CN
Search Within
V900392
应用筛选条件
关键词:'V900392'
显示 1-30 共 1865 条结果 关于 "V900392" 范围 论文
Dongxia Hou et al.
PloS one, 10(11), e0142442-e0142442 (2015-11-12)
Trophoblasts (TR) are specialized cells of the placenta and play an important role in embryo implantation. The in vitro culture of trophoblasts provided an important tool to investigate the mechanisms of implantation. In the present study, porcine trophoblast cells were
Yanli Liu et al.
Gene, 564(2), 210-219 (2015-04-02)
Increasing amounts of evidence have indicated that noncoding RNAs (ncRNAs) have important regulatory potential in various biological processes. However, the contributions of ncRNAs, especially long noncoding RNAs (lncRNAs), to peritoneal fibrosis remain largely unknown. The aim of this study was
Qing-Qing Wang et al.
Journal of Asian natural products research, 17(7), 778-782 (2014-12-11)
The leaves of Rhododendron seniavinii Maxim with little phytochemical information are used as folk remedies for the treatment of acute and chronic bronchitis in China. In our pursuing for the biologically active chemical constituents in the leaves, a new flavonoid
Marc R Mansour et al.
British journal of haematology, 168(2), 230-238 (2014-09-27)
Activating mutations of the interleukin-7 receptor (IL7R) occur in approximately 10% of patients with T cell acute lymphoblastic leukaemia (T-ALL). Most mutations generate a cysteine at the transmembrane domain leading to receptor homodimerization through disulfide bond formation and ligand-independent activation
Osama I Abd El-Salam et al.
Molecules (Basel, Switzerland), 20(11), 20434-20447 (2015-11-19)
A series of novel benzosuberone derivatives were synthesized and evaluated as antimicrobial agents by using substituted benzosuberone derivatives 1a,b as starting materials. Treatment of 1a,b with phenyl isothiocyanate in dimethylformamide was followed by treatment with cold HCl solution to afford
Neha Kaushik et al.
Scientific reports, 5, 8726-8726 (2015-03-05)
In this study, we show the selective and efficient anti-cancer effects of plasma (at a low dose) when cell metabolic modifiers are also included. 2-deoxy-D-glucose (2-DG), a glycolytic inhibitor, was used with effective doses of non-thermal plasma, synergistically attenuating cell
Tse-Yao Wang et al.
Life sciences, 139, 153-159 (2015-08-19)
The discovery of different shades of fat has been implicated in the pathogenesis of obesity-related metabolic disorders. However, the effects of early and intermittent exposure to cold temperature on systemic metabolic changes in adult life remain unclear. To elucidate the
Yuan Lu et al.
Applied biochemistry and biotechnology, 177(5), 1164-1175 (2015-08-19)
Interferon (IFN)-λ, also known as IL-28A, IL-28B, or IL-29, is a new type III IFN, which shares many functional characteristics with type I IFN (α/β). Currently, IFN-α is used in the treatment of certain forms of cancer with severe adverse
D L Kolesnik et al.
Experimental oncology, 37(2), 126-129 (2015-06-27)
A hallmark of malignancy is excessive tumor glycolysis, even in the presence of oxygen, which causes lactacidosis in the tumor microenvironment and favors tumor cell proliferation and survival. For this reason antimetabolic agents which target tumor cell metabolism are being
Rafael Duran et al.
Theranostics, 6(1), 28-39 (2016-01-02)
Embolotherapy using microshperes is currently performed with soluble contrast to aid in visualization. However, administered payload visibility dimishes soon after delivery due to soluble contrast washout, leaving the radiolucent bead's location unknown. The objective of our study was to characterize
Markus Basan et al.
Nature, 528(7580), 99-104 (2015-12-04)
Overflow metabolism refers to the seemingly wasteful strategy in which cells use fermentation instead of the more efficient respiration to generate energy, despite the availability of oxygen. Known as the Warburg effect in the context of cancer growth, this phenomenon
Yoshiharu Matsumae et al.
Analytica chimica acta, 842, 20-26 (2014-08-17)
We evaluated the intracellular quinone oxidoreductase (NQO) activity of single HeLa cells by using the menadione-ferrocyanide double-mediator system combined with scanning electrochemical microscopy (SECM). The double-mediator system was used to amplify the current response from the intracellular NQO activity and
Mahdy Ranjbar et al.
Ophthalmic research, 53(3), 136-140 (2015-02-28)
Disease-modifying antirheumatic drugs (DMARDs) have been suggested in the treatment of inflammatory ophthalmological diseases. The aim of the present study was to investigate the effects of these DMARDs on bovine retinal function. Bovine retina preparations were perfused with a standard
L H Vähätalo et al.
Acta physiologica (Oxford, England), 213(4), 902-919 (2014-12-09)
Neuropeptide Y (NPY) co-localized with noradrenaline in central and sympathetic nervous systems seems to play a role in the control of energy metabolism. In this study, the aim was to elucidate the effects and pathophysiological mechanisms of increased NPY in
Visesato Mor et al.
mBio, 6(3), e00647-e00647 (2015-06-25)
Recent estimates suggest that >300 million people are afflicted by serious fungal infections worldwide. Current antifungal drugs are static and toxic and/or have a narrow spectrum of activity. Thus, there is an urgent need for the development of new antifungal
Giovanna Bianchi et al.
