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Alison A Staton et al.
Nature protocols, 6(12), 2035-2049 (2011-12-03)
MicroRNAs (miRNAs) regulate gene expression by pairing with complementary sequences in the 3' untranslated regions (UTRs) of transcripts. Although the molecular mechanism underlying miRNA biogenesis and activity is becoming better understood, determining the physiological role of the interaction of an
Jemina Lehto et al.
Cancers, 13(6) (2021-04-04)
The C-X3-C motif chemokine receptor 1 (CX3CR1, fractalkine receptor) is associated with neoplastic transformation, inflammation, neurodegenerative diseases and aging, and the small molecule inhibitor KAND567 targeting CX3CR1 (CX3CR1i) is evaluated in clinical trials for acute systemic inflammation upon SARS-CoV-2 infections.
Gopal Kushawah et al.
Developmental cell, 54(6), 805-817 (2020-08-10)
Early embryonic development is driven exclusively by maternal gene products deposited into the oocyte. Although critical in establishing early developmental programs, maternal gene functions have remained elusive due to a paucity of techniques for their systematic disruption and assessment. CRISPR-Cas13
Alberto Balderas et al.
Neurochemistry international, 73, 139-145 (2013-11-12)
Glutamate, the major excitatory amino acid, activates a wide variety of signal transduction cascades. Ionotropic and metabotropic glutamate receptors are critically involved in long-term synaptic changes, although recent findings suggest that the electrogenic Na(+)-dependent glutamate transporters, responsible for its removal
Claus Hedegaard et al.
FEBS open bio, 3, 411-420 (2013-11-20)
Synapsin 1 (SYN1) is a phosphoprotein involved in nerve signal transmission. The porcine SYN1 promoter orthologue was cloned and characterized to provide a means of expressing a transgene specifically in neurons. The nucleotide sequence of the promoter displayed a high
Valerio Matozzo et al.
Fish & shellfish immunology, 45(2), 528-533 (2015-05-20)
The cuttlefish Sepia officinalis is an important fishery resource in the Northern Adriatic Sea (Italy). During reproduction, fertilised eggs are released by adult females in coastal waters and embryo development can take over two months. During this period, embryos rely
Nora Grahl et al.
PLoS pathogens, 11(8), e1005133-e1005133 (2015-09-01)
Candida albicans is both a major fungal pathogen and a member of the commensal human microflora. The morphological switch from yeast to hyphal growth is associated with disease and many environmental factors are known to influence the yeast-to-hyphae switch. The
Ashok Aspatwar et al.
PloS one, 10(7), e0134263-e0134263 (2015-07-29)
Carbonic anhydrase related proteins (CARPs) X and XI are highly conserved across species and are predominantly expressed in neural tissues. The biological role of these proteins is still an enigma. Ray-finned fish have lost the CA11 gene, but instead possess
Zheng Fu et al.
Cell reports, 28(1), 159-171 (2019-07-04)
Regulatory T cells (Tregs) are pivotal for immune suppression. Cellular metabolism is important for Treg homeostasis and function. However, the exact role of mitochondrial respiration in Tregs remains elusive. Mitochondrial transcription factor A (Tfam) is essential for mitochondrial respiration and controls
Ilya A Rodionov et al.
Soft matter, 11(24), 4921-4931 (2015-05-27)
Freeze-thaw processing of bovine serum albumin (BSA) aqueous solutions, which contain also the additives of denaturants (urea in this case) and thiol-bearing reductants [cysteine (Cys) in this case] leads to the formation of wide-pore cryogels. The properties and porous morphology
Tsiry Rasamiravaka et al.
PloS one, 10(7), e0132791-e0132791 (2015-07-18)
Recently, extracts of Dalbergia trichocarpa bark have been shown to disrupt P. aeruginosa PAO1 quorum sensing (QS) mechanisms, which are key regulators of virulence factor expression and implicated in biofilm formation. One of the active compounds has been isolated and
Haiyun Chen et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 21(11), 1230-1236 (2014-08-31)
Schizophyllum commune (SC) is widely consumed by Chinese, especially in southern part of China. The aim of the present study was to assess the extract of SC on vascular tone and the mechanisms involved. Experiments were performed on aorta of
Marcus D Goncalves et al.
Science (New York, N.Y.), 363(6433), 1345-1349 (2019-03-23)
Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated with obesity and with an increased risk of colorectal cancer. Whether HFCS contributes directly to tumorigenesis is unclear. We investigated the effects of daily oral administration of HFCS
Line Mygland et al.
iScience, 24(7), 102807-102807 (2021-08-03)
Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors are effective antitumor agents in selected tumor cell lines and mouse models. Here, we characterized the response signatures and the in-depth mechanisms for the antiproliferative effect of tankyrase inhibition (TNKSi). The TNKS1/2-specific
Cyril Sobolewski et al.
The Journal of pharmacology and experimental therapeutics, 355(2), 308-328 (2015-09-04)
Cyclooxygenase-2 (COX-2) is an essential regulator of cancer promotion and progression. Extensive efforts to target this enzyme have been developed to reduce growth of cancer cells for chemopreventive and therapeutic reasons. In this context, cyclooxygenase-2 inhibitors present interesting antitumor effects.
