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Anthony Sclafani et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(12), R1448-R1457 (2014-10-17)
Recent studies indicate that, unlike glucose, fructose has little or no post-oral preference conditioning actions in C57BL/6J (B6) mice. The present study determined whether this is also the case for FVB mice, which overconsume fructose relative to B6 mice. In
Zheng Tian et al.
Langmuir : the ACS journal of surfaces and colloids, 30(41), 12411-12420 (2014-09-25)
Carbon films with interdigitated bimodal three-dimensionally ordered mesoporosity (ib3DOm) are realized by a scalable nanoreplication process that removes the common need plaguing hard-templating strategies for multistep prefabrication of porous sacrificial templates. Specifically, evaporation-induced convective codeposition of size-tunable (ca. 20-50 nm)
R L Anderson
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 26(7), 637-644 (1988-07-01)
An hypothesis is presented of a mechanism for the sodium saccharin (NaS)-associated tumorigenesis of the urinary bladder that occurs in male rats. The ingestion of high doses of NaS is associated with increased urine volume and bladder mass. In rats
Bitter taste receptors for saccharin and acesulfame K
Kuhn C, et al.
The Journal of Neuroscience, 24(45), 10260-10265 (2004)
D C Martyn et al.
Current pharmaceutical design, 5(6), 405-415 (1999-07-03)
The inhibition of human leukocyte elastase (HLE), and other serine proteases, by succinimide and saccharin-based compounds is reviewed. The succinimide compounds are unique in that the inactivating species is generated within the enzyme active site via a molecular rearrangement. The
Linda A Parker et al.
Psychopharmacology, 232(3), 583-593 (2014-08-03)
To determine the role of the endocannabinoid, 2-arachodonyl glycerol (2-AG), in the regulation of nausea and vomiting. We evaluated the effectiveness of the potent selective monoacylglycerol lipase (MAGL) inhibitor, MJN110, which selectively elevates the endocannabinoid 2-AG, to suppress acute nausea
Annelies Grimonprez et al.
Brain stimulation, 8(1), 13-20 (2014-12-03)
Depression is the most common psychiatric comorbidity in epilepsy patients. The lack of success with current pharmacological interventions for this patient population, highlights the importance of optimizing non-pharmacological neuromodulatory treatments such as vagus nerve stimulation (VNS). Studies on the antidepressant
Nathalie Vanhille et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(3), 577-589 (2014-08-15)
Drug addiction is associated with a relative devaluation of natural or socially-valued reinforcers that are unable to divert addicts from seeking and consuming the drug. Before protracted drug exposure, most rats prefer natural rewards, such as saccharin, over cocaine. However
Saccharin and its salts.
IARC monographs on the evaluation of carcinogenic risks to humans, 73, 517-624 (2000-05-11)
D L Arnold et al.
Toxicology, 27(3-4), 179-256 (1983-07-01)
Saccharin, first synthesized in 1879, eventually became popular as an inexpensive substitute for sugar, particularly as a non-caloric sweetner. The dispute concerning the safety of saccharin for human consumption is almost as old as saccharin itself. In this article, the
Alessandra T Peana et al.
Behavioural pharmacology, 25(7), 618-628 (2014-08-15)
Recent evidence has shown that Withania somnifera Dunal (Ashwagandha or Indian ginseng), a herbal remedy used in traditional medicine, impairs morphine-elicited place conditioning. Here, we investigated the effect of W. somnifera roots extract (WSE) on motivation for drinking ethanol using
S A Miller et al.
Diabetes care, 12(1), 74-80 (1989-01-01)
Saccharin, a nonnutritive sweetener discovered in 1879, has been the subject of controversy concerning its effect on public health on several occasions during this century. Over this period, the substance has come to be regarded as a useful commodity in
Status report on saccharin in humans.
G R Newell et al.
Journal of the National Cancer Institute, 61(2), 275-276 (1978-08-01)
L B Ellwein et al.
Critical reviews in toxicology, 20(5), 311-326 (1990-01-01)
Almost from its discovery in 1879, the use of saccharin as an artificial, non-nutritive sweetener has been the center of several controversies regarding potential toxic effects, most recently focusing on the urinary bladder carcinogenicity of sodium saccharin in rats when
Saccharin consumption increases food consumption in rats.
Nutrition reviews, 48(3), 163-165 (1990-03-01)
Marilyn E Carroll et al.
