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Choon Meng Tan et al.
PloS one, 10(2), e0117067-e0117067 (2015-02-04)
XopDXcc8004, a type III effector of Xanthomonas campestris pv. campestris (Xcc) 8004, is considered a shorter version of the XopD, which lacks the N-terminal domain. To understand the functions of XopDXcc8004, in planta, a transgenic approach combined with inducible promoter
Ji-Feng Xu et al.
PloS one, 9(12), e114627-e114627 (2014-12-17)
The physiological role of microRNAs (miRNAs) in osteoblast differentiation remains elusive. Exosomal miRNAs isolated from human bone marrow-derived mesenchymal stem cells (BMSCs) culture were profiled using miRNA arrays containing probes for 894 human matured miRNAs. Seventy-nine miRNAs (∼8.84%) could be
Matthew J Betts et al.
Nucleic acids research, 43(2), e10-e10 (2014-11-14)
Systematic interrogation of mutation or protein modification data is important to identify sites with functional consequences and to deduce global consequences from large data sets. Mechismo (mechismo.russellab.org) enables simultaneous consideration of thousands of 3D structures and biomolecular interactions to predict
David B Beck et al.
Journal of proteome research, 13(12), 6135-6143 (2014-10-15)
Accurate and sensitive detection of protein-protein and protein-RNA interactions is key to understanding their biological functions. Traditional methods to identify these interactions require cell lysis and biochemical manipulations that exclude cellular compartments that cannot be solubilized under mild conditions. Here
IgG-lymphoplasmacytic lymphoma following polycythemia vera: JAK2 V617F and MYD88 L265P mutations separated in the same house.
Luisa Anelli et al.
Annals of hematology, 93(9), 1605-1607 (2014-01-11)
Hamdi Hosni Hamdan Hamama et al.
The journal of adhesive dentistry, 16(6), 507-516 (2014-12-18)
To evaluate the effect of enzyme-based (Papacárie) and sodium-hypochlorite-based (Carisolv) chemomechanical caries removal methods on bonding of self-etching adhesives to caries-affected dentin, in comparison to the standard rotary-instrument caries removal method. Seventy-eight carious permanent molars exhibiting frank cavitation into dentin
Javier E Ramirez et al.
Food chemistry, 176, 106-114 (2015-01-28)
The HPLC profiles of six fruits endemic of the VIII region of Chile were investigated using high resolution mass analysis (HR-ToF-ESI-MS). The anthocyanin fingerprints generated for the fruits were compared and the antioxidant capacities measured by the scavenging of the
Shoujun Chen et al.
The FEBS journal, 280(10), 2120-2137 (2013-01-22)
Small leucine-rich proteoglycans (SLRPs) are involved in a variety of biological and pathological processes. This review focuses on their regulatory roles in matrix assembly. SLRPs have protein cores and hypervariable glycosylation with multivalent binding abilities. During development, differential interactions of
Cheng Wang et al.
Toxicology letters, 229(3), 474-481 (2014-06-25)
Chronic arsenicosis induced by excessive arsenic intake can cause damages to multi-organ systems, skin cancer and various internal cancers. However, the key metabolic changes and biomarkers which can reflect these changes remain unclear resulting in a lack of effective prevention
Juanjuan Pi et al.
Journal of separation science, 38(6), 886-893 (2015-01-08)
A rapid, sensitive, and reliable approach for analyzing five kinds of erythrocyte phospholipids in Sprague-Dawley rats was provided by ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry with MassLynx(TM) MassFragment. Improving conventional high performance
N M Violato et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 46(9), 615-620 (2014-03-20)
Insulin secretion is mainly regulated by blood glucose concentration. On the other hand, changes in peripheral insulin sensitivity induce compensatory adaptations in pancreatic β-cells to maintain normoglycaemia. Tumour presence causes dramatic alterations in glucose homeostasis and insulin secretion because of
Daniel M Kulakowski et al.
Journal of chromatography. A, 1364, 74-82 (2014-09-15)
This study presents a strategy based on repeatable reversed-phase LC-TOF-MS methods and chemometric statistical tools, including untargeted PCA and supervised OPLS-DA models, to identify low-yielding compounds with potent immunostimulant activity in Phaleria nisidai (Thymelaeaceae), a plant with a history of
Xabier Osteikoetxea et al.
PloS one, 10(3), e0121184-e0121184 (2015-03-24)
In recent years the study of extracellular vesicles has gathered much scientific and clinical interest. As the field is expanding, it is becoming clear that better methods for characterization and quantification of extracellular vesicles as well as better standards to
Sarah Afshordel et al.
Journal of neurochemistry, 129(4), 732-742 (2014-01-17)
Synaptic impairment rather than neuronal loss may be the leading cause of cognitive dysfunction in brain aging. Certain small Rho-GTPases are involved in synaptic plasticity, and their dysfunction is associated with brain aging and neurodegeneration. Rho-GTPases undergo prenylation by attachment
M Pelà et al.
Die Pharmazie, 69(7), 496-499 (2014-07-31)
The synthesis of non natural amino acid 2-amino-3,3,4-trimethyl-pentanoic acid (Ipv) ready for solid phase peptide synthesis has been developed. Copper (I) chloride Michael addition, followed by a Curtius rearrangement are the key steps for the lpv synthesis. The racemic valine/leucine
Maoqing Wang et al.