Arabella Young et al.
BMC cancer, 14, 808-808 (2014-11-06)
Radiotherapy is a chosen treatment option for prostate cancer patients and while some tumours respond well, up to 50% of patients may experience tumour recurrence. Identification of functionally relevant predictive biomarkers for radioresponse in prostate cancer would enable radioresistant patients
Teresa Lee et al.
The Journal of biological chemistry, 289(33), 22798-22814 (2014-07-06)
DHX9 is an ATP-dependent DEXH box helicase with a multitude of cellular functions. Its ability to unwind both DNA and RNA, as well as aberrant, noncanonical polynucleotide structures, has implicated it in transcriptional and translational regulation, DNA replication and repair
Elahe Tajbakhsh et al.
Annals of clinical microbiology and antimicrobials, 14, 37-37 (2015-08-01)
Integrons play important role in the spread and maintenance of antimicrobial resistance among strains of Escherichia coli (E. coli) and other species of Enterobacteriaceae. This study investigated the prevalence of class 1 and 2 integrons among E. coli strains isolated
Vepika Kandjou et al.
Journal of hazardous materials, 380, 120840-120840 (2019-07-08)
The increasing depletion of freshwater necessitates the re-use and purification of wastewaters. Among the existing separation membrane materials, graphene oxide (GO) is a promising candidate, owing to its tunable physicochemical properties. However, the widening of GO membranes pore gap in
Sandra Thiemann et al.
The Journal of biological chemistry, 290(37), 22662-22677 (2015-07-29)
During inflammation, dendritic cells emigrate from inflamed tissue across the lymphatic endothelium into the lymphatic vasculature and travel to regional lymph nodes to initiate immune responses. However, the processes that regulate dendritic cell tissue egress and migration across the lymphatic
Vasiliy M Petrov et al.
The Journal of biological chemistry, 277(36), 33041-33048 (2002-06-28)
DNA polymerase (gp43) of phage T4 plays two biological roles, one as an essential DNA binding replication enzyme and the other as an mRNA-specific autogenous translational repressor. Binding of T4 gp43 to its mRNA target (translational operator RNA) interferes with
Erica di Martino et al.
Molecular cancer research : MCR, 13(1), 138-148 (2014-09-17)
Activating mutations of FGFR3 are a common and early event in bladder cancer. Ectopic expression of mutant FGFR3 in normal urothelial cells has both pro-proliferative and antiapoptotic effects at confluence, suggesting that mutant cells are insensitive to cell-cell contact inhibition.
Hendrik Manner et al.
Surgical endoscopy, 29(7), 1888-1896 (2014-10-09)
A prerequisite for endoscopic treatment (ET) of not only mucosal, but also submucosal early adenocarcinoma of the esophagus (EAC) would be a rate of lymph node (LN) metastasis below the mortality rate of esophagectomy (2-5%). The aim of the present
Monika Dabrzalska et al.
International journal of pharmaceutics, 492(1-2), 266-274 (2015-06-29)
Dendrimers due to their unique architecture may play an important role in drug delivery systems including chemotherapy, gene therapy and recently, photodynamic therapy as well. We investigated two dendrimer-photosensitizer systems in context of potential use of these systems in photodynamic
Sawsan Almohammed et al.
The journal of physical chemistry letters, 10(8), 1878-1887 (2019-03-30)
Semiconductor-graphene oxide-based surface-enhanced Raman spectroscopy substrates represent a new frontier in the field of surface-enhanced Raman spectroscopy (SERS). However, the application of graphene oxide has had limited success because of the poor Raman enhancement factors that are achievable in comparison
DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline
Trudler D, et al.
Journal of Neurochemistry, 129(3) (2014)
Gianluigi Li Bassi et al.
Chest, 147(5), 1327-1335 (2014-12-17)
Improvements in the design of the endotracheal tube (ETT) have been achieved in recent years. We evaluated tracheal injury associated with ETTs with novel high-volume low-pressure (HVLP) cuffs and subglottic secretions aspiration (SSA) and the effects on mucociliary clearance (MCC).
Ying Liu et al.
Biosensors & bioelectronics, 64, 43-50 (2014-09-06)
Inflammatory cytokines are secreted by immune cells in response to infection or injury. Quantification of multiple cytokines in parallel may help with disease diagnosis by illuminating inflammatory pathways related to disease onset and progression. This paper describes development of an
Betul Kul Babur et al.
Cell and tissue research, 361(3), 755-768 (2015-05-01)
Engineered biphasic osteochondral tissues may have utility in cartilage defect repair. As bone-marrow-derived mesenchymal stem/stromal cells (MSC) have the capacity to make both bone-like and cartilage-like tissues, they are an ideal cell population for use in the manufacture of osteochondral
Tanur Sinha et al.
Journal of colloid and interface science, 453, 115-131 (2015-05-16)
The common household material, egg shell of Anas platyrhynchos is utilized for the synthesis of Silver and Gold-Silver core shell nanoparticles using greener, environment friendly and economic way. The egg shell extracts were acting as a stabilizing and reducing agents.
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