SAB4700672
Monoclonal Anti-KRT18-FITC antibody produced in mouse
clone DC-10, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-Cytokeratin 18
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
FITC conjugate
Clone:
DC-10, monoclonal
Application:
FACS
Citations:
3
biological source
mouse
Quality Level
conjugate
FITC conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
DC-10, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
0.1 mg/mL
technique(s)
flow cytometry: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... KRT18(3875)
General description
Keratin 18/cytokeratin 18 (CK18) is a structural protein. It is present in single-layer epithelia. It is located on human chromosome 12q13.
The antibody DC-10 reacts with Cytokeratin 18 (45 kDa). Cytokeratins are a member of intermediate filaments subfamily represented in epithelial tissues.
Immunogen
Human breast carcinoma cell line PMC-42
Application
The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 5-10 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Biochem/physiol Actions
Keratins help to maintain the structural integrity. They also control Fas‐mediated apoptosis and regulate cell size and protein synthesis. Keratin 18 plays a major role in the development of lung cancer. It acts as a therapeutic target for non-small cell lung cancer (NSCLC).
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Cytokeratin 18 knockdown decreases cell migration and increases chemosensitivity in non-small cell lung cancer.
Zhang B
Journal of Cancer Research and Clinical Oncology, 142, 2479-2487 (2016)
Characterization of New Members of the Human Type II Keratin Gene Family and a General Evaluation of the Keratin Gene Domain on Chromosome 12q13.13
Rogers MA
The Journal of Investigative Dermatology, 124, 536-544 (2005)
Ricardo Rodrigues-Pinto et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 34(8), 1327-1340 (2016-02-26)
In humans, the nucleus pulposus (NP) is composed of large vacuolated notochordal cells in the fetus but, soon after birth, becomes populated by smaller, chondrocyte-like cells. Although animal studies indicate that notochord-derived cells persist in the adult NP, the ontogeny
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB4700672-100UG | 04061829673130 |