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J4455

Sigma-Aldrich

JSH-23

≥98% (HPLC), solid

Synonym(s):

4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine

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100 μL
CN¥4,489.38

CN¥4,489.38

Estimated to ship onJuly 08, 2025Details

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100 μL
CN¥4,489.38

About This Item

Empirical Formula (Hill Notation):
C16H20N2
CAS Number:
749886-87-1
Molecular Weight:
240.34
UNSPSC Code:
51111800
NACRES:
NA.77

CN¥4,489.38

Estimated to ship onJuly 08, 2025Details

A recombinant, preservative-free antibody is available for your target. Try ZRB1760
Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

off-white to gray-pink

solubility

DMSO: >10 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

N(CCCc2ccccc2)c1c(cc(cc1)C)N

InChI

1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3

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Show Differences

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Manganese powder, ≥99.9% trace metals basis

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Manganese

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Manganese

form

powder

form

powder

form

powder

form

powder

assay

≥99.9% trace metals basis

assay

99.5%

assay

99.5%

assay

99.5%

bp

1962 °C (lit.)

bp

1962 °C (lit.)

bp

1962 °C (lit.)

bp

1962 °C (lit.)

resistivity

185 μΩ-cm, 20°C

resistivity

185 μΩ-cm, 20°C

resistivity

185 μΩ-cm, 20°C

resistivity

185 μΩ-cm, 20°C

mp

1244 °C (lit.)

mp

1244 °C (lit.)

mp

1244 °C (lit.)

mp

1244 °C (lit.)

density

7.3 g/mL at 25 °C (lit.)

density

7.3 g/mL at 25 °C (lit.)

density

7.3 g/mL at 25 °C (lit.)

density

7.3 g/mL at 25 °C (lit.)

Application

JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.[1][2][3]

Biochem/physiol Actions

JSH-23 is an inhibitor of NF-kB nuclear translocation.
JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.

Other Notes

Light and air sensitive.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Information

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000287114
    0000320982
    0000320982
    0000287114
    0000174552

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    Manganese in ferrous powder metallurgy
    Salak A, et al.
    Powder Metallurgy Progress, 1(1), 41-58 (2001)
    Novel synthesis of LiMn2O4 with large tap density by oxidation of manganese powder
    Guo H, et al.
    Energy Conversion and Management , 52(4), 2009-2014 (2011)
    Investigating surface properties of OHNS die steel after electrical discharge machining with manganese powder mixed in the dielectric
    Kumar S and Singh R
    The International Journal of Advanced Manufacturing Technology, 50(5-8), 625-633 (2010)
    D Mergler et al.
    Neurotoxicology, 20(2-3), 327-342 (1999-07-01)
    Excessive manganese (Mn) has been associated with neurobehavioral deficits and neurological and/or neuropsychiatric illness, but the level at which this metal can cause adverse neurotoxic effects, particularly with long-term exposure, is still unknown. The objective of the present study was
    D G Barceloux
    Journal of toxicology. Clinical toxicology, 37(2), 293-307 (1999-06-26)
    Manganese is a very hard, brittle metal, which is used to increase the strength of steel alloys. Absorption from the gastrointestinal tract occurs in the divalent and tetravalent forms. Permanganates, which are strong oxidizing agents, have a +7 valence. The
    View All Related Papers

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