SML4011
BPTPE
≥98% (HPLC)
Synonym(s):
1,1-Bis(4-hydroxyphenyl)-2-phenyl-1-butene, 4,4′-(2-Phenyl-1-butenylidene)bis-phenol, 4,4′-(2-Phenylbut-1-ene-1,1-diyl)diphenol; triphenylethylene bisphenol
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About This Item
Empirical Formula (Hill Notation):
C22H20O2
CAS Number:
Molecular Weight:
316.39
UNSPSC Code:
51111800
MDL number:
NACRES:
NA.21
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Potent partial estrogen agonist.
BPTPE, an angular estrogen, is a potent partial estrogen agonist. It induces cell cycle regulated genes that are like those activated by E2 in MCF7 cells. BPTPE exhibits delayed induction of unfolded protein response (UPR) and apoptosis in numerous breast cancer models.
BPTPE, an angular estrogen, is a potent partial estrogen agonist. It induces cell cycle regulated genes that are like those activated by E2 in MCF7 cells. BPTPE exhibits delayed induction of unfolded protein response (UPR) and apoptosis in numerous breast cancer models.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Balkees Abderrahman et al.
Molecular pharmacology, 98(4), 364-381 (2020-08-14)
Long-term estrogen deprivation (LTED) with tamoxifen (TAM) or aromatase inhibitors leads to endocrine-resistance, whereby physiologic levels of estrogen kill breast cancer (BC). Estrogen therapy is effective in treating patients with advanced BC after resistance to TAM and aromatase inhibitors develops.
I E Obiorah et al.
British journal of pharmacology, 171(17), 4062-4072 (2014-05-14)
Triphenylethylene (TPE)-like compounds were the first agents to be used in the treatment of metastatic breast cancer in postmenopausal women. Although structurally related to the anti-oestrogen, 4-hydroxytamoxifen, TPEs possess oestrogenic properties in fully oestrogenized breast cancer cells but do not
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