CN

Effect of Chaenomeles sinensis Extract on Choline Acetyltransferase Activity and Trimethyltin-Induced Learning and Memory Impairment in Mice.

Effect of Chaenomeles sinensis Extract on Choline Acetyltransferase Activity and Trimethyltin-Induced Learning and Memory Impairment in Mice.

Chemical & pharmaceutical bulletin (2015-12-04)

Yoon Kyung Kwon, Soo Jung Choi, Cho Rong Kim, Jae Kyeom Kim, Hye Kyung Kim, Jong Hun Choi, Sang-Wook Song, Chang-Ju Kim, Gwi Gun Park, Cheung-Seog Park, Dong-Hoon Shin

摘要

The aim of this study was to search for a novel choline acetyltransferase (ChAT) activator from plants traditionally grown in Korea. An ethanol extract from Chaenomeles sinensis Koehne showed the highest ChAT-activating effect in vitro in an assay that used human neuroblastoma cells and [(14)C]acetyl-CoA. The active compound was speculated to be stearic acid methyl ester (SAME). In an in vivo experiment, C. sinensis extract and SAME improved trimethyltin (TMT)-induced deficits in learning and memory in mice as assessed by a Y-maze behavioral test and a passive avoidance test. The C. sinensis extract might attenuate the TMT-induced brain disorder. This study suggests that SAME from C. sinensis might be useful in the treatment of Alzheimer's disease.

材料

货号

品牌

产品描述

Sigma-Aldrich

纯乙醇, 200 proof, for molecular biology

Sigma-Aldrich

甲苯, anhydrous, 99.8%

Sigma-Aldrich

纯乙醇, 200 proof, anhydrous, ≥99.5%

Sigma-Aldrich

纯乙醇, 200 proof, ACS reagent, ≥99.5%

Sigma-Aldrich

氯化钠, BioXtra, ≥99.5% (AT)

Sigma-Aldrich

甲苯, ACS reagent, ≥99.5%

Sigma-Aldrich

氯化钠, for molecular biology, DNase, RNase, and protease, none detected, ≥99% (titration)

Sigma-Aldrich

纯乙醇, 200 proof, HPLC/spectrophotometric grade

Sigma-Aldrich

氯化钠溶液, 5 M in H₂O, BioReagent, for molecular biology, suitable for cell culture

Sigma-Aldrich

乙二胺四乙酸, ACS reagent, 99.4-100.6%, powder

Sigma-Aldrich

氯化胆碱, ≥98%

Sigma-Aldrich

氯化钠溶液, 0.9% in water, BioXtra, suitable for cell culture

Sigma-Aldrich

氯化钠溶液, 5 M

Sigma-Aldrich

纯乙醇, 200 proof, meets USP testing specifications

Sigma-Aldrich

纯乙醇, 190 proof, ACS spectrophotometric grade, 95.0%

Sigma-Aldrich

氯化钠, meets analytical specification of Ph. Eur., BP, USP, 99.0-100.5%

Sigma-Aldrich

氯化钠, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥99%

Sigma-Aldrich

纯乙醇, 190 proof, for molecular biology

SAFC

氯化钠溶液, 5 M

Sigma-Aldrich

乙二胺四乙酸, BioUltra, anhydrous, ≥99% (titration)

Sigma-Aldrich

纯乙醇, 190 proof, meets USP testing specifications

Sigma-Aldrich

乙二胺四乙酸溶液, 0.02% in DPBS (0.5 mM), sterile-filtered, BioReagent, suitable for cell culture

Sigma-Aldrich

氯化胆碱, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98%

Sigma-Aldrich

四苯基硼酸钠, ACS reagent, ≥99.5%

Sigma-Aldrich

乙二胺四乙酸, purified grade, ≥98.5%, powder

Sigma-Aldrich

氯化胆碱, ≥99%

Sigma-Aldrich

氯化钠溶液, BioUltra, for molecular biology, ~5 M in H₂O

Sigma-Aldrich

乙二胺四乙酸, anhydrous, crystalline, BioReagent, suitable for cell culture

Sigma-Aldrich

氯化钠, 99.999% trace metals basis

Sigma-Aldrich

氯化钠, BioUltra, for molecular biology, ≥99.5% (AT)