Sanjay Poman
Sildenafil, sold under the brand name Viagra, among others, is a medication that can be used as a selective inhibitor of cyclic GMP- specific photodiesterase (type V) with vasodilator action. It can be used to treat erectile dysfunction and pulmonary arterial hypertension. In 1994, Pfizer filed a patent covering the use of sildenafil to treat erectile dysfunction. This patent will expire in 2019.
In the present study we demonstrate compliance of silica gel 60 F254 HPTLC plates with USP requirements, and how HPTLC plates are suitable for the Sildenafil citrate- Limit of Imidazole test.
Figure 1.5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
Figure 2.TLC Plate after development
Figure 3.System suitability (SST) chromatograms
Figure 4.Chromatographic Data (Standard Solution)
Figure 5.Chromatographic Data (SST Solution)
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