Merck
CN

SCN2A

sodium channel, voltage-gated, type II, alpha subunit

别名:
BFIC3, BFIS3, BFNIS, EIEE11, HBA, HBSCI, HBSCII, NAC2, Na(v)1.2, Nav1.2, SCN2A1, SCN2A2
物种:
UniProtKB ID:
基因ID:
  • Human(6326) Summary: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
  • domestic cat(101080472) sodium channel, voltage-gated, type II, alpha subunit
  • dog(478773) sodium channel, voltage-gated, type II, alpha subunit
  • chicken(395945) sodium channel, voltage-gated, type II, alpha subunit
  • naked mole-rat(101715020) sodium channel, voltage-gated, type II, alpha subunit
  • Horse(100051816) sodium channel, voltage-gated, type II, alpha subunit
  • domestic guinea pig(100716680) sodium channel, voltage-gated, type II, alpha subunit
  • sheep(101103126) sodium channel, voltage-gated, type II, alpha subunit
  • cow(539718) sodium channel, voltage-gated, type II, alpha subunit

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Small Molecule - Antagonist

货号
说明
物种
利鲁唑, solid,
物种
rat, human
奥卡西平, ≥98% (HPLC), solid,
物种
rat, human
BIA 2-093, ≥98% (HPLC), solid,
物种
rat, human
拉莫三嗪, ≥98%, powder,
物种
rat, human
普罗帕酮 盐酸盐, United States Pharmacopeia (USP) Reference Standard,
物种
human

Antibodies

货号
说明
物种反应性
应用
Anti-Sodium Channel Antibody, Voltage Gated, Brain Type II, Chemicon®, from rabbit,
物种反应性
mouse, rat
应用
immunohistochemistry
western blot
Anti-SCN2A Antibody, clone 5H10.2, clone 5H10.2, from mouse,
物种反应性
human
应用
western blot
Anti-SODIUM CHANNEL-PAN antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry

western blot
Pan单克隆抗 钠通道 小鼠抗, ~1 mg/mL, clone K58/35, purified immunoglobulin,
物种反应性
mammals
应用
immunofluorescence
immunohistochemistry

western blot

Small Molecule - Blocker

货号
说明
物种
利多卡因, Pharmaceutical Secondary Standard; Certified Reference Material,
物种
human
利多卡因, Pharmaceutical Secondary Standard; Certified Reference Material,
物种
human
普鲁卡因 盐酸盐, ≥97%,
物种
human
普鲁卡因酰胺 盐酸盐, ≥98% (HPLC),
物种
human
拉莫三嗪, Pharmaceutical Secondary Standard; Certified Reference Material,
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting mouse Scn2a,
物种
mouse
MISSION® esiRNA, targeting human SCN2A,
物种
human