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关键词:'N7634'
显示 1-30 共 357 条结果 关于 "N7634" 范围 论文
Jussep Salgado-Almario et al.
Theranostics, 12(3), 1012-1029 (2022-02-15)
In vivo models of cardiac function maintain the complex relationship of cardiomyocytes with other heart cells, as well as the paracrine and mechanoelectrical feedback mechanisms. We aimed at imaging calcium transients simultaneously with heart contraction in zebrafish larvae. Methods: To
Francisco J Prado-Prado et al.
Bioorganic & medicinal chemistry, 18(6), 2225-2231 (2010-02-27)
There are many of pathogen parasite species with different susceptibility profile to antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of drugs against only one parasite species. Consequently, predicting the probability with which a drug is active against
Ulrike Klenke et al.
Endocrinology, 155(5), 1851-1863 (2014-02-26)
Metabolic dysfunctions are often linked to reproductive abnormalities. Adiponectin (ADP), a peripheral hormone secreted by white adipose tissue, is important in energy homeostasis and appetite regulation. GnRH neurons are integral components of the reproductive axis, controlling synthesis, and release of
Fen Hu et al.
PloS one, 9(9), e107217-e107217 (2014-09-26)
The local concentration of extracellular Ca(2+) ([Ca(2+)]o) in bone microenvironment is accumulated during bone remodeling. In the present study we investigated whether elevating [Ca(2+)]o induced store-operated calcium entry (SOCE) in primary rat calvarial osteoblasts and further examined the contribution of
Yuliya Voskobiynyk et al.
eLife, 9 (2020-07-14)
Genome-wide association studies identified the BIN1 locus as a leading modulator of genetic risk in Alzheimer's disease (AD). One limitation in understanding BIN1's contribution to AD is its unknown function in the brain. AD-associated BIN1 variants are generally noncoding and
Shimul Chandra Saha et al.
PloS one, 10(7), e0131286-e0131286 (2015-07-07)
This paper describes the use of a newly-developed micro-chip bilayer platform to examine the electrophysiological properties of the prokaryotic voltage-gated sodium channel pore (Na(v)Sp) from Silicibacter pomeroyi. The platform allows up to 6 bilayers to be analysed simultaneously. Proteoliposomes were
Jun Sun et al.
Pharmacology, 93(5-6), 216-219 (2014-06-20)
Proteinase-activated receptor 2 (PAR2) may be implicated in skin disorders. Intracellular calcium mobilization is a key step in PAR2-induced signaling. In this study, we investigated the effects of nifedipine, verapamil, and low-molecular-weight heparin (LMWH) on SLIGRL-NH₂-induced PAR2-mediated calcium mobilization within
Mohammed Sedeeq et al.
Molecular neurobiology, 59(5), 2932-2945 (2022-03-05)
Medulloblastoma (MB) is the most common malignant paediatric brain tumour. In our previous studies, we developed a novel 3D assay for MB cells that was used to screen a panel of plasma membrane calcium channel modulators for their effect on
Thomas Eliot Haworth et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(9), R1157-R1166 (2014-08-29)
Sturgeon (family Acipenseridae) are regarded as living fossils due to their ancient origin and exceptionally slow evolution. To extend our knowledge of fish cardiac excitability to a Chondrostei fish, we examined electrophysiological phenotype of the Siberian sturgeon (Acipenser baerii) heart
Nigel Greene et al.
Chemical research in toxicology, 23(7), 1215-1222 (2010-06-18)
Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential
Bharath K Mani et al.
Endocrinology, 155(1), 98-107 (2013-11-06)
Ghrelin is an orexigenic hormone secreted principally from a distinct population of gastric endocrine cells. Molecular mechanisms regulating ghrelin secretion are mostly unknown. Recently, norepinephrine (NE) was shown to enhance ghrelin release by binding to β1-adrenergic receptors on ghrelin cells.
Khadija Syeda et al.
Biochemical pharmacology, 86(9), 1338-1346 (2013-09-03)
Nuclear lamins form the lamina on the interior of the nuclear envelope, and are involved in the regulation of various cellular processes, including DNA replication and chromatin organization. Despite this evidence, little is known about potential alterations in nuclear metabolism
Shinya Hosaka et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(1), 27-33 (2014-10-17)
Cynomolgus monkeys are widely used in preclinical studies during drug development because of their evolutionary closeness to humans, including their cytochrome P450s (P450s). Most cynomolgus monkey P450s are almost identical (≥90%) to human P450s; however, CYP2C76 has low sequence identity
E L Lagerqvist et al.
Journal of pharmacological and toxicological methods, 74, 17-25 (2015-05-10)
Pluripotent stem cells offer an unparalleled opportunity to investigate cardiac physiology, pharmacology, toxicology and pathophysiology. In this paper we describe the use of both mouse (Nkx2-5(eGFP/w)) and human (NKX2-5(eGFP/w)) pluripotent stem cell reporter lines, differentiated toward cardiac lineage, for live
César Martín et al.
Scientific reports, 5, 13774-13774 (2015-09-09)
Bordetella pertussis causes whooping cough, a respiratory infectious disease that is the fifth largest cause of vaccine-preventable death in infants. Though historically considered an extracellular pathogen, this bacterium has been detected both in vitro and in vivo inside phagocytic and
Jan Weiss et al.
