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5-HTTLPR rs25531A > G differentially influence paroxetine and fluvoxamine antidepressant efficacy: a randomized, controlled trial.
Masaki Kato et al.
Journal of clinical psychopharmacology, 33(1), 131-132 (2013-01-05)
FDA approval of paroxetine for menopausal hot flushes.
Ronald J Orleans et al.
The New England journal of medicine, 370(19), 1777-1779 (2014-05-09)
Claudia Schilling et al.
Journal of clinical psychopharmacology, 33(1), 99-103 (2013-01-02)
Treatment with several psychopharmacological agents has been associated with increased leptin plasma concentrations. We measured leptin plasma concentrations in 76 adult depressed patients after a 6-day washout phase and again after 35 days of treatment with amitriptyline or paroxetine, as
Kristoff T Homan et al.
Molecular pharmacology, 85(2), 237-248 (2013-11-14)
Recently we identified the serotonin reuptake inhibitor paroxetine as an inhibitor of G protein-coupled receptor kinase 2 (GRK2) that improves cardiac performance in live animals. Paroxetine exhibits up to 50-fold selectivity for GRK2 versus other GRKs. A better understanding of
Paroxetine (Brisdelle) for hot flashes.
The Medical letter on drugs and therapeutics, 55(1428), 85-86 (2013-10-30)
Miguel M Carvalho et al.
Molecular neurodegeneration, 8, 14-14 (2013-04-30)
Parkinson's disease (PD) is a chronic neurodegenerative condition that is characterized by motor symptoms as a result of dopaminergic degeneration, particularly in the mesostriatal pathway. However, in recent years, a greater number of clinical studies have focused on the emergence
Clare M Mathes et al.
Chemical senses, 38(3), 211-220 (2012-12-21)
Increased serotonergic activity has been shown to reduce motivation to ingest, which may involve, in part, gustatory processes. Here, we examined the effect of paroxetine, a selective serotonin reuptake inhibitor, on appetitive responding for a preferred and an avoided taste
Wojciech Waldman et al.
Przeglad lekarski, 69(8), 587-588 (2012-12-19)
Hydroxycarbamide (HCB), also known as hydroxyurea, is an urea derivative used mainly as antineoplastic and antisickling agent. We described a 31 yrs. female, with essential thrombocythemia, who was admitted to our clinic because of double suicidal ingestion of hydroxycarbamide. First
Manish B Shah et al.
The Journal of pharmacology and experimental therapeutics, 346(1), 113-120 (2013-05-02)
An X-ray crystal structure of CYP2B4 in complex with the drug paroxetine [(3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine] was solved at 2.14 Å resolution. The structure revealed a conformation intermediate to that of the recently solved complex with amlodipine and that of the more compact
Sebastian H Scharf et al.
Neuropharmacology, 72, 38-46 (2013-04-23)
Exposure to chronic stress during developmental periods is a risk factor for a number of psychiatric disorders. While the direct effects of stress exposure have been studied extensively, little is known about the long-lasting effects and the interaction with ageing.
Serotonin and yawning: A possible adverse drug reaction during antidepressant therapy.
Johana Béné et al.
Presse medicale (Paris, France : 1983), 43(10 Pt 1), 1135-1136 (2014-05-06)
Nicolas Vodovar et al.
JACC. Heart failure, 3(8), 629-636 (2015-08-08)
This study sought to hypothesize that elevated B-type natriuretic peptide (BNP) could act as an endogenous neprilysin inhibitor. A hallmark of acute decompensated heart failure (ADHF) is the overproduction of natriuretic peptides (NPs) by stretched cardiomyocytes. Various strategies have been
Huibin Yang et al.
The Journal of biological chemistry, 278(15), 13278-13285 (2003-01-23)
The Ras-GRF1 exchange factor, which is regulated by increases in intracellular calcium and the release of G beta gamma subunits from heterotrimeric G proteins, plays a critical role in the activation of neuronal Ras. Activation of G protein-coupled receptors stimulates
J Saus et al.
The Journal of biological chemistry, 263(14), 6742-6745 (1988-05-15)
We have determined the complete primary structure for human matrix metalloproteinase-3 (MMP-3), which has 477 residues including a 17-residue signal peptide. The result indicates that MMP-3 is identical with stromelysin (Whitham, S. E., Murphy, G., Angel, P., Rahmsdorf, H.-J., Smith
Wenquan Niu et al.
Clinica chimica acta; international journal of clinical chemistry, 411(5-6), 324-328 (2009-12-29)
Numerous studies have attempted to associate -58C/T polymorphism of bradykinin B2 receptor gene (BDKRB2) with hypertension, whereas results were often irreproducible. We performed a meta-analysis aiming to provide a comprehensive evaluation of this polymorphism and hypertension. Case-control reports published in
L J Schoenfield et al.
