M-108

应用筛选条件

关键词:'M-108'

显示 1-30 共 244 条结果关于 "M-108" 范围论文

Simultaneous analysis of pesticides from different chemical classes by using a derivatisation step and gas chromatography-mass spectrometry.

Caroline Raeppel et al.

Journal of chromatography. A, 1218(44), 8123-8129 (2011-10-04)

This work presents a new method to analyse simultaneously by GC-MS 31 pesticides from different chemical classes (2,4 D, 2,4 MCPA, alphacypermethrin, bifenthrin, bromoxynil, buprofezin, carbaryl, carbofuran, clopyralid, cyprodinil, deltamethrin dicamba, dichlobenil, dichlorprop, diflufenican, diuron, fenoxaprop, flazasulfuron, fluroxypyr, ioxynil, isoxaben

Simultaneous determination of 2-naphthol and 1-hydroxy pyrene in urine by gas chromatography-mass spectrometry.

Ho-Sang Shin et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(7-8), 489-494 (2011-02-01)

A gas chromatography-mass spectrometric (GC-MS) method was developed for the determination of 2-naphthol (2-NAP) and 1-hydroxypyrene (1-HOP) in human urine. Extraction from urine after the enzyme hydrolysis with β-glucuronidase/arylsulfatase was achieved with a liquid extraction using 5 mL of pentane.

Analysis of endocrine disrupting compounds, pharmaceuticals and personal care products in sewage sludge by gas chromatography-mass spectrometry.

Yong Yu et al.

Talanta, 89, 258-263 (2012-01-31)

Endocrine disrupting compounds (EDCs) and pharmaceuticals and personal care products (PPCPs) have been acknowledged as emerging pollutants due to widespread contamination in environment. A rapid and reliable analytical method, based on ultrasonic extraction, clean up on Envi-carb cartridge, derivatized with

One-step extraction and derivatization liquid-phase microextraction for the determination of chlorophenols by gas chromatography-mass spectrometry.

Xiaowei Wang et al.

Journal of chromatography. A, 1216(35), 6267-6273 (2009-07-31)

A sample pretreatment method for the determination of 18 chlorophenols (CPs) in aqueous samples by derivatization liquid-phase microextraction (LPME) was investigated using gas chromatography-mass spectrometry. Derivatization reagent was spiked into the extraction solvent to combine derivatization and extraction into one

Solid phase microextraction procedure for the determination of alkylphenols in water by on-fiber derivatization with N-tert-butyl-dimethylsilyl-N-methyltrifluoroacetamide.

Yi-Ping Pan et al.

Analytica chimica acta, 624(2), 247-252 (2008-08-19)

The solid phase microextraction (SPME) technique with on-fiber derivatization was evaluated for the analysis of alkylphenols (APs), including 4-tert-octylphenol (4-t-OP), technical nonylphenol isomers (t-NPs) and 4-nonylphenol (4-NP), in water. The 85 microm polyacrylate (PA) fiber was used and a two-step

A multiresidue method for the analysis of phenols and nitrophenols in the atmosphere.

Stephane Morville et al.

Journal of environmental monitoring : JEM, 6(12), 963-966 (2004-11-30)

A method using GC-MS and derivatization with N-(t-butyldimethylsilyl)-N-methyltrifluoroacetamide (MTBSTFA) was developed for the analysis of 20 phenolic compounds in atmospheric samples (gas and particles). Air sampling was carried out using a Hi-Vol sampler with glass fibre filter and XAD-2 resin

Dispersive liquid-liquid microextraction applied to the simultaneous derivatization and concentration of triclosan and methyltriclosan in water samples.

R Montes et al.

Journal of chromatography. A, 1216(2), 205-210 (2008-12-17)

A fast and novel sample preparation procedure for the determination of triclosan (TCS) and methyltriclosan (MTCS) in water samples is presented. Dispersive liquid-liquid microextraction, using a ternary mixture consisting of a disperser, an extractant and N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide (MTBSTFA) as derivatization reagent

Determination of nitrogen mustard hydrolysis products, ethanolamines by gas chromatography-mass spectrometry after tert-butyldimethylsilyl derivatization.

