Mass spectrometry

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facet applications:Mass spectrometry

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LC/MS/MS法测定谷物中的草甘膦、AMPA和草铵膦

使用 HPLC 和 SPE 的离子交换聚合物基颗粒测定燕麦片和婴儿谷物中的草甘膦及相关化合物。获得低水平的检测结果。

使用分子印迹聚合物SPE提取安非他明及相关药物

质量解析

氨基酸衍生化和GC-MS分析

用于药物分析的Supel-Select HLB SPE

Select HLB SPE是一种亲水性聚合物相，用于从水性基质中提取分析物。在本文中，它将用于从血浆中提取他汀类药物，以及从饮用水中提取48种药物分析物。

用在药品微量元素杂质评估过程中的超纯水

在药品开发和生产的各个阶段，必须监测和控制其中的元素杂质含量。建议使用 Milli-Q® 纯水系统产出的超纯水进行 ICP-MS 和 ICP-OES 微量元素分析。

Mass Spectrometry

What is Mass Spectrometry or MS? What is it used for and how does it work? Read this detailed article with diagrams and example graphs to understand how to use mass spec in your research.

Determination of Stevioside and Rebaudioside A in Stevia leaves, beverages and food additives using HPTLC-MS

HPTLC-MS was used to analyze stevioside and rebaudioside in artificial sweeteners, stevia plants, cola and isotonic drinks with a minimum of sample preparation.

Validation of RNAi Knockdown Using Multiple Reaction Monitoring and Protein-AQUA

The field of proteomics is continually looking for new ways to investigate protein dynamics within complex biological samples. Recently, many researchers have begun to use RNA interference (RNAi) as a method of manipulating protein levels within their samples, but the

Rapid Determination of Protein Binding Affinity Using Solid Phase Microextraction

Accurate protein binding affinities were measured using bioSPME more rapidly than membrane dialysis (RED) techniques. Binding affinities correlated to the reference values.

Bioanalysis with SPME

Biocompatible SPME devices employ C18 bonded porous silica sorbent particles, in a binder which resists fouling by biological matrix components

Ion-Suppression & Phospholipid Contamination

We are presenting an article focusing on ion-suppression and phospholipid contamination and some of their major causes and difficulties.

Supel™-Select Polymeric SPE

Supel-Select HLB SPE - a hydrophilic modified styrene based polymer developed for the solid phase extraction of a broad range of compounds from aqueous samples.

Derivatization Agents for LC/MS – An Improved Detection of Estradiol with ESI-MS

Improved LC/MS Detection of Estradiol using 4-(Dimethylamino) benzoyl chloride (DMABC) derivatization agent relative to dansyl chloride.

Quantification of Infliximab in Human Serum by LC-MS/MS Using A Full-Length Stable Isotope Labeled Internal Standard

Infliximab, a chimeric monoclonal antibody, is used to treat rheumatoid arthritis, psoriatic arthritis, Crohn’s disease, and other autoimmune diseases.

Evaluation of Different Enzymes on Hydrolysis Efficiencies of Glucuronide Drug Metabolites in Urine

β-glucuronidase (GUS) enzymes are utilized to hydrolyze glucuronide (gluc) drug metabolites to the parent drug, facilitating analysis by LC-MS/MS.

Optimising the LC-MS Analysis of Biomolecules

We present an article concerning optimising the LC-MS analysis of biomolecules.

The Effect of Container Materials on Production of Light Induced Off-Flavors in Milk – A Study Using SPME-GC-MS

Various plastics used as barriers to the production of off-flavors in light exposed milk were examined using HS-SPME with a new Carboxen®/PDMS coated Nitinol fiber followed by GC-MS analysis allowing detection of low MW analytes at levels <1 ng/mL.

SPME in the Analysis of Illicit Drugs

SPME is used in the analysis of amphetamine compounds by doing pre-extraction derivatization, and is also used in general determinations of other drugs of abuse.

Chiral and Achiral LC-MS Analysis of Warfarin™ in Plasma Samples

Clinical laboratories are beginning to reap the benefits of LC-MS in terms of its sensitivity, specificity, throughput, and potential to reduce cost per sample. The purpose of this study was to demonstrate the LC-MS analysis of Warfarin in plasma samples

HybridSPE-Phospholipid Technology

This Sigma-Aldrich article discusses how the HybridSPE-Phospholipid Technology works and how the phospholipids are removed.

Chromatography Profile Analysis of Phosphorothioate Oligonucleotides

The ultimate goal of most antisense research is to develop therapeutic agents for diseases such as diabetes, cancer, and HIV/ AIDS. Phosphorothioate oligonucleotides (commonly referred to as S-oligos) are often the molecules of choice because of their resistance to cellular

Synthesis and HILIC/MS Analysis of Acylcarnitines

HILIC mode chromatography using an Ascentis® Express OH5 resolved the majority of the acyl-L-carnitines tested. It may be possible to use MS/MS and particular fragment ions to resolve the two coeluting pairs.

Ultrapure Water for LC MS Biomedical Analyses

This study assesses the suitability of ultrapure water from a Milli-Q® water system for sensitive LC-MS analyses of hormones.

How to Maximize Sensitivity in LC-MS

Various measures and options for maximized LC-MS sensitivity and low limit of detection (LOD) are shown on this page. Each and every tip avoids contaminations causing signal suppression, adduct formation, elevated background noise and increased spectrum complexity.

Complete Workflow for the Analysis of California List of Pesticides in Cannabis by LC-MS/MS and GC-MS/MS

To show product safety, it is mandatory to test cannabis flowers for the presence of pesticides. In this article, we show a complete workflow for sample preparation and analysis of cannabis for the pesticides registered in California, by LC-MS/MS and

Sample Cleanliness Using BioSPME

Learn about Supel™ BioSPME C18 96-pin tool to prepare a clean sample with minimal matrix effects for an LC-MS/MS analysis from human plasma and its comparison with acetonitrile-based precipitation.

Flame Retardant Analytical Standards

Flame Retardant Standards: PBDE Standards. Polybrominated diphenyl ether standards accompany our chromatography products for this important analysis.

Analysis of Tetrahydrocannabinol (THC) and Carboxytetrahydrocannabinol (THCCOOH) in Surface Waters by SPME and GC/MS

Ion Pairing for Analysis of Phosphonate Compounds

Phosphonates are a class of compounds commonly used for therapeutic applications of antiviral drugs. These compounds can be difficult to analyze due to their highly polar nature and lack of UV active chromophores.

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