Annals of internal medicine, 95(3), 257-282 (1981-09-01)
A double-masked study was conducted to determine the efficacy and safety of randomly allocated chenodiol (chenodeoxycholic acid, 750 mg/d or 350 mg/d) or placebo administered for 2 years to 916 patients for dissolution of radiolucent gallstones. There was confirmed complete
Katarzyna Zembrzuska et al.
Oncology reports, 41(5), 2703-2716 (2019-03-22)
Glioblastoma (GBM) is the most common primary brain tumor. Tumor hypoxia is a pivotal factor responsible for the progression of this malignant glioma, and its resistance to radiation and chemotherapy. Thus, improved tumor tissue oxygenation may promote greater sensitivity to
Shilpa H Jain et al.
Diabetes care, 32(5), 903-908 (2009-02-19)
To test the association of regional fat depots with circulating adiponectin and resistin concentrations and to assess the potential mediating effect of adipokines on associations between abdominal fat depots and cardiometabolic risk factors. Participants from the Framingham Heart Study offspring
Ilan Goldenberg et al.
Hypertension (Dallas, Tex. : 1979), 48(4), 693-699 (2006-08-31)
The M235T mutation of the human angiotensinogen gene has been shown to be associated with elevated circulating angiotensinogen concentrations and essential hypertension. The frequencies of the 235T allele are significantly different in black and white subjects. We analyzed the independent
Alexander Gröbe et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(2), 425-433 (2013-11-13)
Current staging methods for squamous cell carcinomas (SCC) of the oral cavity (OSCC) need to be improved to predict the risk of individual patients. Because hematogenous tumor cell dissemination is a key event in tumor progression, we assessed the prognostic
A Alkhalaf et al.
Diabetologia, 53(12), 2562-2568 (2010-08-17)
Homozygosity for a five leucine repeat (5L-5L) in the carnosinase gene (CNDP1) has been found to be cross-sectionally associated with a low frequency of diabetic nephropathy (DN), mainly in type 2 diabetes. We prospectively investigated in patients with type 1
Ho Jun Chin et al.
Journal of Korean medical science, 24 Suppl, S30-S37 (2009-02-12)
The induction of heme oxygenase-1 (HO-1) ameliorates oxidative stress and inflammatory process, which play important roles in IgA nephropathy. We hypothesized length polymorphism in the promoter region of the HO-1 gene, which is related to the level of gene transcription
Y Gao et al.
The Journal of biological chemistry, 276(13), 9838-9845 (2001-01-20)
Dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) on Ser/Thr residues is ubiquitous in higher eukaryotes and is analogous to protein phosphorylation. The enzyme for the addition of this modification, O-GlcNAc transferase, has been cloned from several
Robert Y L Zee et al.
Stroke, 33(4), 892-895 (2002-04-06)
Genetic polymorphisms of the CD14 lipopolysaccharide receptor gene (CD14) and the CD18 leukocyte adhesion molecule gene (CD18) have recently been hypothesized to be risk factors for atherothrombosis. However, no prospective data on subsequent risk of stroke are available. The present
Robert Y L Zee et al.
Human molecular genetics, 13(4), 389-396 (2003-12-19)
Candidate gene polymorphisms related to inflammation, thrombosis and lipid metabolism have been implicated in the development of ischemic stroke. Using DNA samples collected at baseline in a prospective cohort of 14 916 initially healthy American men, we genotyped 92 polymorphisms
Hirohiko Hirano et al.
Journal of human genetics, 48(6), 288-292 (2003-05-02)
Natural tooth loss represents a major medical issue within the elderly population, since it impairs masticatory function critical for oral intake of essential nutrition. Contribution of genetic factors has been implicated in the determination of natural tooth loss; degree of
Xue Zheng et al.
Molecular biology reports, 38(6), 4053-4061 (2010-11-27)
Leucine aminopeptidase 3 (LAP3) is an aminopeptidase which catalyses the removal of N-terminal amino acids and is involved in protein maturation and degradation. In this study, we detected the polymorphisms of LAP3 gene by polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP)
Vitalyi O Rybin et al.
The Journal of biological chemistry, 284(4), 2332-2343 (2008-11-26)
Protein kinase D1 (PKD1) is a physiologically important signaling enzyme that is activated via protein kinase C-dependent trans-phosphorylation of the activation loop at Ser744 and Ser748 followed by PKD1 autophosphorylation at Ser916. Although PKD-Ser916 autophosphorylation is widely used to track
Zrinka Biloglav et al.
Croatian medical journal, 50(1), 34-42 (2009-03-05)
To assess the frequency of 32 base pair deletion in CCR5 (CCR5Delta32), which has been shown to confer resistance to HIV infection in a homozygous form, in 10 isolated island communities of Dalmatia, Croatia, with different histories of exposure to
Haiqing Shen et al.
Arteriosclerosis, thrombosis, and vascular biology, 30(12), 2648-2654 (2010-09-18)
The vitamin D endocrine system is essential for calcium homeostasis, and low levels of vitamin D metabolites have been associated with cardiovascular disease risk. We hypothesized that DNA sequence variation in genes regulating vitamin D metabolism and signaling pathways might
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