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Showing 31-60 of 5504 results for "CN34891" within Papers
Elisabeth Eckert et al.
Journal of chromatography. A, 1410, 173-180 (2015-08-06)
Di(2-ethylhexyl) phthalate (DEHP) and tri(2-ethylhexyl) trimellitate (TEHTM or TOTM) are common plasticizers that are also largely used for PVC medical devices, e.g. bags and tubing for blood transfusions and infusions. The leachability of medical devices is a well-known situation of
Chamira Dilanka Fernando et al.
Nutrition journal, 14, 74-74 (2015-08-01)
Tea is the most consumed beverage in the world which is second only to water. Tea contains a broad spectrum of active ingredients which are responsible for its health benefits. The composition of constituents extracted to the tea brew depends
Tianshi Feng et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 1086-1093 (2014-10-12)
PLGA porous microspheres loaded with doxorubicin (DOX) and paclitaxel (PTX) were developed for in situ treatment of metastatic lung cancer. The synergistic effect of the combined drugs was investigated against B16F10 cells to obtain the optimal prescription for in vivo
Yoshimasa Taniguchi et al.
Bioscience, biotechnology, and biochemistry, 79(10), 1684-1694 (2015-05-23)
The bitter acids in hops (Humulus lupulus L.) and beer, such as α-, β-, and iso-α-acids, are known to affect beer quality and display various physiological effects. However, these compounds readily oxidize, and the effect of the oxides on the
Coleman T Turgeon et al.
Molecular genetics and metabolism, 114(1), 46-50 (2014-12-08)
Pre-symptomatic hematopoietic stem cell transplantation is essential to achieve best possible outcomes for patients with the childhood cerebral form of X-linked adrenoleukodystrophy (X-ALD). We describe a high-throughput method for measurement of C20-C26 lysophosphatidylcholines (LPCs) and biochemical diagnosis of X-ALD using
Yisheng Chen et al.
Journal of chromatography. A, 1356, 249-257 (2014-07-13)
The world-wide usage and partly abuse of veterinary antibiotics resulted in a pressing need to control residues in animal-derived foods. Large-scale screening for residues of antibiotics is typically performed by microbial agar diffusion tests. This work employing high-performance thin-layer chromatography
Zachary Ridgway et al.
Biopolymers, 104(4), 384-394 (2015-02-12)
Tryptophan (Trp) is a naturally occurring amino acid, which exhibits fluorescence emission properties that are dependent on the polarity of the local environment around the Trp side chain. However, this sensitivity also complicates interpretation of fluorescence emission data. A non-natural
David Ilko et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 94, 569-574 (2014-12-03)
The fatty acid (FA) composition of polysorbate 80 (PS80), a sorbitan oleic acid ester copolymerized with about 20mole of ethylene oxide, is typically characterized by gas chromatography. Here, an alternative method was developed. After saponification with potassium hydroxide the FA
Yoshiaki Ohtsu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 997, 56-63 (2015-06-21)
We developed and validated bioanalytical methods for a potent helicase-primase inhibitor ASP2151 that has two conformers. These conformers elute as unseparated broad peaks under ordinary high-performance liquid chromatographic conditions, indicating discernable differences in hydrophobicity. We observed that column temperature and
Roberta Jeane B Jorge et al.
Journal of proteomics, 114, 93-114 (2014-12-03)
The Caatinga lancehead, Bothrops erythromelas, is a medically relevant species, responsible for most of the snakebite accidents in most parts of its distribution range in northeastern Brazil. The spectrum and geographic variability of its venom toxins were investigated applying a
Quantitative lipidomic analysis of plasma and plasma lipoproteins using MALDI-TOF mass spectrometry.
Jorge Serna et al.
Chemistry and physics of lipids, 189, 7-18 (2015-05-26)
Knowledge of the plasma lipid composition is essential to clarify the specific roles of different lipid species in various pathophysiological processes. In this study, we developed an analytical strategy combining high-performance liquid chromatography with evaporative light scattering detection (HPLC-ELSD) and
Lauriane Goldwirt et al.
Journal of neuro-oncology, 122(2), 273-281 (2015-03-22)
Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. Prognosis of GBM patients is poor with median overall survival around 15 months. Temozolomide is the chemotherapeutic agent used in the standard of care of newly diagnosed GBM
Boning Wu et al.
The journal of physical chemistry. B, 119(46), 14790-14799 (2015-10-27)
Ionic liquids with electron-donating anions are used to investigate rates and mechanisms of photoinduced bimolecular electron transfer to the photoexcited acceptor 9,10-dicyanoanthracene (9,10-DCNA). The set of five cyano anion ILs studied comprises the 1-ethyl-3-methylimidazolium cation paired with each of these
Mark Berlin et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 93, 267-280 (2015-04-15)
Many active pharmaceutical ingredients (APIs) exhibit a highly variable pharmacokinetic (PK) profile. This behavior may be attributable to pre-absorptive, absorptive and/or post-absorptive factors. Pre-absorptive factors are those related to dosage form disintegration, drug dissolution, supersaturation, precipitation and gastric emptying. Absorptive
Nani Wang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 990, 64-72 (2015-04-12)
Epimedii herba is a traditional Chinese medicine for the treatment of osteoporosis. Epimedin A, B and C and icariin are the primary effective ingredients of this medicine. In this study, a simple and low-cost method based on pipette tip solid-phase
Filip Kiekens et al.
