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关键词:'E6758'
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Joanne Muter et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(4), 1603-1614 (2015-01-13)
Implantation requires coordinated interactions between the conceptus and surrounding decidual cells, but the involvement of clock genes in this process is incompletely understood. Circadian oscillations are predicated on transcriptional-translational feedback loops, which balance the activities of the transcriptional activators CLOCK
Determinants of maternal pregnancy one-carbon metabolism and newborn human DNA methylation profiles.
Nina H van Mil et al.
Reproduction (Cambridge, England), 148(6), 581-592 (2014-11-14)
Maternal one-carbon (1-C) metabolism provides methylgroups for fetal development and programing by DNA methylation as one of the underlying epigenetic mechanisms. We aimed to investigate maternal 1-C biomarkers, folic acid supplement use, and MTHFR C677T genotype as determinants of 1-C
Gursimran Chandhok et al.
PloS one, 9(6), e98809-e98809 (2014-06-04)
Mutations in the copper (Cu) transporter gene ATP7B, the primary cause of Wilson disease (WD), result in high liver Cu and death of hepatocytes. Cu chelators and zinc salts are the two most important drugs used in the treatment of
Marie Vajrychova et al.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 29(1), 12-21 (2014-11-27)
Our recent exploratory proteomic study suggested increased levels of neutrophil-gelatinase associated lipocalin (P80188, NGAL_HUMAN) due to microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) in women with preterm prelabor rupture of the membranes. In this study, we
Noriko Takahashi et al.
Nature communications, 6, 8531-8531 (2015-10-07)
It remains unclear how readiness for Ca(2+)-dependent exocytosis depends on varying degrees of SNARE complex assembly. Here we directly investigate the SNARE assembly using two-photon fluorescence lifetime imaging (FLIM) of Förster resonance energy transfer (FRET) between three pairs of neuronal
Daniela Michlmayr et al.
Journal of virology, 88(17), 9553-9567 (2014-06-06)
The encephalitic response to viral infection requires local chemokine production and the ensuing recruitment of immune and inflammatory leukocytes. Accordingly, chemokine receptors present themselves as plausible therapeutic targets for drugs aimed at limiting encephalitic responses. However, it remains unclear which
Tae Mi Yoon et al.
Oncology reports, 33(4), 1717-1722 (2015-02-25)
The transcription factor, early growth response 1 (EGR1) belongs to the early growth response family. EGR1 regulates the transactivation of genes involved in growth inhibition and apoptosis by ionizing radiation. The aims of the present study were to evaluate the expression
Pu Yang et al.
Virology, 485, 223-232 (2015-08-25)
Respiratory syncytial virus (RSV) nonstructural (NS) proteins 1 and 2 have multiple functions in suppressing the innate immune response and modulating T helper cell subset differentiation. However, little is known about the roles of NS proteins as independent virulence factors.
Piotr Bielecki et al.
Nucleic acids research, 43(13), 6413-6425 (2015-06-18)
Two-component systems (TCS) serve as stimulus-response coupling mechanisms to allow organisms to adapt to a variety of environmental conditions. The opportunistic pathogen Pseudomonas aeruginosa encodes for more than 100 TCS components. To avoid unwanted cross-talk, signaling cascades are very specific
Goran Mucic et al.
Behavioural brain research, 280, 45-50 (2014-12-03)
Although protein kinases and phosphatases have been reported to be involved in fear memory, information about these signalling molecules in the individual phases of contextual fear conditioning (cFC) is limited. C57BL/6J mice were tested in cFC, sacrificed and hippocampi were
Colin W Hay et al.
Psychoneuroendocrinology, 47, 43-55 (2014-07-09)
Expression or introduction of the neuropeptide substance-P (SP; encoded by the TAC1 gene in humans and Tac1 in rodents) in the amygdala induces anxiety related behaviour in rodents. In addition, pharmacological antagonism of the main receptor of SP in humans;
Chikara Tanaka et al.
The Journal of cell biology, 207(1), 91-105 (2014-10-08)
In selective autophagy, degradation targets are specifically recognized, sequestered by the autophagosome, and transported into the lysosome or vacuole. Previous studies delineated the molecular basis by which the autophagy machinery recognizes those targets, but the regulation of this process is
Janne Hakkarainen et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(9), 3806-3816 (2015-05-29)
Hydroxysteroid (17β)-dehydrogenase type 1 (HSD17B1) catalyzes the conversion of low active 17-ketosteroids, androstenedione (A-dione) and estrone (E1) to highly active 17-hydroxysteroids, testosterone (T) and E2, respectively. In this study, the importance of HSD17B1 in ovarian estrogen production was determined using
Muhammad Ismail et al.
Drug and chemical toxicology, 37(4), 466-471 (2014-02-15)
Chlorpyrifos is a widely used insecticide of organophosphate group, which causes severe toxicological effects in non target aquatic organisms especially in fish. In the present study the genotoxic effects of sublethal concentrations of chlorpyrifos were observed in the erythrocytes and
Xuanmao Chen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(1), 339-351 (2015-01-09)
The type 1 adenylyl cyclase (AC1) is an activity-dependent, calcium-stimulated adenylyl cyclase expressed in the nervous system that is implicated in memory formation. We examined the locomotor activity, and impulsive and social behaviors of AC1+ mice, a transgenic mouse strain
Juraiporn Somboonwong et al.