Isaac Ohsawa et al.

Journal of chromatography. A, 1122(1-2), 242-248 (2006-05-19)

A method for determining N-ethyldiethanolamine (EDEA), N-methyldiethanolamine (MDEA) and triethanolamine (TEA), hydrolysis products of nitrogen mustards, in water, urine and blood samples using gas chromatography-mass spectrometry (GC-MS) after derivatization by tert-butyldimethylsilylation (TBDMS) is described. The sample solution was evaporated to

Optimization of N-methyl-N-[tert-butyldimethylsilyl]trifluoroacetamide as a derivatization agent for determining isotopic enrichment of glycerol in very-low density lipoproteins.

Martin Adiels et al.

Rapid communications in mass spectrometry : RCM, 24(5), 586-592 (2010-02-09)

Stable isotope kinetic studies play an important role in the study of very-low density lipoprotein (VLDL) metabolism, including basic and clinical research. Today, [1,1,2,3,3-(2)H(5)]glycerol is the most cost-effective alternative to measure glycerol and triglyceride kinetics. Recycling of glycerol from glycolysis

The detection of various opiates and benzodiazepines by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry.

Bill Guthery et al.

Rapid communications in mass spectrometry : RCM, 23(3), 340-348 (2009-01-07)

A technique using comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry (GC x GC/TOFMS) is applied to qualitative and quantitative drug testing. Human serum was 'spiked' with known quantities of benzodiazepines and a 'street heroin' mixture including some of the major metabolites

Simultaneous analysis of lysine, Nepsilon-carboxymethyllysine and lysinoalanine from proteins.

Lourdes Bosch et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 860(1), 69-77 (2007-11-13)

Protein quality was assayed by simultaneous measurement of lysine (Lys), carboxymethyllysine (CML) and lysinoalanine (LAL). GC-FID analysis of N-tert-butyl dimethylsilyl (tBDMSi) derivatives of these amino acids was undertaken. tBDMSi derivates were separated on a CP-SIL 5CB commercially fused silica capillary

Determination of 14 benzodiazepines and hydroxy metabolites, zaleplon and zolpidem as tert-butyldimethylsilyl derivatives compared with other common silylating reagents in whole blood by gas chromatography-mass spectrometry.

Teemu Gunnar et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 818(2), 175-189 (2005-03-01)

The most common commercially available silylating reagents, N-methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA), N,O-bis-(trimethylsilyl)trifluoroacetamide+1% trimethylchlorosilane (BSTFA+1% TMCS) and N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide (MTBSTFA) were evaluated to achieve optimal derivatization conditions for analyzing various benzodiazepines based on gas chromatography-electron impact ionization-mass spectrometry (GC-EI-MS). Sensitivity, repeatability, retention times and

Determination of hydroxylated metabolites of polycyclic aromatic hydrocarbons in sediment samples by combining subcritical water extraction and dispersive liquid-liquid microextraction with derivatization.

Xiaowei Wang et al.

Analytica chimica acta, 753, 57-63 (2012-10-31)

A sample preparation method for the determination of hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) in sediment samples was developed using gas chromatography-mass spectrometry (GC-MS). Dispersive liquid-liquid microextraction (DLLME) with derivatization was performed following the subcritical water extraction (SWE) that provided which

Determination of ethephon residues in water by gas chromatography with cubic mass spectrometry after ion-exchange purification and derivatisation with N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide.

A Royer et al.

Journal of chromatography. A, 1108(1), 129-135 (2006-01-31)

An analytical method has been developed for the determination of residues of ethephon (2-chloroethyl phosphonic acid) in drinking and surface water. The procedure is based on de-ionisation with an anion/cation-exchange resin, solid phase extraction by means of anion-exchange polystyrene-divinylbenzene extraction

Comparison of MTBSTFA and BSTFA in derivatization reactions of polar compounds prior to GC/MS analysis.

Claude Schummer et al.

