791806
Yu-Wasa Auxiliary
97%
Synonym(s):
2,3,5,6-Tetrafluoro-4-(trifluoromethyl)aniline, 2,3,5,6,α,α,α-Heptafluoro-p-toluidine
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About This Item
Linear Formula:
CF3C6F4NH2
CAS Number:
Molecular Weight:
233.09
UNSPSC Code:
12352101
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
2657893
Quality Segment
assay
97%
form
liquid
reaction suitability
reaction type: C-C Bond Formation, reagent type: catalyst
reaction type: C-H Activation
refractive index
n20/D 1.431 (lit.), n20/D 1.432
bp
186 °C (lit.)
density
1.662 g/mL at 25 °C, 1.687 g/mL at 25 °C (lit.)
functional group
fluoro
SMILES string
Nc1c(F)c(F)c(c(F)c1F)C(F)(F)F
InChI
1S/C7H2F7N/c8-2-1(7(12,13)14)3(9)5(11)6(15)4(2)10/h15H2
InChI key
FJOACTZFMHZHSC-UHFFFAOYSA-N
Other Notes
Acidic amides are superior directing groups for promoting C-H activation reactions with both Pd(0)/PR3 and Pd(II) catalysts.
Used in the Preparation of
Used in the Preparation of
- Lactams via palladium-catalyzed olefination of arylamides with benzylacrylate, followed by 1,4-conjugate addition
- N-(fluorinated aryl)benzamides as substrates for regioselective C-H amination reactions with O-benzoylhydroxylamines
- Substituted succinimides via palladium-catalyzed carbonylation of N-aryl amides
- N-aryl cyclopropanecarboxamide substrates and various amino acid ligands for palladium-catalyzed C-H activation of cyclopropanes
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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