Enhance Bioprocess Sampling with MAST® Autosampling Solution
The MAST® Autosampling Solution is a cutting-edge automated sampling solution for bioprocessing applications that minimizes the contamination risk during sample acquisition and enhances operational efficiency. The MAST® autosampler supports process analytical technology (PAT) implementation by enabling automated, timely sample acquisition, and analytical integration. As a result, utilizing MAST® Autosampling Solution in your bioprocess facilitates real-time monitoring, improved process understanding and tighter process control.
Key Benefits of the MAST® Autosampling Solution
This fully automated solution reduces the time and resources needed for sample processing, allowing for an increased sampling frequency with minimal operator touchpoints.
A unique closed system design and high-pressure cleaning, sanitization, and drying after sample collection protect sample source sterility and minimize contamination risks.
On-line, near real-time analytics with reduced turnaround times contribute to a more comprehensive understanding of the process and ensure timely process adjustments.
Reliable Automated Sampling in Biopharma manufacturing with MAST® Autosampling Solution
The MAST® Autosampling Solution is a versatile, modality-agnostic system that ensures the direct collection and delivery of samples for analysis from multiple sources without manual intervention. This automation enables the generation of significantly more data points which offers enhanced process insights while providing more time to focus on other, value-added tasks. It facilitates near real-time, on-line, or at-line measurements of critical process parameters (CPPs) and critical quality attributes (CQAs) in biopharmaceutical manufacturing, ensuring compliance with stringent regulations.
Configurable to fit any process and scale, MAST® Autosampling Solution can be combined with other PAT technologies, such as Raman spectroscopy, for improved calibration and validation of data-driven models.
The MAST® Autosampling Solution can accommodate:
- Up to ten sample sources, with a provision to support more sampling sources through configuration
- Up to four primary analytical destinations
- Multiple secondary analytical destinations
Components of MAST® Autosampling Solution
At its foundation, the MAST® Autosampling Solution comprises several integral components designed to fit your processing needs with ease.
Central component of the MAST® Autosampling Solution, designed to ensure sample source sterility while collecting samples for reliable delivery to their intended destinations. Two options exist for an ideal fit to the respective process set-up and scale.
Integral components, supported by the MASTconnect Software Suite, include the Master Controller for integrating Sample Pilots with valves and pumps; the Sample Navigator Controller for routing multiple Sample Pilots from different sources; and the Analytical Navigator for directing samples to primary analytical devices.
Implementation of MAST® Autosampling Solution
The MAST® Autosampling Solution is versatile and designed to operate with various analytical technologies and devices. It offers:
- Flexibility: Implement the MAST® Autosampling Solution at virtually any stage of your bioprocess. It allows for sample collection from process development scale to large-scale stainless-steel and single-use bioreactors in a GMP environment, and across upstream and downstream processing steps meeting stringent biopharmaceutical regulations.
- Services and Support: We provide comprehensive services by global experts to facilitate seamless integration. These services include application assessment, qualification, training, and tailored service reliance plans to save time, lower costs, and ensure compliance.
Sampling Throughout the Biomanufacturing Workflow
The MAST® Autosampling Solution offers a robust option for routine process monitoring throughout biopharmaceutical processes, from development to commercial stages. The system is particularly beneficial for processes requiring close monitoring and frequent sampling, such as those utilizing process analytical technology (PAT). Whenever critical sterility, mycoplasma, bioburden, and endotoxin testing is required, NovaSeptum® manual sterile sampling solutions can be used to complement the automated aseptic testing system.
Need more information? Jump to our technical article Bioprocess Sampling Systems: Find the Right Sampling Approach for Your Needs
Frequently Asked Questions
What are the benefits of using automated sampling in a bioprocess?
Automated sampling enhances process efficiency by reducing manual intervention and time needed to process and analyze collected samples. It allows for higher measurement frequency and faster turnaround times, contributing to improved process understanding and tighter control. Read our technical article to explore how automated sampling accelerates the collection of representative process data and supports process analytical technology (PAT) and Quality by Design (QbD) approaches
What is the MAST® Autosampling Solution?
The MAST® Autosampling Solution is an automated aseptic sampling system designed for biopharmaceutical manufacturing. It allows for the direct collection and delivery of samples from multiple sources and supports near real-time, on-line and at-line measurements of critical quality attribute (CQAs) and critical process parameters (CPPs) for maximum efficiency and regulatory compliance. Watch webinar for more information.
How does automated sampling improve data quality in biopharmaceutical manufacturing?
Automated sampling systems ensure that samples are collected in a controlled manner, reducing variability and human error. It is especially beneficial for routine process monitoring and where frequent data points are needed to gain process understanding, process control, and maintain product quality. When used as a component of process analytical technology (PAT) approaches, automated sampling enables a timely analysis of samples and rapid process optimization. Learn more about how automated sampling supports PAT in our dedicated technical article.
Can automated sampling be integrated with other analytical technologies?
Yes, automated sampling can be integrated with various analytical technologies, such as liquid chromatography and biochemistry analyzers, to enhance data collection and analysis. Integrating PAT into a bioprocess enables Quality by Design (QbD) by providing near real-time process understanding and control. Learn more about PAT and QbD in this technical article.
Will automated sampling cover all my sampling needs?
Automated sampling is especially beneficial for routine process monitoring and where frequent data points are needed to gain process understanding, improve process control and maintain product quality. For critical bioburden, sterility, and endotoxin testing, manual sterile sampling technologies are highly recommended to mitigate the risk of sample and process contamination.
Related Webinars
In this webinar we will explore the regulatory framework that guides sampling methodologies and outline the key qualifications necessary for effective sampling assembly, including system integrity evaluations.
we will focus on an automated sampling system and its utilization in perfusion cell culture for upstream process development. We will demonstrate an increased frequency of data acquisition for the online measurement of CPPs and automation of a sample processing workflow to reduce the time to measure CQAs in perfusion cultures.
This webinar explores how automation strategies and control schemes facilitate rapid analytical results, crucial for managing glycosylation variability that affects product quality.
Related Articles
- Key considerations for process analytical technology (PAT) implementation in biopharma and its role in enabling the facility of the future.
- Discover how automated aseptic sampling as a PAT tool accelerates access to analytical and quality data, supporting Quality by Design and real-time bioprocess control.
- Assessing on-line automated sampling as part of a PAT approach to shorten bioprocess development times through rapid, data-driven decisions.
- Discover how automated sampling technology facilitates and accelerates the integration of an in-line Raman analyzer in the bioprocessing workflow.
Related Documents
- Data Sheet: MAST® Autosampling Solution
The MAST®Autosampling Solution is a versatile & modality-agnostic aseptic autosampling solution for reliable on-line and near real-time sample analysis.
- White Paper: Automated Aseptic Sampling for Accelerated Access to Process and Quality Data in Upstream Bioprocessing
This white paper focuses on PAT and the use of automated sampling technology to accelerate analytical and quality control methods and provide an approach for access to in-line data to monitor processes in real time.
- Application Note: Enabling Accelerated Raman Model Calibration for Seamless and Reproducible Real-Time Monitoring by Combining Raman and Automated Sampling Technologies
Explore how automated sampling can accelerate the integration of a Raman analyzer for a bioreactor application and speed up the model building phase.
- White Paper: Accelerate Process Development with Automated Aseptic Sampling
This whitepaper describes evaluation of the MAST® Autosampling Solution as part of an automated PAT system implemented by Takeda Pharmaceuticals.
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