CN
Search Within
F7250
应用筛选条件
关键词:'F7250'
显示 1-30 共 1348 条结果 关于 "F7250" 范围 论文
Iris J Gonzalez-Leal et al.
PLoS neglected tropical diseases, 8(9), e3194-e3194 (2014-09-26)
Resistance and susceptibility to Leishmania major infection in the murine model is determined by the capacity of the host to mount either a protective Th1 response or a Th2 response associated with disease progression. Previous reports involving the use of
Shinji Ono et al.
Investigative ophthalmology & visual science, 55(9), 5752-5759 (2014-08-02)
Prostacyclin (PGI2) is usually described as an endoEDRFsthelium-derived relaxing factor, but the vasoreactivity to PGI2 in the retinal arterioles and the underlying mechanisms are not fully understood. We examined the effects of PGI2 on the retinal microcirculation using beraprost sodium
Christina Duftner et al.
PloS one, 9(6), e99302-e99302 (2014-07-01)
Antiphospholipid antibodies (aPLs) frequently occur in autoimmune and cardiovascular diseases and correlate with a worse clinical outcome. In the present study, we evaluated the association between antiphospholipid antibodies (aPLs), markers of inflammation, disease progression and the presence of an intra-aneurysmal
Wadie D Mahauad-Fernandez et al.
Breast cancer research : BCR, 16(6), 493-493 (2014-12-17)
Several innate immunity genes are overexpressed in human cancers and their roles remain controversial. Bone marrow stromal antigen 2 (BST-2) is one such gene whose role in cancer is not clear. BST-2 is a unique innate immunity gene with both
Geng Jia et al.
OncoTargets and therapy, 8, 303-311 (2015-02-13)
Tubeimoside-1 (TBMS1) is a natural compound isolated from tubeimoside, which has been widely used as a traditional Chinese herbal medicine. The purpose of the present study is to investigate the anti-tumor effect and the underling mechanism of TBMS1 on glioma
Marc R Mansour et al.
British journal of haematology, 168(2), 230-238 (2014-09-27)
Activating mutations of the interleukin-7 receptor (IL7R) occur in approximately 10% of patients with T cell acute lymphoblastic leukaemia (T-ALL). Most mutations generate a cysteine at the transmembrane domain leading to receptor homodimerization through disulfide bond formation and ligand-independent activation
Nino Muradashvili et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(9), 1472-1482 (2014-05-29)
Increased blood level of homocysteine (Hcy), called hyperhomocysteinemia (HHcy) accompanies many cognitive disorders including Alzheimer's disease. We hypothesized that HHcy-enhanced cerebrovascular permeability occurs via activation of matrix metalloproteinase-9 (MMP9) and leads to an increased formation of fibrinogen-β-amyloid (Fg-Aβ) complex. Cerebrovascular
Chi-Feng Hung et al.
Age (Dordrecht, Netherlands), 37(2), 21-21 (2015-02-28)
Ultraviolet (UV) exposure and menopause are known as the inducers of damage to the skin structure. The combination of these two factors accelerates the skin aging process. In this study, we aimed to evaluate the influence of UV and ovariectomy
Xiangxin Lou et al.
Journal of translational medicine, 12, 150-150 (2014-06-03)
Previous reports showed the presence of limited numbers of stem cells in neonatal murine cochlear sensory epithelia and these cells are progressively lost during the postnatal development. The goal of this study was to investigate whether stem cells can be
Kun Zhang et al.
Scientific reports, 5, 8766-8766 (2015-03-06)
Ultrasound contrast agents (UCAs) designed by the conventional composition-based strategy, often suffer from relatively low ultrasound utilization efficiency. In this report, a structure-based design concept of double-scattering/reflection in a single nanoparticle for enhancing ultrasound imaging has been proposed. To exemplify
Marjolein Bijlard et al.
Molecular and cellular biology, 35(4), 675-687 (2014-12-17)
Myelination of axons by oligodendrocytes is essential for saltatory nerve conduction. To form myelin membranes, a coordinated synthesis and subsequent polarized transport of myelin components are necessary. Here, we show that as part of the mechanism to establish membrane polarity
Joshua Choi et al.
Clinical and vaccine immunology : CVI, 21(5), 769-776 (2014-03-29)
A Gram-negative pathogen Haemophilus influenzae has a truncated endotoxin known as lipooligosaccharide (LOS). Recent studies on H. influenzae LOS highlighted its structural and compositional implications for bacterial virulence; however, the role of LOS in the activation of innate and adaptive
Xu Chen et al.
International journal of biological macromolecules, 129, 433-441 (2019-02-05)
The objective of this study was to investigate the porcine pancreatic α-amylase (PPA) inhibitory activity of botanical food proteins, represented by soy protein isolate (SPI) and wheat gluten protein (WGP). The half maximal inhibitory concentration (IC50) was determined, and the
Sunhee Hwang et al.
Stem cells and development, 23(21), 2661-2671 (2014-06-11)
A hyaluronic-acid-rich node and duct system (HAR-NDS) was found on the surface of internal organs of mice, and inside their blood and lymph vessels. The nodes (HAR-Ns) were filled with immune cells of the innate system and were especially enriched
Timothy J Brazil et al.
