6 inhibition (CDK4/6i) would increase the radiosensitivity not only of estrogen receptor-positive (ER+) cells, but also
EGFR inhibition leads to enhanced desmosome assembly and cardiomyocyte cohesion via ROCK activation.
Maria Shoykhet et al.
JCI insight (2023-02-17)
Arrhythmogenic cardiomyopathy (AC) is a familial heart disease partly caused by impaired desmosome turnover. Thus, stabilization of desmosome integrity may provide potential new treatment options. Desmosomes, apart from cellular cohesion, provide the structural framework of a signaling hub. Here, we
Anna R Michmerhuizen et al.
NPJ breast cancer, 8(1), 31-31 (2022-03-12)
Endocrine therapy (ET) is an effective first-line therapy for women with estrogen receptor-positive (ER + ) breast cancers. While both ionizing radiation (RT) and ET are used for the treatment of women with ER+ breast cancer, the most effective sequencing of therapy and
Haopeng Xiao et al.
Cell, 180(5), 968-983 (2020-02-29)
Mammalian tissues engage in specialized physiology that is regulated through reversible modification of protein cysteine residues by reactive oxygen species (ROS). ROS regulate a myriad of biological processes, but the protein targets of ROS modification that drive tissue-specific physiology in vivo
Longlong Wang et al.
Cell reports, 39(4), 110736-110736 (2022-04-28)
The deacetylase HDAC6 has tandem catalytic domains and a zinc finger domain (ZnF) binding ubiquitin (Ub). While the catalytic domain has an antiviral effect, the ZnF facilitates influenza A virus (IAV) infection and cellular stress responses. By recruiting Ub via
Theodore A Craig et al.
Biochemical and biophysical research communications, 402(2), 421-424 (2010-10-19)
To gain insights into the mechanism of action of sclerostin, a protein that regulates bone mass, we performed yeast two-hybrid analyses using human SOST (sclerostin) cDNA cloned into pGBKT7 DNA-binding domain vector as a bait, and a normalized, high-complexity, universal
Trishna Pani et al.
Cell death & disease, 12(2), 171-171 (2021-02-12)
Global dysregulation of RNA splicing and imbalanced sphingolipid metabolism has emerged as promoters of cancer cell transformation. Here, we present specific signature of alternative splicing (AS) events of sphingolipid genes for each breast cancer subtype from the TCGA-BRCA dataset. We
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