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Melvys Valledor et al.
Cell reports, 42(7), 112686-112686 (2023-06-29)
XIST RNA triggers chromosome-wide gene silencing and condenses an active chromosome into a Barr body. Here, we use inducible human XIST to examine early steps in the process, showing that XIST modifies cytoarchitecture before widespread gene silencing. In just 2-4
Martin Cusack et al.
Genome research, 30(10), 1393-1406 (2020-09-24)
Epigenetic modifications on chromatin play important roles in regulating gene expression. Although chromatin states are often governed by multilayered structure, how individual pathways contribute to gene expression remains poorly understood. For example, DNA methylation is known to regulate transcription factor
Yuting Wang et al.
Frontiers in oncology, 12, 872444-872444 (2022-06-17)
Axin1 is a fundamental scaffolding protein of the destruction complex in the canonical Wnt signaling pathway, which plays a critical role in various biological processes. However, how Axin1 is regulated in the activation of the canonical Wnt signaling pathway remains
Aubrey R Tiernan et al.
Experimental cell research, 330(1), 212-221 (2014-10-12)
Histone deacetylase inhibitors (HDACi) were recently identified as having significant clinical potential in reversing β-cell functional inhibition caused by inflammation, a shared precursor of Type 1 and Type 2 diabetes. However, HDACi are highly complex and little is known of
Subhashis Debsharma et al.
iScience, 27(4), 109384-109384 (2024-03-29)
Gastric cancer (GC) is a deadly malignancy that demands effective therapeutic intervention capitalizing unique drug target/s. Here, we report that indomethacin, a cyclooxygenase non-selective non-steroidal anti-inflammatory drug, arrests GC cell growth by targeting mitochondrial deacetylase Sirtuin 3 (SIRT3). Interaction study
Nadia Jeremiah et al.
The Journal of experimental medicine, 220(5) (2023-02-24)
In innate immune cells, intracellular sensors such as cGAS-STING stimulate type I/III interferon (IFN) expression, which promotes antiviral defense and immune activation. However, how IFN-I/III expression is controlled in adaptive cells is poorly understood. Here, we identify a transcriptional rheostat
Selective induction of cyclin-dependent kinase inhibitors and their roles in cell cycle arrest caused by trichostatin A, an inhibitor of histone deacetylase.
Y B Kim et al.
Annals of the New York Academy of Sciences, 886, 200-203 (2000-02-10)
Hanlin Lu et al.
Nature communications, 14(1), 5891-5891 (2023-09-22)
Endothelial dysfunction represents a major cardiovascular risk factor for hypertension. Sp1 and Sp3 belong to the specificity protein and Krüppel-like transcription factor families. They are ubiquitously expressed and closely associated with cardiovascular development. We investigate the role of Sp1 and
Samir Softic et al.
Cell metabolism, 30(4), 735-753 (2019-10-03)
Dietary sugars, fructose and glucose, promote hepatic de novo lipogenesis and modify the effects of a high-fat diet (HFD) on the development of insulin resistance. Here, we show that fructose and glucose supplementation of an HFD exert divergent effects on
Mikhlid H Almutairi et al.
Pharmaceuticals (Basel, Switzerland), 15(11) (2022-11-11)
The expression of human germline genes is restricted to the germ cells of the gonads, which produce sperm and eggs. The germline genes involved in testis development and potentially activated in cancer cells are known as cancer-testis (CT) genes. These
Fariba Moulavi et al.
Methods in molecular biology (Clifton, N.J.), 2647, 283-303 (2023-04-12)
Camels play very important economic and sociocultural roles for communities residing in arid and semi-arid countries. The positive impacts of cloning on genetic gain in camel species are indisputable, considering the unique ability of cloning to produce a large number
Saulius Lukauskas et al.
Nature, 627(8004), 671-679 (2024-03-07)
DNA and histone modifications combine into characteristic patterns that demarcate functional regions of the genome1,2. While many 'readers' of individual modifications have been described3-5, how chromatin states comprising composite modification signatures, histone variants and internucleosomal linker DNA are interpreted is
Zhaodi Liao et al.
Nature communications, 15(1), 5-5 (2024-01-17)
Somatic cell nuclear transfer (SCNT) successfully clones cynomolgus monkeys, but the efficiency remains low due to a limited understanding of the reprogramming mechanism. Notably, no rhesus monkey has been cloned through SCNT so far. Our study conducts a comparative analysis
Numan Al-Rayyan et al.
Cancer letters, 347(1), 139-150 (2014-02-12)
COUP-TFII is reduced in endocrine-resistant breast cancer cells and is negatively associated with tumor grade. Transient re-expression of COUP-TFII restores antiestrogen sensitivity in resistant LCC2 and LCC9 cells and repression of COUP-TFII results in antiestrogen-resistance in MCF-7 endocrine-sensitive cells. We
Higher Expression Levels of SSX1 and SSX2 in Patients with Colon Cancer: Regulated In Vitro by the Inhibition of Methylation and Histone Deacetylation.
Alrubie, et al.