Oncotarget, 6(14), 11806-11819 (2015-04-25)
Tumor chemoresistance is associated with high aerobic glycolysis rates and reduced oxidative phosphorylation, a phenomenon called "Warburg effect" whose reversal could impair the ability of a wide range of cancer cells to survive in the presence or absence of chemotherapy.
Yasuo Uchida et al.
Drug metabolism and pharmacokinetics, 30(2), 205-208 (2015-03-15)
The purpose of the present study was to evaluate and compare the absolute protein expression levels of 28 drug-related transporters in Caco-2 cell monolayers cultured for 2, 3, and 4 weeks. Plasma membrane fractions of Caco-2 cells cultured on Transwell
Alejo Efeyan et al.
Nature, 517(7534), 302-310 (2015-01-17)
The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite for life. Nutrient scarcity is a selective pressure that has shaped the evolution of most cellular processes. Different pathways that detect intracellular and extracellular levels
Kouichi Itoh et al.
Journal of food science, 80(7), H1619-H1626 (2015-05-28)
A rare sugar, D-allulose (also called D-psicose), has recently been applied as a food supplement in view of controlling diabetes and obesity in Japan. D-allulose has been proven to have unique effects against hyperglycemia and hyperlipidemia in a number of
Vincent C Luca et al.
Science (New York, N.Y.), 347(6224), 847-853 (2015-02-24)
Notch receptors guide mammalian cell fate decisions by engaging the proteins Jagged and Delta-like (DLL). The 2.3 angstrom resolution crystal structure of the interacting regions of the Notch1-DLL4 complex reveals a two-site, antiparallel binding orientation assisted by Notch1 O-linked glycosylation.
P V Zhuravlev et al.
Gigiena i sanitariia, (1)(1), 56-58 (2013-06-29)
Due to intensive anthropogenic pollution of water environment generally accepted indicators of epidemic security of water bodies--common bacteria (CB) and thermotolerant coliform bacteria (TCB) do not always permit to obtain an objective characterization of bacterial contamination of tap water. From
Emilia Joanna Orzechowska et al.
Oncology reports, 33(5), 2143-2150 (2015-03-12)
Overexpression of the BH3-interacting domain death agonist (BID) protein sensitizes certain cancer cell lines to apoptosis induced by anticancer agents, particularly by those acting through death receptors (e.g. TRAIL). Previously, we showed that recombinant BID fused with TAT cell penetrating
Masahiro Abe et al.
Medical mycology, 52(8), 835-840 (2014-10-29)
The aim of this study was to evaluate the usefulness of serum (1,3)-beta-D-glucan (BDG) for earlier detection of breakthrough candidemia. We reviewed the medical records of patients with candidemia from January 2008 to March 2013. Serum BDG was measured by
Sang Hyun Han et al.
Archives of pharmacal research, 38(7), 1312-1316 (2015-04-15)
A phytochemical investigation of Allium tuberosum Rottler afforded two new phenylpropane glycosides, named tuberonoid A (1) and B (2), along with four known flavonoids, kaempferol 3-O-β-sophoroside (3), 3-O-β-D-(2-O-feruloyl)-glucosyl-7,4'-di-O-β-D-glucosylkaempferol (4), 3-O-β-sophorosyl-7-O-β-D-(2-O-feruloyl)glucosyl kaempferol (5), kaempferol 3,4'-di-O-β-D-glucoside (6). The identification and structural elucidation
W Addah et al.
Journal of animal science, 93(5), 2309-2321 (2015-05-29)
The objective of this study was to investigate the effects of chop length and inoculation of barley silage on feeding behavior, rumen fermentation, and growth performance of finishing feedlot steers. Barley forage (22-35% DM) was chopped to a theoretical chop
Shi-Yang Tang et al.
Analytical and bioanalytical chemistry, 407(12), 3437-3448 (2015-02-24)
Budding yeast cells are quick and easy to grow and represent a versatile model of eukaryotic cells for a variety of cellular studies, largely because their genome has been widely studied and links can be drawn with higher eukaryotes. Therefore
Lawrence M House et al.
Cardiovascular diabetology, 14, 56-56 (2015-05-20)
Endotoxin (i.e. LPS) administration induces a robust inflammatory response with accompanying cardiovascular dysfunction and insulin resistance. Overabundance of nitric oxide (NO) contributes to the vascular dysfunction. However, inflammation itself also induces insulin resistance in skeletal muscle. We sought to investigate
V Pathak et al.
Molecular and cellular endocrinology, 401, 120-129 (2014-12-03)
Compromise of gastric inhibitory polypeptide (GIP) receptor signalling represents a possible therapeutic strategy for the treatment of obesity-related diabetes. This study has characterised and evaluated the C-terminally fatty acid derivatised GIP analogues, GIP(3-30)Cex-K(40)[Pal] and Pro(3)GIP(3-30)Cex-K(40)[Pal], as potential GIP inhibitors. Both
Mei Liu et al.
Biotechnology for biofuels, 8, 132-132 (2015-09-05)
Contamination of corn mash by lactic acid bacteria (LAB) reduces the efficiency of the ethanol fermentation process. The industry relies heavily on antibiotics for contamination control and there is a need to develop alternative methods. The goals of this study
Marta Pokrywczynska et al.
Pancreas, 43(5), 801-808 (2014-04-18)
This study was designed to evaluate the impact of fructose-rich diet and chronic kidney disease (CKD) on the in vitro function of pancreatic islets. Fifty-four rats were divided into 3 equal groups as follows: control, rats with CKD 1/2 that
1/63