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Julia Dinger et al.
Analytical and bioanalytical chemistry, 406(18), 4453-4464 (2014-05-17)
Knowledge about the cytochrome P450 (CYP) inhibition potential of new drug candidates is important for drug development because of its risk of interactions. For novel psychoactive substances (NPS), corresponding data are not available. For developing a general drug inhibition cocktail
Robert Jablonowski et al.
Radiology, 274(2), 370-378 (2014-09-24)
To provide proof of concept that expansion of myocardial extracellular volume (MECV), measured at contrast material-enhanced multidetector computed tomography (CT), can be used as a (a) marker for viability based on histologic confirmation and (b) predictor of severity of myocardial
Karen Rowland Yeo et al.
European journal of clinical pharmacology, 69(6), 1311-1320 (2013-01-12)
To predict the impact of the CYP2C8 3 genotype on rosiglitazone exposure in the absence and presence of trimethoprim. Prior in vitro and in vivo information for rosiglitazone and trimethoprim were collated from the literature. Specifically, data on the frequency
I Michael et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(6), 1260-1271 (2013-03-20)
The overall aim of this work was to examine the degradation of trimethoprim (TMP), which is an antibacterial agent, during the application of two advanced oxidation process (AOP) systems in secondary treated domestic effluents. The homogeneous solar Fenton process (hv/Fe(2+)/H2O2)
Arif Hussain et al.
Antimicrobial agents and chemotherapy, 58(12), 7240-7249 (2014-09-24)
In view of the epidemiological success of CTX-M-15-producing lineages of Escherichia coli and particularly of sequence type 131 (ST131), it is of significant interest to explore its prevalence in countries such as India and to determine if antibiotic resistance, virulence
Xin Yang et al.
Environmental science and pollution research international, 20(8), 5864-5875 (2013-04-24)
The occurrence and fate of eight PPCPs was studied in river waters from upstream to downstream of the three rivers in the Pearl River Delta, China. The correlations of PPCP levels and water quality parameters were also investigated. The analytes
Naoko Hara et al.
Journal of immunology (Baltimore, Md. : 1950), 189(8), 3805-3814 (2012-09-19)
Microbes were hypothesized to play a key role in the progression of type 1 diabetes (T1D). We used the LEW1.WR1 rat model of Kilham rat virus (KRV)-induced T1D to test the hypothesis that the intestinal microbiota is involved in the
Wendy Itzel Escobedo Hinojosa et al.
Journal of ethnopharmacology, 155(2), 1156-1163 (2014-06-28)
The root barks of Hippocratea celastroides have been used for decades in Mexican traditional medicine to treat gastritis and ulcers. To investigate the anti-Helicobacter pylori, gastroprotective, anti-inflammatory, and cytotoxic activities of methanolic extracts obtained from the leaves, stems, and root
Irina Amorim et al.
Helicobacter, 19(4), 249-259 (2014-04-03)
The gastric mucosa of dogs is often colonized by non-Helicobacter pylori helicobacters (NHPH), while H. pylori is the predominant gastric Helicobacter species in humans. The colonization of the human gastric mucosa by H. pylori is highly dependent on the recognition
Trimethoprim.
Nursing times, 101(5), 31-31 (2005-03-01)
Ganna Fedorova et al.
Chemosphere, 111, 55-60 (2014-07-07)
In this study, the stability of 124 target analytes in influent and effluent wastewater samples during short-term (4°C) and long-term (-18°C) storage was assessed. The most common storage scenario was considered, in which samples were frozen immediately after sampling without
Min Zhu et al.
Journal of leukocyte biology, 96(2), 349-357 (2014-05-02)
Individuals with T2D and PD suffer significantly from the ability of one disease to intensify the other. Disease-associated inflammation is one mechanism thought to fuel this pathogenic feed-forward loop. Several lines of evidence indicate that proinflammatory B cells promote T2D
Mayu Kamimura et al.
Bioscience, biotechnology, and biochemistry, 78(3), 438-447 (2014-07-19)
Protein kinases are key regulators of cell function that constitute one of the largest and most functionally diverse gene families. We developed a novel assay system, based on the bimolecular fluorescence complementation (BiFC) technique in Escherichia coli, for detecting transient
Laurel K Dodgen et al.
Environmental pollution (Barking, Essex : 1987), 198, 144-153 (2015-01-17)
The reuse of treated wastewater for agricultural irrigation in arid and hot climates where plant transpiration is high may affect plant accumulation of pharmaceutical and personal care products (PPCPs) and endocrine disrupting chemicals (EDCs). In this study, carrot, lettuce, and
Concentration evolution of pharmaceutically active compounds in raw urban and industrial wastewater.
Dolores Camacho-Muñoz et al.
Chemosphere, 111, 70-79 (2014-07-07)
The distribution of pharmaceutically active compounds in the environment has been reported in several works in which wastewater treatment plants have been identified as the main source of these compounds to the environment. The concentrations of these compounds in influent
Trimethoprim resistance.
