Vaccine manufacturing

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Evolution of Vaccine Processing to Accelerate Innovation presented by Oliver Prince, PhD. The COVID pandemic and Industry 4.0 acceleration have highlighted the need for concrete solutions for agile vaccine manufacturing. For this talk, we will discuss recent trends, solutions and

Egg-based and Cell-based Influenza Vaccine Manufacturing Methods

Influenza vaccines are commonly made using egg-based and cell-based manufacturing strategies. Find step-by-step information on the manufacturing process for each method.

Cost Modeling Vaccine Manufacturing: Estimate Production Costs for mRNA and other Vaccine Modalities

A custom-designed cost model is used to explore the economics of vaccine manufacturing across several different modalities including mRNA. The model enables greater process understanding, simulates bottlenecks, and helps to optimize production efficiency.

Cell Harvest, Lysis, Neutralization and Clarification of Plasmid DNA (pDNA) for mRNA, plasmid-based DNA Vaccines, and Viral Vector applications

An overview of the cell harvest, lysis, neutralization, and clarification steps used for pDNA purification along with case study and practical advice.

Vaccine Manufacturing

From early phase development, through downstream purification to large scale vaccine production: learn more about vaccine process development and application expertise.

mRNA Vaccine Manufacturing

mRNA vaccine technology offers rapid development and scalable manufacturing for disease prevention.

Plasmid DNA Vaccines Manufacturing

Learn about overcoming challenges in manufacturing pDNA vaccines, including low productivity and separation issues.

Platform Technologies to Accelerate Novel Vaccine Development and Manufacturing

In this webinar, we present a comparison of novel technologies, discuss key considerations for manufacturing, and share selected case studies for platforms such as virus-like-particles, viral vectors, plasmid DNA, and mRNA platforms.

Manufacturing Strategies for mRNA Vaccines and Therapeutics

mRNA technology uses non-viral delivery systems and offers a great deal of versatility. Delivery of an mRNA into the cytosol of a cell can induce the production of a target protein which can function as a therapeutic or prophylactic, act

mRNA Synthesis for the Development of Vaccines and Therapeutics

Understand how mRNA vaccines induce immunity. and read how synthetic mRNA is prepared for vaccine immunogens and other biopharmaceuticals. Find reagents for synthesis of mRNA.

Virus-like Particle (VLP) Vaccine Bioprocessing and Formulation Steps

This technical article breaks down the steps of upstream and downstream bioprocessing and formulation of virus-like particle vaccines.

BIO International

We warmly invite you to visit booth 4735 at BIO International and connect with the MilliporeSigma team.

Virus-Based Vaccine Manufacturing

Manufacturing viral vaccines is complex and there is no templated approach. Each process must be tailored to the shape, size, nature, physico-chemical behavior, stability, and host specificity of the virus. Learn all about this core platform technology and how expertise—empowered

Virus-like Particles (VLPs) Vaccine Manufacturing

VLP vaccine manufacturers must optimize upstream productivity with reliable scale-up, achieve yield and efficiency goals with robust impurity removal, maximize downstream recovery, and ensure patient safety. Merck’s integrated portfolio, regulatory and applications expertise can help address these process challenges.

Viral Vector Vaccine Manufacturing

A relatively templated manufacturing process can be used to produce live vector vaccines. Challenges exist, however, and include yield loss due to sterile filtration, vector aggregation and scaling adherent cultures. Learn all about this core platform technology and how expertise—empowered

Plasmid DNA (pDNA) Manufacturing Process: Downstream Purification

Get a step-by-step overview of the plasmid DNA manufacturing process and the challenges in pDNA downstream purification. Read our free pDNA downstream purification eBook for mRNA, plasmid-based DNA Vaccines, and Viral Vector applications.

Protein Subunit Vaccine Manufacturing

This page provides an overview of protein subunit vaccines, which incorporate a recombinant protein fragment derived from the viral pathogen. It includes a description of the subunit vaccine manufacturing workflow and the products and technologies that are essential to ensure