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Merck
CN

441511

N-Acetyl-L-leucine

99%, for peptide synthesis, ReagentPlus®

Synonym(s):

N-Acetyl-L-(-)-leucine, Acetylleucine

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About This Item

Linear Formula:
(CH3)2CHCH2CH(NHCOCH3)CO2H
CAS Number:
1188-21-2
Molecular Weight:
173.21
NACRES:
NA.22
PubChem Substance ID:
24867665
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
214-706-3
MDL number:
MFCD00065131
Beilstein/REAXYS Number:
1724849

Key Documents

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Product Name

N-Acetyl-L-leucine, ReagentPlus®, 99%

InChI key

WXNXCEHXYPACJF-ZETCQYMHSA-N

InChI

1S/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12)/t7-/m0/s1

SMILES string

CC(C)C[C@H](NC(C)=O)C(O)=O

product line

ReagentPlus®

assay

99%

form

solid

optical activity

[α]25/D −23±3°, c = 2 in ethanol

reaction suitability

reaction type: C-H Activation, reaction type: solution phase peptide synthesis, reagent type: catalyst
reaction type: Peptide Synthesis

mp

187-190 °C (lit.)

application(s)

peptide synthesis

functional group

amine, carboxylic acid

Quality Level

100

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Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ3091
MKCX5210
MKCW5674
MKCW5675
MKCT7899

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Three-dimensional solid-state NMR experiment that correlates the chemical shift and dipolar coupling frequencies of two heteronuclei.
A Ramamoorthy et al.
Journal of magnetic resonance. Series B, 107(1), 88-90 (1995-04-01)
Silke Dorner et al.
Nucleic acids research, 33(9), 3065-3071 (2005-05-27)
The ribosome is a large RNP complex but its main enzymatic activity, the peptidyl transferase, is a ribozyme. As many RNA enzymes use divalent metal ions in catalysis, one of the hypotheses put forward proposed that metal ions might aid
Alexander A Nevzorov et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 164(1), 182-186 (2003-08-23)
A pulse sequence for high resolution separated local field spectroscopy based on "magic sandwich" elements is demonstrated on a single crystal sample. Simulations and experimental results show that this pulse sequence has a reduced frequency offset dependence compared to PISEMA
C Ferber-Viart et al.
Audiology & neuro-otology, 14(1), 17-25 (2008-07-30)
For 40 years, the amino acid acetyl-DL-leucine (or isoleucine - Tanganil) has been used in clinical practice to reduce imbalance and autonomic manifestations associated with acute vertigo crises. In animal models, acetyl-DL-leucine accelerates vestibular compensation following unilateral labyrinthectomy, and has
Gilles Clément et al.
Journal of vestibular research : equilibrium & orientation, 17(5-6), 227-237 (2008-07-16)
Pitch head-and-trunk movements during constant velocity rotation are a provocative vestibular stimulus that produces vertigo and nausea. When exposed to this stimulus repeatedly, motion sickness symptoms diminish as the subjects habituate. Acetylleucine is a drug that is used to treat
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