Behavioural pharmacology, 19(5-6), 435-460 (2008-08-12)
A positive relationship between the consumption of sweetened dietary substances (e.g. saccharin and sucrose) and drug abuse has been reported in both the human and other animal literature. The proposed genetic contribution to this relationship has been based on evidence
Organ-specific modifying effects of phenobarbital, saccharin and antioxidants on 2-stage chemical carcinogenesis.
N Ito
Developments in toxicology and environmental science, 12, 359-369 (1986-01-01)
A G Renwick
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 23(4-5), 429-435 (1985-04-01)
Recent studies on saccharin in animals and man have allowed a detailed understanding of its fate in the body. Saccharin is slowly absorbed from the gut but rapidly eliminated in the urine, largely by renal tubular secretion. Saccharin does not
Saccharin-induced bladder cancer in rats.
E M Garland et al.
Progress in clinical and biological research, 391, 237-243 (1995-01-01)
J Ashby
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 23(4-5), 507-519 (1985-04-01)
The literature indicates that sodium saccharin is non-reactive to DNA and inactive as a gene mutagen in vitro. At elevated dose levels it is capable of producing structural disturbances in eukaryotic chromosomes in vitro, and it shows intermittent activity as
V Echeverry-Alzate et al.
British journal of pharmacology, 171(12), 3023-3036 (2014-02-18)
Recent and ongoing clinical studies have indicated that topiramate (Topamax®) could be effective in treating ethanol or cocaine abuse. However, the effects of topiramate on the co-administration of ethanol and cocaine remain largely unknown. We studied the effects of topiramate
Saccharin analysis in pharmaceutical and cosmetic preparations by derivative ultraviolet spectrophotometry
Vianna-Soares CD and Martins JLS
Brazilian Journal of Pharmaceutical Sciences , 38(4), 471-478 (2002)
Haim Einat
Pharmacological reports : PR, 66(4), 722-725 (2014-06-21)
The inhibition of protein kinase C (PKC) was recently suggested as a novel approach for the development of mood stabilizing drugs. To further evaluate this possibility, the aim of the present study was to test the effects of peripheral (intraperitoneal)
Jean-Christophe Delpech et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(7), 3022-3033 (2015-02-24)
The cerebral innate immune system is able to modulate brain functioning and cognitive processes. During activation of the cerebral innate immune system, inflammatory factors produced by microglia, such as cytokines and adenosine triphosphate (ATP), have been directly linked to modulation
J Whysner et al.
Pharmacology & therapeutics, 71(1-2), 225-252 (1996-01-01)
Sodium saccharin (NaSac) produces bladder tumors consistently in male rats only after lifetime exposure that begins at birth. NaSac is not metabolized and is negative in most genotoxicity tests. NaSac-induced cell damage and proliferation have been proposed as important factors
Amy E B Packard et al.
Psychoneuroendocrinology, 47, 178-188 (2014-07-09)
The incidence of type-2 diabetes (T2D) and the burden it places on individuals, as well as society as a whole, compels research into the causes, factors and progression of this disease. Epidemiological studies suggest that chronic stress exposure may contribute
C I Chappel
Regulatory toxicology and pharmacology : RTP, 15(3), 253-270 (1992-06-01)
Dietary sodium saccharin is associated with bladder tumors when fed at high levels to the male rat. Under these conditions urinary pH, sodium concentration, and volume are elevated and proliferative changes are present in the urothelium. Extensive epidemiological studies have
Paweł Kubica et al.
Analytical and bioanalytical chemistry, 407(5), 1505-1512 (2014-12-05)
The method for the determination of acesulfame-K, saccharine, cyclamate, aspartame, sucralose, alitame, neohesperidin dihydrochalcone, neotame and five common steviol glycosides (rebaudioside A, rebaudioside C, steviol, steviolbioside and stevioside) in soft and alcoholic beverages was developed using high-performance liquid chromatography and
M D Reuber
Environmental health perspectives, 25, 173-200 (1978-08-01)
Saccharin is carcinogenic for the urinary bladder in rats and mice, and most likely is carcinogenic in human beings. The neoplasms of the urinary bladder are malignant and invade and metastasize. Male rats are more susceptible to urinary bladder carcinogenesis
Sabine Klein et al.
Experimental neurology, 263, 263-271 (2014-09-16)
Among the comorbidities observed in epilepsy patients depression is the most frequent one. Likewise, depression by itself is accompanied by an increased risk to develop epilepsy. Both epilepsy and depression are characterized by a high incidence of pharmacoresistance, which might
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