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Xiaofeng Xu et al.
Molecular medicine reports, 11(3), 2191-2198 (2014-11-19)
The incidence and mortality rate of biliary tract cancer have been increasing worldwide; however, its diagnosis and prognosis have not improved in recent years. A novel approach, termed 'metabolomics', may have the potential to be developed as an effective diagnostic
D Joe Millward
The Journal of nutrition, 142(12), 2212S-2219S (2012-10-19)
Leucine's wide-ranging metabolic influences have made it subject to special interest. It is abundant in the diet, especially in some milk and cereal proteins, in part due to its allocation of 6 codons in the genetic code, and individual dietary
Allison M B Lehman et al.
Molecular pharmacology, 86(5), 570-579 (2014-08-30)
The retinoid X receptor (RXR) partners with numerous nuclear receptors, such as the peroxisome proliferator activated receptor (PPAR) family, liver X receptors (LXRs), and farnesoid X receptor (FXR). Although each heterodimer can be activated by specific ligands, a subset of
Behzad Rowshanravan et al.
Journal of cell science, 127(Pt 13), 2849-2861 (2014-05-13)
The GTPase Ras can either promote or inhibit cell survival. Inactivating mutations in Drosophila RasGAP (encoded by vap), a Ras GTPase-activating protein, lead to age-related brain degeneration. Genetic interactions implicate the epidermal growth factor receptor (EGFR)-Ras pathway in promoting neurodegeneration
Mellissa Gomez et al.
International journal of pharmaceutics, 593, 120121-120121 (2020-12-06)
Protection against primarily respiratory infectious diseases, such as tuberculosis (TB), can likely be enhanced through mucosal immunization induced by direct delivery of vaccines to the nose or lungs. A thermostable inhalable dry powder vaccine offers further advantages, such as independence
Jichun Yang et al.
Nutrition reviews, 68(5), 270-279 (2010-05-27)
Leucine, a branched-chain amino acid that must be supplied in the daily diet, plays an important role in controlling protein synthesis and regulating cell metabolism in various cell types. In pancreatic beta cells, leucine acutely stimulates insulin secretion by serving
Óscar J Pozo et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(2), 248-257 (2014-12-04)
In recent years, many new designer drugs have emerged, including the group of cathinone derivatives. One frequently occurring drug is mephedrone; although mephedrone was originally considered as a "legal high" product, it is currently banned in most Western countries. Despite
Suryani Tan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 988, 116-120 (2015-03-17)
Liquid chromatography-mass spectrometry (LC-MS) has been used to detect polyphenolic curcuminoids found in turmeric but studies of metabolism by bacterial and mammalian cells in vitro are compromised by poor recovery from the culture medium. We report a liquid-liquid extraction procedure
Hai-Bo Wang et al.
Chemical & pharmaceutical bulletin, 62(11), 1100-1109 (2014-11-05)
An ultra performance liquid chromatography (UPLC) coupled with quadrupole time-of-flight mass spectrometry (Q-TOF/MS) method has been optimized and established for the rapid analysis of the alkaloids in 22 samples originating from five Uncaria (U.) species. The accurate mass measurement of
Esthelle Hoedt et al.
PloS one, 9(8), e104563-e104563 (2014-08-15)
Lactoferrins exhibit antitumoral activities either as a secretory lactoferrin or an intracellular delta-lactoferrin isoform. These activities involve processes such as regulation of the cell cycle and apoptosis. While lactoferrin has been shown to exert its function by activating different transduction
Hui Sun et al.
Omics : a journal of integrative biology, 19(3), 186-195 (2015-01-15)
Metabolomics has been increasingly applied to discovering biomarkers and identifying perturbed pathways. Berberine has been shown to exhibit anti-inflammatory, antioxidant, and anticancer properties, but its mechanisms for treating nonbacterial prostatitis (NBP) remain unclear completely. We developed the untargeted metabolomics approach
H Jiang et al.
Methods (San Diego, Calif.), 68(2), 317-324 (2014-02-22)
Stable isotopes are ideal labels for studying biological processes because they have little or no effect on the biochemical properties of target molecules. The NanoSIMS is a tool that can image the distribution of stable isotope labels with up to
M M F Queiroz et al.
Phytochemical analysis : PCA, 26(3), 183-188 (2015-01-27)
Tetrapterys mucronata Cav. (Malpighiaceae) is a plant used in some regions of Brazil in the preparation of ayahuasca. To determine the content of the main tryptamine alkaloids in the stem bark of T. mucronata Cav. and assess their possible toxic
Slimming down in old age.
Gordon I Smith et al.
The American journal of clinical nutrition, 101(2), 247-248 (2015-02-04)
A Suryawan et al.
Journal of animal science, 89(7), 2004-2016 (2010-10-12)
The postprandial increases in AA and insulin independently stimulate protein synthesis in skeletal muscle of piglets. Leucine is an important mediator of the response to AA. We have shown that the postprandial increase in leucine, but not isoleucine or valine
Qian Mao et al.
