Clarification Depth Filters & Pretreatment Solutions
Our clarification portfolio provides flexibility to the biopharma manufacturer for efficient cell, cellular debris and other insoluble contaminant removal and impurity clearance from different process streams from process development through large-scale manufacturing. Millistak+®, Millistak+® HC Pro and Clarisolve® Depth filters are available in Pod devices.
Products
Millistak+® HC Pro Filters
MILLISTAK+® HC PRO FILTERS
These are high capacity fully synthetic depth filters for primary and secondary clarification and downstream polishing applications.
Millistak+® Depth Filters
Millistak+® Depth Filters
These filters are offered in both Pod and lenticular formats.
- Millistak+® HC filters combine multiple layers of charged depth media for enhanced particulate retention and filter capacity for clarification and polishing applications.
- Millistak+® Carbon offers enhanced impurity clearance for turbidity reduction and polishing.
- Millistak+® DE filters are single layer clarification filters containing diatomaceous earth and a charged resin binder.
- Millistak+® CE filters are single layer clarification filters containing cellulose.
Clarisolve® Depth Filters and Flocculation Polymers
Clarisolve® depth filters offer a gradient density structure designed for efficient primary clarification of pretreated cell culture harvests.
- pDADMAC (poly(diallyldimethyl-ammonium chloride) is a cationic polymer for flocculation of cellular debris.
Support for Qualification, Risk Assessment, and Process Optimization
Complementing our product portfolio, the Emprove® Program provides three types of dossiers to support different stages of development and manufacturing operations such as qualification, risk assessment, and process optimization. The dossiers consolidate comprehensive product-specific testing data, quality statements, and regulatory information in a readily available format to simplify your compliance needs.
Related Product Resources
- Guide: Clarification Portfolio Guide
- Flyer: Clarification of Mammalian Cell Cultures by Depth Filtration
- Millistak+® HC Pro Synthetic Depth Filters
- Data Sheet: Millistak+® HC Pro Synthetic Depth Filters
- Data Sheet: Millistak+® Pod Carbon Depth Filter Media System
- Data Sheet: Clarification Solutions for Pre-treated Feed Streams
- Data Sheet: Millistak+® Pod Disposable Depth Filter System
- Industrial application of flocculation to streamline antibody purification process
- Article: pDADMAC Flocculation in Monoclonal Antibody Production Processes – Overcoming Regulatory Challenges with Quality Risk Management
Flocculants, like pDADMAC, remove cell debris during downstream monoclonal antibody production, but their adoption has been difficult due to perceived regulatory concerns.
- Article: Generic Process of Virus-Like Particle (VLP) Based Vaccine Manufacturing
- Article: Complete Clarification Solution for Processing High Density Cell Culture
- Article: Selection of Clarification Methods for Improved Downstream Performance and Economics
- Article: Evolving Clarification Strategies to Meet New Challenges
- Article: Industrial Application of Impurity Flocculation to Streamline Antibody Purification Processes
- Article: Development of a Novel and Efficient Cell Culture Flocculation Process Using a Stimulus Responsive Polymer to Streamline Antibody Purification Processes
- Guide: Millistak+® Pod Disposable Depth Filter Performance
- Application Note: Millistak+® Activated Carbon for mAb Downstream Purification
- Application Note: pDADMAC Flocculant Reagent for Use with Clarisolve® Depth Filters
- User Guide: Pod Depth Filters
- User Guide: μPod® Filters
How to standardize the process development approach for a two-step clarification process ensuring development of a robust, scalable unit operation.
pDADMAC for pretreatment of mammalian cell culture harvest utilizing Clarisolve® depth filters for improved primary & secondary clarification of flocculated feeds.
Join to hear case studies on effective separation of host cell proteins (HCPs), antibody fragments and low molecular weight substances from solutions containing mAbs.
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