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Showing 31-60 of 5504 results for "CN34891" within Papers
Xia Li et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 978-979, 138-144 (2014-12-30)
A sensitive and rapid method based on formate-adduct ion detection was developed and fully validated for digoxin determination in rat plasma. For LC/MS/MS detection with formate-adducts as precursor ions, transitions of m/z 825.5→779.9 for digoxin and m/z 809.5→763.4 for the
John F Valliere-Douglass et al.
Journal of pharmaceutical sciences, 104(2), 652-665 (2014-12-04)
We report that a unique type of chemical modification occurs on lyophilized proteins. Freeze-dried mAbs and antibody-drug conjugates (ADCs) can be covalently modified with buffer and excipient molecules on the side chains of Glu, Asp, Thr, and Ser amino acids
Maryam Rajabi et al.
Journal of separation science, 38(14), 2496-2502 (2015-05-20)
In this work, two disperser-free microextraction methods, namely, air-agitated liquid-liquid microextraction and ultrasound-assisted emulsification microextraction are compared for the determination of a number of polycyclic aromatic hydrocarbons in aqueous samples, followed by gas chromatography with flame ionization detection. The effects
Keisuke Ohsumi et al.
The Journal of antibiotics, 67(10), 707-711 (2014-05-29)
A novel antifungal agent, AS2077715, was isolated from the fermentation broth of a fungal strain (339855) identified as a new Capnodium species based on morphological characteristics and large-subunit ribosomal DNA sequencing. AS2077715 was isolated as a white powder via solvent
Lei Wang et al.
Biochimie, 112, 129-138 (2015-03-15)
Cone snails are incredibly rich sources of bioactive conopeptides with potential for use in neuroscience research and novel drug development. In order to investigate the synthesis of diversified conopeptides in venom glands, the proteome and peptidome profiles of conus venom
Tangeng Ma et al.
BMC research notes, 8, 687-687 (2015-11-20)
Use of allogeneic cancer cells-based immunotherapy for treatment of established prostate cancer (PCa) has only been marginally effective. One reason for failure could stem from the mismatch of antigenic signatures of vaccine cells and cancer in situ. Hence, it is
Salim Sioud et al.
Rapid communications in mass spectrometry : RCM, 28(22), 2389-2397 (2014-10-11)
The formation of ions during atmospheric pressure photoionization (APPI) mass spectrometry in the positive mode usually provides radical cations and/or protonated species. Intriguingly, during the analysis of some N-alkyl-substituted thieno[3,4-c]pyrrole-4,6-dione (TPD) derivatives synthesized in our laboratory, unusual [M-H](+) ion peaks
Marco Pistolozzi et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(3), 344-352 (2014-12-17)
This work describes the sequential hydrolysis of bambuterol enantiomers and their monocarbamate metabolites (MONO) catalyzed by human butyrylcholinesterase (BChE) as well as the enzyme inhibition resulting from this process. Particular emphasis is given to the contribution given by MONO to
Wei Li et al.
Die Pharmazie, 70(5), 340-346 (2015-06-13)
In the present work, we report efficient production of ginsenoside M1 (G-M1) from ginsenoside Rd (G-Rd) by snailase hydrolysis using response surface methodology (RSM). During investigation of the hydrolysis of ginsenoside Rd by various glycoside hydrolases, snailase showed a strong
Qingce Zang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 989, 91-97 (2015-03-31)
Usually, insufficient intratumoral concentration of therapeutic drugs is one of the reasons for tumor treatment failure. However, little is known about intratumoral distribution of bromocriptine in non-responding prolactinomas because of extremely low drug concentration and small prolactinoma tissue samples. In
Teresa L Parsons et al.
Antimicrobial agents and chemotherapy, 58(11), 6747-6757 (2014-09-04)
The quantification of antituberculosis drug concentrations in multinational trials currently requires the collection of modest blood volumes, centrifugation, aliquoting of plasma, freezing, and keeping samples frozen during shipping. We prospectively enrolled healthy individuals into the Tuberculosis Trials Consortium Study 29B
Vindhya Edpuganti et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 964, 153-163 (2013-10-19)
The cytochrome P450 metabolites of arachidonic acid (AA) are mostly present in tissues, such as the liver, as bound to phospholipids, with only a small fraction available as free acids. The purpose of this study was to develop and validate
Cong-Mei Cao et al.
Journal of chromatographic science, 53(7), 1044-1047 (2014-12-04)
An analytical method based on high-performance liquid chromatography-photodiode array detection was developed for the simultaneous determination of three anti-proliferative withanolides [withalongolide A ( 1: ), withaferin A ( 2: ) and withalongolide B ( 3: )] present in the aboveground
Chaolan Shi et al.
International immunopharmacology, 24(2), 211-218 (2014-12-17)
The sulfated polysaccharide from Porphyra was hypothesized to exhibit immunoregulatory, anti-tumor and anti-inflammatory activity, but its anti-allergic activity is not fully understood. Therefore, the aim of this study was to isolate sulfated polysaccharide from Porphyra haitanensis (PHPS) and investigate its
Nikolaos Lemonakis et al.
Talanta, 147, 402-409 (2015-11-26)
A multistage optimization of all the parameters affecting detection/response in an LTQ-orbitrap analyzer was performed, using a design of experiments methodology. The signal intensity, a critical issue for mass analysis, was investigated and the optimization process was completed in three
John Warner et al.