Journal of pharmaceutical and biomedical analysis, 97, 129-140 (2014-05-29)
In present study, an ultra high performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS/MS) based metabolomics approach was established to investigate the metabolic profiles and characteristic chemical markers for distinguishing between leaves of Panax ginseng (LPG) and Panax quinquefolius (LPQ). The
Gabriela I Guzmán et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(3), 929-934 (2015-01-08)
Enzyme promiscuity toward substrates has been discussed in evolutionary terms as providing the flexibility to adapt to novel environments. In the present work, we describe an approach toward exploring such enzyme promiscuity in the space of a metabolic network. This
K E Lee et al.
Journal of dental research, 93(4), 371-375 (2014-02-04)
Oligodontia is the developmental absence of more than 5 permanent teeth except for the third molar. Familial oligodontia can occur as an isolated form or as part of a genetic syndrome. Mutations in the MSX1, PAX9, AXIN2, EDA, and WNT10A
Haruya Takahashi et al.
Journal of lipid research, 56(2), 254-265 (2014-12-17)
PPARα is well known as a master regulator of lipid metabolism. PPARα activation enhances fatty acid oxidation and decreases the levels of circulating and cellular lipids in obese diabetic patients. Although PPARα target genes are widely known, little is known
Richard D Moulton et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(5), 756-761 (2015-03-11)
To characterize the hydrolysis of the peptide prodrug pomaglumetad methionil (LY2140023; (1R,4S,5S,6S)-4-(L-methionylamino)-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide), to the active drug LY404039 [(1R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide], a series of in vitro studies were performed in various matrices, including human intestinal, liver, kidney homogenate, and
Libo He et al.
BMC genomics, 16, 184-184 (2015-04-19)
Compensatory growth is accelerated compared with normal growth and occurs when growth-limiting conditions are overcome. Most animals, especially fish, are capable of compensatory growth, but the mechanisms remain unclear. Further investigation of the mechanism of compensatory growth in fish is
Mara Stefanelli et al.
Chemico-biological interactions, 215, 54-61 (2014-03-29)
Cyanotoxins (CTX) are widely produced by several cyanobacteria (CB), increasingly spreading in most water bodies and terrestrial habitats, and represent a risk for human health. CB are prokaryotes, and although mostly autotrophic, several examples of heterotrophy in symbiotic relationship with
Xi Fu et al.
PloS one, 9(10), e110181-e110181 (2014-10-22)
Acute neurological crises involving striatal degeneration induced by a deficiency of glutaryl-CoA dehydrogenase (GCDH) and the accumulation of glutaric (GA) and 3-hydroxyglutaric acid (3-OHGA) are considered to be the most striking features of glutaric aciduria type I (GA1). In the
Monitoring bisphenol A and estrogenic chemicals in thermal paper with yeast-based bioreporter assay.
Johanna Rajasärkkä et al.
Analytical and bioanalytical chemistry, 406(23), 5695-5702 (2014-05-13)
Bioluminescent Saccharomyces cerevisiae yeast-based bioreporters were used to monitor bisphenol A and other estrogenic chemicals in thermal paper samples collected mainly from Finland on two occasions in 2010/2011, and 2013. The bisphenol A-targeted (BPA-R) and the human oestrogen receptor (hERα)
Xingqiang Wu et al.
Journal of hazardous materials, 286, 395-401 (2015-01-21)
The kinetics of the anoxic biodegradation of intracellular and dissolved microcystin (MCs) and the effects of soluble organic materials on the process were investigated via a series of well-controlled microcosm experiments. The potential for the removal of intracellular and dissolved
Minerva M Thame et al.
The British journal of nutrition, 112(11), 1779-1786 (2014-10-18)
During pregnancy, adult women with a normal BMI synthesise extra amino acids after an overnight fast by increasing body protein breakdown and decreasing amino acid oxidation. It is not known whether adolescent girls can make these adaptations during pregnancy. The
Paul M Flanigan et al.
Journal of the American Society for Mass Spectrometry, 25(9), 1572-1582 (2014-07-12)
The internal energy distributions for dried and liquid samples that were vaporized with femtosecond duration laser pulses centered at 800 nm and postionized by electrospray ionization-mass spectrometry (LEMS) were measured and compared with conventional electrospray ionization mass spectrometry (ESI-MS). The
Yanan Cao et al.
Science (New York, N.Y.), 344(6186), 913-917 (2014-04-05)
Adrenal Cushing's syndrome is caused by excess production of glucocorticoid from adrenocortical tumors and hyperplasias, which leads to metabolic disorders. We performed whole-exome sequencing of 49 blood-tumor pairs and RNA sequencing of 44 tumors from cortisol-producing adrenocortical adenomas (ACAs), adrenocorticotropic
J Marc Rhoads et al.
Amino acids, 37(1), 111-122 (2009-01-09)
Glutamine and leucine are abundant constituents of plant and animal proteins, whereas the content of arginine in foods and physiological fluids varies greatly. Besides their role in protein synthesis, these three amino acids individually activate signaling pathway to promote protein
Xabier Osteikoetxea et al.
PloS one, 10(3), e0121184-e0121184 (2015-03-24)
In recent years the study of extracellular vesicles has gathered much scientific and clinical interest. As the field is expanding, it is becoming clear that better methods for characterization and quantification of extracellular vesicles as well as better standards to
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