Journal of proteome research, 13(9), 4131-4142 (2014-07-23)
Nutritional rickets is a worldwide public health problem; however, the current diagnostic methods retain shortcomings for accurate diagnosis of nutritional rickets. To identify urinary biomarkers associated with nutritional rickets and establish a noninvasive diagnosis method, urinary metabonomics analysis by ultra-performance
Leonard O Hargiss et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 971, 120-125 (2014-10-06)
An ultra high-pressure liquid chromatography/mass spectrometry (UHPLC/MS) separation and analysis method has been devised for open access analysis of synthetic reactions used in the production of DNA-encoded chemical libraries. The aqueous mobile phase is 100mM hexafluoroisopropanol and 8.6mM triethylamine; the
Sheng-Yuan Wang et al.
Molecular bioSystems, 11(4), 1146-1155 (2015-02-18)
Acrylamide (ACR) is known to induce neurotoxicity in humans and occupational exposure to ACR has an effect on human health. Since some animal experiments indicate the metabolic change caused by the ACR based on the metabolomics, increasing concern is the
Mostafizur Mazumder et al.
Nucleic acids research, 42(14), 9514-9522 (2014-07-25)
Modularity in controlling gene expression artificially is becoming an essential aspect of synthetic biology. Artificial transcriptional control of gene expression is one of the most well-developed methods for the design of novel synthetic regulatory networks. Such networks are intended to
Eric M Rosenberg et al.
Cell chemical biology, 26(5), 662-673 (2019-03-05)
The G protein-coupled receptor (GPCR) CXCR4 is a co-receptor for HIV and is involved in cancers and autoimmune diseases. We characterized five purine or quinazoline core polyamine pharmacophores used for targeting CXCR4 dysregulation in diseases. All were neutral antagonists for
M Allen McAlexander et al.
The Journal of pharmacology and experimental therapeutics, 349(1), 118-125 (2014-02-08)
Prior studies have demonstrated that the ion channel transient receptor potential vanilloid 4 (TRPV4) is functionally expressed in airway smooth muscle cells and that TRPV4 single nucleotide polymorphisms are associated with airflow obstruction in patients with chronic obstructive pulmonary disease.
Jonas Bergan et al.
Cellular and molecular life sciences : CMLS, 71(21), 4285-4300 (2014-04-18)
Shiga toxin-producing Escherichia coli bacteria cause hemorrhagic colitis and hemolytic uremic syndrome in humans. Currently, only supportive treatment is available for diagnosed patients. We show here that 24-h pretreatment with an ether lipid precursor, the alkylglycerol sn-1-O-hexadecylglycerol (HG), protects HEp-2
A Paul Mould et al.
The Biochemical journal, 464(3), 301-313 (2014-10-22)
Failure of Arg-Gly-Asp (RGD)-based inhibitors to reverse integrin-ligand binding has been reported, but the prevalence of this phenomenon among integrin heterodimers is currently unknown. In the present study we have investigated the interaction of four different RGD-binding integrins (α5β1, αVβ1
Cell biology. Making sense of amino acid sensing.
Robert T Abraham
Science (New York, N.Y.), 347(6218), 128-129 (2015-01-13)
Christopher Brooks Mobley et al.
Journal of the International Society of Sports Nutrition, 11, 38-38 (2014-08-19)
The purpose of this study was to examine if L-leucine (Leu), β-hydroxy-β-methylbutyrate (HMB), or creatine monohydrate (Crea) prevented potential atrophic effects of myostatin (MSTN) on differentiated C2C12 myotubes. After four days of differentiation, myotubes were treated with MSTN (10 ng/ml) for
Humberto Nicastro et al.
Amino acids, 40(2), 287-300 (2010-06-02)
The characterization of the mechanisms underlying skeletal muscle atrophy under different conditions has been a constant focus of research. Among anti-atrophic therapies, amino acid supplementation, particularly with leucine, has received a lot of attention. Supplementation has been shown to have
Yunnuo Bai et al.
Clinica chimica acta; international journal of clinical chemistry, 436, 207-216 (2014-06-10)
Acute lymphoblastic leukemia (ALL) is a common hematological malignant neoplasm that typically affects children. Although intense chemotherapeutic regimens have been useful to combat the disease, approximately 20% of patients will relapse despite treatment. Diagnosing ALL requires bone marrow puncture procedure
Jinyu Chen et al.
Cancer research, 75(3), 554-565 (2014-12-17)
Breast cancer brain metastasis is resistant to therapy and a particularly poor prognostic feature in patient survival. Altered metabolism is a common feature of cancer cells, but little is known as to what metabolic changes benefit breast cancer brain metastases.
Weifeng Yao et al.
Analytical and bioanalytical chemistry, 406(28), 7367-7378 (2014-09-24)
Metabolomics techniques are the comprehensive assessment of endogenous metabolites in a biological system and may provide additional insight into the molecular mechanisms. Er-Zhi-Wan (EZW) is a traditional Chinese medicine formula, which contains Fructus Ligustri Lucidi (FLL) and Herba Ecliptae (HE).
Thomas G Rosano et al.
Journal of analytical toxicology, 38(8), 495-506 (2014-09-14)
High-resolution mass spectrometry (HRMS) is being applied in postmortem drug screening as an alternative to nominal mass spectrometry, and additional evaluation in quantitative casework is needed. We report quantitative analysis of benzoylecgonine, citalopram, cocaethylene, cocaine, codeine, dextromethorphan, dihydrocodeine, diphenhydramine, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
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