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Merck
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GRIA2

glutamate receptor, ionotropic, AMPA 2

Synonyms:
GLUR2, GLURB, GluA2, GluR-K2, HBGR2
Species:
Human GRIA2 (2891), Mouse Gria2 (14800), Rat Gria2 (29627), chicken GRIA2 (414894), cow GRIA2 (614283), naked mole-rat Gria2 (101708417), domestic guinea pig Gria2 (100379153), sheep GRIA2 (443272), Horse GRIA2 (100069331), domestic cat GRIA2 (101088234)
UniProtKB ID:
P42262, Q96FP6
Gene ID:
  • Human(2891) Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(14800) glutamate receptor, ionotropic, AMPA2 (alpha 2)
  • Rat(29627) glutamate receptor, ionotropic, AMPA 2
  • chicken(414894) glutamate receptor, ionotropic, AMPA 2
  • cow(614283) glutamate receptor, ionotropic, AMPA 2
  • naked mole-rat(101708417) glutamate receptor, ionotropic, AMPA 2
  • domestic guinea pig(100379153) glutamate receptor, ionotropic, AMPA2 (alpha 2)
  • sheep(443272) glutamate receptor, ionotropic, AMPA 2
  • Horse(100069331) glutamate receptor, ionotropic, AMPA 2
  • domestic cat(101088234) glutamate receptor, ionotropic, AMPA 2
  • dog(482667) glutamate receptor, ionotropic, AMPA 2
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