Journal of chromatography. A, 1398, 20-28 (2015-05-06)
A stable isotope dilution LC-MS/MS method is the method of choice for the selective quantitative determination of several folate species in clinical samples. By implementing an integrated approach to determine both the plasma and red blood cell (RBC) folate status
L Hernychová et al.
Physiological research, 64 Suppl 1, S85-S93 (2015-10-09)
As a part of the innate immunity, NK (Natural Killer) cells provide an early immune response to different stimuli, e.g. viral infections and tumor growths. However, their functions are more complex; they play an important role in reproduction, alloimmunity, autoimmunity
Jana Paulsen et al.
Phytochemistry, 111, 149-153 (2015-02-11)
The genuine major benzylisoquinoline alkaloid occurring in the traditional medicinal plant greater celandine (Chelidonium majus L.) is 13,14-dihydrocoptisine and not - as described previously - coptisine. Structure of 13,14-dihydrocoptisine was elucidated. The discrepancy between the alkaloid pattern of the living
Srinivas Rao Chennamaneni et al.
Pharmaceutical research, 31(11), 3179-3190 (2014-06-21)
To advance therapy for the treatment of concurrent uveitis and post-cataract surgical inflammation; we evaluated pharmacokinetics and pharmacodynamics of Bioerodible Dexamethasone Implant (BDI) containing 0.3 mg of dexamethasone (DXM) in Concanavalin A (Con A) induced uveitis followed by phacoemulsification in
Sylwia Magiera et al.
Journal of separation science, 37(22), 3314-3315 (2014-08-28)
A novel analytical approach has been developed for the determination of selected drugs (milrinone, enalapril, carvedilol, spironolactone, acenocumarol, ticlopidine, cilazapril) and their metabolites (2-oxoticlopidine, cilazaprilat, canrenone, 5'-hydroxycarvedilol, O-desmethyl-carvedilol, enalaprilat) in human urine, based on a miniaturized extraction technique; semiautomatic microextraction by
C Ortiz-Bolsico et al.
Journal of chromatography. A, 1350, 51-60 (2014-06-04)
A mixture of compounds often cannot be resolved with a single chromatographic column, but the analysis can be successful using columns of different nature, serially combined through zero-dead volume junctions. In previous work (JCA 1281 (2013) 94), we developed an
Thomas J Raub et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(9), 1360-1371 (2015-07-08)
Effective treatments for primary brain tumors and brain metastases represent a major unmet medical need. Targeting the CDK4/CDK6-cyclin D1-Rb-p16/ink4a pathway using a potent CDK4 and CDK6 kinase inhibitor has potential for treating primary central nervous system tumors such as glioblastoma
Jun Zhang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 995-996, 1-7 (2015-05-27)
A simple, selective, and sensitive LC/MS/MS method was developed and validated for simultaneous determination of eupalinolide A, eupalinolide B, and hyperoside in rat plasma. Plasma samples were processed by protein precipitation with acetonitrile. The three analytes, together with internal standard
John S Hargreaves et al.
Nucleosides, nucleotides & nucleic acids, 34(10), 691-707 (2015-09-24)
The reaction of 2'-deoxynucleoside phosphoramidites with water is an important degradation reaction that limits the lifetimes of reagents used for chemical deoxyoligonucleotide synthesis. The hydrolysis of nucleoside phosphoramidites in solution has therefore been investigated. The degree of degradation depends not
Maofeng Dong et al.
Journal of separation science, 38(13), 2245-2252 (2015-04-25)
A sensitive, simple and reliable analytical method based on a modified quick, easy, cheap, effective, rugged, safe sample preparation and liquid chromatography with tandem mass spectrometry detection was developed for the simultaneous determination of amicarbazone and its two major metabolites
Ren-Bo Ding et al.
Journal of agricultural and food chemistry, 63(9), 2413-2422 (2015-02-11)
The aim of present study was to evaluate the effects of Panax notoginseng saponins (PNS) against acute ethanol-induced liver injury and further to elucidate its probable mechanisms. Mice were treated with PNS (100 or 300 mg/kg) once daily for seven
Xiao Yang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 972, 111-116 (2014-12-03)
A simple extraction method based on acetonitrile-K2HPO4 aqueous two-phase system was developed for separation and enrichment of five triazines in milk samples. Acetonitrile was used for extraction of analytes from milk sample and precipitation of milk protein. Deproteinization and extraction
Naseer Ali Shah et al.
BioMed research international, 2014, 726241-726241 (2014-07-02)
Jurinea dolomiaea Boiss., family Compositae, is a medicinally important plant of alpine region. Its tuberous roots are used in various ailments in folk medicine. This study was undertaken to estimate total phenolic (TPC) and total flavonoid contents (TFC) and to
Yuqin Li et al.
World journal of microbiology & biotechnology, 31(5), 773-783 (2015-03-01)
A structured heterotrophic-iron (II) induction (HII) strategy was proposed to enhance lipid accumulation in oleaginous Chlorella protothecoides. C. protothecoides subjected to heterotrophic-iron (II) induction achieved a favorable lipid accumulation up to 62 % and a maximum lipid productivity of 820.17 mg/day
Jose Castro-Perez et al.
Rapid communications in mass spectrometry : RCM, 28(22), 2471-2479 (2014-10-11)
The ability to quantify rates of formation, regression and/or remodeling of atherosclerotic plaque should facilitate a better understanding of the pathogenesis and management of cardiovascular disease. In the current study, we coupled a stable isotope labeled tracer protocol with matrix-assisted
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