Medicina (Kaunas, Lithuania), 59 (2023)
Christophe Guilluy et al.
Nature cell biology, 16(4), 376-381 (2014-03-13)
Mechanical forces influence many aspects of cell behaviour. Forces are detected and transduced into biochemical signals by force-bearing molecular elements located at the cell surface, in adhesion complexes or in cytoskeletal structures. The nucleus is physically connected to the cell
Dobrochna Dolicka et al.
Cellular and molecular gastroenterology and hepatology, 11(2), 597-621 (2020-09-29)
Tristetraprolin (TTP) is a key post-transcriptional regulator of inflammatory and oncogenic transcripts. Accordingly, TTP was reported to act as a tumor suppressor in specific cancers. Herein, we investigated how TTP contributes to the development of liver inflammation and fibrosis, which
Ziyi Yin et al.
Autophagy, 15(7), 1234-1257 (2019-02-20)
Macroautophagy/autophagy is critical for normal appressorium formation and pathogenicity of the rice blast fungus Magnaporthe oryzae, but the molecular base of autophagy linked to pathogenicity remains elusive in this or other pathogenic fungi. We found that MoHat1, a histone acetyltransferase
Jiandong Shi et al.
Science advances, 9(22), eadf0211-eadf0211 (2023-05-31)
The emergence of a series of SARS-CoV-2 variants has necessitated the search for broad-spectrum antiviral targets. The aryl hydrocarbon receptor (AhR) senses tryptophan metabolites and is an immune regulator. However, the role of AhR in SARS-CoV-2 infection and whether AhR
Neutralization of the Positive Charges on Histone Tails by RNA Promotes an Open Chromatin Structure.
Rositsa Dueva et al.
Cell chemical biology, 26(10), 1436-1449 (2019-08-27)
RNA associates extensively with chromatin and can influence its structure; however, the potential role of the negative charges of RNA on chromatin structure remains unknown. Here, we demonstrate that RNA prevents precipitation of histones and can attenuate electrostatic interactions between
Ting Zhang et al.
International journal of molecular medicine, 39(1), 126-134 (2016-12-23)
Ubiquitin-like with PHD and ring finger domains 2 (UHRF2) is a multi-domain E3 ubiquitin ligase which is involved in epigenetic regulation and plays an essential role in tumorigenesis. However, the role of UHRF2 in histone H3 acetylation has not yet been fully elucidated
Genlai Li et al.
The Journal of nutrition, 144(12), 1887-1895 (2014-10-17)
Short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, are the main products of microbial fermentation in the gut and might mediate some of the effects of gut microbiota and nutrition on development, metabolism, and pathogenesis of obesity and other
Sippy Kaur et al.
Clinical epigenetics, 7, 20-20 (2015-03-15)
Altered expression of microRNAs (miRNAs) commonly accompanies colorectal (CRC) and endometrial carcinoma (EC) development, but the underlying mechanisms and clinicopathological correlations remain to be clarified. We focused on epigenetic mechanisms and aimed to explore if DNA methylation patterns in tumors
Joanna Morończyk et al.
Cells, 11(5) (2022-03-11)
Somatic embryogenesis (SE), which is a process that involves the in vitro-induced embryogenic reprogramming of plant somatic cells, requires dynamic changes in the cell transcriptome. These changes are fine-tuned by many genetic and epigenetic factors, including posttranslational histone modifications such
Jacob T Sanders et al.
Scientific reports, 12(1), 4721-4721 (2022-03-20)
Layers of genome organization are becoming increasingly better characterized, but less is known about how these structures respond to perturbation or shape changes. Low-salt swelling of isolated chromatin fibers or nuclei has been used for decades to investigate the structural
Bioprobes: Biochemical Tools for Investigating Cell Function, 11, 2104-2104 (2012)
Barbara Wójcikowska et al.
BMC genomics, 25(1), 788-788 (2024-08-16)
Somatic embryogenesis (SE) exemplifies the unique developmental plasticity of plant cells. The regulatory processes, including epigenetic modifications controlling embryogenic reprogramming of cell transcriptome, have just started to be revealed. To identify the genes of histone acetylation-regulated expression in SE, we
Keisuke Kurimoto et al.
Epigenetics, 12(10), 865-874 (2017-11-04)
Therapeutic strategies for esophageal cancer largely depend on histopathological assessment. To select appropriate treatments of individual patients, we examined the background molecular characteristics of tumor malignancy and sensitivity to multidisciplinary therapy. Seventy-eight surgically-resected esophageal squamous cell carcinoma (ESCC) cases during
Cross-sectional Neuromuscular Phenotyping Study of Patients With Arhinia With SMCHD1 Variants.
Mohassel, et al.
Neurology, 98, e1384-e1396 (2023)
Nazanin Rohani et al.
Cancer research, 79(8), 1952-1966 (2019-02-14)
Acidosis is a fundamental feature of the tumor microenvironment, which directly regulates tumor cell invasion by affecting immune cell function, clonal cell evolution, and drug resistance. Despite the important association of tumor microenvironment acidosis with tumor cell invasion, relatively little
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