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N3788

Anti-Nap1 (N-terminal) antibody produced in rabbit

Name: Anti-Nap1 (N-terminal) antibody produced in rabbit
Brand: SIGMA

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-NCK-associated protein 1, Anti-NCKAP1, Anti-p125Nap1

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

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Properties

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~125 kDa

species reactivity

rat, mouse, human

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1 mg/mL

technique(s)

western blot: 0.5-1 μg/mL using 3T3 cells lysate and HEK-293T cells expressing human Nap1

UniProt accession no.

Q9Y2A7

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NCKAP1(10787)
mouse ... Nckap1(50884)
rat ... Nckap1(58823)

Description

General description

Nap1 (N-terminal) interacts with Nck and may be involved in the downstream signaling of Nck [RGD].

Nap1 is also known as Nap125, Nck-associated protein 1, NCKAP1 or histone chaperone NAP1. It is an essential component of this signaling complex. This gene is located on human chromosome 2q32. It is an important apoptosis-related gene.

The gene encoding NCK associated protein 1 (NAP-1) is localized on human chromosome 2q32 and is expressed in neuronal cells.

Application

Anti-Nap1 (N-terminal) antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

NCK associated protein 1 (NAP-1) has been shown to be downregulated in Alzheimer′s disease.

Nck-associated protein 1 (NAP1/NCKAP1) along with Sra1 and ABI1 (Abl interactor 1) is involved in stabilizing WAVE2. Removal of Nap1 or Sra1 by RNAi abrogated the formation of lamellipodia induced by growth factor. Nap1 interacts directly with Abi1. It has been shown that Nap1 mediates the interaction of the Nap1-PIR121 complex to Abi1. Nap1 may participates in neuronal cell death in Alzheimer′s disease (AD).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

078M4825V

048K4801

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Global Trade Item Number

SKU	GTIN
N3788-200UL	04061837720970