Talanta, 146, 279-284 (2015-12-24)
Solvent tolerance of immobilized enzymes is important for many biosensing and biotechnological applications. In this paper we report an acetylcholinesterase (AChE) biosensor based on chitosan that exhibits high solvent resistance and enables sensitive detection of pesticides in presence of a
Karen E Parrish et al.
Molecular cancer therapeutics, 14(12), 2735-2743 (2015-10-07)
PARP inhibition can enhance the efficacy of temozolomide and prolong survival in orthotopic glioblastoma (GBM) xenografts. The aim of this study was to evaluate the combination of the PARP inhibitor rucaparib with temozolomide and to correlate pharmacokinetic and pharmacodynamic studies
Elena Geromichalou et al.
European journal of medicinal chemistry, 96, 47-57 (2015-04-16)
Recent science evidenced the interlinkage of oxidative stress and cancer. Due to the inherent complexity of cancer and its accompanying effect of oxidative stress, novel molecules, containing combinatorial functionalities should be targeted. Herein, we synthesized gemcitabine-5'-O-lipoate derived from a regioselective
Niketkumar Patel et al.
Pharmaceutical development and technology, 20(4), 442-457 (2014-01-29)
Freshly excised rat skin and side-by-side permeation cells were used to study the effect of electronic and formulation variables on transdermal iontophoretic delivery of tacrine. Current strength at 0.1-0.3 mA was observed to be the driving force resulting in tacrine
Florian Hladik et al.
eLife, 4 (2015-02-04)
Tenofovir gel is being evaluated for vaginal and rectal pre-exposure prophylaxis against HIV transmission. Because this is a new prevention strategy, we broadly assessed its effects on the mucosa. In MTN-007, a phase-1, randomized, double-blinded rectal microbicide trial, we used
Luca Campone et al.
Analytical and bioanalytical chemistry, 407(10), 2899-2911 (2015-02-20)
According to current demands and future perspectives in food safety, this study reports a fast and fully automated analytical method for the simultaneous analysis of the mycotoxins with high toxicity and wide spread, aflatoxins (AFs) and ochratoxin A (OTA) in
Maria Gonzalez-Rey et al.
Marine pollution bulletin, 96(1-2), 384-400 (2015-05-23)
This paper deals with the detection and quantification of APIs and other priority substances in the Arade River estuary (Portugal) providing the usefulness of Polar Organic Compound Integrative Samplers (POCIS). Thirteen APIs were detected whose variation was site and time
Matthew B O'Rourke et al.
Rapid communications in mass spectrometry : RCM, 29(19), 1836-1840 (2015-09-04)
This paper, in conjunction with a work published earlier this year by O'Rourke et al., aims to provide a comprehensive set of protocols for the analysis of formalin-fixed paraffin-embedded (FFPE) tissue via matrix-assisted laser desorption/ionisation imaging mass spectrometry (MALDI IMS)
Soubhagya Kumar Bhuyan et al.
Scientific reports, 5, 13911-13911 (2015-09-10)
Microbial communities in rhizosphere interact with each other and form a basis of a cumulative impact on plant growth. Rhizospheric microorganisms like Piriformospora indica and Azotobacter chroococcum are well known for their beneficial interaction with plants. These features make P.
Magali Kemmerich et al.
Journal of chromatography. A, 1412, 82-89 (2015-08-19)
The use of pesticides in agriculture has generated numerous consequences to the environment, requiring analysis of the persistent residues in soil, water and air. The variability of soil properties interferes in the extraction of pesticide residues with robustness and accuracy.
Wei Liu et al.
PloS one, 10(4), e0122366-e0122366 (2015-04-08)
Vasicine (VAS), a potential natural cholinesterase inhibitor, exhibited promising anticholinesterase activity in preclinical models and has been in development for treatment of Alzheimer's disease. This study systematically investigated the in vitro and in vivo metabolism of VAS in rat using
Nitesh K Kunda et al.
International journal of pharmaceutics, 492(1-2), 213-222 (2015-07-15)
Pulmonary delivery of macromolecules has been the focus of attention as an alternate route of delivery with benefits such as; large surface area, thin alveolar epithelium, rapid absorption and extensive vasculature. In this study, a model protein, bovine serum albumin
Paweł Kubica et al.
Analytical and bioanalytical chemistry, 407(5), 1505-1512 (2014-12-05)
The method for the determination of acesulfame-K, saccharine, cyclamate, aspartame, sucralose, alitame, neohesperidin dihydrochalcone, neotame and five common steviol glycosides (rebaudioside A, rebaudioside C, steviol, steviolbioside and stevioside) in soft and alcoholic beverages was developed using high-performance liquid chromatography and
Xin Zhao et al.
Colloids and surfaces. B, Biointerfaces, 130, 1-9 (2015-04-17)
Implantable tissue engineering scaffolds with temporally programmable multi-drug release are recognized as promising tools to improve therapeutic effects. A good example would be one that exhibits initial anti-inflammatory and long-term anti-tumor activities after tumor resection. In this study, a new
Yi Huang et al.
Pharmaceutical biology, 52(6), 681-687 (2014-05-16)
Alismatis rhizome (RA) (Water Plantain Family, also called "Zexie" in Chinese), one of the commonly used components of traditional Chinese medicines, is derived from the dried rhizomes of Alisma orientalis (Sam.) Juzep. (Alismataceae). This study explores the RA influences on
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