The European journal of neuroscience, 40(10), 3422-3435 (2014-09-10)
We investigated the role of voltage-activated calcium (Cav) channels for synaptic transmission at mouse olfactory and vomeronasal nerve terminals at the first synapse of the main and accessory olfactory pathways, respectively. We provided evidence for a central role of the
Tiong Chai Seah et al.
International journal of toxicology, 34(5), 454-468 (2015-08-14)
A cell-based assay to measure cytochrome P450 3A4 (CYP3A4) induction was developed to screen for potential CYP3A4 inducers. This 96-well format assay utilizes HepG2 cells transfected with a gene construct of CYP3A4 proximal promoter linked to green fluorescence protein (GFP)
E Chang et al.
European journal of pain (London, England), 19(5), 639-648 (2014-08-28)
Overexpression of the voltage-gated calcium channel (VGCC) alpha-2-delta1 subunit protein (Cav α2 δ1 ) has been shown to cause pain states. However, whether VGCC are involved in pain states driven by abnormal Cav α2 δ1 expression is not known. Intrathecal
Alessandra Ulivieri et al.
Scientific reports, 12(1), 568-568 (2022-01-14)
Prolongation of cardiac repolarization (QT interval) represents a dangerous and potentially life-threatening electrical event affecting the heart. Thyroid hormones (THs) are critical for cardiac development and heart function. However, little is known about THs influence on ventricular repolarization and controversial
Jian-Bing Shen et al.
American journal of physiology. Heart and circulatory physiology, 307(10), H1469-H1477 (2014-09-23)
P2X4 receptors (P2X4Rs) are ligand-gated ion channels capable of conducting cations such as Na(+). Endogenous cardiac P2X4R can mediate ATP-activated current in adult murine cardiomyocytes. In the present study, we tested the hypothesis that cardiac P2X receptors can induce Na(+)
Gen Yoshino
Drugs, 66 Spec No 1, 22-24 (2008-01-19)
The usefulness of angiotensin-converting enzyme (ACE) inhibitors has been established in hypertensive patients with diabetes mellitus. However, Ca2+ channel antagonists have not been rigorously evaluated in this population. The randomised J-MIND (Japan Multicenter Investigation of Antihypertensive Treatment for Nephropathy in
Charumathi Pushparaj et al.
The international journal of biochemistry & cell biology, 68, 166-175 (2015-10-03)
Voltage-gated calcium channel blockers are widely used for the management of cardiovascular diseases, however little is known about their effects on cardiac cells in vitro. We challenged neonatal ventricular cardiomyocytes (CMs) with therapeutic L-type and T-type Ca(2+) channel blockers (nifedipine
Francesca Borrelli et al.
Journal of natural products, 69(6), 903-906 (2006-06-24)
Boerhaavia diffusa is an Ayurvedic remedy used traditionally for the treatment of a number of diseases, including those affecting the gastrointestinal tract. In the current investigation, a methanol extract obtained from roots of B. diffusa exhibited a significant spasmolytic activity
Kentaro Nagane et al.
International journal of pharmaceutics, 493(1-2), 55-62 (2015-07-23)
The objective of this study is to prepare and characterize solid dispersions of nifedipine (NP) using porous spherical silicate micro beads (MB) that were approximately 100 μm in diameter with vinylpyrrolidone/vinyl acetate copolymer (PVP/VA) and a Wurster-type fluidized bed granulator.
Joju George et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(10), 3288-3301 (2009-03-13)
A range of extrinsic signals, including afferent activity, affect neuronal growth and plasticity. Neuronal activity regulates intracellular Ca(2+), and activity-dependent calcium signaling has been shown to regulate dendritic growth and branching (Konur and Ghosh, 2005). NMDA receptor (NMDAR) stimulation of
Xiaomei Fan et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(12), 1982-1990 (2014-09-14)
Schisandra sphenanthera is widely used as a tonic and restorative in many countries to enhance the function of liver and other organs. Wuzhi tablet (WZ) is a preparation of an ethanol extract of Schisandra sphenanthera. Our previous study demonstrated that
Jinbin Tian et al.
Pflugers Archiv : European journal of physiology, 466(7), 1301-1316 (2013-10-15)
In the central nervous system, canonical transient receptor potential (TRPC) channels have been implicated in mediating neuronal excitation induced by stimulating metabotropic receptors, including group 1 metabotropic glutamate receptors (mGluRs). Lateral septal (LS) neurons express high levels of TRPC4 and
Agustín Conde-Agudelo et al.
American journal of obstetrics and gynecology, 209(6), 551-551 (2013-07-31)
The purpose of this study was to evaluate the efficacy and safety of transdermal nitroglycerin as a tocolytic agent in women with preterm labor. We conducted a systematic review and metaanalysis of randomized controlled trials. Thirteen studies were included (1302
Sindhuri Maddineni et al.
AAPS PharmSciTech, 16(2), 444-454 (2014-11-02)
The objective of the present study was to investigate the effects of processing variables and formulation factors on the characteristics of hot-melt extrudates containing a copolymer (Kollidon® VA 64). Nifedipine was used as a model drug in all of the
Chun-Yu Deng et al.
PloS one, 9(9), e107128-e107128 (2014-09-10)
5-Hydroxytryptamine (5-HT) is a powerful constrictor of coronary arteries and is considered to be involved in the pathophysiological mechanisms of coronary-artery spasm. However, the mechanism of enhancement of coronary-artery constriction to 5-HT during the development of coronary artery disease remains
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