Life sciences, 139, 46-51 (2015-08-19)
Diabetes mellitus is associated with disturbed zinc homeostasis and down-regulation of zinc transporter 8 (ZnT8); these changes contribute to the defective biosynthesis, storage, and secretion of insulin. Previous studies have reported an improvement in diabetic status and insulin levels in
Fuminori Kawano et al.
Journal of applied physiology (Bethesda, Md. : 1985), 119(10), 1042-1052 (2015-09-26)
Numerous studies have reported alterations in skeletal muscle properties and phenotypes in response to various stimuli such as exercise, unloading, and gene mutation. However, a shift in muscle fiber phenotype from fast twitch to slow twitch is not completely induced
Juan He et al.
Nephrology (Carlton, Vic.), 20(9), 591-600 (2015-04-25)
Micro-vesicles (MVs) from bone mesenchymal stem cells (MSCs) have been shown to contribute to the recovery of damaged kidney. The aims of the present study are to investigate the biological effects and repair mechanisms of MVs. Micro-vesicles were obtained from
Jennifer R Fleming et al.
PLoS neglected tropical diseases, 8(6), e2936-e2936 (2014-06-13)
Animal African Trypanosomosis (AAT) presents a severe problem for agricultural development in sub-Saharan Africa. It is caused by several trypanosome species and current means of diagnosis are expensive and impractical for field use. Our aim was to discover antigens for
S K Hasan et al.
Human & experimental toxicology, 34(6), 628-641 (2014-10-30)
2-Acetylaminofluorene (2-AAF) is a known hepatic carcinogen which leads to tumour formation in rodents. 18-β Glycyrrhetinic acid (18β-GA) derived from liquorice plant has various pharmacological properties such as anti-ulcer, anti-inflammatory, antiviral, hepatoprotective and antioxidant. This study is designed to elucidate
Ali Karimi et al.
Gene, 554(2), 224-232 (2014-12-03)
Artemisia dracunculus L. (tarragon), a small shrubby perennial herb, is cultivated for the use of its aromatic leaves in seasoning, salads, etc., and in the preparation of tarragon vinegar. In the present work, genetic analysis of 29 cultivated individuals of
Zhili Ma et al.
International journal of molecular sciences, 16(9), 22062-22080 (2015-09-18)
In this study, the effects of mixed corn peptides and synthetic pentapeptide (QLLPF) on hepatocyte apoptosis induced by ethanol were investigated in vivo. QLLPF, was previously characterized from corn protein hydrolysis, which had been shown to exert good facilitating alcohol
Chunzhao Zhao et al.
PLoS genetics, 10(5), e1004389-e1004389 (2014-05-17)
Mitogen-activated protein (MAP) kinase signaling cascades play important roles in the regulation of plant defense. The Raf-like MAP kinase kinase kinase (MAPKKK) EDR1 negatively regulates plant defense responses and cell death. However, how EDR1 functions, and whether it affects the
Fuyao Liu et al.
Small (Weinheim an der Bergstrasse, Germany), 11(30), 3676-3685 (2015-04-29)
Hydrophobic ultrasmall nanoparticles synthesized in nonpolar solvents exhibit great potential in biomedical applications. However, a major challenge when applying these nanomaterials in biomedical research is the lack of a versatile strategy to render them water dispersible while preserving the hydrodynamic
Abdulkader Albasri et al.
Anticancer research, 34(8), 3969-3974 (2014-07-31)
To determine whether phosphorylated focal adhesion kinase (P-FAK) has prognostic value in colorectal cancer (CRC) and to test whether it has any association with Tensin 4 (TNS4) expression. P-FAK expression was assessed using immunohistochemistry in 462 CRC cases arrayed on
Yoon Kyung Kwon et al.
Chemical & pharmaceutical bulletin, 63(12), 1076-1080 (2015-12-04)
The aim of this study was to search for a novel choline acetyltransferase (ChAT) activator from plants traditionally grown in Korea. An ethanol extract from Chaenomeles sinensis Koehne showed the highest ChAT-activating effect in vitro in an assay that used
William F Borschel et al.
The Journal of biological chemistry, 290(44), 26846-26855 (2015-09-16)
Among glutamate-gated channels, NMDA receptors produce currents that subside with unusually slow kinetics, and this feature is essential to the physiology of central excitatory synapses. Relative to the homologous AMPA and kainate receptors, NMDA receptors have additional intersubunit contacts in
Shuai Wu et al.
Molecules (Basel, Switzerland), 20(10), 18704-18716 (2015-10-27)
Tongmai formula (TMF) is a well-known Chinese medicinal preparation that contains isoflavones as its major bioactive constituents. As traditional Chinese medicines (TCMs) are usually used by oral administration, their fate inside the intestinal lumen, including their biotransformation by human intestinal
Harpreet Bhatia et al.
Journal of applied toxicology : JAT, 35(7), 806-816 (2014-10-29)
The aim of the present study was to evaluate whether long-term exposures to environmentally relevant concentrations of di-n-butyl phthalate (DnBP) disrupt the reproduction-based endpoints in juvenile Murray rainbowfish (Melanotaenia fluviatilis). Fish were exposed to 5, 15 or 50 µg l(-1) DnBP for
Oluwaseun Adebayo Bamodu et al.
Cancer letters, 364(2), 125-134 (2015-05-16)
Triple-negative breast cancer (TNBC) is chemotherapy-refractory and associated with poor clinical prognosis. Doxorubicin (Doxo), a class I anthracycline and first-line anticancer agent, effective against a wide spectrum of neoplasms including breast carcinoma, is associated with several cumulative dose-dependent adverse effects
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