Veterinary journal (London, England : 1997), 202(3), 536-542 (2014-09-23)
The aim of this study was to characterise constitutive apoptosis in equine peripheral blood neutrophils, including assessment of factors that potentially modulate neutrophil survival through alteration of the rate of constitutive apoptosis. Cells underwent spontaneous time-dependent constitutive apoptosis when aged
Hsiao-Fan Chen et al.
Nature communications, 5, 4697-4697 (2014-08-26)
The mechanisms controlling tumour-induced angiogenesis are presently not clear. In principle, angiogenesis can be achieved through the activation of endothelial cells in existing vessels or by transdifferentiation of tumour cells into endothelial cells. However, whether tumour cells can go through
Annette Hayden et al.
Urologic oncology, 32(6), 806-814 (2014-05-20)
Cisplatin is the key systemic chemotherapeutic agent used for bladder cancer, but chemoresistance is a major clinical problem. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) regulates various critical cellular processes, including cellular antioxidant response, cellular detoxification, and
Yung-Chih Kuo et al.
International journal of pharmaceutics, 479(1), 138-149 (2015-01-07)
Lactoferrin (Lf) and folic acid (FA) were crosslinked on poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) for transporting etoposide across the blood-brain barrier (BBB) and treating human brain malignant glioblastoma. Lf- and FA-grafted PLGA NPs (Lf/FA/PLGA NPs) were employed to permeate the monolayer
Yifeng Xue et al.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 12(3), 253-260 (2014-06-09)
To evaluate the immunomodulatory properties of human amniotic mesenchymal stromal cells. Human amniotic mesenchymal stromal cells were isolated, characterized by flow cytometry, cultured in vitro, and evaluated in allogeneic and xenogeneic mixed lymphocyte reactions. The proliferation of T cells and
Cammi N Valdez et al.
The American journal of pathology, 184(10), 2618-2626 (2014-08-06)
Diabetes can lead to vision loss because of progressive degeneration of the neurovascular unit in the retina, a condition known as diabetic retinopathy. In its early stages, the pathology is characterized by microangiopathies, including microaneurysms, microhemorrhages, and nerve layer infarcts
Y Shimazu et al.
Gene therapy, 22(2), 146-154 (2014-11-14)
Reduced expression in immortalized cells/Dickkopf-3 (REIC/Dkk-3) was identified as a gene whose expression is reduced in many human cancers. REIC/Dkk-3 expression is also downregulated in malignant glioma and regulates cell growth through caspase-dependent apoptosis. cRGD (EMD121974), an antagonist of integrins
Andrea Delekate et al.
Nature communications, 5, 5422-5422 (2014-11-20)
Astrocytic network alterations have been reported in Alzheimer's disease (AD), but the underlying pathways have remained undefined. Here we measure astrocytic calcium, cerebral blood flow and amyloid-β plaques in vivo in a mouse model of AD using multiphoton microscopy. We
Peng Lai et al.
Life sciences, 114(2), 62-69 (2014-08-03)
Our previous studies revealed that echinocystic acid (EA) showed obvious attenuation of atherosclerosis in rabbits fed a high-fat diet. However, the underlying mechanisms remain to be elucidated. Considering the importance of endothelial progenitor cells (EPCs) in atherosclerosis, we hypothesise that
Takele Argaw et al.
Virology, 475, 110-119 (2014-12-03)
Previously, we found that mutation of glutamine to proline in the endoproteolytic cleavage signal of the PERV-C envelope (RQKK to RPKK) resulted in non-infectious vectors. Here, we show that RPKK results in a non-infectious vector when placed in not only
Yuichi Hara et al.
The American journal of pathology, 184(11), 3026-3039 (2014-09-24)
Hepatitis C virus (HCV) causes mitochondrial injury and oxidative stress, and impaired mitochondria are selectively eliminated through autophagy-dependent degradation (mitophagy). We investigated whether HCV affects mitophagy in terms of mitochondrial quality control. The effect of HCV on mitophagy was examined
Jiyoon Kim et al.
Current biology : CB, 30(9), 1614-1625 (2020-03-15)
Cells can sense and respond to various mechanical stimuli from their surrounding environment. One of the explanations for mechanosensitivity, a lipid-bilayer model, suggests that a stretch of the membrane induced by mechanical force alters the physical state of the lipid
Kornelis S M van der Geest et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(7), 1927-1938 (2014-03-14)
Several lines of evidence indicate that B cells may be involved in the immunopathology of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR). This study was undertaken to examine the distribution of defined B cell subsets, including effector B (Beff)
Haydar Alturaihi et al.
European journal of immunology, 45(2), 592-602 (2014-11-19)
In addition to its classical receptor, CD40, it is now well established that CD154 also binds αIIbβ3, α5β1, and αMβ2 integrins. Although these integrins are all members of the same family, they bind CD154 differently. The current investigation aims to
Réka Albert et al.
Biochimica et biophysica acta, 1850(2), 435-446 (2014-12-03)
The apopto-phagocytic gene expression patterns during clearance of dying cells in the retina and the effect of triamcinolone (TC) upon these processes have relevance to development of age-related macular degeneration (AMD). ARPE-19 cells and primary human retinal pigment epithelium (hRPE)
Li Wu et al.
Reproductive biology and endocrinology : RB&E, 12, 74-74 (2014-08-05)
Several types of T cells have been associated with the pathogenesis of unexplained recurrent spontaneous abortion (URSA), including Th1/Th2/Th17/Tregs cell. It has been appreciated that immunotherapy with paternal or third party lymphocytes is an effective method of treatment for URSA
1/45