Talanta, 77(4), 1473-1482 (2008-12-17)

In this study, MTBSTFA and BSTFA, which are among the preferred derivatization reagents for silylation were both tested on derivatization of six different groups of polar chemicals to get information about usefulness in terms of sensitivity and specificity of both

Differential metabolomics using stable isotope labeling and two-dimensional gas chromatography with time-of-flight mass spectrometry.

Xiaodong Huang et al.

Analytical chemistry, 80(1), 107-114 (2007-12-07)

This work describes an approach to differential metabolomics that involves stable isotope labeling for relative quantification as part of sample analysis by two-dimensional gas chromatography/mass spectrometry (GCxGC/MS). The polar metabolome in control and experimental samples was extracted and differentially derivatized

Simultaneous retention index analysis of urinary amino acids and carboxylic acids for graphic recognition of abnormal state.

Man-Jeong Paik et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 821(1), 94-104 (2005-05-17)

Simultaneous profiling analysis of urinary amino acids (AAs) and carboxylic acids (CAs) was combined with retention index (I) analysis for graphic recognition of abnormal metabolic state. The temperature-programmed I values of the AA and CA standards measured as ethoxycarbonyl (EOC)/methoxime

Philip A Smith et al.

Journal of chromatography. A, 1217(33), 5444-5448 (2010-07-14)

Derivatization with N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide (MTBSTFA) was used for gas chromatography-mass spectrometry (GC-MS) analysis of citrulline and ornithine. Aqueous 50 microl aliquots at 1 and 10 mM concentrations were dried and derivatized separately, and 70 eV electron ionization or CH(4) positive chemical

Selection of the derivatization reagent--the case of human blood cholesterol, its precursors and phytosterols GC-MS analyses.

David Saraiva et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(32), 3806-3811 (2011-11-18)

Phytosterols (PS; β-sitosterol and campesterol) and cholesterol precursors (CP; desmosterol and lathosterol) have been suggested as important biochemical markers of cholesterol intestinal absorption and liver biosynthesis, respectively. Given that these compounds appear in human blood in low amounts, sensitive and

Excretion of 2,3-dihydroxy-propionamide (OH-PA), the hydrolysis product of glycidamide, in human urine after single oral dose of deuterium-labeled acrylamide.

Eva C Hartmann et al.

Archives of toxicology, 85(6), 601-606 (2010-10-19)

A dose of 0.99 mg d(3)-acrylamide (d(3)-AA) (13.2 μg/kg body weight) was ingested by a healthy male volunteer. Urine samples were collected over a period of 46 h after the intake and analyzed for the hydrolysis product of glycidamide (GA), 2,3-dihydroxy-propionamide (OH-PA), a

Neurochemical analysis of amino acids, polyamines and carboxylic acids: GC-MS quantitation of tBDMS derivatives using ammonia positive chemical ionization.

Paul L Wood et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 831(1-2), 313-319 (2006-01-13)

The GC-MS quantitation of a large number of neurochemicals utilizing a single derivatization step is not common but is provided by the reagent N-(tert-butyldimethylsilyl)-N-methyltrifluro-acetamide (MTBSTFA). Previous workers have utilized this derivative for GC-MS analyses of amino acids, carboxylic acids and

Optimization of silylation using N-methyl-N-(trimethylsilyl)-trifluoroacetamide, N,O-bis-(trimethylsilyl)-trifluoroacetamide and N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide for the determination of the estrogens estrone and 17alpha-ethinylestradiol by gas chromatography-mass spectrometry.

Ali Shareef et al.

Journal of chromatography. A, 1108(1), 121-128 (2006-02-01)

This paper reports an improved silylation procedure for simultaneous determination of the steroid hormones 17alpha-ethinylestradiol (EE2) and estrone (E1) using gas chromatography-mass spectrometry (GC-MS). This follows a re-assessment of some of the popular silylation procedures using N-methyl-N-trimethylsilyltrifluoroacetamide (MSTFA), N-O-bis-(trimethylsilyl)-trifluoroacetamide (BSTFA)

Optimization of solid-phase microextraction conditions for the determination of triclosan and possible related compounds in water samples.