Huovinen P
Antimicrobial Agents and Chemotherapy, 31(10), 1451-1456 (1987)
Paul M Luethy et al.
Journal of bacteriology, 197(9), 1592-1605 (2015-02-19)
Campylobacter jejuni is a leading cause of bacterial diarrheal disease and a frequent commensal of the intestinal tract in poultry and other animals. For optimal growth and colonization of hosts, C. jejuni employs two-component regulatory systems (TCSs) to monitor environmental
Umayal Lakshmanan et al.
Combinatorial chemistry & high throughput screening, 17(9), 790-803 (2014-10-21)
Melioidosis is a serious emerging endemic infectious disease caused by Burkholderia pseudomallei, a gram-negative pathogen. Septicemic melioidosis has a mortality rate of 50% even with treatment. Like other gram-negative bacteria, B. pseudomallei is resistant to a number of antibiotics and
Magda Targa Martins et al.
Talanta, 129, 374-383 (2014-08-17)
In routine laboratory work, screening methods for multiclass analysis can process a large number of samples in a short time. The main challenge is to develop a methodology to detect as many different classes of residues as possible, combined with
Alia Ungurean et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 102, 52-58 (2012-12-12)
Structural investigations by different vibrational spectroscopic methods: FTIR, FT-Raman and surface-enhanced Raman scattering (SERS) spectroscopy, as well as density functional theory (DFT) calculations were performed on trimethoprim (5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine). A reliable assignment of vibrational IR, Raman and SERS bands was possible
M Stephan-Güldner
Journal of chemotherapy (Florence, Italy), 5(6), 400-410 (1993-12-01)
The toxicology and safety pharmacology of brodimoprim (Ro 10-5970), a new dihydrofolate reductase inhibitor for antimicrobial chemotherapy, are reported. The toxicity is compared to trimethoprim and other dihydrofolate reductase inhibitors of the trimethoprim type. In safety pharmacological tests brodimoprim showed
A Burian et al.
Pharmacology, 90(5-6), 281-287 (2012-10-06)
Although major impairment of activity at lower pH values has been reported for fluoroquinolones, acidification is a widely recommended practice for the prophylaxis and treatment of uncomplicated urinary tract infections (UTIs). Until now, there is little evidence for the influence
Anandi Martin et al.
Journal of clinical microbiology, 47(8), 2632-2634 (2009-06-06)
The objective of this study was to evaluate the performance of a low-cost method, the thin layer agar (TLA) method, for the diagnosis of smear-negative patients. This prospective study was performed in Homa Bay District Hospital in Kenya. Out of
[Hyperkalemia after trimethoprim or pentamidine. Until now, a little noticed side effect of antimicrobial therapeutic measures in AIDS patients].
G Gabriëls et al.
Deutsche medizinische Wochenschrift (1946), 123(45), 1351-1355 (1998-12-04)
T Trinh et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 66(9), 1856-1863 (2012-08-29)
Emerging wastewater treatment processes such as membrane bioreactors (MBRs) have attracted a significant amount of interest internationally due to their ability to produce high quality effluent suitable for water recycling. It is therefore important that their efficiency in removing hazardous
Andreia Freitas et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 976-977, 49-54 (2014-12-08)
A multiresidue quantitative screening method covering 39 antibiotics from 7 different families by ultra-high-pressure-liquid-chromatography-tandem mass spectrometry (UHPLC-MS/MS) is described. Sulfonamides, trimethoprim, tetracyclines, macrolides, quinolones, penicillins and chloramphenicol are simultaneously detected in liver tissue. A simple sample treatment method consisting of
Jian-Wei Liu et al.
Methods in molecular biology (Clifton, N.J.), 978, 229-236 (2013-02-21)
Low protein solubility is a problem in many areas of protein science. Although chemical methods have been developed to solubilize proteins these are not always effective and add to the cost of producing the protein. One way of overcoming these
Yang Song et al.
Advanced materials (Deerfield Beach, Fla.), 31(14), e1807436-e1807436 (2019-01-31)
Neutrophil extracellular traps (NETs) are decondensed chromatin networks released by neutrophils that can trap and kill pathogens but can also paradoxically promote biofilms. The mechanism of NET functions remains ambiguous, at least in part, due to their complex and variable
A Romano et al.
Physiology & behavior, 136, 55-62 (2014-05-08)
Chronic exposure to a diet rich in fats changes the gastrointestinal milieu and alters responses to several signals involved in the control of food intake. Oleoylethanolamide (OEA) is a gut-derived satiety signal released from enterocytes upon the ingestion of dietary
Julia Martín et al.
The Science of the total environment, 503-504, 97-104 (2014-06-10)
Sewage sludge disposal onto lands has been stabilized previously but still many pollutants are not efficiently removed. Special interest has been focused on pharmaceutical compounds due to their potential ecotoxicological effects. Nowadays, there is scarce information about their occurrence in
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