P Canosa et al.

Journal of chromatography. A, 1072(1), 107-115 (2005-05-11)

A solid-phase microextraction (SPME) method for the determination of triclosan, methyl triclosan, 2,4-dichlorophenol and 2,3,4-trichlorophenol (considered as possible triclosan metabolites) in water samples was optimised. Analytes were first concentrated on a SPME fibre, directly exposed to the sample, and then

Comparison and evaluation of analysis procedures for the quantification of (2-methoxyethoxy)acetic acid in urine.

Clayton B'Hymer et al.

Analytical and bioanalytical chemistry, 383(2), 201-209 (2005-09-15)

Several extraction and derivatization procedures were evaluated for the quantification of (2-methoxyethoxy)acetic acid (MEAA) in urine. MEAA is a metabolite and a biomarker for exposure to 2-(2-methoxyethoxy)ethanol, a glycol ether with widespread use in various industrial applications and the specific

Determination of creatine and guanidinoacetate by GC-MS: study of their stability in urine at different temperatures.

José Angel Prieto et al.

Clinical biochemistry, 42(1-2), 125-128 (2008-11-11)

Evaluation of a GC-MS method using N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide (MTBSTFA) as the silylating agent for GC-MS. Study of the stability of creatine and guanidinoacetate in urine. 22 urines were kept at RT, 4 degrees C and -30 degrees C for 15 days.

Effects of KRC-108 on the Aurora A activity and growth of colorectal cancer cells.

Hye Jin Chung et al.

Biochemical and biophysical research communications, 461(4), 605-611 (2015-04-29)

Aurora A is involved in regulating multiple steps of mitosis. Over-expression of Aurora A is related to tumorigenesis and poor prognosis. KRC-108 is a novel multi-kinase inhibitor which has anti-tumor activity in vivo. In this study, we identified the inhibitory effects

Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells.

Yue-Qin Wang et al.

Acta pharmacologica Sinica, 37(12), 1587-1596 (2016-09-13)

Inhibition of heat shock protein (Hsp90) has been proven to be effective in overriding primary and acquired resistance of kinase inhibitors. In this study, we investigated the role of FS-108, a newly developed Hsp90 inhibitor, to overcome gefitinib resistance in

Phase I, dose-escalation study of the targeted cytotoxic LHRH analog AEZS-108 in patients with castration- and taxane-resistant prostate cancer.

Stephen V Liu et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 20(24), 6277-6283 (2014-10-04)

AEZS-108, formerly AN-152, is a cytotoxic hybrid molecule consisting of a luteinizing hormone-releasing hormone (LHRH) agonist moiety covalently coupled to doxorubicin, allowing it to deliver doxorubicin selectively to cells expressing LHRH receptors. LHRH receptors are expressed on the cell membrane

Isolation and sequence determination of human brain natriuretic peptide in human atrium.

Y Kambayashi et al.

FEBS letters, 259(2), 341-345 (1990-01-01)

We isolated human brain natriuretic peptide (human BNP) from the human atrium. Sequence analysis has revealed that it is a 32-amino-acid peptide with the sequence S-P-K-M-V-Q-G-S-G-C-F-G-R-K-M-D-R-I-S-S-S-S-G-L-G-C-K-V-L-R-R-H, which is identical to the C-terminal sequence (77-108) of the human BNP precursor deduced

Effect of nitration on the activity of bovine erythrocyte Cu,Zn-superoxide dismutase (BESOD) and a kinetic analysis of its dimerization-dissociation reaction as examined by subunit exchange between the native and nitrated BESODs.

Hiroshi Oneda et al.

Journal of biochemistry, 134(5), 683-690 (2003-12-23)

Bovine erythrocyte Cu,Zn-superoxide dismutase (BESOD) is a dimeric enzyme composed of identical subunits associated through unusually strong non-covalent interactions. The state of the unique tyrosyl residue (Tyr 108) of BESOD was examined, and the kinetics of subunit exchange was studied

1/9